{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T20:38:12Z","timestamp":1780519092808,"version":"3.54.1"},"reference-count":68,"publisher":"The Company of Biologists","issue":"21","license":[{"start":{"date-parts":[[1997,11,1]],"date-time":"1997-11-01T00:00:00Z","timestamp":878342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Transcriptional silencing by the Polycomb Group of genes maintains the position-specific repression of homeotic genes throughout Drosophila development. The Polycomb Group of genes characterized to date encode chromatinassociated proteins that have been suggested to form heterochromatin-like structures. By studying the expression of reporter genes, we have identified a 725 bp fragment, called MCP725, in the homeotic gene Abdominal-B, that accurately maintains position-specific silencing during proliferation of imaginal cells. Silencing by MCP725 requires the Polycomb and the Polycomblike genes, indicating that it contains a Polycomb response element. To investigate the mechanisms of transcriptional silencing by MCP725, we have studied its temporal requirements by removing MCP725 from the transgene at various times during development. We have discovered that excision of MCP725 during larval stages leads to loss of silencing. Our findings indicate that the silencer is required for the maintenance of the repressed state throughout cell proliferation. They also suggest that propagation of the silenced state does not occur merely by templating of a heterochromatin structure by virtue of protein-protein interactions. Rather, they suggest that silencers play an active role in the maintenance of the position-specific repression throughout development.<\/jats:p>","DOI":"10.1242\/dev.124.21.4343","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T03:05:35Z","timestamp":1619406335000},"page":"4343-4350","source":"Crossref","is-referenced-by-count":97,"title":["A silencer is required for maintenance of transcriptional repression throughout <i>Drosophila<\/i> development"],"prefix":"10.1242","volume":"124","author":[{"given":"Ana","family":"Busturia","sequence":"first","affiliation":[{"name":"University of Utah Department of Human Genetics, 5200 Eccles Institute of Human Genetics , , Salt Lake City, UT 84112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Wightman","sequence":"additional","affiliation":[{"name":"University of Utah Department of Human Genetics, 5200 Eccles Institute of Human Genetics , , Salt Lake City, UT 84112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Sakonju","sequence":"additional","affiliation":[{"name":"University of Utah Department of Human Genetics, 5200 Eccles Institute of Human Genetics , , Salt Lake City, UT 84112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1997,11,1]]},"reference":[{"key":"2025021405141078600_DEVELOP_124_21_4343C1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1242\/dev.101.1.1","article-title":"The molecular basis for metameric pattern in the Drosophila embryo","volume":"101","author":"Akam","year":"1987","journal-title":"Development"},{"key":"2025021405141078600_DEVELOP_124_21_4343C2","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1002\/j.1460-2075.1993.tb05751.x","article-title":"Cell-type-specific mechanisms of transcriptional repression by the homeotic gene products Ubx and abd-A in Drosophila embryos","volume":"12","author":"Appel","year":"1993","journal-title":"EMBO J"},{"key":"2025021405141078600_DEVELOP_124_21_4343C3","volume-title":"Drosophila: A Laboratory Handbook","author":"Ashburner","year":"1989"},{"key":"2025021405141078600_DEVELOP_124_21_4343C4","first-page":"955","article-title":"Molecular mechanisms of determination in Drosophila. Curr. Opin","volume":"4","author":"Bienz","year":"1992","journal-title":"Cell Biol"},{"key":"2025021405141078600_DEVELOP_124_21_4343C5","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1002\/bies.950170907","article-title":"Transciptional silencing of homeotic genes in Drosophila","volume":"17","author":"Bienz","year":"1995","journal-title":"BioEssays"},{"key":"2025021405141078600_DEVELOP_124_21_4343C6","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/0092-8674(85)90059-5","article-title":"Characterization of a \u2018silencer\u2019 in yeast: A DNA sequence with properties opposite to those of a transcriptional enhancer","volume":"41","author":"Brand","year":"1985","journal-title":"Cell"},{"key":"2025021405141078600_DEVELOP_124_21_4343C7","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1038\/368154a0","article-title":"The human X-inactivation center is not required for maintenance of X-chromosome inactivation","volume":"368","author":"Brown","year":"1994","journal-title":"Nature"},{"key":"2025021405141078600_DEVELOP_124_21_4343C8","first-page":"1721","article-title":"Transcriptional repression by Drosophila and mammalian Polycomb group proteins in transfected mmammalian cells","volume":"14","author":"Bunker","year":"1994","journal-title":"Mol. Cell Biol"},{"key":"2025021405141078600_DEVELOP_124_21_4343C9","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1002\/j.1460-2075.1993.tb05785.x","article-title":"Silencers in Abdominal-B, a homeotic Drosophila gene","volume":"12","author":"Busturia","year":"1993","journal-title":"EMBO J"},{"key":"2025021405141078600_DEVELOP_124_21_4343C10","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1242\/dev.121.6.1855","article-title":"Regulation of the infraabdominal regions of the bithorax complex of Drosophila by gap genes","volume":"121","author":"Casares","year":"1995","journal-title":"Development"},{"key":"2025021405141078600_DEVELOP_124_21_4343C11","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1242\/dev.114.4.877","article-title":"Function of an Ultrabithorax minigene in imaginal cells","volume":"114","author":"Castelli-Gair","year":"1992","journal-title":"Development"},{"key":"2025021405141078600_DEVELOP_124_21_4343C12","doi-asserted-by":"publisher","first-page":"4277","DOI":"10.1002\/j.1460-2075.1990.tb07876.x","article-title":"The molecular genetics of the Bithorax complex of Drosophila: cis-regulation in the Abdominal-B domain","volume":"9","author":"Celniker","year":"1990","journal-title":"EMBO J"},{"key":"2025021405141078600_DEVELOP_124_21_4343C13","doi-asserted-by":"publisher","first-page":"2553","DOI":"10.1002\/j.1460-2075.1994.tb06545.x","article-title":"A Polycomb response element in the Ubx gene that determines an epigenetically inherited state of repression","volume":"13","author":"Chan","year":"1994","journal-title":"EMBO J"},{"key":"2025021405141078600_DEVELOP_124_21_4343C14","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/0925-4773(94)90064-7","article-title":"Imaginal disc silencers from Ultrabithorax: evidence for Polycomb response elements","volume":"48","author":"Christen","year":"1994","journal-title":"Mech. Dev"},{"key":"2025021405141078600_DEVELOP_124_21_4343C15","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/S0092-8674(00)81240-4","article-title":"Perturbation of nuclear architecture by long-distance chromosome interactions","volume":"85","author":"Dernburg","year":"1996","journal-title":"Cell"},{"key":"2025021405141078600_DEVELOP_124_21_4343C16","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1093\/genetics\/102.1.49","article-title":"Polycomblike: A gene that appears to be required for the normal expression of the bithorax and Antennapedia gene complexes of Drosophila melanogaster","volume":"102","author":"Duncan","year":"1982","journal-title":"Genetics"},{"key":"2025021405141078600_DEVELOP_124_21_4343C17","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1146\/annurev.ge.21.120187.001441","article-title":"The bithorax complex","volume":"21","author":"Duncan","year":"1987","journal-title":"Ann. Rev. Genet"},{"key":"2025021405141078600_DEVELOP_124_21_4343C18","doi-asserted-by":"publisher","first-page":"9923","DOI":"10.1073\/pnas.87.24.9923","article-title":"Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position effect variegation in Drosophila melanogaster","volume":"87","author":"Eissenberg","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025021405141078600_DEVELOP_124_21_4343C19","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/oso\/9780199635764.003.0008","article-title":"Epigenetic regulation in Drosophila: a conspiracy of silence","volume-title":"In Chromatin Structure and Gene Expression","author":"Eissenberg","year":"1995"},{"key":"2025021405141078600_DEVELOP_124_21_4343C20","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1242\/dev.107.3.651","article-title":"Analysis of maternal effect mutant combinations elucidates regulation and function of the overlap of hunchback and Kr\u00fcppel gene expression in the Drosophila blastoderm embryo","volume":"107","author":"Gaul","year":"1989","journal-title":"Development"},{"key":"2025021405141078600_DEVELOP_124_21_4343C21","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/0092-8674(94)90292-5","article-title":"Homeodomain-DNA recognition","volume":"78","author":"Gehring","year":"1994","journal-title":"Cell"},{"key":"2025021405141078600_DEVELOP_124_21_4343C22","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/0092-8674(89)90033-0","article-title":"The FLP recombinase of yeast catalyzes site-specific recombination in the Drosophila genome","volume":"59","author":"Golic","year":"1989","journal-title":"Cell"},{"key":"2025021405141078600_DEVELOP_124_21_4343C23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/oso\/9780199633913.003.0001","article-title":"Generating mosaics by site specific recombination","volume-title":"Cellular Interactions in Development. A Practical Approach","author":"Golic","year":"1993"},{"key":"2025021405141078600_DEVELOP_124_21_4343C24","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1093\/genetics\/143.1.385","article-title":"A quantitative measure of the mitotic pairing of alleles in Drosophila melanogaster and the influence of structural heterozygosity","volume":"143","author":"Golic","year":"1996","journal-title":"Genetics"},{"key":"2025021405141078600_DEVELOP_124_21_4343C25","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/25.18.3665","article-title":"FLP-mediated DNA mobilization to specific target sites in Drosophila chromosomes","volume-title":"Nucl. Acids Res","author":"Golic","year":"1997"},{"key":"2025021405141078600_DEVELOP_124_21_4343C26","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1242\/dev.110.4.1319","article-title":"Blocking cell division does not remove the requirement for Polycomb function in Drosophila embryogenesis","volume":"110","author":"Gould","year":"1990","journal-title":"Development"},{"key":"2025021405141078600_DEVELOP_124_21_4343C27","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1101\/gad.4.7.1079","article-title":"Region specific recombination and expression are directed by portions of the Drosophila engrailed promoter","volume":"4","author":"Hama","year":"1990","journal-title":"Genes Dev"},{"key":"2025021405141078600_DEVELOP_124_21_4343C28","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1002\/j.1460-2075.1988.tb02801.x","article-title":"Gap genes define the limits of Antennapedia and Bithorax gene expression during early development in Drosophila","volume":"7","author":"Harding","year":"1988","journal-title":"EMBO J"},{"key":"2025021405141078600_DEVELOP_124_21_4343C29","doi-asserted-by":"publisher","first-page":"3202","DOI":"10.1101\/gad.10.24.3202","article-title":"Fab-7 functions as a chromatin domain boundary to ensure proper segment specification by the Drosophila bithorax complex","volume":"10","author":"Hargstrom","year":"1996","journal-title":"Genes Dev"},{"key":"2025021405141078600_DEVELOP_124_21_4343C30","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1101\/gad.10.8.1021","article-title":"Silencers are required for inheritance of the repressed state in yeast","volume":"10","author":"Holmes","year":"1996","journal-title":"Genes Dev"},{"key":"2025021405141078600_DEVELOP_124_21_4343C31","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1093\/genetics\/126.1.185","article-title":"Genetics analysis of the Enhancer of zeste and its role in gene regulation in Drosophila melanogaster","volume":"126","author":"Jones","year":"1993","journal-title":"Genetics"},{"key":"2025021405141078600_DEVELOP_124_21_4343C32","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/316153a0","article-title":"A group of genes controlling the spatial expression of the bithorax complex in Drosophila","volume":"316","author":"J\u00fcrgens","year":"1985","journal-title":"Nature"},{"key":"2025021405141078600_DEVELOP_124_21_4343C33","doi-asserted-by":"publisher","first-page":"3138","DOI":"10.1093\/nar\/22.15.3138","article-title":"Mcp and Fab-7: molecular analyssis of putative boundaries of cis-regulatory domains in the bithorax complex of Drosophila melanogaster","volume":"22","author":"Karch","year":"1994","journal-title":"Nucl. Acids Res"},{"key":"2025021405141078600_DEVELOP_124_21_4343C34","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/0092-8674(85)90014-5","article-title":"The abdominal region of the Bithorax complex","volume":"43","author":"Karch","year":"1985","journal-title":"Cell"},{"key":"2025021405141078600_DEVELOP_124_21_4343C35","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1016\/0092-8674(89)90341-3","article-title":"Transcriptional activation and repression by Ultrabithorax proteins in cultured Drosophila cells","volume":"57","author":"Krasnow","year":"1989","journal-title":"Cell"},{"key":"2025021405141078600_DEVELOP_124_21_4343C36","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1128\/mr.56.4.543-560.1992","article-title":"Silencers, silencing and heritable transcriptional states","volume":"56","author":"Laurenson","year":"1992","journal-title":"Microbiol. Rev"},{"key":"2025021405141078600_DEVELOP_124_21_4343C37","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/276565a0","article-title":"A gene complex controlling segmentation in Drosophila","volume":"276","author":"Lewis","year":"1978","journal-title":"Nature"},{"key":"2025021405141078600_DEVELOP_124_21_4343C38","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1093\/genetics\/120.1.181","article-title":"Dosage-dependent modifiers of position effect variegation in Drosophila and a mass action model that explains their effect","volume":"120","author":"Locke","year":"1988","journal-title":"Genetics"},{"key":"2025021405141078600_DEVELOP_124_21_4343C39","doi-asserted-by":"publisher","first-page":"2629","DOI":"10.1242\/dev.120.9.2629","article-title":"Molecular characterization of the Polycomblike gene of Drosophila melanogaster, a trans-acting negative regulator of homeotic gene expression","volume":"120","author":"Lonie","year":"1994","journal-title":"Development"},{"key":"2025021405141078600_DEVELOP_124_21_4343C40","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1146\/annurev.cb.11.110195.002511","article-title":"Silencing and heritable domains of gene expression","volume":"11","author":"Loo","year":"1995","journal-title":"Ann. Rev. Cell Biol"},{"key":"2025021405141078600_DEVELOP_124_21_4343C41","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1002\/j.1460-2075.1996.tb00389.x","article-title":"Probes for chromatin accessibility in the Drosophila bithorax complex respond differently to Polycomb mediated repression","volume":"15","author":"McCall","year":"1996","journal-title":"EMBO J"},{"key":"2025021405141078600_DEVELOP_124_21_4343C42","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1002\/dvg.1020150606","article-title":"Spreading the silence: epigenetic transcriptional regulation during Drosophila development","volume":"15","author":"Moehrle","year":"1994","journal-title":"Dev. Genet"},{"key":"2025021405141078600_DEVELOP_124_21_4343C43","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1002\/j.1460-2075.1991.tb07662.x","article-title":"Long range repression conferring boundaries of Ultrabithorax expression in the Drosophila embryo","volume":"10","author":"M\u00fcller","year":"1991","journal-title":"EMBO J"},{"key":"2025021405141078600_DEVELOP_124_21_4343C44","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1101\/gad.4.6.1053","article-title":"Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila","volume":"4","author":"Orenic","year":"1990","journal-title":"Genes Dev"},{"key":"2025021405141078600_DEVELOP_124_21_4343C45","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1016\/0092-8674(93)90328-N","article-title":"Mapping Polycomb-repressed domains in the bithorax complex using in vivo formaldehyde cross-linked chromatin","volume":"75","author":"Orlando","year":"1993","journal-title":"Cell"},{"key":"2025021405141078600_DEVELOP_124_21_4343C46","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/0959-437X(95)80005-0","article-title":"Chromatin multiprotein complexes involved in the maintenance of transcription patterns","volume":"5","author":"Orlando","year":"1995","journal-title":"Curr. Opin. Genet. Dev"},{"key":"2025021405141078600_DEVELOP_124_21_4343C47","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1073\/pnas.88.1.263","article-title":"The Polycomb protein shares a homologous domain with heterochromatin-associated protein in Drosophila","volume":"88","author":"Paro","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025021405141078600_DEVELOP_124_21_4343C48","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/S0959-437X(97)80135-9","article-title":"PcG complexes and chromatin silencing","volume":"7","author":"Pirrotta","year":"1997","journal-title":"Curr. Opin. Genet. Dev"},{"key":"2025021405141078600_DEVELOP_124_21_4343C49","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1002\/bies.950160808","article-title":"white gene expression, repressive chromatin domains and homeotic gene silencing in Drosophila","volume":"16","author":"Pirrotta","year":"1994","journal-title":"BioEssays"},{"key":"2025021405141078600_DEVELOP_124_21_4343C50","doi-asserted-by":"publisher","first-page":"5977","DOI":"10.1002\/j.1460-2075.1994.tb06943.x","article-title":"The Drosophila GAGA transcription factor is associated with specific regions of heterochromatin throughout cell cycle","volume":"13","author":"Raff","year":"1994","journal-title":"EMBO J"},{"key":"2025021405141078600_DEVELOP_124_21_4343C51","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1242\/dev.111.2.437","article-title":"Control of the expression of the bithorax complex genes abdominal-A and Abdominal-B by cis-regulatory regions in Drosophila embryos","volume":"111","author":"S\u00e1nchez-Herrero","year":"1991","journal-title":"Development"},{"key":"2025021405141078600_DEVELOP_124_21_4343C52","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1242\/dev.107.2.321","article-title":"Spatially ordered transcription of regulatory DNA in the bithorax complex of Drosophila","volume":"107","author":"S\u00e1nchez-Herrero","year":"1989","journal-title":"Development"},{"key":"2025021405141078600_DEVELOP_124_21_4343C53","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/313108a0","article-title":"Genetic organization of Drosophila bithorax complex","volume":"313","author":"S\u00e1nchez-Herrero","year":"1985","journal-title":"Nature"},{"key":"2025021405141078600_DEVELOP_124_21_4343C54","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/oso\/9780199635764.003.0009","article-title":"Domains and boundaries","volume-title":"In Chromatin Structure and Gene Expression","author":"Schedl","year":"1995"},{"key":"2025021405141078600_DEVELOP_124_21_4343C55","first-page":"25","article-title":"The structure and function of the homeodomain","volume":"989","author":"Scott","year":"1989","journal-title":"Biochem. Biophys. Acta"},{"key":"2025021405141078600_DEVELOP_124_21_4343C56","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/0955-0674(95)80093-X","article-title":"Locking in stable states of gene expression: transcriptional control during Drosophila development","volume":"7","author":"Simon","year":"1995","journal-title":"Curr. Opin. Cell Biol"},{"key":"2025021405141078600_DEVELOP_124_21_4343C57","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1242\/dev.114.2.493","article-title":"Ten different Polycomb group genes are required for spatial control of the abd-A and Abd-B homeotic products","volume":"114","author":"Simon","year":"1992","journal-title":"Development"},{"key":"2025021405141078600_DEVELOP_124_21_4343C58","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1006\/dbio.1993.1174","article-title":"Elements of the Drosophila Bithorax complex that mediate repression by Polycomb group products","volume":"158","author":"Simon","year":"1993","journal-title":"Dev. Biol"},{"key":"2025021405141078600_DEVELOP_124_21_4343C59","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1093\/genetics\/140.1.231","article-title":"Comparison of germline mosaics of genes in the Polycomb Group of Drosophila melanogaster","volume":"140","author":"Soto","year":"1995","journal-title":"Genetics"},{"key":"2025021405141078600_DEVELOP_124_21_4343C60","first-page":"3259","article-title":"Altered distributions of Ultrabithorax transcripts in extra sex combs mutant embryos of Drosophila","volume-title":"EMBO J","author":"Struhl","year":"1985"},{"key":"2025021405141078600_DEVELOP_124_21_4343C61","doi-asserted-by":"publisher","first-page":"3621","DOI":"10.1093\/emboj\/16.12.3621","article-title":"Co-localization of Polycomb protein and GAGA factor on regulatory elements responsible for the maintenance of homeotic gene expression","volume":"16","author":"Strutt","year":"1997","journal-title":"EMBO J"},{"key":"2025021405141078600_DEVELOP_124_21_4343C62","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/332281a0","article-title":"Regulation of the Drosophila segmentation gene hunchback by two maternal morphogenetic centres","volume":"332","author":"Tautz","year":"1988","journal-title":"Nature"},{"key":"2025021405141078600_DEVELOP_124_21_4343C63","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1016\/0092-8674(89)90340-1","article-title":"Transcriptional activation by the Antennapedia and fushi tarazu proteins in cultured Drosophila cells","volume":"57","author":"Winslow","year":"1989","journal-title":"Cell"},{"key":"2025021405141078600_DEVELOP_124_21_4343C64","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1242\/dev.117.4.1223","article-title":"Analysis of genetic mosaics in developing and adult Drosophila tissues","volume":"117","author":"Xu","year":"1993","journal-title":"Development"},{"key":"2025021405141078600_DEVELOP_124_21_4343C65","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1101\/gad.3.12a.1969","article-title":"The morphogenetic and regulatory functions of the Drosophila Abdominal-B gene are encoded in overlapping RNAs transcribed from separate promoters","volume":"3","author":"Zavortink","year":"1989","journal-title":"Genes Dev"},{"key":"2025021405141078600_DEVELOP_124_21_4343C66","doi-asserted-by":"publisher","first-page":"7511","DOI":"10.1073\/pnas.89.16.7511","article-title":"Segmental determination in Drosophila conferred by hunchback (hb), a repressor of the homeotic gene Ultrabithorax","volume":"89","author":"Zhang","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025021405141078600_DEVELOP_124_21_4343C67","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1242\/dev.113.4.1171","article-title":"Target sequences for hunchback in a control region conferring Ultabithorax expression boundaries","volume":"113","author":"Zhang","year":"1991","journal-title":"Development"},{"key":"2025021405141078600_DEVELOP_124_21_4343C68","doi-asserted-by":"publisher","first-page":"3195","DOI":"10.1101\/gad.10.24.3195","article-title":"The Fab-7 element of the bithorax complex attenuates enhancer-promoter interactions in the Drosophila embryo","volume":"10","author":"Zhou","year":"1996","journal-title":"Genes Dev"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/124\/21\/4343\/3127577\/develop_124_21_4343.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/124\/21\/4343\/3127577\/develop_124_21_4343.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T05:14:28Z","timestamp":1739510068000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/124\/21\/4343\/39565\/A-silencer-is-required-for-maintenance-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,11,1]]},"references-count":68,"journal-issue":{"issue":"21","published-print":{"date-parts":[[1997,11,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.124.21.4343","relation":{},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,11,1]]}}}