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Altricial mammals undergo a dramatic metabolic transition from ectothermy to endothermy in early post-natal life, which may influence the ontogenetic development of respiratory traits at high altitude. We examined the developmental changes in respiratory and haematological traits in deer mice (Peromyscus maniculatus) native to high altitude, comparing the respiratory responses to progressive hypoxia between highland and lowland deer mice. Among adults, highlanders exhibited higher total ventilation and a more effective breathing pattern (relatively deeper tidal volumes), for mice that were caught and tested at their native altitudes and those lab-raised in normoxia. Lab-raised progeny of each population were also tested at post-natal day (P)7, 14, 21 and 30. Highlanders developed an enhanced hypoxic ventilatory response by P21, concurrent with the full maturation of the carotid bodies, and their more effective breathing pattern arose by P14; these ages correspond to critical benchmarks in the full development of homeothermy in highlanders. However, highlanders exhibited developmental delays in ventilatory sensitivity to hypoxia, hyperplasia of type I cells in the carotid body and increases in blood haemoglobin content compared with lowland mice. Nevertheless, highlanders maintained consistently higher arterial O2 saturation in hypoxia across development, in association with increases in blood\u2013O2 affinity that were apparent from birth. We conclude that evolved changes in respiratory physiology in high-altitude deer mice become expressed in association with the post-natal development of endothermy.<\/jats:p>","DOI":"10.1242\/jeb.219360","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T20:05:19Z","timestamp":1581624319000},"source":"Crossref","is-referenced-by-count":23,"title":["Ontogenesis of evolved changes in respiratory physiology in deer mice native to high altitude"],"prefix":"10.1242","volume":"223","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4713-4423","authenticated-orcid":false,"given":"Catherine M.","family":"Ivy","sequence":"first","affiliation":[{"name":"McMaster University 1 Department of Biology , , Hamilton, ON L8S 4K1 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary A.","family":"Greaves","sequence":"additional","affiliation":[{"name":"McMaster University 1 Department of Biology , , Hamilton, ON L8S 4K1 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth D.","family":"Sangster","sequence":"additional","affiliation":[{"name":"McMaster University 1 Department of Biology , , Hamilton, ON L8S 4K1 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6769-2852","authenticated-orcid":false,"given":"Cayleih E.","family":"Robertson","sequence":"additional","affiliation":[{"name":"McMaster University 1 Department of Biology , , Hamilton, ON L8S 4K1 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4841-0426","authenticated-orcid":false,"given":"Chandrasekhar","family":"Natarajan","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Nebraska 2 , Lincoln, NE 68588 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5448-7924","authenticated-orcid":false,"given":"Jay F.","family":"Storz","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Nebraska 2 , Lincoln, NE 68588 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1500-9983","authenticated-orcid":false,"given":"Grant B.","family":"McClelland","sequence":"additional","affiliation":[{"name":"McMaster University 1 Department of Biology , , Hamilton, ON L8S 4K1 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4225-7475","authenticated-orcid":false,"given":"Graham R.","family":"Scott","sequence":"additional","affiliation":[{"name":"McMaster University 1 Department of Biology , , Hamilton, ON L8S 4K1 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2020,3,11]]},"reference":[{"key":"2022080600044017900_JEB219360C1","first-page":"36","article-title":"Image processing with Imagej","volume":"11","author":"Abr\u00e0moff","year":"2004","journal-title":"Biophotonics Int."},{"key":"2022080600044017900_JEB219360C2","first-page":"45","article-title":"Regulation of breathing at birth","volume":"15","author":"Adamson","year":"1991","journal-title":"J. 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