{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:40:21Z","timestamp":1773290421197,"version":"3.50.1"},"reference-count":65,"publisher":"The Company of Biologists","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5,1]]},"abstract":"<jats:p>At early stages of vertebrate ontogeny, blood and endothelial cells develop from a common mesodermal progenitor, the haemangioblast. Upon haematopoietic commitment, the haemangioblast generates blood precursors through populations of endothelial cells with haemogenic properties. Although several transcription factors have been implicated in haemangioblast differentiation, the precise mechanisms governing cell fate decisions towards the generation of haemogenic endothelium precursors remain largely unknown. Under defined conditions, embryonic stem (ES) cells can be differentiated into haemangioblast-like progenitors that faithfully recapitulate early embryonic haematopoiesis. Here, we made use of mouse ES cells as a model system to understand the role of SOX7, a member of a large family of transcription factors involved in a wide range of developmental processes. During haemangioblast differentiation, SOX7 is expressed in haemogenic endothelium cells and is downregulated in nascent blood precursors. Gain-of-function assays revealed that the enforced expression of Sox7 in haemangioblast-derived blast colonies blocks further differentiation and sustains the expression of endothelial markers. Thus, to explore the transcriptional activity of SOX7, we focused on the endothelial-specific adhesion molecule VE-cadherin. Similar to SOX7, VE-cadherin is expressed in haemogenic endothelium and is downregulated during blood cell formation. We show that SOX7 binds and activates the promoter of VE-cadherin, demonstrating that this gene is a novel downstream transcriptional target of SOX7. Altogether, our findings suggest that SOX7 is involved in the transcriptional regulation of genes expressed in the haemogenic endothelium and provide new clues to decipher the molecular pathways that drive early embryonic haematopoiesis.<\/jats:p>","DOI":"10.1242\/dev.071282","type":"journal-article","created":{"date-parts":[[2012,4,3]],"date-time":"2012-04-03T13:33:33Z","timestamp":1333460013000},"page":"1587-1598","source":"Crossref","is-referenced-by-count":71,"title":["SOX7 regulates the expression of VE-cadherin in the haemogenic endothelium at the onset of haematopoietic development"],"prefix":"10.1242","volume":"139","author":[{"given":"Guilherme","family":"Costa","sequence":"first","affiliation":[{"name":"Cancer Research UK Stem Cell Research Group, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK."},{"name":"Graduate Program in Areas of Basic and Applied Biology (GABBA), University of Porto, 4099-002 Porto, Portugal."}]},{"given":"Andrzej","family":"Mazan","sequence":"additional","affiliation":[{"name":"Cancer Research UK Stem Cell Research Group, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK."}]},{"given":"Arnaud","family":"Gandillet","sequence":"additional","affiliation":[{"name":"Cancer Research UK Haematopoietic Stem Cell Group, London Research Institute, 44 Lincoln\u2019s Inn Fields, London WC2A 3LY, UK."}]},{"given":"Stella","family":"Pearson","sequence":"additional","affiliation":[{"name":"Cancer Research UK Stem Cell Research Group, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK."}]},{"given":"Georges","family":"Lacaud","sequence":"additional","affiliation":[{"name":"Stem Cell Biology Group, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK."}]},{"given":"Valerie","family":"Kouskoff","sequence":"additional","affiliation":[{"name":"Cancer Research UK Stem Cell Research Group, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK."}]}],"member":"237","reference":[{"key":"2021042606412200900_R1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature08738","article-title":"Haematopoietic stem cells derive directly from aortic endothelium during development","volume":"464","author":"Bertrand","year":"2010","journal-title":"Nature"},{"key":"2021042606412200900_R2","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1182\/blood-2007-08-105346","article-title":"Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin","volume":"111","author":"Birdsey","year":"2008","journal-title":"Blood"},{"key":"2021042606412200900_R3","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/nature08764","article-title":"In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium","volume":"464","author":"Boisset","year":"2010","journal-title":"Nature"},{"key":"2021042606412200900_R4","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1006\/dbio.2000.9883","article-title":"Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators","volume":"227","author":"Bowles","year":"2000","journal-title":"Dev. 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