{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:35:41Z","timestamp":1788305741768,"version":"build-2803163510"},"reference-count":20,"publisher":"The Company of Biologists","issue":"12","license":[{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/100008294","name":"Louisiana State University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008294","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008294","name":"Louisiana State University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008294","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008294","name":"Louisiana State University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008294","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000888","name":"W. M. Keck Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000888","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R35GM138116"],"award-info":[{"award-number":["R35GM138116"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Sex-specific differences in animal behavior commonly reflect unique reproductive interests. In the nematode Caenorhabditis elegans, hermaphrodites can reproduce without a mate and thus prioritize feeding to satisfy the high energetic costs of reproduction. However, males, which must mate to reproduce, sacrifice feeding to prioritize mate-searching behavior. Here, we demonstrate that these behavioral differences influence sexual dimorphism at the organelle level; young males raised on a rich food source show constitutive induction of gut tubular lysosomes, a non-canonical lysosome morphology that forms in the gut of hermaphrodites when food is limited or as animals age. We found that constitutive induction of gut tubular lysosomes in males results from self-imposed dietary restriction through DAF-7\/TGF\u03b2, which promotes exploratory behavior. In contrast, age-dependent induction of gut tubular lysosomes in hermaphrodites is stimulated by self-fertilization activity. Thus, separate reproductive tradeoffs influence tubular lysosome induction in each sex, potentially supporting different requirements for reproductive success.<\/jats:p>","DOI":"10.1242\/jeb.244282","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T04:33:34Z","timestamp":1653626014000},"source":"Crossref","is-referenced-by-count":5,"title":["Reproductive tradeoffs govern sexually dimorphic tubular lysosome induction in\n                    <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1242","volume":"225","author":[{"given":"Cara D.","family":"Ramos","sequence":"first","affiliation":[{"name":"Louisiana State University Department of Biological Sciences , , Baton Rouge, LA 70803 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2590-460X","authenticated-orcid":false,"given":"K. Adam","family":"Bohnert","sequence":"additional","affiliation":[{"name":"Louisiana State University Department of Biological Sciences , , Baton Rouge, LA 70803 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9356-2808","authenticated-orcid":false,"given":"Alyssa E.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Louisiana State University Department of Biological Sciences , , Baton Rouge, LA 70803 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2022,6,22]]},"reference":[{"key":"2022062210582019100_JEB244282C1","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1093\/genetics\/125.1.29","article-title":"fog-1, a regulatory gene required for specification of spermatogenesis in the germ line of Caenorhabditis elegans","volume":"125","author":"Barton","year":"1990","journal-title":"Genetics"},{"key":"2022062210582019100_JEB244282C2","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2021.1990647","article-title":"Degradative tubular lysosomes link pexophagy to starvation and early aging in C. elegans","author":"Dolese","year":"2021","journal-title":"Autophagy"},{"key":"2022062210582019100_JEB244282C3","doi-asserted-by":"publisher","first-page":"e21166","DOI":"10.7554\/eLife.21166","article-title":"Sexually dimorphic control of gene expression in sensory neurons regulates decision-making behavior in C. elegans","volume":"6","author":"Hilbert","year":"2017","journal-title":"Elife"},{"key":"2022062210582019100_JEB244282C4","doi-asserted-by":"publisher","first-page":"3646","DOI":"10.1016\/j.celrep.2017.11.108","article-title":"The sexual dimorphism of dietary restriction responsiveness in Caenorhabditis elegans","volume":"21","author":"Honjoh","year":"2017","journal-title":"Cell Rep."},{"key":"2022062210582019100_JEB244282C5","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/nature01278","article-title":"Systematic functional analysis of the Caenorhabditis elegans genome using RNAi","volume":"421","author":"Kamath","year":"2003","journal-title":"Nature"},{"key":"2022062210582019100_JEB244282C6","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1093\/genetics\/120.2.435","article-title":"Developmental genetics of chromosome I spermatogenesis-defective mutants in the nematode Caenorhabditis elegans","volume":"120","author":"L'Hernault","year":"1988","journal-title":"Genetics"},{"key":"2022062210582019100_JEB244282C7","doi-asserted-by":"publisher","first-page":"7427","DOI":"10.1523\/JNEUROSCI.1746-04.2004","article-title":"Mate searching in Caenorhabditis elegans: a genetic model for sex drive in a simple invertebrate","volume":"24","author":"Lipton","year":"2004","journal-title":"J. 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Neurobiol."}],"container-title":["Journal of Experimental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/jeb\/article-pdf\/doi\/10.1242\/jeb.244282\/2146261\/jeb244282.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/jeb\/article-pdf\/doi\/10.1242\/jeb.244282\/2149333\/jeb244282.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/jeb\/article-pdf\/doi\/10.1242\/jeb.244282\/2149333\/jeb244282.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T06:58:36Z","timestamp":1655881116000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/jeb\/article\/225\/12\/jeb244282\/275775\/Reproductive-tradeoffs-govern-sexually-dimorphic"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,15]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,6,15]]}},"URL":"https:\/\/doi.org\/10.1242\/jeb.244282","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.03.16.484652","asserted-by":"object"}]},"ISSN":["0022-0949","1477-9145"],"issn-type":[{"value":"0022-0949","type":"print"},{"value":"1477-9145","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,15]]},"article-number":"jeb244282"}}