{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:33:07Z","timestamp":1782397987631,"version":"3.54.5"},"reference-count":66,"publisher":"The Company of Biologists","issue":"20","license":[{"start":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:00:00Z","timestamp":1728950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["20AIREA35080049"],"award-info":[{"award-number":["20AIREA35080049"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Illumina Grants Program Development Award"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Exposure to winter cold causes an increase in energy demands to meet the challenge of thermoregulation. In small rodents, this increase in cardiac output leads to a profound cardiac hypertrophy, 2\u20133 times that typically seen with exercise training. The nature of this hypertrophy and its relevance to winter mortality remains unclear. Our goal was to characterize cold-induced cardiac hypertrophy and to assess its similarity to either exercise-induced (physiological) hypertrophy or the pathological hypertrophy of hypertension. We hypothesized that cold-induced hypertrophy will most closely resemble exercise-induced hypertrophy, but be another unique pathway for physiological cardiac growth. We found that cold-induced hypertrophy was largely reversed after a return to warm temperatures. Further, metabolic rates were elevated while gene expression and mitochondrial enzyme activities indicative of pathology were absent. A gene expression panel comparing hearts of exercised and cold-exposed mice further suggests that these activities are similar, although not identical. In conclusion, we found that chronic cold led to a phenotype that most closely resembled physiological hypertrophy, with enhanced metabolic rate, without induction of fetal genes, but with decreased expression of genes associated with fatty acid oxidation, suggesting that heart failure is not a cause of winter mortality in small rodents and identifying a novel approach for the study of cardiac growth.<\/jats:p>","DOI":"10.1242\/jeb.247476","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T09:21:15Z","timestamp":1724923275000},"source":"Crossref","is-referenced-by-count":6,"title":["Chronic cold exposure causes left ventricular hypertrophy that appears to be physiological"],"prefix":"10.1242","volume":"227","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8061-0479","authenticated-orcid":false,"given":"McKenna P. A.","family":"Burns","sequence":"first","affiliation":[{"name":"Miami University Department of Biology , , Oxford, OH 45056 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4230-5297","authenticated-orcid":false,"given":"Caroline R.","family":"Reges","sequence":"additional","affiliation":[{"name":"Miami University Department of Biology , , Oxford, OH 45056 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3592-4775","authenticated-orcid":false,"given":"Spencer W.","family":"Barnhill","sequence":"additional","affiliation":[{"name":"Miami University Department of Biology , , Oxford, OH 45056 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8358-6988","authenticated-orcid":false,"given":"Kenna N.","family":"Koehler","sequence":"additional","affiliation":[{"name":"Miami University Department of Biology , , Oxford, OH 45056 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon C.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Miami University Department of Biology , , Oxford, OH 45056 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8224-8939","authenticated-orcid":false,"given":"Alyssa T.","family":"Colombo","sequence":"additional","affiliation":[{"name":"Miami University Department of Biology , , Oxford, OH 45056 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick J.","family":"Felter","sequence":"additional","affiliation":[{"name":"Miami University Department of Biology , , Oxford, OH 45056 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6230-8121","authenticated-orcid":false,"given":"Paul J.","family":"Schaeffer","sequence":"additional","affiliation":[{"name":"Miami University Department of Biology , , Oxford, OH 45056 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"key":"2024101709112093800_JEB247476C1","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1093\/cvr\/cvr015","article-title":"Mitochondrial adaptations to physiological vs. pathological cardiac hypertrophy","volume":"90","author":"Abel","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"2024101709112093800_JEB247476C2","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1079\/PNS2004334","article-title":"Involvement of PPAR gamma co-activator-1, nuclear respiratory factors 1 and 2, and PPAR alpha in the adaptive response to endurance exercise","volume":"63","author":"Baar","year":"2004","journal-title":"Proc. Nutr. Soc."},{"key":"2024101709112093800_JEB247476C63","doi-asserted-by":"publisher","first-page":"20190135","DOI":"10.1098\/rstb.2019.0135","article-title":"Uncoupling of sarcoendoplasmic reticulum calcium ATPase pump activity by sarcolipin as the basis for muscle non-shivering thermogenesis","volume":"375","author":"Bal","year":"2020","journal-title":"Phil. Trans. R. Soc. B."},{"key":"2024101709112093800_JEB247476C3","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1007\/s40265-017-0701-9","article-title":"JAK-STAT Signaling as a target for inflammatory and autoimmune diseases: current and future prospects","volume":"77","author":"Banerjee","year":"2017","journal-title":"Drugs"},{"key":"2024101709112093800_JEB247476C4","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.3390\/cells12131780","article-title":"The microenvironment of the pathogenesis of cardiac hypertrophy","volume":"12","author":"Bazgir F","year":"2023","journal-title":"Cells"},{"key":"2024101709112093800_JEB247476C5","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1007\/s00442-011-2120-z","article-title":"Population dynamics of red-backed voles (Myodes) in North America","volume":"168","author":"Boonstra","year":"2012","journal-title":"Oecologia"},{"key":"2024101709112093800_JEB247476C64","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1089\/hum.2016.047","article-title":"AAV delivery of endothelin-1 shRNA attenuates cold-induced hypertension","volume":"28","author":"Chen","year":"2017","journal-title":"Hum. Gene Ther."},{"key":"2024101709112093800_JEB247476C6","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/j.bbalip.2008.07.006","article-title":"Cold acclimation induces physiological cardiac hypertrophy and increases assimilation of triacylglycerol metabolism through lipoprotein lipase","volume":"1781","author":"Cheng","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"2024101709112093800_JEB247476C8","doi-asserted-by":"publisher","first-page":"e42297","DOI":"10.1371\/journal.pone.0042297","article-title":"Distinct cardiac transcriptional profiles defining pregnancy and exercise","volume":"7","author":"Chung","year":"2012","journal-title":"PLoS One"},{"key":"2024101709112093800_JEB247476C9","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1093\/cvr\/cvu013","article-title":"Pregnancy as a cardiac stress model","volume":"101","author":"Chung","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"2024101709112093800_JEB247476C10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12872-018-0748-x","article-title":"Cold exposure induced oxidative stress and apoptosis in the myocardium by inhibiting the Nrf2-Keap1 signaling pathway","volume":"18","author":"Cong","year":"2018","journal-title":"BMC Cardiovasc. Disord."},{"key":"2024101709112093800_JEB247476C11","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1002\/uog.17360","article-title":"Physiological adaptation of maternal plasma volume during pregnancy: a systematic review and meta-analysis","volume":"49","author":"de Haas","year":"2017","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"2024101709112093800_JEB247476C12","doi-asserted-by":"publisher","first-page":"2414","DOI":"10.1016\/j.bbadis.2013.07.023","article-title":"Regulation of fetal gene expression in heart failure","volume":"1832","author":"Dirkx","year":"2013","journal-title":"BBA Mol. Basis Dis."},{"key":"2024101709112093800_JEB247476C13","doi-asserted-by":"publisher","first-page":"22","DOI":"10.2174\/1573402114666180918102735","article-title":"Three generations of \u03b2-blockers: history, class differences and clinical applicability","volume":"15","author":"do Vale","year":"2019","journal-title":"Curr. Hypertens. Rev."},{"key":"2024101709112093800_JEB247476C14","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1161\/HYPERTENSIONAHA.106.079426","article-title":"The fuzzy logic of physiological cardiac hypertrophy","volume":"49","author":"Dorn","year":"2007","journal-title":"Hypertension"},{"key":"2024101709112093800_JEB247476C15","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1124\/pr.109.001560","article-title":"Regulation of skeletal muscle physiology and metabolism by peroxisome proliferator-activated receptor delta","volume":"61","author":"Ehrenborg","year":"2009","journal-title":"Pharmacol. Rev."},{"key":"2024101709112093800_JEB247476C17","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/BF03192487","article-title":"Comparing life histories of shrews and rodents","volume":"47","author":"Gliwicz","year":"2002","journal-title":"Acta Theriol."},{"key":"2024101709112093800_JEB247476C18","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1172\/JCI108079","article-title":"Wall stress and patterns of hypertrophy in the human left ventricle","volume":"56","author":"Grossman","year":"1975","journal-title":"J. Clin. Invest"},{"key":"2024101709112093800_JEB247476C19","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s00360-021-01423-4","article-title":"Phenotypic plasticity to chronic cold exposure in two species of Peromyscus from different environments","volume":"192","author":"Hayward","year":"2022","journal-title":"J. Comp. Physiol. B"},{"key":"2024101709112093800_JEB247476C20","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1172\/JCI24405","article-title":"Mitochondrial energy metabolism in heart failure: a question of balance","volume":"115","author":"Huss","year":"2005","journal-title":"J. Clin. Invest"},{"key":"2024101709112093800_JEB247476C21","doi-asserted-by":"publisher","first-page":"S68","DOI":"10.1097\/00005344-199106182-00015","article-title":"The cardiomyopathy of overload: a hypothesis","volume":"18","author":"Katz","year":"1991","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"2024101709112093800_JEB247476C22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0034-5687(85)90013-1","article-title":"Volume overload hypertrophy elicited by cold and its effects on myocardial capillarity","volume":"59","author":"Kayar","year":"1985","journal-title":"Resp. Physiol."},{"key":"2024101709112093800_JEB247476C23","doi-asserted-by":"publisher","first-page":"580811","DOI":"10.3389\/fphys.2020.580811","article-title":"Unraveling the mystery of cold stress-induced myocardial injury","volume":"11","author":"Kong","year":"2020","journal-title":"Front. Physiol."},{"key":"2024101709112093800_JEB247476C24","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1161\/CIRCRESAHA.117.305205","article-title":"Exercise and the cardiovascular system clinical science and cardiovascular outcomes","volume":"117","author":"Lavie","year":"2015","journal-title":"Circ. Res."},{"key":"2024101709112093800_JEB247476C25","first-page":"H1793","article-title":"Cardiovascular response to thermoregulatory challenges","volume":"309","author":"Liu","year":"2015","journal-title":"Am. J. Physiol."},{"key":"2024101709112093800_JEB247476C26","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1161\/CIRCRESAHA.117.311456","article-title":"PDK4 inhibits cardiac pyruvate oxidation in late pregnancy","volume":"121","author":"Liu","year":"2017","journal-title":"Circ. Res."},{"key":"2024101709112093800_JEB247476C27","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1056\/NEJMoa012630","article-title":"Myocardial gene expression in dilated cardiomyopathy treated with beta-blocking agents","volume":"346","author":"Lowes","year":"2002","journal-title":"NEJM"},{"key":"2024101709112093800_JEB247476C28","first-page":"2","article-title":"The role of matrix metalloproteinase-3 in the development of atherosclerosis and cardiovascular events","volume":"17","author":"Magdalena","year":"2006","journal-title":"EJIFCC"},{"key":"2024101709112093800_JEB247476C29","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.cbpa.2011.12.012","article-title":"Chronic cold acclimation increases thermogenic capacity, non-shivering thermogenesis and muscle citrate synthase activity in both wild-type and brown adipose tissue deficient mice","volume":"161","author":"Mineo","year":"2012","journal-title":"Comp. Biochem. Physiol. A"},{"key":"2024101709112093800_JEB247476C30","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1139\/H07-083","article-title":"Skeletal muscle adaptation to fatty acid depends on coordinated actions of the PPARs and PGC1 alpha: implications for metabolic disease","volume":"32","author":"Muoio","year":"2007","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"2024101709112093800_JEB247476C31","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/s41569-018-0007-y","article-title":"Mechanisms of physiological and pathological cardiac hypertrophy","volume":"15","author":"Nakamura","year":"2018","journal-title":"Nat. Rev. Cardiol"},{"key":"2024101709112093800_JEB247476C32","doi-asserted-by":"publisher","first-page":"2362","DOI":"10.1172\/JCI119776","article-title":"Myosin heavy chain gene expression in human heart failure","volume":"100","author":"Nakao","year":"1997","journal-title":"J. Clin. Invest"},{"key":"2024101709112093800_JEB247476C33","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/0033-0620(72)90029-1","article-title":"Myocardial utilization of carbohydrate and lipids","volume":"15","author":"Neely","year":"1972","journal-title":"Prog. Cardiovasc. Dis."},{"key":"2024101709112093800_JEB247476C34","doi-asserted-by":"publisher","first-page":"889","DOI":"10.3389\/fphys.2017.00889","article-title":"Muscle non-shivering thermogenesis and its role in the evolution of endothermy","volume":"8","author":"Nowack","year":"2017","journal-title":"Front. Physiol."},{"key":"2024101709112093800_JEB247476C35","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s10545-013-9611-5","article-title":"Pathophysiology of fatty acid oxidation disorders and resultant phenotypic variability","volume":"36","author":"Olpin","year":"2013","journal-title":"J. Inherit. Metab. Dis."},{"key":"2024101709112093800_JEB247476C36","doi-asserted-by":"publisher","first-page":"92","DOI":"10.3389\/fphys.2020.00092","article-title":"Heart plasticity in response to pressure- and volume-overload: a review of findings in compensated and decompensated phenotypes","volume":"11","author":"Pitoulis","year":"2020","journal-title":"Front. Physiol."},{"key":"2024101709112093800_JEB247476C37","doi-asserted-by":"publisher","first-page":"142","DOI":"10.31083\/j.rcm2405142","article-title":"Physical activity and cardiac morphologic adaptations","volume":"24","author":"Pittaras","year":"2023","journal-title":"Rev. Cardiovasc. Med."},{"key":"2024101709112093800_JEB247476C38","doi-asserted-by":"publisher","first-page":"103598","DOI":"10.1016\/j.jtherbio.2023.103598","article-title":"A systematic review of the effects of cold exposure on pathological cardiac remodeling in mice","volume":"114","author":"Portes","year":"2023","journal-title":"J. Therm. Biol."},{"key":"2024101709112093800_JEB247476C65","doi-asserted-by":"publisher","first-page":"790125","DOI":"10.3389\/fimmu.2021.790125","article-title":"Janus kinase inhibitors in the treatment of vitiligo: a review","volume":"12","author":"Qi","year":"2021","journal-title":"Front. Immunol."},{"key":"2024101709112093800_JEB247476C39","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1016\/j.amjcard.2010.08.023","article-title":"Beta-blockers in hypertension","volume":"106","author":"Ram","year":"2010","journal-title":"AJC"},{"key":"2024101709112093800_JEB247476C40","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1093\/ejechocard\/jep017","article-title":"Left ventricular hypertrophy in athletes","volume":"10","author":"Rawlins","year":"2009","journal-title":"Eur. J. Echocardiogr"},{"key":"2024101709112093800_JEB247476C41","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/j.cjca.2023.07.002","article-title":"Impact of environmental factors on hypertension and associated cardiovascular disease","volume":"39","author":"Rios","year":"2023","journal-title":"Can. J. Cardiol."},{"key":"2024101709112093800_JEB247476C42","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1038\/s41569-023-00887-x","article-title":"Metabolic mechanisms in physiological and pathological cardiac hypertrophy: new paradigms and challenges","volume":"20","author":"Ritterhoff","year":"2023","journal-title":"Nat. Rev. Cardiol"},{"key":"2024101709112093800_JEB247476C43","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/189235a0","article-title":"Seasonal variation in blood pressure in man","volume":"7","author":"Rose","year":"1961","journal-title":"Nature"},{"key":"2024101709112093800_JEB247476C44","doi-asserted-by":"publisher","first-page":"39593","DOI":"10.1074\/jbc.M403649200","article-title":"Calcineurin and calcium\/calmodulin-dependent protein kinase activate distinct metabolic gene regulatory programs in cardiac muscle","volume":"279","author":"Schaeffer","year":"2004","journal-title":"J Biol. Chem."},{"key":"2024101709112093800_JEB247476C45","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1086\/378916","article-title":"Chronic cold exposure increases skeletal muscle oxidative structure and function in Monodelphis domestica, a marsupial lacking brown adipose tissue","volume":"76","author":"Schaeffer","year":"2003","journal-title":"Physiol. Biochem. Zool."},{"key":"2024101709112093800_JEB247476C46","first-page":"R42","article-title":"Cold exposure increases running VO2 max and cost of transport in goats","volume":"280","author":"Schaeffer","year":"2001","journal-title":"Am. J. Physiol. R"},{"key":"2024101709112093800_JEB247476C47","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1007\/s00392-002-0877-0","article-title":"Alterations of left ventricular systolic and diastolic function in pregnant women with insulin-dependent diabetes mellitus","volume":"91","author":"Schannwell","year":"2002","journal-title":"Z. Kardiol"},{"key":"2024101709112093800_JEB247476C48","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1161\/01.HYP.17.6.763","article-title":"Prevention of cold-induced increase in blood pressure of rats by captopril","volume":"17","author":"Shechtman","year":"1991","journal-title":"Hypertension"},{"key":"2024101709112093800_JEB247476C49","doi-asserted-by":"publisher","first-page":"2418","DOI":"10.1242\/jeb.061168","article-title":"Acclimatization of seasonal energetics in northern cardinals (Cardinalis cardinalis) through plasticity of metabolic rates and ceilings","volume":"215","author":"Sgueo","year":"2012","journal-title":"J. Exp. Biol."},{"key":"2024101709112093800_JEB247476C50","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1139\/y90-126","article-title":"Reversibility of cold-induced hypertension after removal of rats from cold","volume":"68","author":"Shechtman","year":"1990","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"2024101709112093800_JEB247476C51","doi-asserted-by":"publisher","first-page":"jeb247747","DOI":"10.1242\/jeb.247747","article-title":"The hearts of large mammals generate higher pressures, are less efficient and use more energy than those of small mammals","volume-title":"J. Exp. Biol.","author":"Snelling","year":"2024"},{"key":"2024101709112093800_JEB247476C52","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s10336-015-1192-7","article-title":"Environmental, ecological and mechanistic drivers of avian seasonal metabolic flexibility in response to cold winters","volume":"156","author":"Swanson","year":"2015","journal-title":"J. Ornithol."},{"key":"2024101709112093800_JEB247476C67","doi-asserted-by":"publisher","first-page":"495","DOI":"10.2741\/e108","article-title":"Cardiovascular responses to cold exposure","volume":"2","author":"Sun","year":"2010","journal-title":"Front. Biosci."},{"key":"2024101709112093800_JEB247476C53","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/S0031-9384(97)00033-4","article-title":"Effect of chronic treatment with propranolol on the cardiovascular responses to chronic cold exposure","volume":"62","author":"Sun","year":"1997","journal-title":"Physiol. Behav."},{"key":"2024101709112093800_JEB247476C54","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1111\/j.1749-6632.1997.tb51767.x","article-title":"Cold-induced hypertension. A model of mineralocorticoid-induced hypertension","volume":"813","author":"Sun","year":"1997","journal-title":"Ann. NY. Acad. Sci."},{"key":"2024101709112093800_JEB247476C55","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1139\/y95-010","article-title":"Effect of renal denervation on elevation of blood pressure in cold-exposed rats","volume":"73","author":"Sun","year":"1995","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"2024101709112093800_JEB247476C56","doi-asserted-by":"publisher","first-page":"R433","DOI":"10.1152\/ajpregu.00466.2004","article-title":"Genetic AT1A receptor deficiency attenuates cold-induced hypertension","volume":"288","author":"Sun","year":"2005","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2024101709112093800_JEB247476C57","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1161\/01.HYP.0000050964.96018.FA","article-title":"Angiotensinogen gene knockout delays and attenuates cold-induced hypertension","volume":"41","author":"Sun","year":"2003","journal-title":"Hypertension"},{"key":"2024101709112093800_JEB247476C58","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1161\/01.HYP.0000050964.96018.FA","article-title":"Angiotensinogen gene knockout delays and attenuates cold-induced hypertension","volume":"41","author":"Sun","year":"2003","journal-title":"Hypertension"},{"key":"2024101709112093800_JEB247476C59","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1111\/j.1749-6632.2009.05100.x","article-title":"Return to the fetal gene program: a suggested metabolic link to gene expression in the heart","volume":"1188","author":"Taegtmeyer","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2024101709112093800_JEB247476C66","doi-asserted-by":"publisher","first-page":"e23","DOI":"10.1371\/journal.pgen.0010023","article-title":"Medium-chain acyl-CoA dehydrogenase deficiency in gene-targeted mice","volume":"1","author":"Tolwani","year":"2005","journal-title":"PLoS Genet."},{"key":"2024101709112093800_JEB247476C60","doi-asserted-by":"publisher","first-page":"2361","DOI":"10.1016\/j.jacc.2022.11.005","article-title":"The global burden of cardiovascular diseases and risk: a compass for future health","volume":"80","author":"Vaduganathan","year":"2022","journal-title":"J. Am. Coll. Cardiol"},{"key":"2024101709112093800_JEB247476C61","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1016\/j.cmet.2017.04.025","article-title":"Molecular mechanisms underlying cardiac adaptation to exercise","volume":"25","author":"Vega","year":"2017","journal-title":"Cell Metab."},{"key":"2024101709112093800_JEB247476C68","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1007\/s10545-008-1005-8","article-title":"Metabolism as a complex genetic trait, a systems biology approach: implications for inborn errors of metabolism and clinical diseases","volume":"31","author":"Vockley","year":"2008","journal-title":"J. Inher. Metab. Dis."},{"key":"2024101709112093800_JEB247476C62","first-page":"97","article-title":"The athlete\u2018s heart vs. the failing heart: can signaling explain the two distinct outcomes?","volume":"26","author":"Weeks","year":"2011","journal-title":"Physiology (Bethesda)"}],"container-title":["Journal of Experimental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/jeb\/article-pdf\/doi\/10.1242\/jeb.247476\/3562134\/jeb247476.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/jeb\/article-pdf\/doi\/10.1242\/jeb.247476\/3571256\/jeb247476.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/jeb\/article-pdf\/doi\/10.1242\/jeb.247476\/3571256\/jeb247476.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T09:11:41Z","timestamp":1729156301000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/jeb\/article\/227\/20\/jeb247476\/362391\/Chronic-cold-exposure-causes-left-ventricular"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,15]]},"references-count":66,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2024,10,15]]}},"URL":"https:\/\/doi.org\/10.1242\/jeb.247476","relation":{},"ISSN":["0022-0949","1477-9145"],"issn-type":[{"value":"0022-0949","type":"print"},{"value":"1477-9145","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,15]]},"article-number":"jeb247476"}}