{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:23:51Z","timestamp":1792268631817,"version":"4.4.0"},"reference-count":145,"publisher":"The Company of Biologists","issue":"20","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["F32 HL170637"],"award-info":[{"award-number":["F32 HL170637"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 GM029090"],"award-info":[{"award-number":["R01 GM029090"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001674","name":"Leducq Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Some vertebrates evolved to have a remarkable capacity for anatomical and physiological plasticity in response to environmental challenges. One example of such plasticity can be found in the ambush-hunting snakes of the genus Python, which exhibit reversible cardiac growth with feeding. The predation strategy employed by pythons is associated with months-long fasts that are arrested by ingestion of large prey. Consequently, digestion compels a dramatic increase in metabolic rate and hypertrophy of multiple organs, including the heart. In this Review, we summarize the post-prandial cardiac adaptations in pythons at the whole-heart, cellular and molecular scales. We highlight circulating factors and cellular signaling pathways that are altered during digestion to affect cardiac form and function and propose possible mechanisms that may drive the post-digestion regression of cardiac mass. Adaptive physiological cardiac hypertrophy has also been observed in other vertebrates, including in fish acclimated to cold water, birds flying at high altitudes and exercising mammals. To reveal potential evolutionarily conserved features, we summarize the molecular signatures of reversible cardiac remodeling identified in these species and compare them with those of pythons. Finally, we offer a perspective on the potential of biomimetics targeting the natural biology of pythons as therapeutics for human heart disease.<\/jats:p>","DOI":"10.1242\/jeb.247445","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T07:53:50Z","timestamp":1727682830000},"source":"Crossref","is-referenced-by-count":10,"title":["Molecular regulation of reversible cardiac remodeling: lessons from species with extreme physiological adaptations"],"prefix":"10.1242","volume":"227","author":[{"given":"Thomas G.","family":"Martin","sequence":"first","affiliation":[{"name":"University of Colorado Boulder 1 Molecular, Cellular, and Developmental Biology Department , , Boulder, CO 80309 ,","place":["USA"]},{"name":"BioFrontiers Institute, University of Colorado Boulder 2 , Boulder, CO 80303 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1470-4810","authenticated-orcid":false,"given":"Leslie A.","family":"Leinwand","sequence":"additional","affiliation":[{"name":"University of Colorado Boulder 1 Molecular, Cellular, and Developmental Biology Department , , Boulder, CO 80309 ,","place":["USA"]},{"name":"BioFrontiers Institute, University of Colorado Boulder 2 , Boulder, CO 80303 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"key":"2024093007511219900_JEB247445C1","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s003600000171","article-title":"Cold acclimation increases basal heart rate but decreases its thermal tolerance in rainbow trout (Oncorhynchus mykiss)","volume":"171","author":"Aho","year":"2001","journal-title":"J. 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