{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:58:44Z","timestamp":1790312324336,"version":"4.1.0"},"reference-count":62,"publisher":"The Company of Biologists","issue":"19","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-2\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"crossref","award":["UMO 2019\/35\/B\/NZ4\/03828"],"award-info":[{"award-number":["UMO 2019\/35\/B\/NZ4\/03828"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007088","name":"Uniwersytet Jagiello\u0144ski w Krakowie","doi-asserted-by":"crossref","award":["N18\/DBS\/000021"],"award-info":[{"award-number":["N18\/DBS\/000021"]}],"id":[{"id":"10.13039\/501100007088","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The adverse effects of Western diets (WDs), high in both fat and simple sugars, which contribute to obesity and related disorders, have been extensively studied in laboratory rodents, but not in non-laboratory animals, which limits the scope of conclusions. Unlike laboratory mice or rats, non-laboratory rodents that reduce body mass for winter do not become obese when fed a high-fat diet. However, it is not known whether these rodents are also resistant to the adverse effects of WDs. Here, we investigated the effects of WDs on body composition, locomotor performance and blood biochemical profile in such a rodent, the bank vole. Young voles were fed either a standard diet or one of six versions of WD (varying in fat, sucrose and cholesterol content) from the age of 21\u2005days until adulthood, and then several morpho-physiological and biochemical traits were analyzed. Body mass, fat content and blood glucose were not elevated by WDs. Basal metabolic rate, sprint speed, endurance distance and aerobic exercise capacity were also not significantly affected by the diet. However, in the WD groups (especially in those receiving cholesterol-supplemented WD), liver and spleen mass and the concentrations of cholesterol, high-density lipoprotein (HDL), non-HDL and several liver enzymes were increased, indicating hyperlipidemia and altered liver function. Bank voles appeared to be resistant to diet-induced obesity and diabetes, but not to other adverse effects of WDs, especially cholesterol-supplemented WD. Therefore, the bank vole is a promising model species to study diet-induced liver disease in lean individuals.<\/jats:p>","DOI":"10.1242\/jeb.250698","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T08:52:52Z","timestamp":1757580772000},"source":"Crossref","is-referenced-by-count":2,"title":["Effect of Western diet on body composition, locomotor performance and blood biochemical profile in the bank vole"],"prefix":"10.1242","volume":"228","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1472-6411","authenticated-orcid":false,"given":"Alaa","family":"Hseiky","sequence":"first","affiliation":[{"name":"Institute of Environmental Sciences 1 , Faculty of Biology , , 30-387 Krak\u00f3w ,","place":["Poland"]},{"name":"Jagiellonian University 1 , Faculty of Biology , , 30-387 Krak\u00f3w ,","place":["Poland"]},{"name":", Jagiellonian University 2 Doctoral School of Natural and Exact Sciences , 30-348 Krakow ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3550-4105","authenticated-orcid":false,"given":"Ma\u0142gorzata M.","family":"Lipowska","sequence":"additional","affiliation":[{"name":"Institute of Environmental Sciences 1 , Faculty of Biology , , 30-387 Krak\u00f3w ,","place":["Poland"]},{"name":"Jagiellonian University 1 , Faculty of Biology , , 30-387 Krak\u00f3w ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1240-4814","authenticated-orcid":false,"given":"Edyta T.","family":"Sadowska","sequence":"additional","affiliation":[{"name":"Institute of Environmental Sciences 1 , Faculty of Biology , , 30-387 Krak\u00f3w ,","place":["Poland"]},{"name":"Jagiellonian University 1 , Faculty of Biology , , 30-387 Krak\u00f3w ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7317-260X","authenticated-orcid":false,"given":"Alicja","family":"J\u00f3zkowicz","sequence":"additional","affiliation":[{"name":"Jagiellonian University 3 Department of Medical Biotechnology, Faculty of Biophysics, Biochemistry and Biotechnology , , 30-387 Krak\u00f3w ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1526-3511","authenticated-orcid":false,"given":"Witold N.","family":"Nowak","sequence":"additional","affiliation":[{"name":"Jagiellonian University 3 Department of Medical Biotechnology, Faculty of Biophysics, Biochemistry and Biotechnology , , 30-387 Krak\u00f3w ,","place":["Poland"]},{"name":"August Che\u0142kowski Institute of Physics 4 , Faculty of Science and Technology , , 41-500 Chorz\u00f3w ,","place":["Poland"]},{"name":"University of Silesia in Katowice 4 , Faculty of Science and Technology , , 41-500 Chorz\u00f3w ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0077-4957","authenticated-orcid":false,"given":"Pawe\u0142","family":"Koteja","sequence":"additional","affiliation":[{"name":"Institute of Environmental Sciences 1 , Faculty of Biology , , 30-387 Krak\u00f3w ,","place":["Poland"]},{"name":"Jagiellonian University 1 , Faculty of Biology , , 30-387 Krak\u00f3w ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"key":"2025101004183836500_JEB250698C1","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1093\/bmb\/ldx022","article-title":"The contribution of genetics and environment to obesity","volume":"123","author":"Albuquerque","year":"2017","journal-title":"Br. 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