{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:58:51Z","timestamp":1779343131407,"version":"3.51.4"},"reference-count":51,"publisher":"The Company of Biologists","issue":"2","license":[{"start":{"date-parts":[[1992,10,1]],"date-time":"1992-10-01T00:00:00Z","timestamp":717897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Extracellular signal proteins induce the homeotic gene labial (lab) to high levels of localised expression in the endoderm of Drosophila embryos. We aimed to identify cis-regulatory elements within the lab gene that respond to this induction by analysing the activity of stably integrated reporter gene constructs. Dissection of lab 5 flanking sequences reveals two types of response elements. One of these mediates lab dependent activity, providing evidence that lab induction in the endoderm is autoregulatory. The other element, to a large extent independent of lab function, responds to decapentaplegic (dpp), a signal molecule related to mammalian TGF-. Our evidence suggests that lab induction in the endoderm reflects coordinate action of two distinct factors one of which may be lab protein itself, and another whose localised activity or expression in the midgut depends on the dpp signal.<\/jats:p>","DOI":"10.1242\/dev.116.2.447","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T01:08:55Z","timestamp":1619399335000},"page":"447-456","source":"Crossref","is-referenced-by-count":69,"title":["Induction of <i>labial<\/i> expression in the <i>Drosophila<\/i> endoderm: response elements for <i>dpp<\/i> signalling and for autoregulation"],"prefix":"10.1242","volume":"116","author":[{"given":"Gabi","family":"Tremml","sequence":"first","affiliation":[{"name":"Universit\u00e4t Z\u00fcrich 1 Zoologisches Institut , , Winterthurerstr. 190, 8057 Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariann","family":"Bienz","sequence":"additional","affiliation":[{"name":"2 MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[1992,10,1]]},"reference":[{"key":"2024121722203872900_DEVELOP_116_2_447C1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/dev.101.1.1","article-title":"The molecular basis for metameric pattern in the Drosophila embryo","volume":"101","author":"Akam","year":"1987","journal-title":"Development"},{"key":"2024121722203872900_DEVELOP_116_2_447C2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0092-8674(92)90209-U","article-title":"Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine\/threonine kinase receptors","volume":"68","author":"Attisano","year":"1992","journal-title":"Cell"},{"key":"2024121722203872900_DEVELOP_116_2_447C3","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1002\/j.1460-2075.1987.tb02429.x","article-title":"Molecular cloning of sequences from wingless, a segment polarity gene of Drosophila: the spatial distribution of transcripts in embryos","volume":"6","author":"Baker","year":"1987","journal-title":"EMBO J"},{"key":"2024121722203872900_DEVELOP_116_2_447C4","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/0092-8674(88)90573-9","article-title":"Differential regulation of Ultrabithorax in two germ layers of Drosophila","volume":"53","author":"Bienz","year":"1988","journal-title":"Cell"},{"key":"2024121722203872900_DEVELOP_116_2_447C5","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/333576a0","article-title":"Domain of Ultrabithorax expression in Drosophila visceral mesoderm from autoregulation and exclusion","volume":"333","author":"Bienz","year":"1988","journal-title":"Nature"},{"key":"2024121722203872900_DEVELOP_116_2_447C6","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/0092-8674(87)90039-0","article-title":"Phenocopies induced with antisense RNA identify the wingless gene","volume":"50","author":"Cabrera","year":"1987","journal-title":"Cell"},{"key":"2024121722203872900_DEVELOP_116_2_447C7","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-662-02454-6","volume-title":"The Embryonic Development of Drosophila melanogaster","author":"Campos-Ortega","year":"1985"},{"key":"2024121722203872900_DEVELOP_116_2_447C8","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1002\/j.1460-2075.1987.tb02619.x","article-title":"Double and triple mutant combinations of the bithorax complex in Drosophila","volume":"6","author":"Casanova","year":"1987","journal-title":"EMBO J"},{"key":"2024121722203872900_DEVELOP_116_2_447C9","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1073\/pnas.68.9.2217","article-title":"Determination of blastoderm cells in Drosophila melanogaster","volume":"68","author":"Chan","year":"1971","journal-title":"Proc. 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