{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T07:20:12Z","timestamp":1780730412165,"version":"3.54.1"},"reference-count":74,"publisher":"The Company of Biologists","issue":"6","license":[{"start":{"date-parts":[[1995,6,1]],"date-time":"1995-06-01T00:00:00Z","timestamp":801964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,6,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The expression of the abdominal-A and Abdominal-B genes of the bithorax complex of Drosophila is controlled by cis-regulatory infraabdominal regions. The activation of these regions along the anteroposterior axis of the embryo determines where abdominal-A and Abdominal-B are transcribed. There is spatially restricted transcription of the infraabdominal regions (infraabdominal transcripts) that may reflect this specific activation. We show that the gap genes hunchback, Kr\u00fcppel, tailless and knirps control abdominal-A and Abdominal-B expression early in development. The restriction of abdominal-A and Abdominal-B transcription is preceded by (and requires) the spatially localized activation of regulatory regions, which can be detected by the distribution of infraabdominal transcripts. The activation of these regions (except the infraabdominal-8 one) could require no specific gap gene. Instead, a general mechanism of activation, combined with repression by gap genes in the anteroposterior axis, seems to be responsible for delimiting infraabdominal active domains. The gradients of the hunchback and Kr\u00fcppel products seem to be key elements in this restricted activation.<\/jats:p>","DOI":"10.1242\/dev.121.6.1855","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T02:17:24Z","timestamp":1619403444000},"page":"1855-1866","source":"Crossref","is-referenced-by-count":69,"title":["Regulation of the <i>infraabdominal<\/i> regions of the bithorax complex of <i>Drosophila<\/i> by gap genes"],"prefix":"10.1242","volume":"121","author":[{"given":"Fernando","family":"Casares","sequence":"first","affiliation":[{"name":"Universidad Aut\u00f3noma de Madrid 1 Centro de Biolog\u00eda Molecular \u2018Severo Ochoa\u2019, Facultad de Ciencias , , Cantoblanco - 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"S\u00e1nchez-Herrero","sequence":"additional","affiliation":[{"name":"Universidad Aut\u00f3noma de Madrid 1 Centro de Biolog\u00eda Molecular \u2018Severo Ochoa\u2019, Facultad de Ciencias , , Cantoblanco - 28049 Madrid, Spain"},{"name":"University of Cambridge 2 Department of Genetics , , Downing Street, Cambridge CB2 2QH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1995,6,1]]},"reference":[{"key":"2025011514110998700_DEVELOP_121_6_1855C1","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1242\/dev.111.2.393","article-title":"Molecular definition of the morphogenetic and regulatory functions and the cis-regulatory elements of the Drosophila Abd-B homeotic gene","volume":"111","author":"Boulet","year":"1991","journal-title":"Development"},{"key":"2025011514110998700_DEVELOP_121_6_1855C2","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1242\/dev.107.3.575","article-title":"Genetic structure of the abd-A gene of Drosophila","volume":"107","author":"Busturia","year":"1989","journal-title":"Development"},{"key":"2025011514110998700_DEVELOP_121_6_1855C3","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1002\/j.1460-2075.1993.tb05785.x","article-title":"Silencers in Abdominal-B, a homeotic Drosophila gene","volume":"12","author":"Busturia","year":"1993","journal-title":"EMBO J"},{"key":"2025011514110998700_DEVELOP_121_6_1855C4","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1242\/dev.110.2.621","article-title":"Pattern formation under the control of the terminal system in the Drosophila embryo","volume":"110","author":"Casanova","year":"1990","journal-title":"Development"},{"key":"2025011514110998700_DEVELOP_121_6_1855C5","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/0092-8674(86)90627-6","article-title":"Identification and characterization of a parasegment specific regulatory element of the Abdominal-B gene of Drosophila","volume":"47","author":"Casanova","year":"1986","journal-title":"Cell"},{"key":"2025011514110998700_DEVELOP_121_6_1855C6","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1101\/gad.3.9.1424","article-title":"The molecular genetics of the bithorax complex of Drosophila: characterization of the products of the Abdominal-B domain","volume":"3","author":"Celniker","year":"1989","journal-title":"Genes Dev"},{"key":"2025011514110998700_DEVELOP_121_6_1855C7","doi-asserted-by":"publisher","first-page":"4277","DOI":"10.1002\/j.1460-2075.1990.tb07876.x","article-title":"The molecular genetics of the bithorax complex of Drosophila: cis-regulation in the Abdominal-B domain","volume":"9","author":"Celniker","year":"1990","journal-title":"EMBO J"},{"key":"2025011514110998700_DEVELOP_121_6_1855C8","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1093\/genetics\/134.3.809","article-title":"The 3\u2019 regulatory region of the Abdominal-B gene: genetic analysis supports a model of reiterated and interchangeable regulatory elements","volume":"134","author":"Crosby","year":"1993","journal-title":"Genetics"},{"key":"2025011514110998700_DEVELOP_121_6_1855C9","doi-asserted-by":"publisher","first-page":"3259","DOI":"10.1073\/pnas.87.9.3259","article-title":"Characterization of two RNAs transcribed from the cis-regulatory region of the abd-A domain within the Drosophila bithorax complex","volume":"87","author":"Cumberledge","year":"1990","journal-title":"Proc. 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