{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:27:19Z","timestamp":1783016839436,"version":"3.54.6"},"reference-count":91,"publisher":"The Company of Biologists","issue":"5","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"crossref","award":["PIP 3164"],"award-info":[{"award-number":["PIP 3164"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006668","name":"Fondo para la Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"crossref","award":["PICT 4271"],"award-info":[{"award-number":["PICT 4271"]}],"id":[{"id":"10.13039\/501100006668","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007070","name":"Universidad Nacional de Mar del Plata","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007070","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Animal thermoregulation may have significant costs and compete directly or indirectly with other energetically demanding processes, such as immune function. Although the subterranean environment is characterized by thermally stable conditions, small changes in ambient temperature could be critical in shaping immunity. However, little is known about the effects of ambient temperature, in naturally varying ranges, on immunity of wild species. Therefore, to evaluate the effect of short-term exposure to ambient temperatures on energy metabolism and body temperature during the acute phase immune response (APR) in the subterranean rodent Ctenomys talarum, 70 adult animals were divided into three experimental groups and exposed twice for 1\u2005h to 15, 25 or 32\u00b0C (below, at or near the upper limit of the thermoneutral zone, respectively) before and after injection with saline (control) or lipopolysaccharide (LPS, which induces the APR). Animals exposed to 25 and 32\u00b0C showed a similar APR pattern, characterized by fever (average: 37.1 and 37.7\u00b0C, respectively), a 16% increase in O2 consumption and an increase in the neutrophil\/lymphocyte ratio (N\/L). Body mass loss and symptoms of sickness behavior were detected from 3 and 1\u2005h post-injection, respectively. Individuals exposed to 15\u00b0C increased their metabolic rate by 60%, showed frequent hypothermia (34.3\u00b0C on average) and the characteristic N\/L increase was attenuated. Body mass loss and sickness behavior were mostly detected 24\u2005h post-injection. Our results suggest that the thermoregulation costs in C. talarum may limit the energy available for immunity, leading to different strategies to cope with infection.<\/jats:p>","DOI":"10.1242\/jeb.249634","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T10:35:21Z","timestamp":1738233321000},"source":"Crossref","is-referenced-by-count":2,"title":["Ambient temperature leads to differential immune strategies in the subterranean rodent <i>Ctenomys talarum<\/i>"],"prefix":"10.1242","volume":"228","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1906-7435","authenticated-orcid":false,"given":"Mar\u00eda Celina","family":"Carrizo","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones Marinas y Costeras (IIMyC), CONICET \u2013 Universidad Nacional de Mar del Plata Grupo de Ecolog\u00eda Fisiol\u00f3gica y del Comportamiento , , B7602AYL Mar del Plata, Provincia de Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8454-7665","authenticated-orcid":false,"given":"Roxana Rita","family":"Zenuto","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Marinas y Costeras (IIMyC), CONICET \u2013 Universidad Nacional de Mar del Plata Grupo de Ecolog\u00eda Fisiol\u00f3gica y del Comportamiento , , B7602AYL Mar del Plata, Provincia de Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5323-2644","authenticated-orcid":false,"given":"Facundo","family":"Luna","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Marinas y Costeras (IIMyC), CONICET \u2013 Universidad Nacional de Mar del Plata Grupo de Ecolog\u00eda Fisiol\u00f3gica y del Comportamiento , , B7602AYL Mar del Plata, Provincia de Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9185-9480","authenticated-orcid":false,"given":"Ana Paula","family":"Cutrera","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Marinas y Costeras (IIMyC), CONICET \u2013 Universidad Nacional de Mar del Plata Grupo de Ecolog\u00eda Fisiol\u00f3gica y del Comportamiento , , B7602AYL Mar del Plata, Provincia de Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2025,3,11]]},"reference":[{"key":"2025031109213895500_JEB249634C1","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1242\/jeb.153320","article-title":"Predator exposure-induced immunosuppression: trade-off, immune redistribution or immune reconfiguration?","volume":"220","author":"Adamo","year":"2017","journal-title":"J. Exp. Biol."},{"key":"2025031109213895500_JEB249634C2","doi-asserted-by":"publisher","first-page":"3359","DOI":"10.1111\/j.1460-9568.2006.04854.x","article-title":"Cold-seeking behavior as a thermoregulatory strategy in systemic inflammation","volume":"23","author":"Almeida","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"2025031109213895500_JEB249634C3","first-page":"111","article-title":"Energy budget in subterranean rodents: insights from the tuco-tuco Ctenomys talarum (Rodentia: Ctenomyidae)","volume-title":"The quintessential naturalist: honoring the life and legacy of Oliver P. Pearson","author":"Antinuchi","year":"2007"},{"key":"2025031109213895500_JEB249634C4","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/j.1365-2435.2010.01759.x","article-title":"The role of constraints and limitation in driving individual variation in immune response","volume":"25","author":"Ardia","year":"2011","journal-title":"Funct. Ecol."},{"key":"2025031109213895500_JEB249634C5","first-page":"45","article-title":"Sickness behavior in vertebrates: allostasis, life-history modulation, and hormonal regulation","volume-title":"Ecoimmunology","author":"Ashley","year":"2012"},{"key":"2025031109213895500_JEB249634C6","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.jtherbio.2015.09.002","article-title":"Effect of ambient temperature on evaporative water loss in the subterranean rodent Ctenomys talarum","volume":"53","author":"Baldo","year":"2015","journal-title":"J. Therm. Biol."},{"key":"2025031109213895500_JEB249634C7","doi-asserted-by":"publisher","first-page":"3255","DOI":"10.1242\/jeb.054544","article-title":"Chronic hypoxia stimulates an enhanced response to immune challenge without evidence of an energetic tradeoff","volume":"214","author":"Baze","year":"2011","journal-title":"J. Exp. Biol."},{"key":"2025031109213895500_JEB249634C8","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.pharmthera.2005.10.013","article-title":"Endotoxic fever: new concepts of its regulation suggest new approaches to its management","volume":"111","author":"Blatteis","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"2025031109213895500_JEB249634C9","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1152\/jappl.1999.87.2.699","article-title":"Immune changes in humans during cold exposure: effects of prior heating and exercise","volume":"87","author":"Brenner","year":"1999","journal-title":"J. Appl. Physiol."},{"key":"2025031109213895500_JEB249634C10","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.3389\/fimmu.2018.02453","article-title":"Fueling defense: effects of resources on the ecology and evolution of tolerance to parasite infection","volume":"9","author":"Budischak","year":"2018","journal-title":"Front. Immunol."},{"key":"2025031109213895500_JEB249634C11","first-page":"62","article-title":"Ecophysiological responses of subterranean rodents to underground habitats","volume-title":"Life Underground: The Biology of Subterranean Rodents","author":"Buffenstein","year":"2000"},{"key":"2025031109213895500_JEB249634C12","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1086\/701169","article-title":"How individual variation in host tolerance affects competence to transmit parasites","volume":"92","author":"Burgan","year":"2019","journal-title":"Physiol. Biochem. Zool."},{"key":"2025031109213895500_JEB249634C13","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1242\/jeb.027011","article-title":"Is there an energetic-based trade-off between thermoregulation and the acute phase response in zebra finches?","volume":"213","author":"Burness","year":"2010","journal-title":"J. Exp. Biol."},{"key":"2025031109213895500_JEB249634C14","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/0300-9629(89)90048-0","article-title":"Metabolic rate and thermoregulation in two species of tuco-tuco, Stenomys talarum and Ctenomys australis (Caviomorpha, Octodontidae)","volume":"93","author":"Busch","year":"1989","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"2025031109213895500_JEB249634C15","first-page":"183","article-title":"Population Ecology of Subterranean Rodents","volume-title":"Life Underground: The Biology of Subterranean Rodents","author":"Busch","year":"2000"},{"key":"2025031109213895500_JEB249634C16","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1242\/jeb.120576","article-title":"Body mass affects seasonal variation in sickness intensity in a seasonally breeding rodent","volume":"218","author":"Carlton","year":"2015","journal-title":"J. Exp. Biol."},{"key":"2025031109213895500_JEB249634C17","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.ygcen.2015.11.001","article-title":"Glucose and insulin modulate sickness responses in male Siberian hamsters","volume":"242","author":"Carlton","year":"2017","journal-title":"Gen. Comp. Endocrinol."},{"key":"2025031109213895500_JEB249634C18","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/jez.2675","article-title":"Varying intensity of simulated infection partially affects the magnitude of the acute-phase immune response in the subterranean rodent Ctenomys talarum","volume":"339","author":"Carrizo","year":"2023","journal-title":"J. Exp. Zool. Pt A"},{"key":"2025031109213895500_JEB249634C19","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1098\/rspb.2002.2054","article-title":"Delayed effects of cold stress on immune response in laboratory mice","volume":"269","author":"Cicho\u0144","year":"2002","journal-title":"Proc. R. Soc. Lond. B"},{"key":"2025031109213895500_JEB249634C20","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1016\/S0031-9384(97)00166-2","article-title":"The effects of lipopolysaccharide (LPS) on the fever response in rats at different ambient temperatures","volume":"62","author":"Conrad","year":"1997","journal-title":"Physiol. Behav."},{"key":"2025031109213895500_JEB249634C21","first-page":"517","article-title":"Acute phase response in animals: a review","volume":"59","author":"Cray","year":"2009","journal-title":"Comp. Med."},{"key":"2025031109213895500_JEB249634C22","doi-asserted-by":"publisher","first-page":"235","DOI":"10.4067\/S0716-078X2004000200003","article-title":"Cambios en el pelaje del roedor subterr\u00e1neo Ctenomys talarum: posible mecanismo t\u00e9rmico compensatorio","volume":"7","author":"Cutrera","year":"2004","journal-title":"Rev. Chil. Hist. Nat."},{"key":"2025031109213895500_JEB249634C23","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1086\/718409","article-title":"Acute-phase immune response involves fever, sickness behavior, and an elevated metabolic rate in the subterranean rodent Ctenomys talarum","volume":"95","author":"Cutrera","year":"2022","journal-title":"Physiol. Biochem. Zool."},{"key":"2025031109213895500_JEB249634C24","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.ejphar.2004.07.040","article-title":"Cytokine-induced sickness behaviour: a neuroimmune response to activation of innate immunity","volume":"500","author":"Dantzer","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"2025031109213895500_JEB249634C25","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1111\/j.1365-2435.2008.01467.x","article-title":"The use of leukocyte profiles to measure stress in vertebrates: a review for ecologists","volume":"22","author":"Davis","year":"2008","journal-title":"Funct. Ecol."},{"key":"2025031109213895500_JEB249634C27","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1006\/appe.1997.0116","article-title":"Infection-induced anorexia: active host defence strategy","volume":"29","author":"Exton","year":"1997","journal-title":"Appetite"},{"key":"2025031109213895500_JEB249634C28","doi-asserted-by":"publisher","first-page":"4302","DOI":"10.1002\/joc.5086","article-title":"WorldClim 2: new 1-km spatial resolution climate surfaces for global land areas","volume":"37","author":"Fick","year":"2017","journal-title":"Int. J. Climatol."},{"key":"2025031109213895500_JEB249634C29","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.cell.2019.01.050","article-title":"Energetic trade-offs and hypometabolic states promote disease tolerance","volume":"177","author":"Ganeshan","year":"2019","journal-title":"Cell"},{"key":"2025031109213895500_JEB249634C30","first-page":"565","article-title":"Fever and hypothermia in systemic inflammation","volume-title":"Handbook of Clinical Neurology","author":"Garami","year":"2018"},{"key":"2025031109213895500_JEB249634C31","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.jtherbio.2011.06.008","article-title":"The mouse: an \u201caverage\u201d homeotherm","volume":"37","author":"Gordon","year":"2012","journal-title":"J. Therm. Biol."},{"key":"2025031109213895500_JEB249634C32","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.physbeh.2017.05.026","article-title":"The mouse thermoregulatory system: Its impact on translating biomedical data to humans","volume":"179","author":"Gordon","year":"2017","journal-title":"Physiol. Behav."},{"key":"2025031109213895500_JEB249634C33","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1152\/jappl.1986.60.5.1504","article-title":"Dynamics of endotoxin fever in the rabbit","volume":"60","author":"Graener","year":"1986","journal-title":"J. Appl. Physiol."},{"key":"2025031109213895500_JEB249634C34","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1111\/fwb.12602","article-title":"Predators reduce Batrachochytrium dendrobatidis infection loads in their prey","volume":"60","author":"Groner","year":"2015","journal-title":"Freshw. Biol."},{"key":"2025031109213895500_JEB249634C35","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s13364-018-0375-z","article-title":"Metabolic cost of acute phase response in the frugivorous bat, Artibeus lituratus","volume":"63","author":"Guerrero-Chac\u00f3n","year":"2018","journal-title":"Mamm Res."},{"key":"2025031109213895500_JEB249634C36","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S0149-7634(88)80004-6","article-title":"Biological basis of the behavior of sick animals","volume":"12","author":"Hart","year":"1988","journal-title":"Neurosci. Biobehav. Rev."},{"key":"2025031109213895500_JEB249634C37","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1111\/j.1365-2435.2012.01978.x","article-title":"Additive metabolic costs of thermoregulation and pathogen infection","volume":"26","author":"Hawley","year":"2012","journal-title":"Funct. Ecol."},{"key":"2025031109213895500_JEB249634C38","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3892\/etm.2015.2854","article-title":"Effect of cold stress on immunity in rats","volume":"11","author":"Hu","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"2025031109213895500_JEB249634C39","doi-asserted-by":"publisher","first-page":"1257422","DOI":"10.3389\/fimmu.2023.1257422","article-title":"Neutrophil extracellular traps formation and clearance is enhanced in fever and attenuated in hypothermia","volume":"14","author":"Janko","year":"2023","journal-title":"Front. Immunol."},{"key":"2025031109213895500_JEB249634C40","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/s00359-022-01557-y","article-title":"Bodyweight, locomotion, and behavioral responses of the naked mole rat (Heterocephalus glaber) to lipopolysaccharide administration","volume":"208","author":"Kisipan","year":"2022","journal-title":"J. Comp. Physiol. A"},{"key":"2025031109213895500_JEB249634C94","doi-asserted-by":"publisher","first-page":"R858","DOI":"10.1152\/ajpregu.1997.273.3.R858","article-title":"Effect of heat stress on LPS-induced fever and tumor necrosis factor","volume":"273","author":"Kluger","year":"1997","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2025031109213895500_JEB249634C41","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1242\/jeb.129312","article-title":"Heat dissipation does not suppress an immune response in laboratory mice divergently selected for basal metabolic rate (BMR)","volume":"219","author":"Ksi\u0105\u017cek","year":"2016","journal-title":"J. Exp. Biol."},{"key":"2025031109213895500_JEB249634C42","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.biochi.2023.01.019","article-title":"Does housing temperature influence glucose regulation and muscle-fat crosstalk in mice?","volume":"210","author":"Lac","year":"2023","journal-title":"Biochimie"},{"key":"2025031109213895500_JEB249634C43","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1016\/j.ajem.2015.08.003","article-title":"Accompanying mild hypothermia significantly improved the prognosis of septic mice than artificial mild hypothermia","volume":"33","author":"Li","year":"2015","journal-title":"Am. J. Emerg. Med."},{"key":"2025031109213895500_JEB249634C44","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/978-3-030-65943-1_12","article-title":"The unusual immune system of the naked mole-rat","volume-title":"The Extraordinary Biology of the Naked Mole-Rat. Advances in Experimental Medicine and Biology","author":"Lin","year":"2021"},{"key":"2025031109213895500_JEB249634C45","doi-asserted-by":"publisher","first-page":"e1001006","DOI":"10.1371\/journal.ppat.1001006","article-title":"The coevolution of virulence: tolerance in perspective","volume":"6","author":"Little","year":"2010","journal-title":"PLoS Pathog."},{"key":"2025031109213895500_JEB249634C46","doi-asserted-by":"publisher","first-page":"R1372","DOI":"10.1152\/ajpregu.00023.2012","article-title":"Naturally occurring hypothermia is more advantageous than fever in severe forms of lipopolysaccharide- and Escherichia coli-induced systemic inflammation","volume":"302","author":"Liu","year":"2012","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2025031109213895500_JEB249634C47","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1034\/j.1600-0706.2000.880110.x","article-title":"Trade-offs in evolutionary immunology: just what is the cost of immunity?","volume":"88","author":"Lochmiller","year":"2000","journal-title":"Oikos"},{"key":"2025031109213895500_JEB249634C48","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.cbpa.2005.12.025","article-title":"Energetics and thermoregulation during digging in the rodent tuco-tuco (Ctenomys talarum)","volume":"146","author":"Luna","year":"2007","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"2025031109213895500_JEB249634C49","doi-asserted-by":"publisher","first-page":"2144","DOI":"10.1139\/z02-201","article-title":"Digging energetics in the South American rodent Ctenomys talarum (Rodentia, Ctenomyidae)","volume":"80","author":"Luna","year":"2002","journal-title":"Can. J. Zool."},{"key":"2025031109213895500_JEB249634C50","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1007\/s00360-012-0675-6","article-title":"Maximal thermogenic capacity and non-shivering thermogenesis in the South American subterranean rodent Ctenomys talarum","volume":"182","author":"Luna","year":"2012","journal-title":"J. Comp. Physiol. B"},{"key":"2025031109213895500_JEB249634C51","first-page":"245","article-title":"Macrophysiological patterns in the energetics of Caviomorph rodents: implications in a changing world","volume-title":"Biology of Caviomorph Rodents: Diversity and Evolution","author":"Luna","year":"2015"},{"key":"2025031109213895500_JEB249634C52","doi-asserted-by":"publisher","first-page":"102564","DOI":"10.1016\/j.jtherbio.2020.102564","article-title":"Evaporative water loss in seven species of fossorial rodents: does effect of degree of fossoriality and sociality exist?","volume":"89","author":"Luna","year":"2020","journal-title":"J. Therm. Biol."},{"key":"2025031109213895500_JEB249634C53","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1152\/physiol.00029.2014","article-title":"Translating animal model research: does it matter that our rodents are cold?","volume":"29","author":"Maloney","year":"2014","journal-title":"Physiology"},{"key":"2025031109213895500_JEB249634C54","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.jtherbio.2010.12.004","article-title":"The metabolic cost of fever in Pekin ducks","volume":"36","author":"Marais","year":"2011","journal-title":"J. Therm. Biol."},{"key":"2025031109213895500_JEB249634C55","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1111\/j.1365-2435.2007.01347.x","article-title":"Fever and sickness behaviour vary among congeneric rodents","volume":"22","author":"Martin","year":"2008","journal-title":"Funct. Ecol."},{"key":"2025031109213895500_JEB249634C56","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1016\/j.cbpa.2007.03.003","article-title":"Nutritional responses to different diet quality in the subterranean rodent Ctenomys talarum (tuco-tucos)","volume":"147","author":"Martino","year":"2007","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"2025031109213895500_JEB249634C57","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1126\/science.1214935","article-title":"Disease tolerance as a defense strategy","volume":"335","author":"Medzhitov","year":"2012","journal-title":"Science"},{"key":"2025031109213895500_JEB249634C58","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1002\/jez.2399","article-title":"Bats respond to simulated bacterial infection during the active phase by reducing food intake","volume":"333","author":"Melhado","year":"2020","journal-title":"J. Exp. Zool. Part"},{"key":"2025031109213895500_JEB249634C59","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/s00248-018-1227-8","article-title":"Subterranean desert rodents (genus Ctenomys) create soil patches enriched in root endophytic fungal propagules","volume":"77","author":"Miranda","year":"2019","journal-title":"Microb. Ecol."},{"key":"2025031109213895500_JEB249634C60","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1093\/beheco\/11.1.19","article-title":"Ecological immunology: life history trade-offs and immune defense in birds","volume":"11","author":"Norris","year":"2000","journal-title":"Behav. Ecol."},{"key":"2025031109213895500_JEB249634C61","doi-asserted-by":"publisher","first-page":"e0164938","DOI":"10.1371\/journal.pone.0164938","article-title":"Metabolic cost of the activation of immune response in the fish-eating myotis (Myotis vivesi): the effects of inflammation and the acute phase response","volume":"11","author":"Ot\u00e1lora-Ardila","year":"2016","journal-title":"PLoS ONE"},{"key":"2025031109213895500_JEB249634C62","doi-asserted-by":"publisher","first-page":"3062","DOI":"10.1242\/jeb.02371","article-title":"Seasonal modulation of sickness behavior in free-living northwestern song sparrows (Melospiza melodia morphna)","volume":"209","author":"Owen-Ashley","year":"2006","journal-title":"J. Exp. Biol."},{"key":"2025031109213895500_JEB249634C63","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s10336-007-0197-2","article-title":"Acute phase responses of passerine birds: characterization and seasonal variation","volume":"148","author":"Owen-Ashley","year":"2007","journal-title":"J. Ornithol."},{"key":"2025031109213895500_JEB249634C64","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/S0031-9384(03)00046-5","article-title":"LPS fever in old rats depends on the ambient temperature","volume":"78","author":"Peloso","year":"2003","journal-title":"Physiol. Behav."},{"key":"2025031109213895500_JEB249634C65","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.cbpa.2009.05.013","article-title":"Effect of diet quality and soil hardness on metabolic rate in the subterranean rodent Ctenomys talarum","volume":"154","author":"Perissinotti","year":"2009","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"2025031109213895500_JEB249634C67","volume-title":"R Studio: Integrated development for R","author":"R Studio Team","year":"2023"},{"key":"2025031109213895500_JEB249634C68","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jtherbio.2017.10.005","article-title":"Is there an effect of environmental temperature on the response to an antigen and the metabolic rate in pups of the rodent Octodon degus?","volume":"71","author":"Ramirez-Otarola","year":"2018","journal-title":"J. Therm. Biol."},{"key":"2025031109213895500_JEB249634C69","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s00360-018-1195-9","article-title":"Ecoimmunology in degus: interplay among diet, immune response, and oxidative stress","volume":"189","author":"Ramirez-Otarola","year":"2019","journal-title":"J. Comp. Physiol. B Biochem. Syst. Environ. Physiol."},{"key":"2025031109213895500_JEB249634C71","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/S0306-4565(01)00037-7","article-title":"Febrile and cortisol responses induced in guinea pigs by localized peripheral inflammatory stimulation","volume":"26","author":"Ross","year":"2001","journal-title":"J. Therm. Biol."},{"key":"2025031109213895500_JEB249634C72","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1645\/0022-3395(2002)088[1268:RBHPAD]2.0.CO;2","article-title":"Relationship between helminth parasites and demographic attributes of a population of the subterranean rodent Ctenomys talarum (Rodentia: Octodontidae)","volume":"88","author":"Rossin","year":"2002","journal-title":"J. Parasitol."},{"key":"2025031109213895500_JEB249634C73","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1152\/ajpregu.00370.2005","article-title":"Thermoregulatory responses to lipopolysaccharide in the mouse: dependence on the dose and ambient temperature","volume":"289","author":"Rudaya","year":"2005","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2025031109213895500_JEB249634C74","doi-asserted-by":"publisher","first-page":"ftw106","DOI":"10.1093\/femspd\/ftw106","article-title":"Thermoregulation as a disease tolerance defense strategy","volume":"74","author":"Schieber","year":"2016","journal-title":"Pathogens Dis."},{"key":"2025031109213895500_JEB249634C75","doi-asserted-by":"publisher","first-page":"20150208","DOI":"10.1098\/rsbl.2015.0208","article-title":"Basal blood glucose concentration in free-living striped mice is influenced by food availability, ambient temperature and social tactic","volume":"11","author":"Schradin","year":"2015","journal-title":"Biol. Lett."},{"key":"2025031109213895500_JEB249634C76","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pbio.1002276","article-title":"Why do we feel sick when infected\u2014can altruism play a role?","volume":"13","author":"Shakhar","year":"2015","journal-title":"PLoS Biol."},{"key":"2025031109213895500_JEB249634C77","doi-asserted-by":"publisher","first-page":"2961","DOI":"10.1242\/jeb.122150","article-title":"Body temperature changes during simulated bacterial infection in a songbird: fever at night and hypothermia at day","volume":"218","author":"Sk\u00f6ld-Chiriac","year":"2015","journal-title":"J. Exp. Biol."},{"key":"2025031109213895500_JEB249634C78","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/j.tem.2019.08.012","article-title":"Energy trade-offs in host defense: immunology meets physiology","volume":"30","author":"Steiner","year":"2019","journal-title":"Trends Endocrinol. Metab."},{"key":"2025031109213895500_JEB249634C79","doi-asserted-by":"publisher","first-page":"20150576","DOI":"10.1098\/rsbl.2015.0576","article-title":"No fever and leucocytosis in response to a lipopolysaccharide challenge in an insectivorous bat","volume":"11","author":"Stockmaier","year":"2015","journal-title":"Biol. Lett"},{"key":"2025031109213895500_JEB249634C80","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.anbehav.2018.04.021","article-title":"An immune challenge reduces social grooming in vampire bats","volume":"140","author":"Stockmaier","year":"2018","journal-title":"Anim. Behav."},{"key":"2025031109213895500_JEB249634C81","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.physbeh.2007.04.029","article-title":"Patterns of surface temperatures in two mole-rats (Bathyergidae) with different social systems as revealed by IR-thermography","volume":"92","author":"\u0160umbera","year":"2007","journal-title":"Physiol. Behav."},{"key":"2025031109213895500_JEB249634C82","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1046\/j.1365-2435.1998.00271.x","article-title":"Energetic stress, immunosuppression and the costs of an antibody response","volume":"12","author":"Svensson","year":"1998","journal-title":"Funct. Ecol."},{"key":"2025031109213895500_JEB249634C83","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1093\/icb\/icx051","article-title":"A return to wisdom: using sickness behaviors to integrate ecological and translational research","volume":"57","author":"Sylvia","year":"2017","journal-title":"Integr. Comp. Biol."},{"key":"2025031109213895500_JEB249634C84","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1038\/s41598-021-81404-3","article-title":"Heat dissipation in subterranean rodents: the role of body region and social organisation","volume":"11","author":"Vejm\u011blka","year":"2021","journal-title":"Sci. Rep."},{"key":"2025031109213895500_JEB249634C85","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.cbpa.2008.06.030","article-title":"Decreased glucose tolerance but normal blood glucose levels in the field in the caviomorph rodent Ctenomys talarum: The role of stress and physical activity","volume":"151","author":"Vera","year":"2008","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"2025031109213895500_JEB249634C86","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.ygcen.2018.05.019","article-title":"Different regulation of cortisol and corticosterone in the subterranean rodent Ctenomys talarum: Responses to dexamethasone, angiotensin II, potassium, and diet","volume":"273","author":"Vera","year":"2019","journal-title":"Gen. Comp. Endocrinol."},{"key":"2025031109213895500_JEB249634C87","doi-asserted-by":"publisher","first-page":"588387","DOI":"10.3389\/fimmu.2020.588387","article-title":"Thermoneutrality and immunity: how does cold stress affect disease?","volume":"11","author":"Vialard","year":"2020","journal-title":"Front. Immunol."},{"key":"2025031109213895500_JEB249634C88","doi-asserted-by":"publisher","first-page":"e0301083","DOI":"10.1371\/journal.pone.0301083","article-title":"Combined effects of ambient temperature and food availability on induced innate immune response of a fruit-eating bat (Carollia perspicillata)","volume":"19","author":"Viola","year":"2024","journal-title":"PLoS ONE"},{"key":"2025031109213895500_JEB249634C89","volume-title":"Hematology Techniques and Concepts for Veterinary Technicians","author":"Voigt","year":"2000"},{"key":"2025031109213895500_JEB249634C90","doi-asserted-by":"publisher","first-page":"e75733","DOI":"10.1371\/journal.pone.0075733","article-title":"Lipopolysaccharide-induced neuronal activation in the paraventricular and dorsomedial hypothalamus depends on ambient temperature","volume":"8","author":"Wanner","year":"2013","journal-title":"PLoS ONE"},{"key":"2025031109213895500_JEB249634C91","doi-asserted-by":"publisher","first-page":"e3570","DOI":"10.7717\/peerj.3570","article-title":"Simulated bacterial infection disrupts the circadian fluctuation of immune cells in wrinkle-lipped bats (Chaerephon plicatus)","volume":"5","author":"Weise","year":"2017","journal-title":"PeerJ"},{"key":"2025031109213895500_JEB249634C92","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1152\/jappl.1977.42.1.120","article-title":"Measurement of VO2, VCO2, and evaporative water loss with a flow-through mask","volume":"42","author":"Withers","year":"1977","journal-title":"J. Appl. Physiol. Respir. Environ. Exerc. Physiol."},{"key":"2025031109213895500_JEB249634C93","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-87458-6","volume-title":"Mixed Effects Models and Extensions in Ecology with R","author":"Zuur","year":"2009"}],"container-title":["Journal of Experimental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/jeb\/article-pdf\/doi\/10.1242\/jeb.249634\/3616432\/jeb249634.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/jeb\/article-pdf\/doi\/10.1242\/jeb.249634\/3638614\/jeb249634.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/jeb\/article-pdf\/doi\/10.1242\/jeb.249634\/3638614\/jeb249634.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T13:21:50Z","timestamp":1741699310000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/jeb\/article\/228\/5\/JEB249634\/367325\/Ambient-temperature-leads-to-differential-immune"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,1]]},"references-count":91,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,3,1]]}},"URL":"https:\/\/doi.org\/10.1242\/jeb.249634","relation":{},"ISSN":["0022-0949","1477-9145"],"issn-type":[{"value":"0022-0949","type":"print"},{"value":"1477-9145","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,1]]},"article-number":"JEB249634"}}