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GLP-1 is tightly associated with membranes of mitotic germline cells, supporting its identification as an integral membrane protein. Furthermore, GLP-1 is localized within the germ line to the mitotic region, consistent with the model that GLP-1 acts as a membrane receptor for the distal tip cell signal. Unexpectedly, GLP-1 and the zone of mitosis extend further than the DTC processes. We present three models by which the DTC may influence GLP-1 activity and thereby determine the zone of mitosis. The spatial restriction of GLP-1 appears to be controlled at the translational level in hermaphrodites. We suggest that down-regulation of GLP-1 may be required to effect the transition from mitosis into meiosis.<\/jats:p>","DOI":"10.1242\/dev.120.10.2901","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T01:32:08Z","timestamp":1619400728000},"page":"2901-2911","source":"Crossref","is-referenced-by-count":200,"title":["GLP-1 is localized to the mitotic region of the <i>C. elegans<\/i> germ line"],"prefix":"10.1242","volume":"120","author":[{"given":"Sarah L.","family":"Crittenden","sequence":"first","affiliation":[{"name":"University of Wisconsin 53706, USA Laboratory of Molecular Biology and Department of Biochemistry ,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily R.","family":"Troemel","sequence":"additional","affiliation":[{"name":"University of Wisconsin 53706, USA Laboratory of Molecular Biology and Department of Biochemistry ,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas C.","family":"Evans","sequence":"additional","affiliation":[{"name":"University of Wisconsin 53706, USA Laboratory of Molecular Biology and Department of Biochemistry ,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Kimble","sequence":"additional","affiliation":[{"name":"University of Wisconsin 53706, USA Laboratory of Molecular Biology and Department of Biochemistry ,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[1994,10,1]]},"reference":[{"key":"2024121723423591300_DEVELOP_120_10_2901C1","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1146\/annurev.cb.07.110191.002235","article-title":"The notch locus and the cell biology of neuroblast segregation","volume":"7","author":"Artavanis-Tsakonas","year":"1991","journal-title":"Ann. 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