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Although the physiological changes that occur during hibernation have been comprehensively researched, the role of the nervous system in this process remains relatively underexplored. In this Review, we adopt the perspective that the nervous system plays an active, essential role in facilitating and supporting hibernation. Accumulating evidence strongly suggests that the hypothalamus enters a quiescent state in which powerful drives to thermoregulate, eat and drink are suppressed. Similarly, cardiovascular and pulmonary reflexes originating in the brainstem are altered to permit the profoundly slow heart and breathing rates observed during torpor. The mechanisms underlying these changes to the hypothalamus and brainstem are not currently known, but several neuromodulatory systems have been implicated in the induction and maintenance of hibernation. The intersection of these findings with modern neuroscience approaches, such as optogenetics and in vivo calcium imaging, has opened several exciting avenues for hibernation research.<\/jats:p>","DOI":"10.1242\/jeb.229542","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T08:12:33Z","timestamp":1641283953000},"source":"Crossref","is-referenced-by-count":32,"title":["Towards understanding the neural origins of hibernation"],"prefix":"10.1242","volume":"225","author":[{"given":"Madeleine S.","family":"Junkins","sequence":"first","affiliation":[{"name":"Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA"},{"name":"Department of Neuroscience and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sviatoslav N.","family":"Bagriantsev","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0846-3427","authenticated-orcid":false,"given":"Elena O.","family":"Gracheva","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA"},{"name":"Department of Neuroscience and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2022,1,4]]},"reference":[{"key":"2022010413122764300_JEB229542C1","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.cell.2018.02.057","article-title":"A neural circuit for the suppression of pain by a competing need state","volume":"173","author":"Alhadeff","year":"2018","journal-title":"Cell"},{"key":"2022010413122764300_JEB229542C2","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1038\/nature22381","article-title":"Dynamic corticostriatal activity biases social bonding in monogamous female prairie voles","volume":"546","author":"Amadei","year":"2017","journal-title":"Nature"},{"key":"2022010413122764300_JEB229542C3","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1152\/ajplegacy.1960.199.3.535","article-title":"Electroencephalogram during arousal from hibernation in the birchmouse","volume":"199","author":"Andersen","year":"1960","journal-title":"Am. 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