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Studying desert-adapted species provides a unique opportunity to investigate the survival strategies employed by organisms in some of the harshest habitats on Earth. Two of the primary challenges faced in desert environments are maintaining water balance and thermoregulation. We collected data in a simulated desert environment and a captive colony of cactus mice (Peromyscus eremicus) and used lab-based experiments with real time physiological measurements; energy expenditure, water loss rate and respiratory exchange rate, to characterize the response to water deprivation. Mice without access to water had significantly lower energy expenditures and in turn, reduced water loss compared to mice with access to water after the first 24\u2005h of the experiment. Additionally, we observed significant mass loss that is probably due to dehydration-associated anorexia a response to limit fluid loss by reducing waste and the solute load as well as allowing water reabsorption from the kidneys and gastrointestinal tract. Finally, we observed body temperature correlated with sex, with males without access to water maintaining body temperature when compared with hydrated males, whereas body temperature decreased for females without access to water, suggesting daily metabolic depression in females.<\/jats:p>","DOI":"10.1242\/jeb.246386","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T12:44:01Z","timestamp":1699015441000},"source":"Crossref","is-referenced-by-count":12,"title":["When the tap runs dry: the physiological effects of acute experimental dehydration in <i>Peromyscus eremicus<\/i>"],"prefix":"10.1242","volume":"226","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2129-5541","authenticated-orcid":false,"given":"Danielle M.","family":"Blumstein","sequence":"first","affiliation":[{"name":"University of New Hampshire Department of Molecular, Cellular, and Biomedical Sciences , , Durham, NH 03824 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2368-6960","authenticated-orcid":false,"given":"Matthew D.","family":"MacManes","sequence":"additional","affiliation":[{"name":"University of New Hampshire Department of Molecular, Cellular, and Biomedical Sciences , , Durham, NH 03824 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2023,12,1]]},"reference":[{"key":"2023120109341974600_JEB246386C1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.4314\/bajopas.v3i1.58780","article-title":"Effect of oral administration of aqueous extract of cassia occidentalis l. seeds on serum electrolytes concentration in rats","volume":"3","author":"Abubakar","year":"2010","journal-title":"Bayero J. 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