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Metabolic limits, minimum energy use for self-maintenance and maximum expansion of aerobic performance define individuals' energy allocation capabilities. We studied the co-expression between metabolic limits in a species representing an ancient marsupial lineage and hypothetical plesiomorphic mammalian physiology. We partitioned covariation between basal (BMR) and maximum (V\u0307O2,max) metabolic rates to between- and within-individual components. Contrary to predictions of the aerobic model for endothermy evolution, we found a near-zero BMR\u2013V\u0307O2,max correlation on the between-individual level, suggesting null genetic co-variance, or its cancellation by an among-individual maintenance-to-capacity trade-off. Instead, a substantial within-individual BMR\u2013V\u0307O2,max correlation revealed plastic co-expression of the traits in the wild animals responding to environmental variation. Within-individual V\u0307O2,max\u2013lean mass correlation reinforces the importance of this bioenergetic plasticity mechanism. We conclude that endothermic strategies can be sustained not only by fixed genetic coupling, but also by flexible, condition-dependent trait integration, hypothetically reflecting a physiological plastic property of the early stages of therian evolution.<\/jats:p>","DOI":"10.1242\/jeb.252062","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T10:10:45Z","timestamp":1771582245000},"source":"Crossref","is-referenced-by-count":1,"title":["Co-regulated plasticity between limits to energy budget in\n                    <i>Dromiciops gliroides<\/i>\n                    : a model for ancestral endothermy"],"prefix":"10.1242","volume":"229","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3714-5392","authenticated-orcid":false,"given":"Isidora","family":"Camus","sequence":"first","affiliation":[{"name":"Instituto de Ciencias Ambientales y Evolutivas, Universidad Austral de Chile 1 , 5090000 Valdivia ,","place":["Chile"]}]},{"given":"Roberto F.","family":"Nespolo","sequence":"additional","affiliation":[{"name":"Instituto de Ciencias Ambientales y Evolutivas, Universidad Austral de Chile 1 , 5090000 Valdivia ,","place":["Chile"]},{"name":"Millennium Institute for Integrative Biology (iBio) 2 , 6513677 Santiago ,","place":["Chile"]},{"name":"Millenium Nucleus of Patagonian Limit of Life (LiLi) 3 , 5090000 Valdivia ,","place":["Chile"]},{"name":"Center of Applied Ecology and Sustainability (CAPES) 4 , 6513677 Santiago ,","place":["Chile"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4668-4922","authenticated-orcid":false,"given":"Zbyszek","family":"Boraty\u0144ski","sequence":"additional","affiliation":[{"name":"Association BIOPOLIS, Research Centre in Biodiversity and Genetic Resources (CIBIO), University of Porto 5 , 4485-661 Vaira\u0303o ,","place":["Portugal"]}]}],"member":"237","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"2026031304014815500_JEB252062C1","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s00442-023-05452-4","article-title":"Modeling heterothermic fitness landscapes in a marsupial hibernator using changes in body composition","volume":"203","author":"Abarz\u00faa","year":"2023","journal-title":"Oecologia"},{"key":"2026031304014815500_JEB252062C2","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1111\/1365-2435.12879","article-title":"Resting vs. active: a meta-analysis of the intra- and inter-specific associations between minimum, sustained, and maximum metabolic rates in vertebrates","volume":"31","author":"Auer","year":"2017","journal-title":"Funct. 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