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The role of the renin\u2013angiotensin system (RAS) in regulating spermatogenesis has attracted considerable attention. Our previous study found that red-eared sliders (Trachemys scripta elegans), could survive in 10 PSU water for over 1 year. To understand the chronic impact of salinity on testicular spermatogenesis and underlying mechanisms, male T. s. elegans were subjected to treatment with water of 5 PSU and 10 PSU for a year, and spermatogenesis and regulation of the RAS signal pathway was assessed. Results showed induced inflammation in the testes of T. s. elegans in the 10 PSU group, as evidenced by a decrease in the number of testicular germ cells from 1586 to 943. Compared with the control group, the levels of proinflammatory genes, including TNF-\u03b1, IL-12A and IL-6 were elevated 3.1, 0.3, and 1.4 times, respectively, in animals exposed to 10 PSU water. Testicular antiapoptotic processes of T. s. elegans might involve the vasoactive peptide angiotensin-(1\u20137) in the RAS, as its level was significantly increased from 220.2\u2005ng ml\u22121 in controls to 419.2\u2005ng ml\u22121 in the 10 PSU group. As expected, specific inhibitor (A-779) for the Ang-(1\u20137) acceptor effectively prevented the salinity-induced upregulation of genes encoding anti-inflammatory and antiapoptotic factors (TGF-\u03b21, Bcl-6) in the testis of the 10 PSU animals, whereas it promoted the upregulation of proinflammatory and proapoptotic factors (TNF-\u03b1, IL-12A, IL-6, Bax and caspase-3). Our data indicated that Ang-(1\u20137) attenuates the effect of salinity on inflammation and apoptosis of the testis in T. s. elegans. A new perspective to prevent salinity-induced testis dysfunction is provided.<\/jats:p>","DOI":"10.1242\/jeb.246742","type":"journal-article","created":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T06:04:17Z","timestamp":1703657057000},"source":"Crossref","is-referenced-by-count":7,"title":["Angiotensin-(1\u20137) plays an important role in regulating spermatogenesis in\n                    <i>Trachemys scripta elegans<\/i>\n                    under salinity stress"],"prefix":"10.1242","volume":"227","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7850-2671","authenticated-orcid":false,"given":"Na","family":"Li","sequence":"first","affiliation":[{"name":"Ministry of Education Key Laboratory for Ecology of Tropical Islands, Key Laboratory of Tropical Animal and Plant Ecology of Hainan Province, College of Life Sciences, Hainan Normal University , Haikou 571158 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4626-2625","authenticated-orcid":false,"given":"Qiongyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory for Ecology of Tropical Islands, Key Laboratory of Tropical Animal and Plant Ecology of Hainan Province, College of Life Sciences, Hainan Normal University , Haikou 571158 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3171-4877","authenticated-orcid":false,"given":"Shiyu","family":"Dai","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory for Ecology of Tropical Islands, Key Laboratory of Tropical Animal and Plant Ecology of Hainan Province, College of Life Sciences, Hainan Normal University , Haikou 571158 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1680-3812","authenticated-orcid":false,"given":"Wenzhuo","family":"Rao","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory for Ecology of Tropical Islands, Key Laboratory of Tropical Animal and Plant Ecology of Hainan Province, College of Life Sciences, Hainan Normal University , Haikou 571158 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7138-277X","authenticated-orcid":false,"given":"Haitao","family":"Shi","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory for Ecology of Tropical Islands, Key Laboratory of Tropical Animal and Plant Ecology of Hainan Province, College of Life Sciences, Hainan Normal University , Haikou 571158 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1340-5333","authenticated-orcid":false,"given":"Li","family":"Ding","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory for Ecology of Tropical Islands, Key Laboratory of Tropical Animal and Plant Ecology of Hainan Province, College of Life Sciences, Hainan Normal University , Haikou 571158 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8567-4415","authenticated-orcid":false,"given":"Meiling","family":"Hong","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory for Ecology of Tropical Islands, Key Laboratory of Tropical Animal and Plant Ecology of Hainan Province, College of Life Sciences, Hainan Normal University , Haikou 571158 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2024,1,22]]},"reference":[{"key":"2024012208385368500_JEB246742C1","doi-asserted-by":"publisher","first-page":"312.e1","DOI":"10.1016\/j.urology.2016.04.021","article-title":"The tACE\/angiotensin (1-7)\/Mas axis protects against testicular ischemia reperfusion injury","volume":"94","author":"Al-Maghrebi","year":"2016","journal-title":"Urology"},{"key":"2024012208385368500_JEB246742C2","doi-asserted-by":"publisher","first-page":"425","DOI":"10.14744\/nci.2020.30906","article-title":"The effects of sacubitril\/valsartan and ramipril on the male fertility in hypertensive rats","volume":"7","author":"Aykan","year":"2020","journal-title":"North. 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