{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T16:12:30Z","timestamp":1762272750461},"reference-count":57,"publisher":"The Company of Biologists","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,7,15]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>In teleostean bony fishes, studies on the adults of various species have shown that pineal photoreceptors are maximally sensitive to short- and middle-wavelength light, possibly utilising both rod-like and pineal-specific opsins. Until recently, however, very little was known about the pineal opsins present in embryonic and larval teleosts and their relationships to opsins expressed by retinal photoreceptors. Our immunocytochemical studies have revealed that, in Atlantic halibut, herring and cod, pineal photoreceptors express principal phototransduction molecules during embryonic life before they appear in retinal photoreceptors. In cDNA from embryonic and adult halibut, we identified two partial opsin gene sequences, HPO1 and HPO4, with highest homology to teleost green and ultraviolet cone opsins (72\u201383% and 71\u201383% amino acid identity, respectively). In halibut, these opsins are expressed in the pineal organ of embryos and appear in the retina of larvae. Our recent in situ hybridisation studies with RNA probes for HPO1 and HPO4 demonstrate the presence of green-like opsin mRNAs in the pineal organ and the retina of herring, cod, turbot, haddock, Atlantic salmon, zebrafish and three species of cichlid, and of ultraviolet opsins in the retinas of zebrafish, Atlantic salmon, turbot and the three cichlid species. We conclude that the halibut pineal organ appears to have the potential for both ultraviolet and green photosensitivity from the embryonic stage and that the retina may acquire the same potential during the larval stages. In the other teleosts studied, although both pineal and retinal photoreceptors seem to utilise a green-like opsin from the larval stage, ultraviolet photoreception appears to be restricted to the retina.<\/jats:p>","DOI":"10.1242\/jeb.204.14.2517","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T23:48:41Z","timestamp":1619221721000},"page":"2517-2525","source":"Crossref","is-referenced-by-count":68,"title":["Expression of pineal ultraviolet- and green-like opsins in the pineal organ and retina of teleosts"],"prefix":"10.1242","volume":"204","author":[{"given":"Johan","family":"Forsell","sequence":"first","affiliation":[{"name":"Department of Zoology, University of Lund, Lund, Sweden,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Ekstro\u0308m","sequence":"additional","affiliation":[{"name":"Department of Zoology, University of Lund, Lund, Sweden,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In\u0303igo Novales","family":"Flamarique","sequence":"additional","affiliation":[{"name":"Institute of Marine Research, Austevoll Aquaculture Research Station, N-5392 Storeb\u00f8, Norway,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Holmqvist","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Lund, So\u0308lvegatan 25, 22185, Lund, Sweden and"},{"name":"Department of Molecular Biology, University of Bergen, Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","reference":[{"key":"2021042522165837200_ALI-ETAL-1988","unstructured":"Ali, M. A., Klyne, M. A., Park, E. H. and Lee, S. H. (1988). Pineal and retinal photoreceptors in embryonic Rivulus marmoratus Poey. Anat. Anz.167, 359\u2013369."},{"key":"2021042522165837200_BEAUDET-ETAL-1993","doi-asserted-by":"crossref","unstructured":"Beaudet, L., Browman, H. I. and Hawryshyn, C. W. (1993). Optic nerve response and retinal structure in rainbow trout of different sizes. Vision Res. 33, 1739\u20131746.","DOI":"10.1016\/0042-6989(93)90164-R"},{"key":"2021042522165837200_BLACKSHAW-AND-SNYDER-1997","doi-asserted-by":"crossref","unstructured":"Blackshaw, S. and Snyder, S. (1997). Parapinopsin, a novel catfish opsin localized in the parapineal organ, defines a new gene family. J. Neurosci.17, 8083\u20138092.","DOI":"10.1523\/JNEUROSCI.17-21-08083.1997"},{"key":"2021042522165837200_BLAXTER-1968","doi-asserted-by":"crossref","unstructured":"Blaxter, J. H. S. (1968). Visual thresholds and spectral sensitivity of herring larvae. J. Exp. Biol. 48, 39\u201353.","DOI":"10.1242\/jeb.48.1.39"},{"key":"2021042522165837200_BOWMAKER-AND-HUNT-1999","unstructured":"Bowmaker, J. K. and Hunt, D. M. (1999). Molecular biology of photoreceptor spectral sensitivity. In Adaptive Mechanisms in the Ecology of Vision (ed. S. N. Archer, M. Djamgoz and E. Loew), pp. 439\u2013462. Dordrecht, Boston, London: Kluwer Academic Publisher."},{"key":"2021042522165837200_BOWMAKER-AND-KUNZ-1987","doi-asserted-by":"crossref","unstructured":"Bowmaker, J. K. and Kunz, Y. W. (1987). Ultraviolet receptors, tetrachromatic colour vision and retinal mosaics in the brown trout (Salmo trutta): Age-dependent changes. Vision Res. 27, 2101\u20132108.","DOI":"10.1016\/0042-6989(87)90124-6"},{"key":"2021042522165837200_BOWMAKER-ETAL-1991","doi-asserted-by":"crossref","unstructured":"Bowmaker, J. K., Thorpe, A. and Douglas, R. H. (1991). Ultraviolet-sensitive cones in goldfish. Vision Res. 31, 349\u2013352.","DOI":"10.1016\/0042-6989(91)90087-L"},{"key":"2021042522165837200_CARLETON-ETAL-2000","doi-asserted-by":"crossref","unstructured":"Carleton, K. L., Harosi, F. I. and Kocher, T. D. (2000). Visual pigments of African cichlid fishes: evidence for ultraviolet vision from microspectrophotometric and DNA sequences. Vision Res. 40, 879\u2013890.","DOI":"10.1016\/S0042-6989(99)00238-2"},{"key":"2021042522165837200_CHANG-ETAL-1995","doi-asserted-by":"crossref","unstructured":"Chang, B. S. W., Crandall, K. A., Carulli, J. P. and Hartl, D. L. (1995). Opsin phylogeny and evolution: a model for blue shifts in wavelength regulation. Mol. Phylogenet. Evol. 4, 31\u201343.","DOI":"10.1006\/mpev.1995.1004"},{"key":"2021042522165837200_EKSTROUMLM-ETAL-1983","doi-asserted-by":"crossref","unstructured":"Ekstro\u0308m, P., Borg, B. and van Veen, Th. (1983). Ontogenetic development of the pineal organ, parapineal organ and retina of three-spined stickleback, Gasterosteus aculeatus L. (Teleostei). Cell Tissue Res. 233, 593\u2013609.","DOI":"10.1007\/BF00212227"},{"key":"2021042522165837200_EKSTROUMLM-AND-MEISSL-1997","doi-asserted-by":"crossref","unstructured":"Ekstro\u0308m, P. and Meissl, H. (1997). The pineal organ of teleost fishes. Rev. Fish Biol. Fish.7, 199\u2013284.","DOI":"10.1023\/A:1018483627058"},{"key":"2021042522165837200_FALCON-AND-MEISSL-1981","unstructured":"Falcon, J. and Meissl, H. (1981). The photosensory function of the pineal organ of the pike (Esox lucius L.). Correlation between structure and function. J. Comp. Physiol. A144, 127\u2013137."},{"key":"2021042522165837200_FORSELL-ETAL-1998","unstructured":"Forsell, J., Ekstro\u0308m, P., Helvik, J. V., Blackshaw, S., Kalleso\u0308, T., Degrip, W. J. and Holmqvist, B. (1998). Development and molecular identity of extraretinal photoreceptors in early life stages of marine teleosts. Soc. Neurosci. Abstr. 24, 810."},{"key":"2021042522165837200_FORSELL-ETAL-1997","unstructured":"Forsell, J., Holmqvist, B., Helvik, J. V. and Ekstro\u0308m, P. (1997). Role of the pineal organ in the photoregulated hatching of the Atlantic halibut. Int. J. Devl. Biol. 41, 591\u2013595."},{"key":"2021042522165837200_HAACUTEROSI-1994","doi-asserted-by":"crossref","unstructured":"Ha\u0301rosi, F. I. (1994). An analysis of two spectral properties of vertebrate visual pigments. Vision Res. 34, 1359\u20131367.","DOI":"10.1016\/0042-6989(94)90134-1"},{"key":"2021042522165837200_HAACUTEROSI-AND-HASHIMOTO-1983","doi-asserted-by":"crossref","unstructured":"Ha\u0301rosi, F. I. and Hashimoto, Y. (1983). Ultraviolet visual pigment in a vertebrate: a tetrachromatic cone system in the Japanese dace. Science222, 1021\u20131023.","DOI":"10.1126\/science.6648514"},{"key":"2021042522165837200_HAWRYSHYN-AND-HAACUTEROSI-1994","doi-asserted-by":"crossref","unstructured":"Hawryshyn, C. W. and Ha\u0301rosi, F. I. (1994). Spectral characteristics of visual pigments in rainbow trout (Oncorhynchus mykiss). Vision Res. 34, 1385\u20131392.","DOI":"10.1016\/0042-6989(94)90137-6"},{"key":"2021042522165837200_HELVIK-AND-WALTHER-1992","doi-asserted-by":"crossref","unstructured":"Helvik, J. V. and Walther, B. T. (1992). Photo-regulation of the hatching process of halibut (Hippoglossus hippoglossus) eggs. J. Exp. Zool.263, 204\u2013209.","DOI":"10.1002\/jez.1402630210"},{"key":"2021042522165837200_HISATOMI-ETAL-1996","doi-asserted-by":"crossref","unstructured":"Hisatomi, O., Satoh, T., Barthel, L. K., Stenkamp, D. L., Raymond, P. A. and Tokunaga, F. (1996). Molecular cloning and characterisation of the putative ultraviolet-sensitive visual pigment of goldfish. Vision Res. 36, 933\u2013939.","DOI":"10.1016\/0042-6989(95)00189-1"},{"key":"2021042522165837200_HISATOMI-ETAL-1997","doi-asserted-by":"crossref","unstructured":"Hisatomi, O., Satoh, T. and Tokunaga, F. (1997). The primary structure and distribution of killifish visual pigments. Vision Res. 37, 3089\u20133096.","DOI":"10.1016\/S0042-6989(97)00115-6"},{"key":"2021042522165837200_HOLMQVIST-ETAL-2000","doi-asserted-by":"crossref","unstructured":"Holmqvist, B. I., Ellingsen, B., Alm, P., Forsell, J., O\u0308yan, A.-M., Go\u0308kso\u0308yr, A., Fjose, A. and Seo, H.-C. (2000). Identification and distribution of nitric oxide synthase in the brain of adult zebrafish. Neurosci. Lett. 292, 119\u2013122.","DOI":"10.1016\/S0304-3940(00)01460-9"},{"key":"2021042522165837200_HOLMQVIST-ETAL-1996","unstructured":"Holmqvist, B. I., Forsell, J. and Helvik, J. V. (1996). Patterns of embryonic development of the brain and sensory organs studied in three marine teleost species. Soc. Neurosci. Abstr. 22, 991."},{"key":"2021042522165837200_JOHNSON-ETAL-1993","doi-asserted-by":"crossref","unstructured":"Johnson, R. L., Grant, K. B., Zankel, T. C., Boehm, M. F., Merbs, S. L., Nathans, J. and Nakanishi, K. (1993). Cloning and expression of goldfish opsin sequences. Biochemistry32, 208\u2013214.","DOI":"10.1021\/bi00052a027"},{"key":"2021042522165837200_KAWAMURA-AND-YOKOYAMA-1997","doi-asserted-by":"crossref","unstructured":"Kawamura, S. and Yokoyama, S. (1997). Expression of visual and nonvisual opsins in American chameleon. Vision Res. 37, 1867\u20131871.","DOI":"10.1016\/S0042-6989(96)00309-4"},{"key":"2021042522165837200_KOJIMA-ETAL-2000","doi-asserted-by":"crossref","unstructured":"Kojima, D., Mano, H. and Fukada, Y. (2000). Vertebrate ancient-long opsin: A green-sensitive photoreceptor molecule present in zebrafish deep brain retinal horizontal cells. J. Neurosci.20, 2845\u20132851.","DOI":"10.1523\/JNEUROSCI.20-08-02845.2000"},{"key":"2021042522165837200_KUNZ-ETAL-1994","doi-asserted-by":"crossref","unstructured":"Kunz, Y. W., Wildenbourg, G., Goodrich, L. and Callaghan, E. (1994). The fate of ultraviolet receptors in the retina of the Atlantic salmon (Salmon salar). Vision Res. 34, 1375\u20131383.","DOI":"10.1016\/0042-6989(94)90136-8"},{"key":"2021042522165837200_KUSMIC-ETAL-1993","doi-asserted-by":"crossref","unstructured":"Kusmic, C., Barsanti, L., Passarelli, V. and Gualtieri, P. (1993). Photoreceptor morphology and visual pigment content in the pineal organ and in the retina of the juvenile and adult trout Salmo irideus. Micron24, 279\u2013286.","DOI":"10.1016\/0968-4328(93)90054-5"},{"key":"2021042522165837200_KVENSETH-ETAL-1996","doi-asserted-by":"crossref","unstructured":"Kvenseth, A. M., Pittman, K. and Helvik, J. V. (1996). Eye development in Atlantic halibut (Hippoglossus hippoglossus): differentiation and development of the retina from early yolk sac stages through metamorphosis. Can. J. Aquat. Sci.53, 2524\u20132534.","DOI":"10.1139\/f96-205"},{"key":"2021042522165837200_LEVINE-AND-MACNICHOL-1979","unstructured":"Levine, J. S. and MacNichol, E. F., Jr (1979). Visual pigments in teleost fishes: Effects of habitat, microhabitat and behaviour on visual pigment evolution. Sensory Proc. 3, 95\u2013131."},{"key":"2021042522165837200_MANGOR-JENSEN-AND-WAIWOOD-1995","doi-asserted-by":"crossref","unstructured":"Mangor-Jensen, A. and Waiwood, K. G. (1995). The effect of light exposure on buoyancy of halibut eggs. J. Fish Biol.47, 18\u201325.","DOI":"10.1111\/j.1095-8649.1995.tb01869.x"},{"key":"2021042522165837200_MANO-ETAL-1999","doi-asserted-by":"crossref","unstructured":"Mano, H., Kojima, D. and Fukada, Y. (1999). Exo-rhodopsin: a novel rhodopsin expressed in the zebrafish pineal gland. Mol. Brain Res. 73, 110\u2013118.","DOI":"10.1016\/S0169-328X(99)00242-9"},{"key":"2021042522165837200_MCFARLAND-AND-LOEW-1994","doi-asserted-by":"crossref","unstructured":"McFarland, W. N. and Loew, E. R. (1994). Ultraviolet visual pigments in marine fishes of the family Pomacentridae. Vision Res.34, 1393\u20131396.","DOI":"10.1016\/0042-6989(94)90138-4"},{"key":"2021042522165837200_MEISSL-1997","unstructured":"Meissl, H. (1997). Photic regulation of pineal function. Analogies between retinal and pineal photoreception. Biol. Cell89, 549\u2013554."},{"key":"2021042522165837200_MEISSL-AND-EKSTROUMLM-1988","doi-asserted-by":"crossref","unstructured":"Meissl, H. and Ekstro\u0308m, P. (1988). Photoreceptor responses to light in the isolated pineal organ of the trout, Salmo gairdneri. Neurosci. 24, 1071\u20131076.","DOI":"10.1016\/0306-4522(88)90060-7"},{"key":"2021042522165837200_MEYER-ROCHOW-ETAL-1999","doi-asserted-by":"crossref","unstructured":"Meyer-Rochow, V. B., Morita, Y. and Tamotsu, S. (1999). Immunocytochemical observations of the pineal organ and retina of the Antartic teleosts Pagothenia borchgrevinki and Trematomus bernacchii. J. Neurocytol.28, 125\u2013130.","DOI":"10.1023\/A:1007024222758"},{"key":"2021042522165837200_MOUTSAKI-ETAL-2000","doi-asserted-by":"crossref","unstructured":"Moutsaki, P., Bellingham, J., Soni, B. G., David-Gray, Z. K. and Foster, R. G. (2000). Sequence, genomic structure and tissue expression of carp (Cyprinus carpio L.) vertebrate ancient (VA) opsin. FEBS Lett. 473, 316\u2013322.","DOI":"10.1016\/S0014-5793(00)01550-7"},{"key":"2021042522165837200_NEGISHI-AND-WAGNER-1995","doi-asserted-by":"crossref","unstructured":"Negishi, K. and Wagner, H.-J. (1995). Differentiation of photoreceptors, glia and neurons in the retina of the cichlid fish Aequidens pulcher, an immunohistochemical study. Devl. Brain Res. 89, 87\u2013102.","DOI":"10.1016\/0165-3806(95)00126-X"},{"key":"2021042522165837200_NOVALES-FLAMARIQUE-2000","doi-asserted-by":"crossref","unstructured":"Novales Flamarique, I. (2000). The ontogeny of ultraviolet sensitivity, cone disappearance and regeneration in the sockeye salmon, Oncorhynchus nerka. J. Exp. Biol.203, 1161\u20131172.","DOI":"10.1242\/jeb.203.7.1161"},{"key":"2021042522165837200_NOVALES-FLAMARIQUE-AND-HAACUTEROSI-2000","doi-asserted-by":"crossref","unstructured":"Novales Flamarique, I. and Ha\u0301rosi, F.I. (2000). Photoreceptors, visual pigments and ellipsosomes in the killifish, Fundulus heteroclitus: A microspectrophotometric and histological study. Visual Neurosci. 17, 403\u2013420.","DOI":"10.1017\/S0952523800173080"},{"key":"2021042522165837200_OKANO-ETAL-1994","doi-asserted-by":"crossref","unstructured":"Okano, T., Yoshikawa, T. and Fukada, Y. (1994). Pinopsin is a chicken pineal photoreceptive molecule. Nature372, 94\u201397.","DOI":"10.1038\/372094a0"},{"key":"2021042522165837200_OMURA-AND-OGURI-1993","doi-asserted-by":"crossref","unstructured":"Omura, Y. and Oguri, M. (1993). Early development of the pineal photoreceptors prior to retinal differentiation in the embryonic rainbow trout, Oncorhynchys mykiss (Teleostei). Arch. Histol. Cytol. 56, 283\u2013291.","DOI":"10.1679\/aohc.56.283"},{"key":"2021042522165837200_OUMLSTHOLM-ETAL-1987","doi-asserted-by":"crossref","unstructured":"O\u0308stholm, T., Bra\u0308nna\u0308s, E. and van Veen, Th. (1987). The pineal organ is the first differentiated light receptor in the embryonic salmon, Salmo salar L. Cell Tissue Res. 249, 641\u2013646.","DOI":"10.1007\/BF00217336"},{"key":"2021042522165837200_PHILP-ETAL-2000A","doi-asserted-by":"crossref","unstructured":"Philp, A. R., Bellingham, J., Garcia-Fernandez, J. M. and Foster, R. G. (2000a). A novel rod-like opsin isolated from the extra-retinal photoreceptors of teleost fish. FEBS Lett. 468, 181\u2013188.","DOI":"10.1016\/S0014-5793(00)01217-5"},{"key":"2021042522165837200_PHILP-ETAL-2000B","doi-asserted-by":"crossref","unstructured":"Philp, A. R., Garcia-Fernandez, J. M., Soni, B. G., Lucas, R. J., Bellingham, J. and Foster, R. G. (2000b). Vertebrate ancient (VA) opsin and extraretinal photoreception in the Atlantic salmon (Salmo salar). J. Exp. Biol.203, 1925\u20131936.","DOI":"10.1242\/jeb.203.12.1925"},{"key":"2021042522165837200_RAYMOND-ETAL-1995","doi-asserted-by":"crossref","unstructured":"Raymond, P. A., Barthel, L. K. and Curran, G. A. (1995). Developmental patterning of rod and cone photoreceptors in embryonic zebrafish. J. Comp. Neurol.359, 537\u2013550.","DOI":"10.1002\/cne.903590403"},{"key":"2021042522165837200_RAYMOND-ETAL-1993","doi-asserted-by":"crossref","unstructured":"Raymond, P. A., Barthel, L. K., Rounsifer, M. E., Sullivan, S. A. and Knight, J. K. (1993). Expression of rod and cone visual pigments in goldfish and zebrafish: A rhodopsin-like gene is expressed in cones. Neuron10, 1161\u20131174.","DOI":"10.1016\/0896-6273(93)90064-X"},{"key":"2021042522165837200_ROBINSON-ETAL-1993","doi-asserted-by":"crossref","unstructured":"Robinson, J,, Schmitt, E. A., Harosi, F. I., Reece, R. J. and Dowling, J. E. (1993). Zebrafish ultraviolet visual pigment: Absorption spectrum, sequence and localization. Proc. Natl. Acad. Sci. USA90, 6009\u20136012.","DOI":"10.1073\/pnas.90.13.6009"},{"key":"2021042522165837200_SHAND-AND-FOSTER-1999","unstructured":"Shand, J. and Foster, R. G. (1999). The extraretinal photoreceptors of non-mammalian vertebrates. In Adaptive Mechanisms in the Ecology of Vision (ed. S. N. Archer, M. Djamgoz and E. Loew), pp. 197\u2013222. Dordrecht, Boston, London: Kluwer Academic Publishers."},{"key":"2021042522165837200_SONI-AND-FOSTER-1997","doi-asserted-by":"crossref","unstructured":"Soni, B. G. and Foster, R. G. (1997). A novel and ancient vertebrate opsin. FEBS Lett.406, 279\u2013283.","DOI":"10.1016\/S0014-5793(97)00287-1"},{"key":"2021042522165837200_SONI-ETAL-1998","doi-asserted-by":"crossref","unstructured":"Soni, B. G., Philp, A., Knox, B. E. and Foster, R. G. (1998). Novel retinal photoreceptors. Nature394, 27\u201328.","DOI":"10.1038\/27794"},{"key":"2021042522165837200_STENKAMP-ETAL-1996","unstructured":"Stenkamp, D. L., Hisatomi, O., Barthel, L. K., Tokunaga, F. and Raymond, P. A. (1996). Temporal expression of rod and cone opsins in embryonic goldfish retina predicts the spatial organization of the cone mosaic. Invest. Ophthalmol. Visual Sci.37, 363\u2013376."},{"key":"2021042522165837200_TOVEACUTEE-1995","doi-asserted-by":"crossref","unstructured":"Tove\u0301e, M. J. (1995). Ultra-violet photoreceptors in the animal kingdom: their distribution and function. Trend. Ecol. Evol.10, 455\u2013460.","DOI":"10.1016\/S0169-5347(00)89179-X"},{"key":"2021042522165837200_UCHIDA-AND-MORITA-1990","doi-asserted-by":"crossref","unstructured":"Uchida, K. and Morita, Y. (1990). Intracellular responses from UV-sensitive cells in the photosensory pineal organ. Brain Res.534, 237\u2013242.","DOI":"10.1016\/0006-8993(90)90134-W"},{"key":"2021042522165837200_VIGH-ETAL-1986","unstructured":"Vigh, B., Vigh-Teichmann, I., Reinhard, I., Sze\u0301l, A. and van Veen Th. (1986) Opsin immunoreactions in the developing and adult pineal organ. In The Pineal Gland during Development from Fetus to Adult (ed. D. Gupta and R. G. Foster), pp. 31\u201342. London, Sydney: Croom Helm."},{"key":"2021042522165837200_VIHTELIC-ETAL-1999","doi-asserted-by":"crossref","unstructured":"Vihtelic, T. S., Doro, C. and Hyde, D. R. (1999). Cloning and characterisation of six zebrafish photoreceptor opsin cDNAs and immunolocalization of their corresponding proteins. Visual Neurosci.16, 571\u2013585.","DOI":"10.1017\/S0952523899163168"},{"key":"2021042522165837200_YOKOYAMA-AND-YOKOYAMA-1996","doi-asserted-by":"crossref","unstructured":"Yokoyama, S. and Yokoyama, R. (1996). Adaptive evolution of photoreceptors and visual pigments in vertebrates. Annu. Rev. Ecol. Syst. 27, 543\u2013567.","DOI":"10.1146\/annurev.ecolsys.27.1.543"},{"key":"2021042522165837200_YOKOYAMA-AND-ZHANG-1997","unstructured":"Yokoyama, S. and Zhang, H. (1997). Cloning and characterisation of the pineal gland-specific opsin gene of marine lamprey (Petromyzon marinus). Gene202, 89\u201393."}],"container-title":["Journal of Experimental Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.biologists.com\/jeb\/article-pdf\/204\/14\/2517\/1238840\/2517.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/jeb\/article-pdf\/204\/14\/2517\/1238840\/2517.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,2]],"date-time":"2021-05-02T10:20:07Z","timestamp":1619950807000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/jeb\/article\/204\/14\/2517\/32965\/Expression-of-pineal-ultraviolet-and-green-like"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7,15]]},"references-count":57,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2001,7,15]]}},"URL":"https:\/\/doi.org\/10.1242\/jeb.204.14.2517","relation":{},"ISSN":["1477-9145","0022-0949"],"issn-type":[{"value":"1477-9145","type":"electronic"},{"value":"0022-0949","type":"print"}],"subject":[],"published":{"date-parts":[[2001,7,15]]}}}