{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T16:41:06Z","timestamp":1775234466736,"version":"3.50.1"},"reference-count":51,"publisher":"The Company of Biologists","issue":"8","license":[{"start":{"date-parts":[[1995,8,1]],"date-time":"1995-08-01T00:00:00Z","timestamp":807235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,8,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The patterns of embryonic expression and the activities of Xenopus members of the hedgehog gene family are suggestive of roles in neural induction and patterning. We report that these hedgehog polypeptides undergo autoproteolytic cleavage. Injection into embryos of mRNAs encoding Xenopus banded-hedgehog (X-bhh) or the amino-terminal domain (N) demonstrates that the direct inductive activities of X-bhh are encoded by N. In addition, both N and X-bhh pattern neural tissue by elevating expression of anterior neural genes. Unexpectedly, an internal deletion of X-bhh (\u0394N-C) was found to block the activity of X-bhh and N in explants and to reduce dorsoanterior structures in embryos. As elevated hedgehog activity increases the expression of anterior neural genes, and as \u0394N-C reduces dorsoanterior structures, these complementary data support a role for hedgehog in neural induction and antero-posterior patterning.<\/jats:p>","DOI":"10.1242\/dev.121.8.2349","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T02:24:01Z","timestamp":1619403841000},"page":"2349-2360","source":"Crossref","is-referenced-by-count":53,"title":["Patterning of the neural ectoderm of <i>Xenopus laevis<\/i> by the amino-terminal product of hedgehog autoproteolytic cleavage"],"prefix":"10.1242","volume":"121","author":[{"given":"Cheng-Jung","family":"Lai","sequence":"first","affiliation":[{"name":"University of Washington School of Medicine and Howard Hughes Medical Institute 1 Department of Pharmacology , , Seattle, WA 98195, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen C.","family":"Ekker","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine and Howard Hughes Medical Institute 2 , Department of Molecular Biology and Genetics, Baltimore, MD 21205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip A.","family":"Beachy","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine and Howard Hughes Medical Institute 2 , Department of Molecular Biology and Genetics, Baltimore, MD 21205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randall T.","family":"Moon","sequence":"additional","affiliation":[{"name":"University of Washington School of Medicine and Howard Hughes Medical Institute 1 Department of Pharmacology , , Seattle, WA 98195, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[1995,8,1]]},"reference":[{"key":"2025011514522971000_DEVELOP_121_8_2349C1","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1038\/368208a0","article-title":"Compartment boundaries and the control ofDrosophila limb pattern by hedgehog protein","volume":"368","author":"Basler","year":"1994","journal-title":"Nature"},{"key":"2025011514522971000_DEVELOP_121_8_2349C2","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1016\/0092-8674(83)90292-1","article-title":"Synthesis and assembly of spectrin during avian erythropoiesis: stoichiometric assembly but unequal synthesis of alpha and beta spectrin","volume":"32","author":"Blikstad","year":"1983","journal-title":"Cell"},{"key":"2025011514522971000_DEVELOP_121_8_2349C3","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/0925-4773(93)90089-G","article-title":"The structure and expression of the Xenopus Krox-20 gene: conserved and divergent patterns of expression in rhomobomeres and neural crest","volume":"40","author":"Bradley","year":"1992","journal-title":"Mech. 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