{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:04:59Z","timestamp":1753884299745,"version":"3.41.2"},"reference-count":70,"publisher":"The Company of Biologists","issue":"16","license":[{"start":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T00:00:00Z","timestamp":1692057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/501100001509","name":"Royal Society of New Zealand","doi-asserted-by":"crossref","award":["14-UOA-210"],"award-info":[{"award-number":["14-UOA-210"]}],"id":[{"id":"10.13039\/501100001509","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Oxygen is essential for most eukaryotic lifeforms, as it supports mitochondrial oxidative phosphorylation to supply \u223c90% of cellular adenosine triphosphate (ATP). Fluctuations in O2 present a major stressor, with hypoxia leading to a cascade of detrimental physiological changes that alter cell operations and ultimately induce death. Nonetheless, some species episodically tolerate near-anoxic environments, and have evolved mechanisms to sustain function even during extended hypoxic periods. While mitochondria are pivotal in central metabolism, their role in hypoxia tolerance remains ill defined. Given the vulnerability of the brain to hypoxia, mitochondrial function was tested in brain homogenates of three closely related triplefin species with varying degrees of hypoxia tolerance (Bellapiscis medius, Forsterygion lapillum and Forsterygion varium). High-resolution respirometry coupled with fluorometric measurements of mitochondrial membrane potential (mtMP) permitted assessment of differences in mitochondrial function and integrity in response to intermittent hypoxia and anoxia. Traditional steady-state measures of respiratory flux and mtMP showed no differences among species. However, in the transition into anoxia, the tolerant species B. medius and F. lapillum maintained mtMP at O2 pressures 7- and 4.4-fold lower, respectively, than that of the hypoxia-sensitive F. varium and exhibited slower rates of membrane depolarisation. The results indicate that dynamic oxic-hypoxic mitochondria transitions underlie hypoxia tolerance in these intertidal fish.<\/jats:p>","DOI":"10.1242\/jeb.245926","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T14:13:40Z","timestamp":1690467220000},"source":"Crossref","is-referenced-by-count":2,"title":["Dynamic defence? Intertidal triplefin species show better maintenance of mitochondrial membrane potential than subtidal species at low oxygen pressures"],"prefix":"10.1242","volume":"226","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7066-8954","authenticated-orcid":false,"given":"Alice R.","family":"Harford","sequence":"first","affiliation":[{"name":"School of Biological Sciences, University of Auckland , Auckland 1010 , New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5280-3871","authenticated-orcid":false,"given":"Jules B. L.","family":"Devaux","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Auckland , Auckland 1010 , New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony J. R.","family":"Hickey","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Auckland , Auckland 1010 , New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2023,8,22]]},"reference":[{"key":"2023082207531359600_JEB245926C1","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.3389\/fphys.2019.01199","article-title":"Natural tolerance to ischemia and hypoxemia in diving mammals: a review","volume":"10","author":"Allen","year":"2019","journal-title":"Front. Physiol."},{"key":"2023082207531359600_JEB245926C2","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1146\/annurev.physiol.69.031905.162529","article-title":"Hypoxia tolerance in reptiles, amphibians, and fishes: life with variable oxygen availability","volume":"69","author":"Bickler","year":"2007","journal-title":"Annu. Rev. Physiol."},{"key":"2023082207531359600_JEB245926C3","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/S1095-6433(00)00234-8","article-title":"Surviving hypoxia without really dying","volume":"126","author":"Boutilier","year":"2000","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"2023082207531359600_JEB245926C4","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1046\/j.1471-4159.2000.741263.x","article-title":"Ascorbate inhibits edema in brain slices","volume":"74","author":"Brahma","year":"2000","journal-title":"J. Neurochem."},{"key":"2023082207531359600_JEB245926C5","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/978-3-662-04162-8_44","article-title":"Mitochondrial proton conductance, standard metabolic rate and metabolic depression","volume-title":"Life in the Cold","author":"Brand","year":"2000"},{"key":"2023082207531359600_JEB245926C6","first-page":"333","article-title":"Measurement of ADP\u2013ATP exchange in relation to mitochondrial transmembrane potential and oxygen consumption","volume-title":"Methods in Enzymology","author":"Chinopoulos","year":"2014"},{"key":"2023082207531359600_JEB245926C7","doi-asserted-by":"publisher","first-page":"e00286","DOI":"10.1042\/BSR20150244","article-title":"Simultaneous evaluation of substrate-dependent oxygen consumption rates and mitochondrial membrane potential by TMRM and safranin in cortical mitochondria","volume":"36","author":"Chowdhury","year":"2016","journal-title":"Biosci. Rep."},{"key":"2023082207531359600_JEB245926C8","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.3389\/fphys.2018.01941","article-title":"Acidosis maintains the function of brain mitochondria in hypoxia-tolerant triplefin fish: a strategy to survive acute hypoxic exposure?","volume":"9","author":"Devaux","year":"2018","journal-title":"Front. Physiol."},{"key":"2023082207531359600_JEB245926C9","doi-asserted-by":"publisher","first-page":"jeb191353","DOI":"10.1242\/jeb.191353","article-title":"Mitochondrial plasticity in the cerebellum of two anoxia-tolerant sharks: contrasting responses to anoxia\/re-oxygenation","volume":"222","author":"Devaux","year":"2019","journal-title":"J. Exp. Biol."},{"key":"2023082207531359600_JEB245926C10","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1007\/s00360-023-01495-4","article-title":"Electron transfer and ROS production in brain mitochondria of intertidal and subtidal triplefin fish (Tripterygiidae)","volume":"193","author":"Devaux","year":"2023","journal-title":"J. Comp. Physiol. B"},{"key":"2023082207531359600_JEB245926C11","doi-asserted-by":"publisher","first-page":"cov067","DOI":"10.1093\/conphys\/cov067","article-title":"Progressive hypoxia decouples activity and aerobic performance of skate embryos","volume":"4","author":"Di Santo","year":"2016","journal-title":"Conserv. Physiol."},{"key":"2023082207531359600_JEB245926C12","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.yjmcc.2012.07.015","article-title":"SR and mitochondria: calcium cross-talk between kissing cousins","volume":"55","author":"Dorn","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"key":"2023082207531359600_JEB245926C13","doi-asserted-by":"publisher","first-page":"3427","DOI":"10.1016\/j.febslet.2006.04.097","article-title":"Characterization of dimeric ATP synthase and cristae membrane ultrastructure from Saccharomyces and Polytomella mitochondria","volume":"580","author":"Dudkina","year":"2006","journal-title":"FEBS Lett."},{"key":"2023082207531359600_JEB245926C14","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s00360-014-0806-3","article-title":"Mitochondria from anoxia-tolerant animals reveal common strategies to survive without oxygen","volume":"184","author":"Galli","year":"2014","journal-title":"J. Comp. Physiol. B"},{"key":"2023082207531359600_JEB245926C15","doi-asserted-by":"publisher","first-page":"2845","DOI":"10.1113\/jphysiol.2012.228387","article-title":"Quantitative measurement of mitochondrial membrane potential in cultured cells: calcium\u2013induced de\u2013and hyperpolarization of neuronal mitochondria","volume":"590","author":"Gerencser","year":"2012","journal-title":"J. Physiol."},{"volume-title":"Mitochondrial Pathways and Respiratory Control. An Introduction to OXPHOS Analysis","year":"2007","author":"Gnaiger","key":"2023082207531359600_JEB245926C16"},{"key":"2023082207531359600_JEB245926C17","first-page":"352","article-title":"Polarographic oxygen sensors, the oxygraph and high-resolution respirometry to assess mitochondrial function","volume":"327","author":"Gnaiger","year":"2008","journal-title":"Drug-Induced Mitochondrial Dysfunction"},{"key":"2023082207531359600_JEB245926C18","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1042\/bj1480085","article-title":"The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors","volume":"148","author":"Halestrap","year":"1975","journal-title":"Biochem. J."},{"key":"2023082207531359600_JEB245926C19","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s00360-002-0313-9","article-title":"Key metabolic enzymes and muscle structure in triplefin fishes (Tripterygiidae): a phylogenetic comparison","volume":"173","author":"Hickey","year":"2003","journal-title":"J. Comp. Physiol. B"},{"key":"2023082207531359600_JEB245926C20","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1111\/j.1365-294X.2008.04052.x","article-title":"New Zealand triplefin fishes (family Tripterygiidae): contrasting population structure and mtDNA diversity within a marine species flock","volume":"18","author":"Hickey","year":"2009","journal-title":"Mol. Ecol."},{"key":"2023082207531359600_JEB245926C21","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s00360-011-0599-6","article-title":"A radical approach to beating hypoxia: depressed free radical release from heart fibres of the hypoxia-tolerant epaulette shark (Hemiscyllum ocellatum)","volume":"182","author":"Hickey","year":"2012","journal-title":"J. Comp. Physiol. B"},{"key":"2023082207531359600_JEB245926C22","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1007\/s00360-010-0477-7","article-title":"Temperature sensitivity of cardiac mitochondria in intertidal and subtidal triplefin fishes","volume":"180","author":"Hilton","year":"2010","journal-title":"J. Comp. Physiol. B"},{"key":"2023082207531359600_JEB245926C23","doi-asserted-by":"publisher","first-page":"9493","DOI":"10.1073\/pnas.93.18.9493","article-title":"Unifying theory of hypoxia tolerance: molecular\/metabolic defense and rescue mechanisms for surviving oxygen lack","volume":"93","author":"Hochachka","year":"1996","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2023082207531359600_JEB245926C24","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1172\/JCI24405","article-title":"Mitochondrial energy metabolism in heart failure: a question of balance","volume":"115","author":"Huss","year":"2005","journal-title":"J. Clin. Invest."},{"key":"2023082207531359600_JEB245926C25","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1016\/j.bbamem.2017.03.013","article-title":"Cardiolipin and mitochondrial cristae organization","volume":"1859","author":"Ikon","year":"2017","journal-title":"Biochim. Biophys. Acta. Biomembr."},{"key":"2023082207531359600_JEB245926C26","doi-asserted-by":"publisher","first-page":"e2704","DOI":"10.3791\/2704","article-title":"Determination of mitochondrial membrane potential and reactive oxygen species in live rat cortical neurons","author":"Joshi","year":"2011","journal-title":"J. Vis. Exp"},{"key":"2023082207531359600_JEB245926C27","first-page":"113","article-title":"Ischemia\/reperfusion","volume":"7","author":"Kalogeris","year":"2011","journal-title":"Compr. Physiol."},{"key":"2023082207531359600_JEB245926C28","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/j.1365-2613.2012.00838.x","article-title":"Does an anti\u2013oxidant ascorbic acid improve the condition of hippocampal formation slice preparations?\u2013a micro\u2013EEG approach","volume":"93","author":"Kazmierska","year":"2012","journal-title":"Int. J. Exp. Pathol."},{"key":"2023082207531359600_JEB245926C29","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.1016\/j.bbamem.2008.04.011","article-title":"The ADP and ATP transport in mitochondria and its carrier","volume":"1778","author":"Klingenberg","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"2023082207531359600_JEB245926C30","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s00109-016-1413-4","article-title":"Transgenic overexpression of adenine nucleotide translocase 1 protects ischemic hearts against oxidative stress","volume":"94","author":"Klumpe","year":"2016","journal-title":"J. Mol. Med."},{"key":"2023082207531359600_JEB245926C31","doi-asserted-by":"publisher","first-page":"5446","DOI":"10.1073\/pnas.96.10.5446","article-title":"Oxygen sensing in yeast: evidence for the involvement of the respiratory chain in regulating the transcription of a subset of hypoxic genes","volume":"96","author":"Kwast","year":"1999","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2023082207531359600_JEB245926C70","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.ab.2013.10.023","article-title":"The best approach: homogenization or manual permeabilization of human skeletal muscle fibers for respirometry?","volume":"446","author":"Larsen","year":"2014","journal-title":"Anal. Biochem."},{"key":"2023082207531359600_JEB245926C32","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1093\/molbev\/msx179","article-title":"Evolution of cytochrome c oxidase in hypoxia tolerant sculpins (Cottidae, Actinopterygii)","volume":"34","author":"Lau","year":"2017","journal-title":"Mol. Biol. Evol."},{"key":"2023082207531359600_JEB245926C33","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/978-1-4615-6111-8_24","article-title":"The mitochondrial permeability transition in toxic, hypoxic and reperfusion injury","volume-title":"Detection of Mitochondrial Diseases","author":"Lemasters","year":"1997"},{"key":"2023082207531359600_JEB245926C34","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1242\/jeb.005371","article-title":"Responses to hypoxia and recovery: repayment of oxygen debt is not associated with compensatory protein synthesis in the Amazonian cichlid, Astronotus ocellatus","volume":"210","author":"Lewis","year":"2007","journal-title":"J. Exp. Biol."},{"key":"2023082207531359600_JEB245926C35","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1098\/rspb.2008.1235","article-title":"Mechanisms and evolution of hypoxia tolerance in fish","volume":"276","author":"Mandic","year":"2009","journal-title":"Proc. Biol. Sci."},{"key":"2023082207531359600_JEB245926C36","doi-asserted-by":"publisher","first-page":"jeb189993","DOI":"10.1242\/jeb.189993","article-title":"Hyperoxia increases maximum oxygen consumption and aerobic scope of intertidal fish facing acutely high temperatures","volume":"221","author":"McArley","year":"2018","journal-title":"J. Exp. Biol."},{"key":"2023082207531359600_JEB245926C37","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s00360-019-01216-w","article-title":"Intertidal triplefin fishes have a lower critical oxygen tension (P crit), higher maximal aerobic capacity, and higher tissue glycogen stores than their subtidal counterparts","volume":"189","author":"McArley","year":"2019","journal-title":"J. Comp. Physiol. B"},{"key":"2023082207531359600_JEB245926C38","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1038\/191144a0","article-title":"Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism","volume":"191","author":"Mitchell","year":"1961","journal-title":"Nature"},{"key":"2023082207531359600_JEB245926C39","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1042\/BST20160108","article-title":"Understanding and preventing mitochondrial oxidative damage","volume":"44","author":"Murphy","year":"2016","journal-title":"Biochem. Soc. Trans."},{"key":"2023082207531359600_JEB245926C40","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/S0166-2236(99)01534-9","article-title":"Mitochondrial membrane potential and neuronal glutamate excitotoxicity: mortality and millivolts","volume":"23","author":"Nicholls","year":"2000","journal-title":"Trends Neurosci."},{"key":"2023082207531359600_JEB245926C41","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3389\/fnene.2012.00003","article-title":"Brain glycogen-new perspectives on its metabolic function and regulation at the subcellular level","volume":"4","author":"Obel","year":"2012","journal-title":"Front. Neuroenergetics"},{"key":"2023082207531359600_JEB245926C42","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1139\/cjz-2013-0247","article-title":"Mitochondria: a multimodal hub of hypoxia tolerance","volume":"92","author":"Pamenter","year":"2014","journal-title":"Can. J. Zool."},{"key":"2023082207531359600_JEB245926C43","doi-asserted-by":"publisher","first-page":"20150797","DOI":"10.1098\/rsbl.2015.0797","article-title":"Mitochondrial responses to prolonged anoxia in brain of red-eared slider turtles","volume":"12","author":"Pamenter","year":"2016","journal-title":"Biol. Lett."},{"key":"2023082207531359600_JEB245926C44","doi-asserted-by":"publisher","first-page":"98","DOI":"10.2144\/000113610","article-title":"Mitochondrial membrane potential probes and the proton gradient: a practical usage guide","volume":"50","author":"Perry","year":"2011","journal-title":"BioTechniques"},{"key":"2023082207531359600_JEB245926C45","doi-asserted-by":"publisher","first-page":"C499","DOI":"10.1152\/ajpcell.00006.2014","article-title":"Mitochondrial inefficiencies and anoxic ATP hydrolysis capacities in diabetic rat heart","volume":"307","author":"Pham","year":"2014","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"2023082207531359600_JEB245926C46","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1016\/j.biocel.2009.01.009","article-title":"Evidence for aerobic ATP synthesis in isolated myelin vesicles","volume":"41","author":"Ravera","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"2023082207531359600_JEB245926C47","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/s0196-0644(85)80055-x","article-title":"Brain acidosis","volume":"14","author":"Rehncrona","year":"1985","journal-title":"Ann. Emerg. Med."},{"key":"2023082207531359600_JEB245926C48","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/0735-6757(83)90085-2","article-title":"Tissue lactic acidosis and ischemic brain damage","volume":"1","author":"Rehncrona","year":"1983","journal-title":"Am. J. Emerg. Med."},{"key":"2023082207531359600_JEB245926C49","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1006\/meth.1999.0767","article-title":"Use of ascorbate in the preparation and maintenance of brain slices","volume":"18","author":"Rice","year":"1999","journal-title":"Methods"},{"key":"2023082207531359600_JEB245926C50","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1242\/jeb.047951","article-title":"Physiological, behavioral and biochemical adaptations of intertidal fishes to hypoxia","volume":"214","author":"Richards","year":"2011","journal-title":"J. Exp. Biol."},{"volume-title":"Fish Physiology: Hypoxia","year":"2009","author":"Richards","key":"2023082207531359600_JEB245926C51"},{"key":"2023082207531359600_JEB245926C52","doi-asserted-by":"publisher","first-page":"cow012","DOI":"10.1093\/conphys\/cow012","article-title":"A new analysis of hypoxia tolerance in fishes using a database of critical oxygen level (Pcrit)","volume":"4","author":"Rogers","year":"2016","journal-title":"Conserv. Physiol."},{"key":"2023082207531359600_JEB245926C53","doi-asserted-by":"publisher","first-page":"H743","DOI":"10.1152\/ajpheart.1983.244.6.H743","article-title":"Mitochondrial complexes I, II, III, IV, and V in myocardial ischemia and autolysis","volume":"244","author":"Rouslin","year":"1983","journal-title":"Am. J. Physiol."},{"key":"2023082207531359600_JEB245926C54","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/s1095-6433(01)00484-6","article-title":"Exposure to hypoxia primes the respiratory and metabolic responses of the epaulette shark to progressive hypoxia","volume":"131","author":"Routley","year":"2002","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"2023082207531359600_JEB245926C68","doi-asserted-by":"publisher","first-page":"e13007","DOI":"10.14814\/phy2.13007","article-title":"Simultaneous measurement of mitochondrial respiration and ATP production in tissue homogenates and calculation of effective P\/O ratios","volume":"4","author":"Salin","year":"2016","journal-title":"Physiol Rep."},{"key":"2023082207531359600_JEB245926C69","doi-asserted-by":"publisher","first-page":"3645","DOI":"10.1098\/rspb.2009.0947","article-title":"Evolution of muscle phenotype for extreme high altitude flight in the bar-headed goose","volume":"276","author":"Scott","year":"2009","journal-title":"Proc. Biol. Sci."},{"key":"2023082207531359600_JEB245926C55","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1002\/9780470720691.ch5","article-title":"Lactic acidosis in the brain: occurrence, triggering mechanisms and pathophysiological importance","volume":"87","author":"Siesj\u00f6","year":"1982","journal-title":"Ciba Found. Symp."},{"key":"2023082207531359600_JEB245926C56","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/BF03160355","article-title":"Acidosis and ischemic brain damage","volume":"9","author":"Siesj\u00f6","year":"1988","journal-title":"Neurochem. Pathol."},{"key":"2023082207531359600_JEB245926C57","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1002\/mrm.25468","article-title":"Comparison of brain gray and white matter macromolecule resonances at 3 and 7 Tesla","volume":"74","author":"Snoussi","year":"2015","journal-title":"Magn. Reson. Med."},{"key":"2023082207531359600_JEB245926C58","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1093\/icb\/icy017","article-title":"Mitochondrial adaptations to variable environments and their role in animals\u2019 stress tolerance","volume":"58","author":"Sokolova","year":"2018","journal-title":"Integr. Comp. Biol."},{"key":"2023082207531359600_JEB245926C59","doi-asserted-by":"publisher","first-page":"773734","DOI":"10.3389\/fmars.2021.773734","article-title":"Intrinsic mechanisms underlying hypoxia-tolerant mitochondrial phenotype during hypoxia-reoxygenation stress in a marine facultative anaerobe, the blue mussel Mytilus edulis","volume":"8","author":"Sokolov","year":"2021","journal-title":"Front. Mar. Sci."},{"key":"2023082207531359600_JEB245926C60","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1016\/j.bbabio.2010.02.011","article-title":"Hypoxia and mitochondrial oxidative metabolism","volume":"1797","author":"Solaini","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"2023082207531359600_JEB245926C61","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1242\/jeb.059667","article-title":"Hypoxia tolerance in elasmobranchs. II. Cardiovascular function and tissue metabolic responses during progressive and relative hypoxia exposures","volume":"215","author":"Speers-Roesch","year":"2012","journal-title":"J. Exp. Biol."},{"key":"2023082207531359600_JEB245926C62","doi-asserted-by":"publisher","first-page":"781558","DOI":"10.3389\/fcell.2022.781558","article-title":"Genes involved in maintaining mitochondrial membrane potential upon electron transport chain disruption","volume":"10","author":"Vasan","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"2023082207531359600_JEB245926C63","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1080\/17451000701877282","article-title":"Recovery from hypoxia with and without sulfide in Saduria entomon: potassium, ATP and behavior","volume":"4","author":"Vismann","year":"2008","journal-title":"Mar. Biol. Res."},{"key":"2023082207531359600_JEB245926C64","doi-asserted-by":"publisher","first-page":"R1482","DOI":"10.1152\/ajpregu.00172.2006","article-title":"Seasonal changes in glycogen content and Na+-K+-ATPase activity in the brain of crucian carp","volume":"291","author":"Vornanen","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2023082207531359600_JEB245926C65","doi-asserted-by":"publisher","first-page":"11074","DOI":"10.1038\/s41598-021-90575-y","article-title":"Thermally tolerant intertidal triplefin fish (Tripterygiidae) sustain ATP dynamics better than subtidal species under acute heat stress","volume":"11","author":"Willis","year":"2021","journal-title":"Sci. Rep."},{"key":"2023082207531359600_JEB245926C66","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.cellsig.2015.11.002","article-title":"Adenine nucleotide translocase 1 overexpression protects cardiomyocytes against hypoxia via increased ERK1\/2 and AKT activation","volume":"28","author":"Winter","year":"2016","journal-title":"Cell. Signal."},{"key":"2023082207531359600_JEB245926C67","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.ab.2017.07.009","article-title":"Mitochondrial membrane potential","volume":"552","author":"Zorova","year":"2018","journal-title":"Anal. Biochem."}],"container-title":["Journal of Experimental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/jeb\/article-pdf\/doi\/10.1242\/jeb.245926\/3084086\/jeb245926.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/jeb\/article-pdf\/doi\/10.1242\/jeb.245926\/3106545\/jeb245926.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/jeb\/article-pdf\/doi\/10.1242\/jeb.245926\/3106545\/jeb245926.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,17]],"date-time":"2023-12-17T23:18:13Z","timestamp":1702855093000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/jeb\/article\/226\/16\/jeb245926\/325974\/Dynamic-defence-Intertidal-triplefin-species-show"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,15]]},"references-count":70,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2023,8,15]]}},"URL":"https:\/\/doi.org\/10.1242\/jeb.245926","relation":{},"ISSN":["0022-0949","1477-9145"],"issn-type":[{"type":"print","value":"0022-0949"},{"type":"electronic","value":"1477-9145"}],"subject":[],"published":{"date-parts":[[2023,8,15]]},"article-number":"jeb245926"}}