{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T11:16:26Z","timestamp":1784718986691,"version":"3.55.0"},"reference-count":44,"publisher":"The Company of Biologists","issue":"16","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-2\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"crossref","award":["RGPIN-2019-06495"],"award-info":[{"award-number":["RGPIN-2019-06495"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Quebec Respiratory Health Network"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Species living at high altitude (HA) often exhibit optimized oxygen utilization at adulthood; however, the plasticity of metabolic pathways during postnatal development remains unclear. Because mice, but not rats, are commonly found at HA, we investigated mitochondrial oxygen consumption rates (OCR) in the cerebral cortex of both species across postnatal development and at adulthood at sea level (SL; Quebec, Canada) under normoxia or hypoxia (13.5% O2), and at HA (La Paz, Bolivia, 3600\u2005m) after 50 generations of residency. At postnatal day (P)7, P14 and P21 and in adults (P60\u201390), fresh tissue samples were used to assess mitochondrial OCR under states of proton LEAK (OCRLEAK(N)) and oxidative phosphorylation (OXPHOS) using substrates for complex I (N pathway \u2013 OCRN), complex II (S pathway \u2013 OCRS) and complexes I+II (NS pathways \u2013 OCRNS). Our results showed: (1) at HA, rats exhibit higher OCR at P7, P14 and adulthood compared with their SL counterparts, and (2) HA residency induces a shift from the N pathway to the S pathway at all ages in mice. Finally, these responses were absent in SL animals exposed to postnatal hypoxia, highlighting the importance of studying HA-living species. These findings emphasize key metabolic shifts, with implications for understanding responses to hypoxia in species showing divergent success at HA.<\/jats:p>","DOI":"10.1242\/jeb.250422","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T08:01:57Z","timestamp":1753171317000},"source":"Crossref","is-referenced-by-count":2,"title":["High altitude induces a shift from complex I to complex II in the brain mitochondria of newborn and adult mice"],"prefix":"10.1242","volume":"228","author":[{"given":"Maud","family":"Demarest","sequence":"first","affiliation":[{"name":"Institut Universitaire de Cardiologie et Pneumologie - Universit\u00e9 Laval, D\u00e9partement de P\u00e9diatrie 1 , Qu\u00e9bec, QC , , G1V 4G5","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Aliaga-Raduan","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et Pneumologie - Universit\u00e9 Laval, D\u00e9partement de P\u00e9diatrie 1 , Qu\u00e9bec, QC , , G1V 4G5","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Arias-Reyes","sequence":"additional","affiliation":[{"name":"Norcliffe Foundation Center for Integrative Brain Research - Seattle Children's Research Institute 2 , Seattle, WA 98101 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelino","family":"Gonzales","sequence":"additional","affiliation":[{"name":"Institut 3 o , La Paz ,","place":["Bolivia"]},{"name":"Boliviano de Biologia de Altura (IBBA), Universidad Mayor de San Andr\u00e9s 3 o , La Paz ,","place":["Bolivia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7371-1477","authenticated-orcid":false,"given":"Edith M.","family":"Schneider Gasser","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et Pneumologie - Universit\u00e9 Laval, D\u00e9partement de P\u00e9diatrie 1 , Qu\u00e9bec, QC , , G1V 4G5","place":["Canada"]},{"name":"Institute of Veterinary Physiology, Vetsuisse-Faculty University of Zurich 4 , Winterthurerstrasse 260, CH-8057 Zurich ,","place":["Switzerland"]},{"name":"Neuroscience Center Zurich (ZNZ) 5 , Winterthurerstrasse 190, 8057 Z\u00fcrich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Soliz","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et Pneumologie - Universit\u00e9 Laval, D\u00e9partement de P\u00e9diatrie 1 , Qu\u00e9bec, QC , , G1V 4G5","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3571-9042","authenticated-orcid":false,"given":"Vincent","family":"Joseph","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et Pneumologie - Universit\u00e9 Laval, D\u00e9partement de P\u00e9diatrie 1 , Qu\u00e9bec, QC , , G1V 4G5","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"key":"2025082904390605700_JEB250422C1","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1159\/000111289","article-title":"Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain","volume":"17","author":"Almeida","year":"1995","journal-title":"Dev. 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