{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T01:00:02Z","timestamp":1780966802745,"version":"3.54.1"},"reference-count":65,"publisher":"The Company of Biologists","issue":"22","license":[{"start":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:00:00Z","timestamp":1700006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"name":"Science and Technology Development Fund","award":["046\/2018\/A2"],"award-info":[{"award-number":["046\/2018\/A2"]}]},{"name":"Science and Technology Development Fund","award":["0068\/2020\/A2"],"award-info":[{"award-number":["0068\/2020\/A2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The three otolithic endorgans of the inner ear are known to be involved in sound detection in different teleost fishes, yet their relative roles for auditory\u2013vestibular functions within the same species remain uncertain. In zebrafish (Danio rerio), the saccule and utricle are thought to play key functions in encoding auditory and vestibular information, respectively, but the biological function of the lagena is not clear. We hypothesized that the zebrafish saccule serves as a primary auditory endorgan, making it more vulnerable to noise exposure, and that the lagena might have an auditory function given its connectivity to the saccule and the dominant vestibular function of the utricle. We compared the impact of acoustic trauma (continuous white noise at 168\u2005dB for 24\u2005h) between the sensory epithelia of the three otolithic endorgans. Noise treatment caused hair cell loss in both the saccule and lagena but not in the utricle. This effect was identified immediately after acoustic treatment and did not increase 24\u2005h post-trauma. Furthermore, hair cell loss was accompanied by a reduction in presynaptic activity measured based on ribeye b presence, but mainly in the saccule, supporting its main contribution for noise-induced hearing loss. Our findings support the hypothesis that the saccule plays a major role in sound detection and that the lagena is also acoustically affected, extending the species hearing dynamic range.<\/jats:p>","DOI":"10.1242\/jeb.245992","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T05:30:48Z","timestamp":1695879048000},"source":"Crossref","is-referenced-by-count":8,"title":["Noise-induced damage in the zebrafish inner ear endorgans: evidence for higher acoustic sensitivity of saccular and lagenar hair cells"],"prefix":"10.1242","volume":"226","author":[{"given":"Ieng Hou","family":"Lau","sequence":"first","affiliation":[{"name":"Institute of Science and Environment, University of Saint Joseph 1 , Macao, S.A.R. , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1836-7647","authenticated-orcid":false,"given":"Raquel O.","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Institute of Science and Environment, University of Saint Joseph 1 , Macao, S.A.R. , China"},{"name":"MARE \u2013 Marine and Environmental Sciences Centre\/ARNET - Aquatic Research Network, Faculdade de Ci\u00eancias, Universidade de Lisboa 2 , 1749-016 Lisbon , Portugal"},{"name":"Lus\u00f3fona University 3 EPCV-Department of Life Sciences , , 1749-024 Lisbon , Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2023,11,16]]},"reference":[{"key":"2024010809503712900_JEB245992C1","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1002\/dvdy.10062","article-title":"Atlas of the developing inner ear in zebrafish","volume":"223","author":"Bever","year":"2002","journal-title":"Dev. 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