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This study used molecular approaches, and compared mRNA and proteome-wide expression in captive redheaded buntings that were photostimulated under long-day (LD) conditions for 4\u2005days (early stimulated, LD-eS) or for \u223c3\u2005weeks until each bird had shown 4 successive nights of Zugunruhe (stimulated, LD-S); controls were maintained under short days. After \u223c3\u2005weeks of LD, photostimulated indices of the migratory preparedness (fattening, weight gain and Zugunruhe) were paralleled with upregulated expression of acc, dgat2 and apoa1 genes in the liver, and of cd36, fabp3 and cpt1 genes in the flight muscle, suggesting enhanced fatty acid (FA) synthesis and transport in the LD-S state. Concurrently, elevated expression of genes involved in the calcium ion signalling and transport (camk1 and atp2a2; camk2a in LD-eS), cellular stress (hspa8 and sod1, not nos2) and metabolic pathways (apoa1 and sirt1), but not of genes associated with migratory behaviour (adcyap1 and vps13a), were found in the mediobasal hypothalamus (MBH). Further, MBH-specific quantitative proteomics revealed that out of 503 annotated proteins, 28 were differentially expressed (LD-eS versus LD-S: 21 up-regulated and 7 down-regulated) and they enriched five physiological pathways that are associated with FA transport and metabolism. These first comprehensive results on gene and protein expression suggest that changes in molecular correlates of FA transport and metabolism may aid the decision for migratory departure from wintering areas in obligate songbird migrants.<\/jats:p>","DOI":"10.1242\/jeb.242153","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T14:14:50Z","timestamp":1619792090000},"source":"Crossref","is-referenced-by-count":15,"title":["Molecular changes associated with migratory departure from wintering areas in obligate songbird migrants"],"prefix":"10.1242","volume":"224","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6838-0060","authenticated-orcid":false,"given":"Aakansha","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Zoology, University of Delhi, Delhi 110 007, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1202-9826","authenticated-orcid":false,"given":"Devraj","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Zoology, University of Delhi, Delhi 110 007, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6192-7051","authenticated-orcid":false,"given":"Priya","family":"Gupta","sequence":"additional","affiliation":[{"name":"International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, Delhi 110 067, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3847-2607","authenticated-orcid":false,"given":"Sanjay Kumar","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"Department of Zoology, CCS University, Meerut 250 004, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8778-1396","authenticated-orcid":false,"given":"Inderjeet","family":"Kaur","sequence":"additional","affiliation":[{"name":"International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, Delhi 110 067, India"},{"name":"Department of Biotechnology, Central University of Haryana, Mahendergarh, Haryana 123031, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0523-8689","authenticated-orcid":false,"given":"Vinod","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Zoology, University of Delhi, Delhi 110 007, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2021,6,9]]},"reference":[{"key":"2021060910525272500_JEB242153C1","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1641\/B570207","article-title":"How migrants get there: migratory performance and orientation","volume":"57","author":"\u00c5kesson","year":"2007","journal-title":"Biosci."},{"key":"2021060910525272500_JEB242153C2","volume-title":"Handbooks of the birds of India and Pakistan","author":"Ali","year":"1999"},{"key":"2021060910525272500_JEB242153C3","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1038\/nrn3531","article-title":"Nuclear calcium signalling in the regulation of brain function","volume":"14","author":"Bading","year":"2013","journal-title":"Nat. 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