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Postprandial tachycardia, a well-documented phenomenon in these animals, is mediated by the withdrawal of vagal tone associated with the chronotropic effects of non-adrenergic and non-cholinergic (NANC) factors. However, herbivorous reptiles exhibit a modest metabolic increment during digestion and there is no information about postprandial cardiovascular adjustments. Considering the significant impact of feeding characteristics on physiological responses, we investigated cardiovascular and metabolic responses, as well as the neurohumoral mechanisms of cardiac control, in the herbivorous lizard Iguana iguana during digestion. We measured oxygen consumption rate (O2), heart rate (fH), mean arterial blood pressure (MAP), myocardial activity, cardiac autonomic tone, fH\/MAP variability and baroreflex efficiency in both fasting and digesting animals before and after parasympathetic blockade with atropine followed by double autonomic blockade with atropine and propranolol. Our results revealed that the peak of O2\u00a0in iguanas was reached 24\u2005h after feeding, accompanied by an increase in myocardial activity and a subtle tachycardia mediated exclusively by a reduction in cardiac parasympathetic activity. This represents the first reported case of postprandial tachycardia in digesting reptiles without the involvement of NANC factors. Furthermore, this withdrawal of vagal stimulation during digestion may reduce the regulatory range for short-term fH adjustments, subsequently intensifying the blood pressure variability as a consequence of limiting baroreflex efficiency.<\/jats:p>","DOI":"10.1242\/jeb.247105","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T08:40:40Z","timestamp":1704703240000},"source":"Crossref","is-referenced-by-count":4,"title":["Cardiovascular responses and the role of the neurohumoral cardiac regulation during digestion in the herbivorous lizard <i>Iguana iguana<\/i>"],"prefix":"10.1242","volume":"227","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2168-757X","authenticated-orcid":false,"given":"Igor Noll","family":"Guagnoni","sequence":"first","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP) 1 Department of Biological Sciences , , Rua Crist\u00f3v\u00e3o Colombo, 2265, S\u00e3o Jos\u00e9 do Rio Preto, SP 15054-000 , Brazil"},{"name":"National Institute of Science and Technology in Comparative Physiology (INCT \u2013 FAPESP\/CNPq) 2 , S\u00e3o Paulo, SP 13506-900 , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3933-9346","authenticated-orcid":false,"given":"Vinicius Ara\u00fajo","family":"Armelin","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP) 1 Department of Biological Sciences , , Rua Crist\u00f3v\u00e3o Colombo, 2265, S\u00e3o Jos\u00e9 do Rio Preto, SP 15054-000 , Brazil"},{"name":"National Institute of Science and Technology in Comparative Physiology (INCT \u2013 FAPESP\/CNPq) 2 , S\u00e3o Paulo, SP 13506-900 , Brazil"},{"name":"University of S\u00e3o Paulo (USP) 3 Department of Physiology, Institute of Biosciences (IB) , , S\u00e3o Paulo, SP 05508-090 , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2385-2252","authenticated-orcid":false,"given":"Victor Hugo","family":"da Silva Braga","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP) 1 Department of Biological Sciences , , Rua Crist\u00f3v\u00e3o Colombo, 2265, S\u00e3o Jos\u00e9 do Rio Preto, SP 15054-000 , Brazil"},{"name":"National Institute of Science and Technology in Comparative Physiology (INCT \u2013 FAPESP\/CNPq) 2 , S\u00e3o Paulo, SP 13506-900 , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1178-6673","authenticated-orcid":false,"given":"Diana Amaral","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Carlos (UFSCar) 4 Department of Physiological Sciences , , Rodovia Washington Luiz, km 235, S\u00e3o Carlos, SP 13565\u2013905 , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9430-8935","authenticated-orcid":false,"given":"Luiz Henrique","family":"Florindo","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP) 1 Department of Biological Sciences , , Rua Crist\u00f3v\u00e3o Colombo, 2265, S\u00e3o Jos\u00e9 do Rio Preto, SP 15054-000 , Brazil"},{"name":"National Institute of Science and Technology in Comparative Physiology (INCT \u2013 FAPESP\/CNPq) 2 , S\u00e3o Paulo, SP 13506-900 , Brazil"},{"name":"Federal University of S\u00e3o Carlos (UFSCar) 4 Department of Physiological Sciences , , Rodovia Washington Luiz, km 235, S\u00e3o Carlos, SP 13565\u2013905 , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"key":"2024020509283403300_JEB247105C1","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1172\/JCI111070","article-title":"Influence of \u03b2-adrenergic blockade on glucose-induced thermogenesis in man","volume":"72","author":"Acheson","year":"1983","journal-title":"J. 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