{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:02:16Z","timestamp":1789876936410,"version":"4.0.1"},"reference-count":47,"publisher":"The Company of Biologists","issue":"1","license":[{"start":{"date-parts":[[1980,8,1]],"date-time":"1980-08-01T00:00:00Z","timestamp":333936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1980,8,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Cardiac output and dorsal aorta, ventral aorta, caudal artery, caudal vein, and subintestinal vein pressures have been directly measured in intact unanaesthetized trout. Cardiac output (Q\u0307) averaged 36\u00b77 ml\/kg.min. The pressure drop across the systemic vascular resistance (Rs) was approximately twice that across the gill resistance (Rg), and a significant positive pressure persisted in the venous system. \u03b1-Adrenergic blockade revealed a considerable endogenous vasomotor tone resulting from latent adrenergic constriction of RS. Intravenous adrenaline caused a pressor response throughout the circulatory system which has been analysed in detail with the aid of previous studies on isolated parts of the trout circulation. The complex and variable form of the pressor response reflected differential contributions from changes in Q\u0307, Rg, and Rs. Increases in R3 (\u03b1-receptor activation) were the principal cause of all pressor responses. Rg usually declined slightly due to passive dilation and\/or \u03b2-receptor stimulation, but occasionally increased due to a-receptor activation. The cardiac response reflected a varying balance between a direct \u03b2-stimulatory effect of adrenaline on Q\u0307 and an indirect passive inhibition of Q\u0307 by the increase in peripheral resistance. Both effects were mediated through changes in stroke volume. Occasional tachycardia or more frequent reflex bradycardia were minor components of the cardiac response. The in vivo actions of other adrenergic agents have been similarly analysed.<\/jats:p>","DOI":"10.1242\/jeb.87.1.247","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T15:15:49Z","timestamp":1619363749000},"page":"247-270","source":"Crossref","is-referenced-by-count":104,"title":["Cardiovascular Dynamics and Adrenergic Responses of the Rainbow Trout <i>In Vivo<\/i>"],"prefix":"10.1242","volume":"87","author":[{"given":"Chris M.","family":"Wood","sequence":"first","affiliation":[{"name":"University of East Anglia School of Biological Sciences , , Norwich NR4. 7TJ, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Shelton","sequence":"additional","affiliation":[{"name":"University of East Anglia School of Biological Sciences , , Norwich NR4. 7TJ, England"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1980,8,1]]},"reference":[{"key":"2023092802022609100_JEXBIO_87_1_247C1","volume-title":"Molecular Pharmacology","author":"Ariens","year":"1964"},{"key":"2023092802022609100_JEXBIO_87_1_247C2","article-title":"The control of the function of the heart in teleost fish","volume-title":"M.Sc. thesis","author":"Bennion","year":"1968"},{"key":"2023092802022609100_JEXBIO_87_1_247C3","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1111\/j.1476-5381.1972.tb09583.x","article-title":"Negative inotropic responses of the isolated heart of the rat to isoprenaline","volume":"45","author":"Broadley","year":"1972","journal-title":"Br. J. Pharmac"},{"key":"2023092802022609100_JEXBIO_87_1_247C4","first-page":"247","article-title":"Evolution of the autonomic innervation of visceral and cardiovascular syster| in vertebrates","volume":"21","author":"Burnstock","year":"1969","journal-title":"Pharmac. Rev"},{"key":"2023092802022609100_JEXBIO_87_1_247C5","volume-title":"Physiology and Biophysics of the Circulation","author":"Burton","year":"1972"},{"key":"2023092802022609100_JEXBIO_87_1_247C6","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1139\/f70-123","article-title":"Gas exchange in rainbow trout (Salmo gairdneri) with varying blood oxygen capacity","volume":"27","author":"Cameron","year":"1970","journal-title":"J. Fish. Res. Bd Can"},{"key":"2023092802022609100_JEXBIO_87_1_247C7","article-title":"Automatic nervous systems","volume-title":"In Fish Physiology","author":"Campbell","year":"1970"},{"key":"2023092802022609100_JEXBIO_87_1_247C8","article-title":"Hormonal and haemodynamic factors in the control of water and electrolyte fluxes in the European eel Anguilla anguilla","volume-title":"Ph.D. thesis, University of Sheffield, Department of Zoology","author":"Chan","year":"1967"},{"key":"2023092802022609100_JEXBIO_87_1_247C9","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1002\/jez.1401960103","article-title":"The effect of acetylcholine, biogenic amines, and other vasoactive agents on the cardiovascular functions of the eel, Anguilla japonica","volume":"196","author":"Chan","year":"1976","journal-title":"J. exp. Zool"},{"key":"2023092802022609100_JEXBIO_87_1_247C10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1242\/jeb.54.1.1a","article-title":"Water flow and gas exchange at the gills of the rainbow trout, Salmo gairdneri","volume":"54","author":"Davis","year":"1971","journal-title":"J. exp. Biol"},{"key":"2023092802022609100_JEXBIO_87_1_247C11","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1139\/z78-131","article-title":"Cardiovascular events associated with air breathing in two teleosts, Hoplerythrinus unitaeniatus and Arapaima gigas","volume":"56","author":"Farrel","year":"1978","journal-title":"Can. J. Zool"},{"key":"2023092802022609100_JEXBIO_87_1_247C12","first-page":"4562","article-title":"L\u2019adr\u00e9nalin\u00e9mie du Salmo salar L. \u00e0 quelques \u00e9tapes de son cycle vit\u00e2l et de ses migrations","volume-title":"C. r. hebd. Sianc. Acad. Sci","author":"Fontaine","year":"1963"},{"key":"2023092802022609100_JEXBIO_87_1_247C13","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1111\/j.1749-6632.1967.tb41229.x","article-title":"The pharmacological differentiation of adrenergic receptors","volume":"139","author":"Furchcott","year":"1967","journal-title":"Ann. N.Y. Acad. Sci"},{"key":"2023092802022609100_JEXBIO_87_1_247C14","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/0010-4035(71)90008-5","article-title":"A study of the dual innervation of teleost heart by a field stimulation technique","volume":"2","author":"Gannon","year":"1971","journal-title":"Comp. gen. Pharmac"},{"key":"2023092802022609100_JEXBIO_87_1_247C15","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/0010-406X(69)91627-2","article-title":"Excitatory adrenergic innervation of the fish heart","volume":"29","author":"Gannon","year":"1969","journal-title":"Comp. Biochem. Physiol"},{"key":"2023092802022609100_JEXBIO_87_1_247C16","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1111\/j.1748-1716.1973.tb05482.x","article-title":"Drug effects on pre- and post-branchial blood pressure and heart rate in a free-swimming marine teleost, Gadus morhua","volume":"88","author":"Helgason","year":"1973","journal-title":"Acta physiol. Scand"},{"key":"2023092802022609100_JEXBIO_87_1_247C17","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1242\/jeb.54.1.239","article-title":"Oxygen uptake and transport by the rainbow trout during exposure to carbon monoxide","volume":"54","author":"Holeton","year":"1971","journal-title":"J. exp. Biol"},{"key":"2023092802022609100_JEXBIO_87_1_247C18","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1242\/jeb.46.2.297","article-title":"Changes in blood pressure in the rainbow trout during hypoxia","volume":"46","author":"Holeton","year":"1967","journal-title":"J. exp. Biol"},{"key":"2023092802022609100_JEXBIO_87_1_247C19","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1242\/jeb.46.2.317","article-title":"The effect of hypoxia upon the partial pressure of gases in the blood and water afferent and efferent to the gills of the rainbow trout","volume":"46","author":"Holeton","year":"1967","journal-title":"J. exp. Biol"},{"key":"2023092802022609100_JEXBIO_87_1_247C20","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1242\/jeb.57.2.415","article-title":"The relationship between cardiac and respiratory rhythms in the dogfish, Scyliorhinus canicula L","volume":"57","author":"Huches","year":"1972","journal-title":"J. exp. Biol"},{"key":"2023092802022609100_JEXBIO_87_1_247C21","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1093\/oxfordjournals.bmb.a070982","article-title":"Catecholamine uptake processes","volume":"29","author":"Iversen","year":"1973","journal-title":"Br. med. Bull"},{"key":"2023092802022609100_JEXBIO_87_1_247C22","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/0010-406X(66)90555-X","article-title":"Aortic blood flow in free-swimming elasmobranchs","volume":"19","author":"Johansen","year":"1966","journal-title":"Comp. Biochem. Physiol"},{"key":"2023092802022609100_JEXBIO_87_1_247C23","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1152\/ajplegacy.1974.226.1.90","article-title":"Blood flow in the ventral and dorsal aortas of the cod, Gadus morhua","volume":"226","author":"Jones","year":"1974","journal-title":"Am. J. Physiol"},{"key":"2023092802022609100_JEXBIO_87_1_247C24","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1242\/jeb.69.1.247","article-title":"The oxygen transport system in trout (Salmo gairdneri) during sustained exercise","volume":"69","author":"Kiceniuk","year":"1977","journal-title":"J. exp. Biol"},{"key":"2023092802022609100_JEXBIO_87_1_247C25","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1577\/1548-8659(1977)106&lt;201:PASEOS&gt;2.0.CO;2","article-title":"Primary and secondary effects of stress in fish: some new data with a general review","volume":"106","author":"Mazeaud","year":"1977","journal-title":"Trans. Am. Fish. Soc"},{"key":"2023092802022609100_JEXBIO_87_1_247C26","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1139\/f67-140","article-title":"Catecholamine and carbohydrate metabolism in rainbow trout (Salmo gairdneri) in relation to physical disturbance","volume":"24","author":"Nakano","year":"1967","journal-title":"J. Fish Res. Bd Can"},{"key":"2023092802022609100_JEXBIO_87_1_247C27","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/0300-9629(72)90440-9","article-title":"Cardiovascular responses to spinal cord stimulation and autonomically active drugs in Squalus acanthias","volume":"42 A","author":"Opdyke","year":"1972","journal-title":"Comp. Biochem. Physiol"},{"key":"2023092802022609100_JEXBIO_87_1_247C28","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1086\/physzool.40.2.30152445","article-title":"The regulation of cardiac activity in fish in a hypoxic environment","volume":"40","author":"Randall","year":"1967","journal-title":"Physiol. Zo\u00f6l"},{"key":"2023092802022609100_JEXBIO_87_1_247C29","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/BF00142057","article-title":"The effect of environmental factors on circulation and respiration in teleost fish","volume":"9","author":"Randall","year":"1967","journal-title":"Hydrobiologia"},{"key":"2023092802022609100_JEXBIO_87_1_247C30","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1139\/z65-087","article-title":"Dorsal aortic blood pressures recorded from the rainbow trout (Salmo gairdneri)","volume":"43","author":"Randall","year":"1965","journal-title":"Can. J. Zool"},{"key":"2023092802022609100_JEXBIO_87_1_247C31","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/0010-406X(67)90803-1","article-title":"The role of adrenergic receptors in cardiovascular changes associated with exercise in salmon","volume":"21","author":"Randall","year":"1967","journal-title":"Comp. Biochem. Physiol"},{"key":"2023092802022609100_JEXBIO_87_1_247C32","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.1139\/z78-231","article-title":"Neural regulation of blood pressure in rainbow trout (Salmo gairdneri)","volume":"56","author":"Smith","year":"1978","journal-title":"Can. J. Zool"},{"key":"2023092802022609100_JEXBIO_87_1_247C33","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1139\/f64-064","article-title":"A technique for prolonged blood sampling in free-swimming salmon","volume":"21","author":"Smith","year":"1964","journal-title":"J. Fish. Res. Bd Can"},{"key":"2023092802022609100_JEXBIO_87_1_247C34","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/0300-9629(72)90255-1","article-title":"Factors affecting arterial pressures and blood flow from the heart in intact, unrestrained lingood, Ophiodon elongatus","volume":"43 A","author":"Stevens","year":"1972","journal-title":"Comp. Biochem. Physiol"},{"key":"2023092802022609100_JEXBIO_87_1_247C35","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1242\/jeb.46.2.307","article-title":"Changes in blood pressure, heart rate, and breathing rate during moderate swimming activity in rainbow trout","volume":"46","author":"Stevens","year":"1967","journal-title":"J. exp. Biol"},{"key":"2023092802022609100_JEXBIO_87_1_247C36","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1242\/jeb.46.2.329","article-title":"Changes of gas concentrations in blood and water during moderate swimming activity in rainbow trout","volume":"46","author":"Stevens","year":"1967","journal-title":"J. exp. Biol"},{"key":"2023092802022609100_JEXBIO_87_1_247C37","first-page":"65","article-title":"The role of sympathetic fibres and circulatory catecholamines in controlling the blood pressure and heart rate in the cod, Gadus morhua","volume":"57C","author":"Wahlqvist","year":"1977","journal-title":"Comp. Biochem. Physiol"},{"key":"2023092802022609100_JEXBIO_87_1_247C38","doi-asserted-by":"publisher","first-page":"13 5","DOI":"10.1577\/1548-8659(1963)25[135:PSFFT]2.0.CO;2","article-title":"Physiological salines for freshwater teleosts","volume":"25","author":"Wolf","year":"1963","journal-title":"Progrve. Fish Cult"},{"key":"2023092802022609100_JEXBIO_87_1_247C39","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1242\/jeb.60.1.241","article-title":"A critical examination of the physical and adrenergic factors affecting blood flow through the gills of the rainbow trout","volume":"60","author":"Wood","year":"1974","journal-title":"J. exp. Biol"},{"key":"2023092802022609100_JEXBIO_87_1_247C40","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1002\/jez.1401890216","article-title":"Mayer waves in the circulation of a teleost fish","volume":"189","author":"Wood","year":"1974","journal-title":"J. exp. Zool"},{"key":"2023092802022609100_JEXBIO_87_1_247C41","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1139\/z75-191","article-title":"A pharmacological analysis of the adrenergic and cholinergic mechanisms regulating branchial vascular resistance in the rainbow trout (Salmo gairdneri)","volume":"53","author":"Wood","year":"1975","journal-title":"Can. J. Zool"},{"key":"2023092802022609100_JEXBIO_87_1_247C42","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/BF00691227","article-title":"Pharmacological properties of the adrenergic receptors regulating systemic vascular resistance in the rainbow trout","volume":"107","author":"Wood","year":"1976","journal-title":"J. comp. Physiol. B"},{"key":"2023092802022609100_JEXBIO_87_1_247C43","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/BF00692519","article-title":"Cholinergic mechanisms and the response to ATP in the systemic vasculature of the rainbow trout","volume":"122","author":"Wood","year":"1977","journal-title":"J. comp. Physiol. B"},{"key":"2023092802022609100_JEXBIO_87_1_247C44","first-page":"R201","article-title":"Oxygen exchange and vascular resistance in the totally perfused rainbow trout","volume":"234","author":"Wood","year":"1978","journal-title":"Am. J. Physiol"},{"key":"2023092802022609100_JEXBIO_87_1_247C45","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/0300-9629(71)90303-3","article-title":"The effect of anaemia on ion exchange in the southern flounder (Paralichthys lethostigma)","volume":"39A","author":"Wood","year":"1971","journal-title":"Comp. Biochem. Physiol"},{"key":"2023092802022609100_JEXBIO_87_1_247C46","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1242\/jeb.63.2.505","article-title":"Physical and adrenergic factors affecting systemic vascular resistance in the rainbow trout: a comparison with branchial vascular resistance","volume":"63","author":"Wood","year":"1975","journal-title":"J. exp. Biol"},{"key":"2023092802022609100_JEXBIO_87_1_247C47","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1242\/jeb.87.1.271","article-title":"The reflex control of heart rate and cardiac output in the rainbow trout: interactive influences of hypoxia, haemorrhage, and systemic vasomotor tone. Submitted to","volume":"87","author":"Wood","year":"1980","journal-title":"J. exp. Biol"}],"container-title":["Journal of Experimental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/jeb\/article-pdf\/87\/1\/247\/3194472\/jexbio_87_1_247.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/jeb\/article-pdf\/87\/1\/247\/3194472\/jexbio_87_1_247.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T02:03:59Z","timestamp":1695866639000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/jeb\/article\/87\/1\/247\/22747\/Cardiovascular-Dynamics-and-Adrenergic-Responses"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,8,1]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1980,8,1]]}},"URL":"https:\/\/doi.org\/10.1242\/jeb.87.1.247","relation":{},"ISSN":["0022-0949","1477-9145"],"issn-type":[{"value":"0022-0949","type":"print"},{"value":"1477-9145","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,8,1]]}}}