{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:04:54Z","timestamp":1772168694969,"version":"3.50.1"},"reference-count":60,"publisher":"The Company of Biologists","issue":"7","license":[{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100016934","name":"Troms\u00f8 Forskningsstiftelse","doi-asserted-by":"crossref","award":["TFS2016SW"],"award-info":[{"award-number":["TFS2016SW"]}],"id":[{"id":"10.13039\/100016934","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100016934","name":"Troms\u00f8 Forskningsstiftelse","doi-asserted-by":"crossref","award":["IS3_17_SW"],"award-info":[{"award-number":["IS3_17_SW"]}],"id":[{"id":"10.13039\/100016934","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Universitetet i Troms\u00f8"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Regulation of mitochondrial oxidative phosphorylation is essential to match energy supply to changing cellular energy demands, and to cope with periods of hypoxia. Recent work implicates the circadian molecular clock in control of mitochondrial function and hypoxia sensing. Because diving mammals experience intermittent episodes of severe hypoxia, with diel patterning in dive depth and duration, it is interesting to consider circadian\u2013mitochondrial interaction in this group. Here, we demonstrate that the hooded seal (Cystophora cristata), a deep-diving Arctic pinniped, shows strong daily patterning of diving behaviour in the wild. Cultures of hooded seal skin fibroblasts exhibit robust circadian oscillation of the core clock genes per2 and arntl. In liver tissue collected from captive hooded seals, expression of arntl was some 4-fold higher in the middle of the night than in the middle of the day. To explore the clock\u2013mitochondria relationship, we measured the mitochondrial oxygen consumption in synchronized hooded seal skin fibroblasts and found a circadian variation in mitochondrial activity, with higher coupling efficiency of complex I coinciding with the trough of arntl expression. These results open the way for further studies of circadian\u2013hypoxia interactions in pinnipeds during diving.<\/jats:p>","DOI":"10.1242\/jeb.246990","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T04:05:30Z","timestamp":1710734730000},"source":"Crossref","is-referenced-by-count":2,"title":["Circadian coupling of mitochondria in a deep-diving mammal"],"prefix":"10.1242","volume":"227","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0749-6198","authenticated-orcid":false,"given":"Chiara","family":"Ciccone","sequence":"first","affiliation":[{"name":"Arctic Seasonal Timekeeping Initiative (ASTI), Arctic Chronobiology and Physiology Research Group , Department of Arctic and Marine Biology , , Troms\u00f8 NO-9037 , Norway"},{"name":"UiT \u2013 The Arctic University of Norway , Department of Arctic and Marine Biology , , Troms\u00f8 NO-9037 , Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fayiri","family":"Kante","sequence":"additional","affiliation":[{"name":"Arctic Seasonal Timekeeping Initiative (ASTI), Arctic Chronobiology and Physiology Research Group , Department of Arctic and Marine Biology , , Troms\u00f8 NO-9037 , Norway"},{"name":"UiT \u2013 The Arctic University of Norway , Department of Arctic and Marine Biology , , Troms\u00f8 NO-9037 , Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6580-9156","authenticated-orcid":false,"given":"Lars P.","family":"Folkow","sequence":"additional","affiliation":[{"name":"Arctic Seasonal Timekeeping Initiative (ASTI), Arctic Chronobiology and Physiology Research Group , Department of Arctic and Marine Biology , , Troms\u00f8 NO-9037 , Norway"},{"name":"UiT \u2013 The Arctic University of Norway , Department of Arctic and Marine Biology , , Troms\u00f8 NO-9037 , Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4884-8409","authenticated-orcid":false,"given":"David G.","family":"Hazlerigg","sequence":"additional","affiliation":[{"name":"Arctic Seasonal Timekeeping Initiative (ASTI), Arctic Chronobiology and Physiology Research Group , Department of Arctic and Marine Biology , , Troms\u00f8 NO-9037 , Norway"},{"name":"UiT \u2013 The Arctic University of Norway , Department of Arctic and Marine Biology , , Troms\u00f8 NO-9037 , Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3934-5068","authenticated-orcid":false,"given":"Alexander C.","family":"West","sequence":"additional","affiliation":[{"name":"Arctic Seasonal Timekeeping Initiative (ASTI), Arctic Chronobiology and Physiology Research Group , Department of Arctic and Marine Biology , , Troms\u00f8 NO-9037 , Norway"},{"name":"UiT \u2013 The Arctic University of Norway , Department of Arctic and Marine Biology , , Troms\u00f8 NO-9037 , Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8273-4045","authenticated-orcid":false,"given":"Shona H.","family":"Wood","sequence":"additional","affiliation":[{"name":"Arctic Seasonal Timekeeping Initiative (ASTI), Arctic Chronobiology and Physiology Research Group , Department of Arctic and Marine Biology , , Troms\u00f8 NO-9037 , Norway"},{"name":"UiT \u2013 The Arctic University of Norway , Department of Arctic and Marine Biology , , Troms\u00f8 NO-9037 , Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2024,4,8]]},"reference":[{"key":"2024040808390561000_JEB246990C1","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.cmet.2016.09.014","article-title":"Rhythmic oxygen levels reset circadian clocks through HIF1\u03b1","volume":"25","author":"Adamovich","year":"2017","journal-title":"Cell Metab."},{"key":"2024040808390561000_JEB246990C2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.26508\/lsa.201900534","article-title":"BMAL1 coordinates energy metabolism and differentiation of pluripotent stem cells","volume":"3","author":"Ameneiro","year":"2020","journal-title":"Life Sci. 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