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To determine if this state is reversible in a non-food caching species, we fed hibernating grizzly bears (Ursus arctos horribilis) dextrose for 10\u2005days to replace 53% or 100% of the estimated minimum daily energetic cost of hibernation. Feeding caused serum concentrations of glycerol and ketones (\u03b2-hydroxybutyrate) to return to active season levels irrespective of the amount of glucose fed. By contrast, free fatty acids (FFAs) and indices of metabolic rate, such as general activity, heart rate, strength of heart rate circadian rhythm, and insulin sensitivity were restored to approximately 50% of active season levels. Body temperature was unaffected by feeding. To determine the contribution of adipose to the metabolic effects observed after glucose feeding, we cultured bear adipocytes collected at the beginning and end of the feeding and performed metabolic flux analysis. We found a \u223c33% increase in energy metabolism after feeding. Moreover, basal metabolism before feeding was 40% lower in hibernation cells compared with fed cells or active cells cultured at 37\u00b0C, thereby confirming the temperature independence of metabolic rate. The partial depression of circulating FFAs with feeding likely explains the incomplete restoration of insulin sensitivity and other metabolic parameters in hibernating bears. Further depression of metabolic function is likely to be an active process. Together, the results provide a highly controlled model to examine the relationship between nutrient availability and metabolism on the hibernation phenotype in bears.<\/jats:p>","DOI":"10.1242\/jeb.242560","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T08:34:06Z","timestamp":1621240446000},"source":"Crossref","is-referenced-by-count":11,"title":["Can offsetting the energetic cost of hibernation restore an active season phenotype in grizzly bears (\n                    <i>Ursus arctos horribilis<\/i>\n                    )?"],"prefix":"10.1242","volume":"224","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0178-396X","authenticated-orcid":false,"given":"Heiko T.","family":"Jansen","sequence":"first","affiliation":[{"name":"Dept. Integrative Physiology and Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon","family":"Evans Hutzenbiler","sequence":"additional","affiliation":[{"name":"Dept. Integrative Physiology and Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah R.","family":"Hapner","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, College of Arts and Sciences, Washington State University, Pullman, WA 99164, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeline L.","family":"McPhee","sequence":"additional","affiliation":[{"name":"Dept. Integrative Physiology and Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony M.","family":"Carnahan","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, College of Arts and Sciences, Washington State University, Pullman, WA 99164, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna L.","family":"Kelley","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, College of Arts and Sciences, Washington State University, Pullman, WA 99164, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael W.","family":"Saxton","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, College of Arts and Sciences, Washington State University, Pullman, WA 99164, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles T.","family":"Robbins","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, College of Arts and Sciences, Washington State University, Pullman, WA 99164, USA"},{"name":"School of the Environment, College of Agricultural, Human and Natural Resource Sciences, Washington State University, Pullman, WA 99164, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2021,6,17]]},"reference":[{"key":"2021061714532049400_JEB242560C1","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.ecl.2008.06.007","article-title":"Obesity and free fatty acids","volume":"37","author":"Boden","year":"2008","journal-title":"Endocrinol. 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