{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:14:20Z","timestamp":1792185260932,"version":"4.4.0"},"reference-count":61,"publisher":"The Company of Biologists","issue":"16","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"crossref","award":["BB\/W018039\/1"],"award-info":[{"award-number":["BB\/W018039\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"crossref","award":["MR\/T019409\/1"],"award-info":[{"award-number":["MR\/T019409\/1"]}],"id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The University of Exeter"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>High environmental PCO2\u00a0in aquatic systems typically impairs physiology and performance in ectotherms; however, the effects of high PCO2 on protein degradation, a key process in protein homeostasis and growth, remain poorly understood. In this study, we investigated the effects of increasing environmental PCO2\u00a0(ambient, 5000 and 10,000\u2005\u00b5atm) on metabolism, oxidative stress and protein ubiquitination (an indicator of protein degradation) in whiteleg shrimp (Penaeus vannamei). Standard metabolic rate was elevated by &amp;gt;2-fold at 5000 and 10,000\u2005\u00b5atm PCO2, but this was not associated with increased post-prandial oxygen consumption or oxidative protein damage. However, levels of protein K48 ubiquitin were reduced by up to 10-fold at 10,000\u2005\u00b5atm PCO2\u00a0compared with ambient controls, suggesting high PCO2\u00a0severely affects protein degradation. Our findings reveal that while P. vannamei appear resistant to elevated PCO2, fundamental modifications to protein degradation and homeostasis may affect long-term performance and growth in this species.<\/jats:p>","DOI":"10.1242\/jeb.249906","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T08:50:42Z","timestamp":1753433442000},"source":"Crossref","is-referenced-by-count":2,"title":["The effects of high seawater <i>P<\/i>CO2\u00a0on protein oxidative damage and ubiquitination in <i>Penaeus vannamei<\/i>"],"prefix":"10.1242","volume":"228","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7605-0747","authenticated-orcid":false,"given":"Trystan B.","family":"Sanders","sequence":"first","affiliation":[{"name":"University of Exeter 1 Biosciences , , Exeter EX4 4QD ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9lisoa Amadeus","family":"Derjean","sequence":"additional","affiliation":[{"name":"University of Exeter 1 Biosciences , , Exeter EX4 4QD ,","place":["UK"]},{"name":"School of Biological and Marine Sciences, University of Plymouth 2 , Plymouth PL4 8AA ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2867-1864","authenticated-orcid":false,"given":"Joseph L.","family":"Costello","sequence":"additional","affiliation":[{"name":"University of Exeter 1 Biosciences , , Exeter EX4 4QD ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Ellis","sequence":"additional","affiliation":[{"name":"University of Exeter 1 Biosciences , , Exeter EX4 4QD ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rod W.","family":"Wilson","sequence":"additional","affiliation":[{"name":"University of Exeter 1 Biosciences , , Exeter EX4 4QD ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"key":"2025082904070724400_JEB249906C1","doi-asserted-by":"publisher","first-page":"933","DOI":"10.2741\/2115","article-title":"Marine invertebrate mitochondria and oxidative stress","volume":"12","author":"Abele","year":"2007","journal-title":"Front. 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