{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T09:33:12Z","timestamp":1778664792089,"version":"3.51.4"},"reference-count":78,"publisher":"The Company of Biologists","issue":"23","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","award":["2017\/01652-2"],"award-info":[{"award-number":["2017\/01652-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","award":["2019\/12311-7"],"award-info":[{"award-number":["2019\/12311-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003788","name":"Helge Ax:son Johnsons Stiftelse","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003788","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Svenska Forskningsr\u00e5det Formas","award":["2019-00299"],"award-info":[{"award-number":["2019-00299"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Coronary arteriosclerosis is a common feature of both wild and farmed salmonid fishes and may be linked to stress-induced cardiac pathologies. Yet, the plasticity and capacity for long-term myocardial restructuring and recovery following a restriction in coronary blood supply are unknown. Here, we analyzed the consequences of acute (3\u2005days) and chronic (from 33 to 62\u2005days) coronary occlusion (i.e. coronary artery ligation) on cardiac morphological characteristics and in vivo function in juvenile rainbow trout, Oncorhynchus mykiss. Acute coronary artery occlusion resulted in elevated resting heart rate and decreased inter-beat variability, which are both markers of autonomic dysfunction following acute myocardial ischemia, along with severely reduced heart rate scope (maximum\u2212resting heart rate) relative to sham-operated trout. We also observed a loss of myocardial interstitial collagen and compact myocardium. Following long-term coronary artery ligation, resting heart rate and heart rate scope normalized relative to sham-operated trout. Moreover, a distinct fibrous collagen layer separating the compact myocardium into two layers had formed. This may contribute to maintain ventricular integrity across the cardiac cycle or, alternatively, demark a region of the compact myocardium that continues to receive oxygen from the luminal venous blood. Taken together, we demonstrate that rainbow trout may cope with the aversive effects caused by coronary artery obstruction through plastic ventricular remodeling, which, at least in part, restores cardiac performance and myocardium oxygenation.<\/jats:p>","DOI":"10.1242\/jeb.243578","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T11:12:26Z","timestamp":1637233946000},"source":"Crossref","is-referenced-by-count":13,"title":["It takes time to heal a broken heart: ventricular plasticity improves heart performance after myocardial infarction in rainbow trout, <i>Oncorhynchus mykiss<\/i>"],"prefix":"10.1242","volume":"224","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4422-4458","authenticated-orcid":false,"given":"Lucas A.","family":"Zena","sequence":"first","affiliation":[{"name":"Department of Physiology, Institute of Biosciences, University of S\u00e3o Paulo, 05508-090 S\u00e3o Paulo, Brazil"},{"name":"Department of Biological and Environmental Sciences, University of Gothenburg, 405 30 Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Ekstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Biological and Environmental Sciences, University of Gothenburg, 405 30 Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albin","family":"Gr\u00e4ns","sequence":"additional","affiliation":[{"name":"Department of Animal Environment and Health, Swedish University of Agricultural Sciences, Gothenburg 405 30, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catharina","family":"Olsson","sequence":"additional","affiliation":[{"name":"Department of Biological and Environmental Sciences, University of Gothenburg, 405 30 Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Axelsson","sequence":"additional","affiliation":[{"name":"Department of Biological and Environmental Sciences, University of Gothenburg, 405 30 Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Sundh","sequence":"additional","affiliation":[{"name":"Department of Biological and Environmental Sciences, University of Gothenburg, 405 30 Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Sandblom","sequence":"additional","affiliation":[{"name":"Department of Biological and Environmental Sciences, University of Gothenburg, 405 30 Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2021,12,10]]},"reference":[{"key":"2021121010552109400_JEB243578C1","doi-asserted-by":"publisher","first-page":"4003","DOI":"10.1242\/jeb.00623","article-title":"Effect of coronary perfusion on the basal performance, volume loading and oxygen consumption in the isolated resistance-headed heart of the trout Oncorhynchus mykiss","volume":"206","author":"Agnisola","year":"2003","journal-title":"J. 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Physiol."},{"key":"2021121010552109400_JEB243578C4","doi-asserted-by":"publisher","first-page":"735417","DOI":"10.1016\/j.aquaculture.2020.735417","article-title":"Prevalence and severity of cardiac abnormalities and arteriosclerosis in farmed rainbow trout (Oncorhynchus mykiss)","volume":"526","author":"Brijs","year":"2020","journal-title":"Aquaculture"},{"key":"2021121010552109400_JEB243578C5","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1471-213X-11-21","article-title":"The zebrafish heart regenerates after cryoinjury-induced myocardial infarction","volume":"11","author":"Chablais","year":"2011","journal-title":"BMC Dev. Biol."},{"key":"2021121010552109400_JEB243578C6","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1369\/0022155413493912","article-title":"Systematic characterization of myocardial inflammation, repair, and remodeling in a mouse model of reperfused myocardial infarction","volume":"61","author":"Christia","year":"2013","journal-title":"J. Histochem. Cytochem."},{"key":"2021121010552109400_JEB243578C7","doi-asserted-by":"publisher","first-page":"2771","DOI":"10.1242\/jeb.084251","article-title":"Aerobic scope measurements of fishes in an era of climate change: respirometry, relevance and recommendations","volume":"216","author":"Clark","year":"2013","journal-title":"J. Exp. Biol."},{"key":"2021121010552109400_JEB243578C8","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.ydbio.2014.12.018","article-title":"Differential regenerative capacity of neonatal mouse hearts after cryoinjury","volume":"399","author":"Darehzereshki","year":"2015","journal-title":"Dev. 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Physiol."},{"key":"2021121010552109400_JEB243578C16","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/S1095-6433(02)00049-1","article-title":"Cardiorespiratory performance in salmonids during exercise at high temperature: Insights into cardiovascular design limitations in fishes","volume":"132","author":"Farrell","year":"2002","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"2021121010552109400_JEB243578C17","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/S1095-6433(02)00126-5","article-title":"Coronary arteriosclerosis in salmon: growing old or growing fast?","volume":"132","author":"Farrell","year":"2002","journal-title":"Comp. Biochem. Physiol. Part A Mol. Integr. Physiol."},{"key":"2021121010552109400_JEB243578C18","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1242\/jeb.02781","article-title":"Tribute to P. L. 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