{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T15:40:20Z","timestamp":1781538020762,"version":"3.54.5"},"reference-count":24,"publisher":"The Company of Biologists","issue":"3","license":[{"start":{"date-parts":[[1976,12,1]],"date-time":"1976-12-01T00:00:00Z","timestamp":218246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1976,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Waves of chemotactic movement during the early phase of aggregation in Dictyostelium discoideum are of 2 kinds, concentric waves produced by cells that emit cyclic AMP signals spontaneously, and spirals generated by excitations relayed continuously around loops of excitable cells. The period of a spiral wave is the time taken for the excitation to make one complete circuit of the pacemaker loop. We have compared signal emission from the 2 types of source in time-lapse films made at a variety of temperatures. Our results show that spiral waves have a characteristic period length throughout most if not all of the early phase of aggregation, and that the period of concentric waves is generally longer and more variable. Temperature has a pronounced effect on period length and a lesser effect on propagation velocity. We find that each individual wave is propagated at constant velocity over distances of 1\u20132 cm but that the velocity of successive waves declines. This decline probably reflects some cumulative effect of the chemotactic excitations on the excitable properties of the aggregating cells.<\/jats:p>","DOI":"10.1242\/jcs.22.3.645","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T20:44:23Z","timestamp":1619469863000},"page":"645-656","source":"Crossref","is-referenced-by-count":94,"title":["Signal emission and signal propagation during early aggregation in <i>Dictyostelium discoideum<\/i>"],"prefix":"10.1242","volume":"22","author":[{"given":"J. D.","family":"Gross","sequence":"first","affiliation":[{"name":"Imperial Cancer Research Fund, Mill Hill, London, NWI IAD, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Peacey","sequence":"additional","affiliation":[{"name":"Imperial Cancer Research Fund, Mill Hill, London, NWI IAD, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J.","family":"Trevan","sequence":"additional","affiliation":[{"name":"Imperial Cancer Research Fund, Mill Hill, London, NWI IAD, England"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1976,12,1]]},"reference":[{"key":"2023062016154625700_JOCES_22_3_645C1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1099\/00221287-85-2-321","article-title":"Signal propagation during aggregation in the slime mould Dictyostelium discoideum","volume":"85","author":"Alcantara","year":"1974","journal-title":"J. gen. Microbiol"},{"key":"2023062016154625700_JOCES_22_3_645C2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jez.1401060102","article-title":"Evidence for the formation of cell aggregates by chemotaxis in the development of the slime mold Dictyostelium discoideum","volume":"106","author":"Bonner","year":"1947","journal-title":"J. exp. 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Aggregation homogener Zellpopulationen und Zentrenbildung","volume":"3","author":"Gerisch","year":"1961","journal-title":"Devi Biol"},{"key":"2023062016154625700_JOCES_22_3_645C9","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/BF00573870","article-title":"Stadienapezifische Aggregationsmuster bei Dictyostelium discoideum","volume":"156","author":"Gerisch","year":"1965","journal-title":"Wilhelm Roux Arch. EntMech"},{"key":"2023062016154625700_JOCES_22_3_645C10","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1073\/pnas.71.5.2118","article-title":"Cyclic-AMP-controlled oscillations in suspended Dictyostelium cells: their relation to morphogenetic cell interactions","volume":"71","author":"Gerisch","year":"1974","journal-title":"Proc. natn. Acad. Sci. 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