{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:23:41Z","timestamp":1760142221734,"version":"build-2065373602"},"reference-count":59,"publisher":"The Company of Biologists","issue":"19","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-2\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"crossref","award":["RGPIN-2018-03912"],"award-info":[{"award-number":["RGPIN-2018-03912"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008459","name":"University of Calgary","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008459","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Bone fracture repair is a unique form of scarless tissue regeneration in mammals that recapitulates many aspects of endochondral ossification seen in developing long bones. For example, transgenic mouse studies have shown that many development-related genes involved in endochondral ossification (EO), which involves transformation of transient cartilaginous tissue into bone, are also redeployed during the bone repair process. While there is an expanding appreciation for the mechanistic overlap between bone development and repair, little is known about the relationship between rates of bone growth and bone repair in natural populations. To examine whether bones that grow faster also heal faster, we employed the Longshanks mouse, which produces 15\u201320% longer tibiae at skeletal maturity than random-bred Control mice, as a result of increased postnatal EO rates. We generated experimental unstabilized tibial fractures in sex-balanced and age-matched Longshanks and Control mice and monitored their recovery over 6\u00a0weeks using longitudinal in vivo micro-computed tomography (\u00b5CT) imaging at key milestones in fracture repair. In parallel, we analyzed callus tissue composition and gene expression in a cross-sectional cohort of Longshanks mouse fractures during repair. In this study, we showed that Longshanks mice produce larger fracture calluses at faster rates than Control mice during EO, without compromising callus bone quality. Moreover, we demonstrated that differences in \u00b5CT fracture mineralization correlated with an accelerated program of EO in Longshanks mouse calluses, favoring earlier cartilage maturation. These findings highlight a deep evolutionary conservation of EO in both development and repair, and provide evidence for correlated selection responses between organism morphology and repair physiology.<\/jats:p>","DOI":"10.1242\/jeb.250106","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T11:40:45Z","timestamp":1756208445000},"source":"Crossref","is-referenced-by-count":1,"title":["Mice selectively bred for increased tibia length exhibit accelerated fracture repair"],"prefix":"10.1242","volume":"228","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6793-8173","authenticated-orcid":false,"given":"Colton M.","family":"Unger","sequence":"first","affiliation":[{"name":"University of Calgary 1 Department of Biological Sciences , , Calgary, AB , , T2N 1N4","place":["Canada"]},{"name":"McCaig Institute for Bone and Joint Health, University of Calgary 2 , Calgary, AB , , T2N 1N4","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9138-4710","authenticated-orcid":false,"given":"Nicoletta A.","family":"Ninkovic","sequence":"additional","affiliation":[{"name":"McCaig Institute for Bone and Joint Health, University of Calgary 2 , Calgary, AB , , T2N 1N4","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0888-9556","authenticated-orcid":false,"given":"Sarah L.","family":"Manske","sequence":"additional","affiliation":[{"name":"McCaig Institute for Bone and Joint Health, University of Calgary 2 , Calgary, AB , , T2N 1N4","place":["Canada"]},{"name":"University of Calgary 3 Department of Radiology, Cumming School of Medicine , , Calgary, AB , , T2N 2T9","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7242-342X","authenticated-orcid":false,"given":"Campbell P.","family":"Rolian","sequence":"additional","affiliation":[{"name":"McCaig Institute for Bone and Joint Health, University of Calgary 2 , Calgary, AB , , T2N 1N4","place":["Canada"]},{"name":"University of Calgary 4 Faculty of Veterinary Medicine , , Calgary, AB , , T2N 4Z6","place":["Canada"]},{"name":"McGill University 5 Department of Anatomy and Cell Biology , , Montreal, QC , , H3A 0G4","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"key":"2025101004033859300_JEB250106C54","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1638\/2015-0180.1","article-title":"Prevalence of healed long-bone fractures in wild carnivores from the Northeastern United States","volume":"47","author":"Argyros","year":"2016","journal-title":"J. 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