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We predicted that, like many other semi-aquatic and fossorial small mammals, star-nosed moles would exhibit: (i) a blunted (i.e. delayed or reduced) hypoxic ventilatory response, (ii) a reduced metabolic rate and (iii) a lowered body temperature (Tb) in hypoxia. We thus non-invasively measured these variables from wild-caught star-nosed moles exposed to normoxia (21% O2) or acute graded hypoxia (21\u20136% O2). Surprisingly, star-nosed moles did not exhibit a blunted HVR or decreased Tb in hypoxia, and only manifested a significant, albeit small (&amp;lt;8%), depression of metabolic rate at 6% O2 relative to normoxic controls. Unlike small rodents inhabiting similar niches, star-nosed moles are thus intolerant to hypoxia, which may reflect an evolutionary trade-off favouring the extreme sensory biology of this unusual insectivore.<\/jats:p>","DOI":"10.1242\/jeb.242972","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T13:17:53Z","timestamp":1631884673000},"source":"Crossref","is-referenced-by-count":7,"title":["Burrowing star-nosed moles (<i>Condylura cristata<\/i>) are not hypoxia tolerant"],"prefix":"10.1242","volume":"224","author":[{"given":"Maiah E. 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