{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:01:29Z","timestamp":1777651289814,"version":"3.51.4"},"reference-count":64,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/100008394","name":"Natur og Univers, Det Frie Forskningsr\u00e5d","doi-asserted-by":"crossref","award":["4181-00094"],"award-info":[{"award-number":["4181-00094"]}],"id":[{"id":"10.13039\/100008394","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002739","name":"Aarhus Universitets Forskningsfond","doi-asserted-by":"publisher","award":["AUFF-E-2016-9-37"],"award-info":[{"award-number":["AUFF-E-2016-9-37"]}],"id":[{"id":"10.13039\/501100002739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20GM121307"],"award-info":[{"award-number":["P20GM121307"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Hydrogen sulfide (H2S) controls numerous physiological responses. To understand its proposed role in metabolic suppression, we measured free H2S and bound sulfane sulfur (BSS) in tissues of the freshwater turtle Trachemys scripta, a species undergoing strong metabolic suppression when cold and anoxic. In warm normoxic turtles, free H2S was higher in red blood cells (RBCs) and kidney (\u223c9-10 \u00b5mol l\u22121) compared to brain, liver and lung (\u223c1-2 \u00b5mol l\u22121). These values overall aligned with the tissue H2S-generating enzymatic activity. BSS levels were similar in all tissues (\u223c0.5 \u00b5mol l\u22121) but \u223c100-fold higher in RBCs, having a high thiol content, suggesting that RBCs function as a circulating H2S reservoir. Cold-acclimation caused significant changes in free and bound H2S in liver, brain and RBCs, but anoxia had no further effect, except for the brain. These results show tissue-dependent sulfide signaling with a potential role in brain metabolic suppression during anoxia in turtles.<\/jats:p>","DOI":"10.1242\/jeb.203976","type":"journal-article","created":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T13:45:10Z","timestamp":1558359910000},"source":"Crossref","is-referenced-by-count":5,"title":["Tissue-dependent variations of hydrogen sulfide homeostasis in anoxic freshwater turtles"],"prefix":"10.1242","author":[{"given":"Birgitte","family":"Jensen","sequence":"first","affiliation":[{"name":"Department of Bioscience, Aarhus University, DK-8000 Aarhus C, Denmark"},{"name":"Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sibile","family":"Pardue","sequence":"additional","affiliation":[{"name":"Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher G.","family":"Kevil","sequence":"additional","affiliation":[{"name":"Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7315-2628","authenticated-orcid":false,"given":"Angela","family":"Fago","sequence":"additional","affiliation":[{"name":"Department of Bioscience, Aarhus University, DK-8000 Aarhus C, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2019,1,1]]},"reference":[{"key":"2021042513220455600_JEB203976C1","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996","article-title":"The possible role of hydrogen sulfide as an endogenous neuromodulator","volume":"16","author":"Abe","year":"1996","journal-title":"J. Neurosci."},{"key":"2021042513220455600_JEB203976C2","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1146\/annurev.physiol.69.031905.162529","article-title":"Hypoxia tolerance in reptiles, amphibians, and fishes: life with variable oxygen availability","volume":"69","author":"Bickler","year":"2007","journal-title":"Annu. Rev. Physiol."},{"key":"2021042513220455600_JEB203976C3","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1126\/science.1108581","article-title":"H2S induces a suspended animation\u2013like state in mice","volume":"308","author":"Blackstone","year":"2005","journal-title":"Science"},{"key":"2021042513220455600_JEB203976C4","doi-asserted-by":"publisher","first-page":"174391","DOI":"10.1242\/jeb.174391","article-title":"Suppression of reactive oxygen species generation in heart mitochondria from anoxic turtles: the role of complex I S-nitrosation","volume":"1","author":"Bundgaard","year":"2018","journal-title":"J. Exp. Biol."},{"key":"2021042513220455600_JEB203976C5","doi-asserted-by":"publisher","first-page":"2850","DOI":"10.1038\/s41598-019-39836-5","article-title":"Metabolic adaptations during extreme anoxia in the turtle heart and their implications for ischemia-reperfusion injury","volume":"9","author":"Bundgaard","year":"2019","journal-title":"Sci. Rep."},{"key":"2021042513220455600_JEB203976C6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphar.2016.00385","article-title":"The role of hydrogen sulfide in renal system","volume":"7","author":"Cao","year":"2016","journal-title":"Front. Pharmacol."},{"key":"2021042513220455600_JEB203976C7","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s00360-019-01204-0","article-title":"Hydrogen sulphide toxicity and the importance of amphibious behaviour in a mangrove fish inhabiting sulphide-rich habitats","volume":"189","author":"Cochrane","year":"2019","journal-title":"J. Comp. Physiol. B"},{"key":"2021042513220455600_JEB203976C8","doi-asserted-by":"publisher","first-page":"22090","DOI":"10.1073\/pnas.0904082106","article-title":"Using a functional enzyme model to understand the chemistry behind hydrogen sulfide induced hibernation","volume":"106","author":"Collman","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042513220455600_JEB203976C9","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/s10863-008-9166-6","article-title":"The inhibition of mitochondrial cytochrome oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: Chemical mechanism and physiological significance","volume":"40","author":"Cooper","year":"2008","journal-title":"J. Bioenerg. Biomembr."},{"key":"2021042513220455600_JEB203976C10","doi-asserted-by":"publisher","first-page":"E4651","DOI":"10.1073\/pnas.1509277112","article-title":"Key bioactive reaction products of the NO\/H2S interaction are S\/N-hybrid species, polysulfides, and nitroxyl","volume":"112","author":"Cortese-Krott","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042513220455600_JEB203976C11","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1089\/ars.2017.7083","article-title":"The reactive species interactome: evolutionary emergence, biological significance and opportunities for redox metabolomics and personalized medicine","volume":"27","author":"Cortese-Krott","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"2021042513220455600_JEB203976C12","doi-asserted-by":"publisher","first-page":"R961","DOI":"10.1152\/ajpregu.00284.2013","article-title":"Hemoglobin isoform differentiation and allosteric regulation of oxygen binding in the turtle, Trachemys scripta","volume":"305","author":"Damsgaard","year":"2013","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2021042513220455600_JEB203976C13","doi-asserted-by":"publisher","first-page":"R243","DOI":"10.1152\/ajpregu.00324.2004","article-title":"Vertebrate phylogeny of hydrogen sulfide vasoactivity","volume":"288","author":"Dombkowski","year":"2004","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2021042513220455600_JEB203976C14","doi-asserted-by":"publisher","first-page":"15560","DOI":"10.1073\/pnas.0705891104","article-title":"Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function","volume":"104","author":"Elrod","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042513220455600_JEB203976C15","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1152\/physiol.00051.2014","article-title":"Hypoxia tolerance, nitric oxide, and nitrite: Lessons from extreme animals","volume":"30","author":"Fago","year":"2015","journal-title":"Physiology"},{"key":"2021042513220455600_JEB203976C16","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1089\/ars.2013.5304","article-title":"Hydrogen sulfide targets EGFR Cys797\/Cys798 residues to induce Na+\/K+-ATPase endocytosis and inhibition in renal tubular epithelial cells and increase sodium excretion in chronic salt-loaded rats","volume":"21","author":"Ge","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"2021042513220455600_JEB203976C17","doi-asserted-by":"publisher","first-page":"3352","DOI":"10.1111\/j.1742-4658.2008.06482.x","article-title":"Three enzymatic activities catalyze the oxidation of sulfide to thiosulfate in mammalian and invertebrate mitochondria","volume":"275","author":"Hildebrandt","year":"2008","journal-title":"FEBS J."},{"key":"2021042513220455600_JEB203976C18","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1006\/bbrc.1997.6878","article-title":"The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide","volume":"237","author":"Hosoki","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021042513220455600_JEB203976C19","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1089\/ars.2008.2132","article-title":"A source of hydrogen sulfide and a mechanism of its release in the brain","volume":"11","author":"Ishigami","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"2021042513220455600_JEB203976C20","doi-asserted-by":"publisher","first-page":"2560","DOI":"10.1242\/jeb.070367","article-title":"Circulating nitric oxide metabolites and cardiovascular changes in the turtle Trachemys scripta during normoxia, anoxia and reoxygenation","volume":"215","author":"Jacobsen","year":"2012","journal-title":"J. Exp. Biol."},{"key":"2021042513220455600_JEB203976C21","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.jinorgbio.2018.02.007","article-title":"Reactions of ferric hemoglobin and myoglobin with hydrogen sulfide under physiological conditions","volume":"182","author":"Jensen","year":"2018","journal-title":"J. Inorg. Biochem."},{"key":"2021042513220455600_JEB203976C22","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1242\/jeb.093179","article-title":"Nitric oxide metabolites during anoxia and reoxygenation in the anoxia-tolerant vertebrate Trachemys scripta","volume":"217","author":"Jensen","year":"2014","journal-title":"J. Exp. Biol."},{"key":"2021042513220455600_JEB203976C23","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1089\/ars.2014.5869","article-title":"Signaling molecules: Hydrogen sulfide and polysulfide","volume":"22","author":"Kimura","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"2021042513220455600_JEB203976C24","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.niox.2014.01.002","article-title":"The physiological role of hydrogen sulfide and beyond","volume":"41","author":"Kimura","year":"2014","journal-title":"Nitric Oxide"},{"key":"2021042513220455600_JEB203976C25","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1089\/ars.2017.7076","article-title":"Hydrogen sulfide and polysulfide signaling","volume":"27","author":"Kimura","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"2021042513220455600_JEB203976C26","doi-asserted-by":"publisher","first-page":"2451","DOI":"10.1096\/fj.12-226415","article-title":"Polysulfides are possible H2S-derived signaling molecules in rat brain","volume":"27","author":"Kimura","year":"2013","journal-title":"FASEB J."},{"key":"2021042513220455600_JEB203976C27","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.3390\/molecules21121753","article-title":"Sulfur atom in its bound state is a unique element involved in physiological functions in mammals","volume":"21","author":"Koike","year":"2016","journal-title":"Molecules"},{"key":"2021042513220455600_JEB203976C28","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.redox.2013.05.001","article-title":"A tale of two gases: NO and H2S, foes or friends for life?","volume":"1","author":"Kolluru","year":"2013","journal-title":"Redox Biol."},{"key":"2021042513220455600_JEB203976C29","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1089\/ars.2016.6909","article-title":"Gasotransmitter heterocellular signaling","volume":"26","author":"Kolluru","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"2021042513220455600_JEB203976C64","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.niox.2013.07.001","article-title":"Chemical foundations of hydrogen sulfide biology","volume":"35","author":"Li","year":"2013","journal-title":"Nitric Oxide"},{"key":"2021042513220455600_JEB203976C30","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1089\/ars.2016.6936","article-title":"Activity-dependent sulfhydration signal controls N-Methyl-D-Aspartate subtype glutamate receptor-dependent synaptic plasticity via increasing D-serine availability","volume":"27","author":"Li","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"2021042513220455600_JEB203976C31","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.niox.2014.10.004","article-title":"Hydrogen sulphide and the kidney: Important roles in renal physiology and pathogenesis and treatment of kidney injury and disease","volume":"46","author":"Lobb","year":"2015","journal-title":"Nitric Oxide"},{"key":"2021042513220455600_JEB203976C32","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/0034-5687(83)90013-0","article-title":"Effect of chronic cold and submergence on blood oxygen transport in the turtle, chrysemys picta","volume":"53","author":"Maginniss","year":"1983","journal-title":"Respir. Physiol."},{"key":"2021042513220455600_JEB203976C33","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/nchembio.1834","article-title":"Biogenesis of reactive sulfur species for signaling by hydrogen sulfide oxidation pathways","volume":"11","author":"Mishanina","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"2021042513220455600_JEB203976C34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep45995","article-title":"Polysulfides (H2Sn) produced from the interaction of hydrogen sulfide (H2S) and nitric oxide (NO) activate TRPA1 channels","volume":"7","author":"Miyamoto","year":"2017","journal-title":"Sci. Rep."},{"key":"2021042513220455600_JEB203976C35","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1039\/C4SC01875C","article-title":"Mechanistic investigations reveal that dibromobimane extrudes sulfur from biological sulfhydryl sources other than hydrogen sulfide","volume":"6","author":"Montoya","year":"2015","journal-title":"Chem. Sci."},{"key":"2021042513220455600_JEB203976C36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1126\/scisignal.262tr1","article-title":"H2S signals through protein S-sulfhydration","volume":"2","author":"Mustafa","year":"2009","journal-title":"Sci. Signal."},{"key":"2021042513220455600_JEB203976C37","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s004180050286","article-title":"Tissue and subcellular distribution of mercaptopyruvate sulfurtransferase in the rat: confocal laser fluorescence and immunoelectron microscopic studies combined with biochemical analysis","volume":"110","author":"Nagahara","year":"1998","journal-title":"Histochem. Cell Biol."},{"key":"2021042513220455600_JEB203976C38","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1515\/cclm-2012-0551","article-title":"Hydrogen sulfide as an oxygen sensor","volume":"51","author":"Olson","year":"2013","journal-title":"Clin. Chem. Lab. Med."},{"key":"2021042513220455600_JEB203976C39","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1152\/physiol.00024.2015","article-title":"The role of hydrogen sulfide in evolution and the evolution of hydrogen sulfide in metabolism and signaling","volume":"31","author":"Olson","year":"2016","journal-title":"Physiology"},{"key":"2021042513220455600_JEB203976C40","doi-asserted-by":"publisher","first-page":"R592","DOI":"10.1152\/ajpregu.00421.2012","article-title":"Thiosulfate: a readily accessible source of hydrogen sulfide in oxygen sensing","volume":"305","author":"Olson","year":"2013","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2021042513220455600_JEB203976C41","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nrm3391","article-title":"H2S signalling through protein sulfhydration and beyond","volume":"13","author":"Paul","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2021042513220455600_JEB203976C42","doi-asserted-by":"publisher","first-page":"R84","DOI":"10.1152\/ajpregu.00024.2017","article-title":"Hemoglobin polymerization via disulfide bond formation in the hypoxia-tolerant turtle Trachemys scripta: implications for antioxidant defense and O2 transport","volume":"314","author":"Petersen","year":"2018","journal-title":"Am. J. Physiol. - Regul. Integr. Comp. Physiol."},{"key":"2021042513220455600_JEB203976C43","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1089\/ars.2010.3698","article-title":"Hydrogen sulfide and hemeproteins: knowledge and mysteries","volume":"15","author":"Pietri","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"2021042513220455600_JEB203976C44","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.freeradbiomed.2014.05.025","article-title":"Hydrogen sulfide and nitric oxide metabolites in the blood of free-ranging brown bears and their potential roles in hibernation","volume":"73","author":"Revsbech","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"2021042513220455600_JEB203976C45","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1016\/j.freeradbiomed.2011.01.025","article-title":"Measurement of plasma hydrogen sulfide in vivo and in vitro","volume":"50","author":"Shen","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"2021042513220455600_JEB203976C46","doi-asserted-by":"publisher","first-page":"2276","DOI":"10.1016\/j.freeradbiomed.2012.04.007","article-title":"Analytical measurement of discrete hydrogen sulfide pools in biological specimens","volume":"52","author":"Shen","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"2021042513220455600_JEB203976C47","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.freeradbiomed.2013.02.024","article-title":"Microbial regulation of host hydrogen sulfide bioavailability and metabolism","volume":"30","author":"Shen","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"2021042513220455600_JEB203976C48","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.niox.2014.06.002","article-title":"Hydrogen sulfide measurement using sulfide dibimane: Critical evaluation with electrospray ion trap mass spectrometry","volume":"41","author":"Shen","year":"2014","journal-title":"Nitric Oxide"},{"key":"2021042513220455600_JEB203976C49","volume-title":"Measurement of H2S In Vivo and in Vitro by the Monobromobimane Method","author":"Shen","year":"2015","edition":"1st edn"},{"key":"2021042513220455600_JEB203976C50","doi-asserted-by":"publisher","first-page":"H256","DOI":"10.1152\/ajpheart.00723.2016","article-title":"Role of thiosulfate in hydrogen sulfide-dependent redox signaling in endothelial cells","volume":"313","author":"Shen","year":"2017","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"2021042513220455600_JEB203976C51","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1038\/ncomms2371","article-title":"A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells","volume":"4","author":"Shibuya","year":"2013","journal-title":"Nat. Commun."},{"key":"2021042513220455600_JEB203976C52","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1242\/jeb.00744","article-title":"Alfa-Adrenergic regulation of systemic peripheral resistance and blood flow distribution in the turtle Trachemys scripta during anoxic submergence at 5 C and 21 C","volume":"207","author":"Stecyk","year":"2004","journal-title":"J. Exp. Biol."},{"key":"2021042513220455600_JEB203976C53","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.neuron.2006.11.023","article-title":"Hypoxia enhances S-nitrosylation-mediated NMDA receptor inhibition via a thiol oxygen sensor motif","volume":"53","author":"Takahashi","year":"2007","journal-title":"Neuron"},{"key":"2021042513220455600_JEB203976C54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep46278","article-title":"New method for quantification of gasotransmitter hydrogen sulfide in biological matrices by LC-MS\/MS","volume":"7","author":"Tan","year":"2017","journal-title":"Sci. Rep."},{"key":"2021042513220455600_JEB203976C55","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1126\/science.1199435","article-title":"Hibernation in black bears: independence of metabolic suppression from body temperature","volume":"331","author":"T\u00f8ien","year":"2011","journal-title":"Science"},{"key":"2021042513220455600_JEB203976C56","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1111\/j.1469-185X.1989.tb00683.x","article-title":"Ecology and physiology of hibernation and overwintering among freshwater fishes, turtles, and snakes","volume":"64","author":"Ultsch","year":"1989","journal-title":"Biol. Rev."},{"key":"2021042513220455600_JEB203976C57","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1017\/S1464793106007032","article-title":"The ecology of overwintering among turtles: where turtles overwinter and its consequences","volume":"81","author":"Ultsch","year":"2006","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"2021042513220455600_JEB203976C58","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1016\/j.bbabio.2016.03.030","article-title":"Bioenergetic relevance of hydrogen sulfide and the interplay between gasotransmitters at human cystathionine \u03b2-synthase","volume":"1857","author":"Vicente","year":"2016","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"key":"2021042513220455600_JEB203976C59","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1096\/fj.02-0211hyp","article-title":"Two's company, three s a crowd: can H2S be the third endogenous gaseous transmitter?","volume":"16","author":"Wang","year":"2002","journal-title":"FASEB J."},{"key":"2021042513220455600_JEB203976C60","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1086\/504617","article-title":"Tissue glycogen and extracellular buffering limit the survival of red-eared slider turtles during anoxic submergence at 3C","volume":"79","author":"Warren","year":"2006","journal-title":"Physiol. Biochem. Zool."},{"key":"2021042513220455600_JEB203976C61","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1124\/jpet.108.149963","article-title":"Production and actions of hydrogen sulfide, a novel gaseous bioactive substance, in the kidneys","volume":"329","author":"Xia","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2021042513220455600_JEB203976C62","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1126\/science.1162667","article-title":"H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase","volume":"322","author":"Yang","year":"2008","journal-title":"Science"},{"key":"2021042513220455600_JEB203976C63","doi-asserted-by":"publisher","first-page":"6008","DOI":"10.1093\/emboj\/20.21.6008","article-title":"The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener","volume":"20","author":"Zhao","year":"2012","journal-title":"EMBO J."}],"container-title":["Journal of Experimental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1242\/jeb.203976","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/jeb\/article-pdf\/doi\/10.1242\/jeb.203976\/1908442\/jeb203976.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/jeb\/article-pdf\/doi\/10.1242\/jeb.203976\/2005645\/jeb_203976v1.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/jeb\/article-pdf\/doi\/10.1242\/jeb.203976\/2005645\/jeb_203976v1.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T21:24:46Z","timestamp":1621373086000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/jeb\/article\/doi\/10.1242\/jeb.203976\/258926\/Tissue-dependent-variations-of-hydrogen-sulfide"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,1]]},"references-count":64,"URL":"https:\/\/doi.org\/10.1242\/jeb.203976","relation":{},"ISSN":["1477-9145","0022-0949"],"issn-type":[{"value":"1477-9145","type":"electronic"},{"value":"0022-0949","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1,1]]},"article-number":"jeb.203976"}}