{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T23:58:14Z","timestamp":1769385494989,"version":"3.49.0"},"reference-count":20,"publisher":"The Company of Biologists","issue":"17","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 pesquisa do Estado de S\u00e3o Paulo"},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Det Frie Forskningsr\u00e5d|Natur og Univers"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>When snakes digest large meals, heart rate is accelerated by withdrawal of vagal tone and an increased non-adrenergic-non-cholinergic tone that seems to stem from circulating blood-borne factors exerting positive chronotropic effects. To investigate whether this tonic elevation of heart rate impairs the ability for autonomic regulation of heart during digestion, we characterised heart rate responses to pharmacological manipulation of blood pressure in the snake Boa constrictor through serial injections of sodium nitroprusside and phenylephrine. Both fasting and digesting snakes responded with a robust tachycardia to hypotension induced by sodium nitroprusside, with digesting snakes attaining higher maximal heart rates than fasting snakes. Both fasting and digesting snakes exhibited small reductions of the cardiac chronotropic response to hypertension, induced by injection of phenylephrine. All heart rate changes were abolished by autonomic blockade with the combination of atropine and propranolol. The digesting snakes retained the capacity for compensatory heart rate responses to hypotension, despite their higher resting values, and the upward shift of the barostatic response curve enables snakes to maintain the cardiac limb of barostatic regulation for blood pressure regulation.<\/jats:p>","DOI":"10.1242\/jeb.242202","type":"journal-article","created":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T13:05:06Z","timestamp":1629810306000},"source":"Crossref","is-referenced-by-count":6,"title":["Maintained barostatic regulation of heart rate in digesting snakes (<i>Boa constrictor<\/i>)"],"prefix":"10.1242","volume":"224","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4350-3682","authenticated-orcid":false,"given":"Tobias","family":"Wang","sequence":"first","affiliation":[{"name":"Zoophysiology, Department of Biology, Aarhus University, 8000 Aarhus C, Denmark"},{"name":"Department of Biodiversity, State University of S\u00e3o Paulo, PO BOX 199 13506-900, Rio Claro, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augusto S.","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Biodiversity, State University of S\u00e3o Paulo, PO BOX 199 13506-900, Rio Claro, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariovaldo P.","family":"Cruz-Neto","sequence":"additional","affiliation":[{"name":"Department of Biodiversity, State University of S\u00e3o Paulo, PO BOX 199 13506-900, Rio Claro, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis V.","family":"Andrade","sequence":"additional","affiliation":[{"name":"Department of Biodiversity, State University of S\u00e3o Paulo, PO BOX 199 13506-900, Rio Claro, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin W.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Biodiversity, State University of S\u00e3o Paulo, PO BOX 199 13506-900, Rio Claro, Sao Paulo, Brazil"},{"name":"School of Biosciences, The University of Birmingham, Edgbaston B15 2TT, England"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2021,9,13]]},"reference":[{"key":"2021091309265916600_JEB242202C1","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.1242\/jeb.201.15.2235","article-title":"Relationships between blood pressure and heart rate in the saltwater crocodile Crocodylus porosus","volume":"201","author":"Altimiras","year":"1998","journal-title":"J. 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