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However, it remains unclear how specialists adapt to only limited nutritional conditions in nature. In this study, we addressed this question by focusing on Drosophila fruit flies. The generalist Drosophila melanogaster can consume a wide variety of foods that contain high glucose levels. In contrast, the specialist Drosophila sechellia consumes only the Indian mulberry, known as noni (Morinda citrifolia), which contains relatively little glucose. We showed that the lifespan of D. sechellia was significantly shortened under a high-glucose diet, but this effect was not observed for D. melanogaster. In D. sechellia, a high-glucose diet induced disorganization of the gut epithelia and visceral muscles, which was associated with abnormal digestion and constipation. RNA-sequencing analysis revealed that many immune-responsive genes were suppressed in the gut of D. sechellia fed a high-glucose diet compared with those fed a control diet. Consistent with this difference in the expression of immune-responsive genes, high glucose-induced phenotypes were restored by the addition of tetracycline or scopoletin, a major nutritional component of noni, each of which suppresses gut bacterial growth. We propose that, in D. sechellia, a high-glucose diet impairs gut immune function, which leads to a change in gut microbiota, disorganization of the gut epithelial structure and a shortened lifespan.<\/jats:p>","DOI":"10.1242\/jeb.244423","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T06:11:00Z","timestamp":1665641460000},"source":"Crossref","is-referenced-by-count":16,"title":["Shortened lifespan induced by a high-glucose diet is associated with intestinal immune dysfunction in\n                    <i>Drosophila sechellia<\/i>"],"prefix":"10.1242","volume":"225","author":[{"given":"Maiko","family":"Abe","sequence":"first","affiliation":[{"name":"Graduate School of Science and Technology, University of Tsukuba 1 Degree Programs in Life and Earth Sciences , , Tennodai 1-1-1, Tsukuba, Ibaraki 305-8572 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Kamiyama","sequence":"additional","affiliation":[{"name":"Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba 2 , Tennodai 1-1-1, Tsukuba, Ibaraki 305-8577 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6726-1246","authenticated-orcid":false,"given":"Yasushi","family":"Izumi","sequence":"additional","affiliation":[{"name":"National Institute for Physiological Sciences 3 Division of Cell Structure , , Okazaki, Aichi 444-8787 , Japan"},{"name":"School of Life Science, SOKENDAI (Graduate University for Advanced Studies) 4 Department of Physiological Sciences , , Okazaki, Aichi 444-8585 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyin","family":"Qian","sequence":"additional","affiliation":[{"name":"School of Integrative and Global Majors, University of Tsukuba 5 PhD Program in Human Biology , , Tennodai 1-1-1, Tsukuba, Ibaraki 305-8577 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuma","family":"Yoshihashi","sequence":"additional","affiliation":[{"name":"Graduate School of Science and Technology, University of Tsukuba 1 Degree Programs in Life and Earth Sciences , , Tennodai 1-1-1, Tsukuba, Ibaraki 305-8572 , Japan"},{"name":"Mountain Science Center, University of Tsukuba 6 Sugadaira Research Station , , Sugadairakogen 1278-294, Nagano 386-2204 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5955-1187","authenticated-orcid":false,"given":"Yousuke","family":"Degawa","sequence":"additional","affiliation":[{"name":"Mountain Science Center, University of Tsukuba 6 Sugadaira Research Station , , Sugadairakogen 1278-294, Nagano 386-2204 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2887-3690","authenticated-orcid":false,"given":"Kaori","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Graduate School of Biostudies, Kyoto University 7 , Kyoto 606-8501 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5977-8501","authenticated-orcid":false,"given":"Yukako","family":"Hattori","sequence":"additional","affiliation":[{"name":"Graduate School of Biostudies, Kyoto University 7 , Kyoto 606-8501 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7204-3606","authenticated-orcid":false,"given":"Tadashi","family":"Uemura","sequence":"additional","affiliation":[{"name":"Graduate School of Biostudies, Kyoto University 7 , Kyoto 606-8501 , Japan"},{"name":"Research Center for Dynamic Living Systems, Kyoto University 8 , Kyoto 606-8501 , Japan"},{"name":"AMED-CREST, AMED 9 , Otemachi 1-7-1, Chiyoda-ku, Tokyo 100-0004 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1716-455X","authenticated-orcid":false,"given":"Ryusuke","family":"Niwa","sequence":"additional","affiliation":[{"name":"Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba 2 , Tennodai 1-1-1, Tsukuba, Ibaraki 305-8577 , Japan"},{"name":"AMED-CREST, AMED 9 , Otemachi 1-7-1, Chiyoda-ku, Tokyo 100-0004 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2022,10,31]]},"reference":[{"key":"2022103108414265200_JEB244423C1","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.ydbio.2016.10.011","article-title":"Metamorphosis of the Drosophila visceral musculature and its role in intestinal morphogenesis and stem cell formation","volume":"420","author":"Aghajanian","year":"2016","journal-title":"Dev. 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