{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T14:15:45Z","timestamp":1760710545816},"reference-count":28,"publisher":"The Company of Biologists","issue":"4","license":[{"start":{"date-parts":[[1991,12,1]],"date-time":"1991-12-01T00:00:00Z","timestamp":691545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>In the E4 (embryonic day 4) chick tectal primordium, engrailed expression is strong at the caudal end and gradually weakens toward the rostral end. We used quail-chick chimeric tecta to investigate how the caudorostral gradient of engrailed expression is established and whether it is correlated with the subsequent rostrocaudal polarity of tectal development.<\/jats:p>\n               <jats:p>To examine the positional value of the tectal primordium, we produced ectopic tecta in the diencephalon by transplanting a part of the mesencephalic alar plate heterotopically. In the ectopic tectum, the gradient of the engrailed expression reversed and the strength of the expression was dependent on the distance from the mes-diencephalon junction; the nearer the ectopic tectum was to the junction, the weaker the expression was. Consequently, the pattern of the engrailed expression in the host and ectopic tecta was nearly a mirror image, suggesting the existence of a repressive influence around the mes-diencephalon junction on the engrailed expression.<\/jats:p>\n               <jats:p>We examined cytoarchitectonie development in the ectopic tecta, which normally proceeds in a gradient along the rostrocaudal axis; the rostral shows more advanced lamination than the caudal. In contrast, the caudal part of the ectopic tecta (near to the mesdiencephalon junction) showed more advanced lamination than the rostral. In both the host and ectopic tecta, advanced lamination was observed where the engrailed expression was repressed, and vice versa.<\/jats:p>\n               <jats:p>Next we studied the correlation between engrailed expression and retinotectal projection from a view of plasticity and rigidity of rostrocaudal polarity in the tectum. We produced ectopic tecta by anisochronal transplantations between E3 host and E2 donor, and showed that there is little repressive influence at E3 around the mes-diencephalon junction. We then made chimeric double-rostral tectum (caudal half of it was replaced by rostral half of the donor tectum) or double-caudal tectum at E3. The transplants kept their original staining pattern in hosts. Consequently, the chimeric tecta showed wholly negative or positive staining of engrailed protein on the grafted side. In such tecta retinotectal projection pattern was disturbed as if the transplants retained their original position-specific characters.<\/jats:p>\n               <jats:p>We propose from these heterotopic and anisochronal experiments that the engrailed expression can be a marker for subsequent rostrocaudal polarity in the tectum, both as regards cytoarchitectonie development and retinotectal projection.<\/jats:p>","DOI":"10.1242\/dev.113.4.1133","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T18:26:51Z","timestamp":1619202411000},"page":"1133-1144","source":"Crossref","is-referenced-by-count":102,"title":["Establishment of rostrocaudal polarity in tectal primordium: <i>engrailed<\/i> expression and subsequent tectal polarity"],"prefix":"10.1242","volume":"113","author":[{"given":"Nobue","family":"Itasaki","sequence":"first","affiliation":[{"name":"Kyoto Prefectural University of Medicine 1 Department of Biology , , 13 Nishitakatsukasa-cho, Taishogun, Kita-ku, Kyoto 603, Japan"},{"name":"Hiroshima University School of Medicine 2 Department of Anatomy , , 1-2-3 Kasumi, Minami-ku, Hiroshima 734, Japan"}]},{"given":"Hiroyuki","family":"Ichijo","sequence":"additional","affiliation":[{"name":"Kyoto Prefectural University of Medicine 3 Department of Pathology , , 13 Nishitakatsukasa-cho, Taishogun, Kita-ku, Kyoto 603, Japan"}]},{"given":"Chihiro","family":"Hama","sequence":"additional","affiliation":[{"name":"4 Division of Molecular Genetics, National Institute of Neuroscience, NCNP, Ogawahigashi-cho, Kodaira, Tokyo 187, Japan"}]},{"given":"Toru","family":"Matsuno","sequence":"additional","affiliation":[{"name":"Kyoto Prefectural University of Medicine 1 Department of Biology , , 13 Nishitakatsukasa-cho, Taishogun, Kita-ku, Kyoto 603, Japan"}]},{"given":"Harukazu","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Kyoto Prefectural University of Medicine 1 Department of Biology , , 13 Nishitakatsukasa-cho, Taishogun, Kita-ku, Kyoto 603, Japan"}]}],"member":"237","published-online":{"date-parts":[[1991,12,1]]},"reference":[{"key":"2023050315324706500_DEVELOP_113_4_1133C1","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/0012-1606(90)90280-V","article-title":"Pluripotentiality of the 2-day-old avian germinative neuroepithelium","volume":"139","author":"Alvarado-Mallart","year":"1990","journal-title":"Devl Biol"},{"key":"2023050315324706500_DEVELOP_113_4_1133C2","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/0012-1606(84)90326-9","article-title":"Homotopic and heterotopic transplantations of quail tectal primordia in chick embryos: Organization of the retinotectal projections in the chimeric embryos","volume":"103","author":"Alvarado-Mallart","year":"1984","journal-title":"Devl Biol"},{"key":"2023050315324706500_DEVELOP_113_4_1133C3","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1038\/258126a0","article-title":"Polarity of structure and of ordered nerve connections in the developing amphibian brain","volume":"258","author":"Chung","year":"1975","journal-title":"Nature"},{"key":"2023050315324706500_DEVELOP_113_4_1133C4","first-page":"389","article-title":"The development of the retinotectal projection: An overview","volume-title":"Molecular Bases of Neural Development","author":"Cowan","year":"1985"},{"key":"2023050315324706500_DEVELOP_113_4_1133C5","first-page":"604","article-title":"Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis","volume-title":"Nature","author":"Dinardo","year":"1988"},{"key":"2023050315324706500_DEVELOP_113_4_1133C6","first-page":"426","article-title":"Expression of an engrailed-Mse gene during development of the early embryonic chick nervous system","volume-title":"J. Neurosci. Res","author":"Gardner"},{"key":"2023050315324706500_DEVELOP_113_4_1133C7","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1002\/jmor.1050880104","article-title":"A series of normal stages in the development of the chick embryo","volume":"88","author":"Hamburger","year":"1951","journal-title":"J. Morph"},{"key":"2023050315324706500_DEVELOP_113_4_1133C8","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1242\/dev.110.2.331","article-title":"Rotation of the tectal primordium reveals plasticity of target recognition in retinotectal projection","volume":"110","author":"Ichuo","year":"1990","journal-title":"Development"},{"key":"2023050315324706500_DEVELOP_113_4_1133C9","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1126\/science.1672471","article-title":"Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox","volume":"251","author":"Joyner","year":"1991","journal-title":"Science"},{"key":"2023050315324706500_DEVELOP_113_4_1133C10","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/0006-8993(71)90053-9","article-title":"The development of the chick optic tectum. I. Normal morphology and cytoarchitectonie development","volume":"28","author":"LaVail","year":"1971","journal-title":"Brain Res"},{"key":"2023050315324706500_DEVELOP_113_4_1133C11","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/0012-1606(73)90061-4","article-title":"A biological cell labeling technique and its use in experimental embryology","volume":"30","author":"Le Douarin","year":"1973","journal-title":"Devl Biol"},{"key":"2023050315324706500_DEVELOP_113_4_1133C12","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/0012-1606(90)90312-7","article-title":"Expression of the homeobox chick-en gene in chick\/quail chimeras with inverted mes-metencephalic grafts","volume":"139","author":"Martinez","year":"1990","journal-title":"Devl Biol"},{"key":"2023050315324706500_DEVELOP_113_4_1133C13","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/0896-6273(91)90237-T","article-title":"Induction of a mesencephalic phenotype in the 2-day-old chick prosencephalon is preceded by the early expression of the homeobox gene en","volume":"6","author":"Martinez","year":"1991","journal-title":"Neuron"},{"key":"2023050315324706500_DEVELOP_113_4_1133C14","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1242\/dev.103.1.157","article-title":"Role of segment polarity genes in the definition and maintenance of cel states in the Drosophila embryo","volume":"103","author":"Martinez Arias","year":"1988","journal-title":"Development"},{"key":"2023050315324706500_DEVELOP_113_4_1133C15","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/0165-3806(91)90014-A","article-title":"Regulation of the rostrocaudal axis of the optic tectum: histological study after rostrocaudal rotation in quail-chick chimeras","volume":"58","author":"Matsuno","year":"1991","journal-title":"Devl Brain Res"},{"key":"2023050315324706500_DEVELOP_113_4_1133C16","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/0092-8674(90)90385-R","article-title":"The Wnt-1 (inr-1) proto-oncogene is required for development of a large region of the mouse brain","volume":"62","author":"McMahon","year":"1990","journal-title":"Cell"},{"key":"2023050315324706500_DEVELOP_113_4_1133C17","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/0006-8993(90)90231-Y","article-title":"Do CNS anlagen have plasticity in differentiation? Analysis in quail-chick chimera","volume":"511","author":"Nakamura","year":"1990","journal-title":"Brain Res"},{"key":"2023050315324706500_DEVELOP_113_4_1133C18","doi-asserted-by":"publisher","first-page":"3776","DOI":"10.1523\/JNEUROSCI.09-11-03776.1989","article-title":"Inaccuracies in initial growth and arborization of chick retinotectal axons followed by course corrections and axon remodeling to develop topographic order","volume":"9","author":"Nakamura","year":"1989","journal-title":"J. Neurosci"},{"key":"2023050315324706500_DEVELOP_113_4_1133C19","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/0092-8674(89)90947-1","article-title":"Expression of engrailed proteins in arthropods, annelids, and chordates","volume":"58","author":"Patel","year":"1989","journal-title":"Cell"},{"key":"2023050315324706500_DEVELOP_113_4_1133C20","first-page":"2723","article-title":"Secreted int-1 protein is associated with the cell surface","volume":"10","author":"Papkoff","year":"1990","journal-title":"Molec. cell. Biol"},{"key":"2023050315324706500_DEVELOP_113_4_1133C21","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/0092-8674(87)90038-9","article-title":"The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless","volume":"50","author":"Rusewuk","year":"1987","journal-title":"Cell"},{"key":"2023050315324706500_DEVELOP_113_4_1133C22","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/0165-3806(86)90088-X","article-title":"Development of the retinotectal system in normal quail embryos: Cytoarchitectonie development and optic fiber innervation","volume":"29","author":"Senut","year":"1986","journal-title":"Devl Brain Res"},{"key":"2023050315324706500_DEVELOP_113_4_1133C23","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/0165-3806(87)90100-3","article-title":"Cytodifferentiation of quail tectal primordium transplanted homotopically into the chick embryo","volume":"32","author":"Senut","year":"1987","journal-title":"Devl Brain Res"},{"key":"2023050315324706500_DEVELOP_113_4_1133C24","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/0896-6273(90)90227-7","article-title":"Biochemical characterization of a putative axonal guidance molecule of the chick visual system","volume":"5","author":"Stahl","year":"1990","journal-title":"Neuron"},{"key":"2023050315324706500_DEVELOP_113_4_1133C25","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1038\/346847a0","article-title":"Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development","volume":"346","author":"Thomas","year":"1990","journal-title":"Nature"},{"key":"2023050315324706500_DEVELOP_113_4_1133C26","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1242\/dev.101.4.909","article-title":"Avoidance of posterior tectal membranes by temporal retinal axons","volume":"101","author":"Walter","year":"1987","journal-title":"Development"},{"key":"2023050315324706500_DEVELOP_113_4_1133C27","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1242\/dev.101.4.685","article-title":"Recognition of position-specific properties of tectal cell membranes by retinal axons in vitro","volume":"101","author":"Walter","year":"1987","journal-title":"Development"},{"key":"2023050315324706500_DEVELOP_113_4_1133C28","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/0092-8674(87)90664-7","article-title":"Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo","volume":"50","author":"Wilkinson","year":"1987","journal-title":"Cell"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/113\/4\/1133\/2809548\/develop_113_4_1133.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/113\/4\/1133\/2809548\/develop_113_4_1133.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T15:37:37Z","timestamp":1683128257000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/113\/4\/1133\/37338\/Establishment-of-rostrocaudal-polarity-in-tectal"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,12,1]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1991,12,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.113.4.1133","relation":{},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,12,1]]}}}