{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T15:02:06Z","timestamp":1785682926782,"version":"3.56.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2009,6,23]],"date-time":"2009-06-23T00:00:00Z","timestamp":1245715200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Surg Oncol"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1245\/s10434-009-0568-4","type":"journal-article","created":{"date-parts":[[2009,6,22]],"date-time":"2009-06-22T09:00:46Z","timestamp":1245661246000},"page":"2555-2564","source":"Crossref","is-referenced-by-count":96,"title":["Hepatic Stellate Cells May Relate to Progression of Intrahepatic Cholangiocarcinoma"],"prefix":"10.1245","volume":"16","author":[{"given":"Hirohisa","family":"Okabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Beppu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromitsu","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Horino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiro","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Komori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Takamori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-ichi","family":"Iyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Baba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,6,23]]},"reference":[{"key":"568_CR1","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1097\/01.sla.0000251366.62632.d3","volume":"245","author":"ML DeOliveira","year":"2007","unstructured":"DeOliveira ML, Cunningham SC, Cameron JL, Kamangar F, Winter JM, Lillemoe KD, et al. Cholangiocarcinoma: 31-year experience with 564 patients at a single institution. Ann Surg. 2007;245:755\u201362.","journal-title":"Ann Surg"},{"key":"568_CR2","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1053\/jhep.2003.50200","volume":"37","author":"GJ Gores","year":"2003","unstructured":"Gores GJ. Cholangiocarcinoma: current concepts and insights. Hepatology. 2003;37:961\u20139.","journal-title":"Hepatology"},{"key":"568_CR3","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1053\/jhep.2001.25087","volume":"33","author":"T Patel","year":"2001","unstructured":"Patel T. Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States. Hepatology. 2001;33:1353\u20137.","journal-title":"Hepatology."},{"key":"568_CR4","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/S0168-8278(96)80267-4","volume":"24","author":"T Terada","year":"1996","unstructured":"Terada T, Makimoto K, Terayama N, et al. Alpha-smooth muscle actin-positive stromal cells in cholangiocarcinomas, hepatocellular carcinomas and metastatic liver carcinomas. J Hepatol. 1996;24:706\u201312.","journal-title":"J Hepatol"},{"key":"568_CR5","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nrc1877","volume":"6","author":"R Kalluri","year":"2006","unstructured":"Kalluri R, Zeisberg M. Fibroblasts in cancer. Nat Rev Cancer. 2006;6:392\u2013401.","journal-title":"Nat Rev Cancer"},{"key":"568_CR6","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/35077241","volume":"411","author":"LA Liotta","year":"2001","unstructured":"Liotta LA, Kohn EC. The microenvironment of the tumour\u2013host interface. Nature. 2001;411:375\u20139.","journal-title":"Nature"},{"key":"568_CR7","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/BF00690602","volume":"14","author":"M Gregoire","year":"1995","unstructured":"Gregoire M, Lieubeau B. The role of fibroblasts in tumor behavior. Cancer Metastasis Rev. 1995;14:339\u201350.","journal-title":"Cancer Metastasis Rev"},{"key":"568_CR8","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/nature03096","volume":"432","author":"NA Bhowmick","year":"2004","unstructured":"Bhowmick NA, Neilson EG, Moses HL. Stromal fibroblasts in cancer initiation and progression. Nature. 2004;432:332\u20137.","journal-title":"Nature"},{"key":"568_CR9","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","volume":"115","author":"R Bataller","year":"2005","unstructured":"Bataller R, Brenner DA. Liver fibrosis. J Clin Invest. 2005;115:209\u201318.","journal-title":"J Clin Invest"},{"key":"568_CR10","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1056\/NEJM199304223281620","volume":"328","author":"SL Friedman","year":"1993","unstructured":"Friedman SL. Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. N Engl J Med. 1993;328:1828\u201335.","journal-title":"N Engl J Med"},{"key":"568_CR11","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1582-4934.2006.tb00292.x","volume":"10","author":"AM Gressner","year":"2006","unstructured":"Gressner AM, Weiskirchen R. Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets. J Cell Mol Med. 2006;10:76\u201399.","journal-title":"J Cell Mol Med."},{"key":"568_CR12","first-page":"135","volume":"38","author":"C Guyot","year":"2006","unstructured":"Guyot C, Lepreux S, Combe C, et al. Hepatic fibrosis and cirrhosis: the (myo)fibroblastic cell subpopulations involved. Int J Biochem Cell Biol. 2006;38:135\u201351.","journal-title":"Int J Biochem Cell Biol"},{"key":"568_CR13","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1042\/CS20060242","volume":"112","author":"NC Henderson","year":"2007","unstructured":"Henderson NC, Iredale JP. Liver fibrosis: cellular mechanisms of progression and resolution. Clin Sci (Lond). 2007;112:265\u201380.","journal-title":"Clin Sci (Lond)"},{"key":"568_CR14","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1053\/j.gastro.2006.01.036","volume":"130","author":"FP Russo","year":"2006","unstructured":"Russo FP, Alison MR, Bigger BW, et al. The bone marrow functionally contributes to liver fibrosis. Gastroenterology. 2006;130:1807\u201321.","journal-title":"Gastroenterology"},{"key":"568_CR15","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/ncpgasthep0881","volume":"4","author":"H Algul","year":"2007","unstructured":"Algul H, Treiber M, Lesina M, Schmid RM. Mechanisms of disease: chronic inflammation and cancer in the pancreas\u2014a potential role for pancreatic stellate cells? Nat Clin Pract Gastroenterol Hepatol. 2007;4:454\u201362.","journal-title":"Nat Clin Pract Gastroenterol Hepatol."},{"key":"568_CR16","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1097\/00006676-200410000-00002","volume":"29","author":"MV Apte","year":"2004","unstructured":"Apte MV, Park S, Phillips PA, et al. Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cells. Pancreas. 2004;29:179\u201387.","journal-title":"Pancreas."},{"key":"568_CR17","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1053\/j.gastro.2004.12.036","volume":"128","author":"MG Bachem","year":"2005","unstructured":"Bachem MG, Schunemann M, Ramadani M, et al. Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells. Gastroenterology. 2005;128:907\u201321.","journal-title":"Gastroenterology"},{"key":"568_CR18","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1158\/0008-5472.CAN-07-5714","volume":"68","author":"RF Hwang","year":"2008","unstructured":"Hwang RF, Moore T, Arumugam T, et al. Cancer-associated stromal fibroblasts promote pancreatic tumor progression. Cancer Res. 2008;68:918\u201326.","journal-title":"Cancer Res"},{"key":"568_CR19","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1172\/JCI30082","volume":"117","author":"MB Omary","year":"2007","unstructured":"Omary MB, Lugea A, Lowe AW, Pandol SJ. The pancreatic stellate cell: a star on the rise in pancreatic diseases. J Clin Invest. 2007;117:50\u20139.","journal-title":"J Clin Invest"},{"key":"568_CR20","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/physrev.00013.2007","volume":"88","author":"SL Friedman","year":"2008","unstructured":"Friedman SL. Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev. 2008;88:125\u201372.","journal-title":"Physiol Rev"},{"key":"568_CR21","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0168-8278(99)80074-9","volume":"30","author":"S Faouzi","year":"1999","unstructured":"Faouzi S, Le Bail B, Neaud V, et al. Myofibroblasts are responsible for collagen synthesis in the stroma of human hepatocellular carcinoma: an in vivo and in vitro study. J Hepatol. 1999;30:275\u201384.","journal-title":"J Hepatol"},{"key":"568_CR22","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1053\/jhep.2001.25758","volume":"34","author":"N Theret","year":"2001","unstructured":"Theret N, Musso O, Turlin B, et al. Increased extracellular matrix remodeling is associated with tumor progression in human hepatocellular carcinomas. Hepatology. 2001;34:82\u20138.","journal-title":"Hepatology."},{"key":"568_CR23","first-page":"1233","volume":"138","author":"A Schmitt-Graff","year":"1991","unstructured":"Schmitt-Graff A, Kruger S, Bochard F, et al. Modulation of alpha smooth muscle actin and desmin expression in perisinusoidal cells of normal and diseased human livers. Am J Pathol. 1991;138:1233\u201342.","journal-title":"Am J Pathol"},{"key":"568_CR24","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0168-8278(01)00260-4","volume":"36","author":"D Cassiman","year":"2002","unstructured":"Cassiman D, Libbrecht L, Desmet V, et al. Hepatic stellate cell\/myofibroblast subpopulations in fibrotic human and rat livers. J Hepatol. 2002;36:200\u20139.","journal-title":"J Hepatol"},{"key":"568_CR25","volume-title":"TMN classification of malignant tumours","author":"LH Sobin","year":"2002","unstructured":"Sobin LH, Wittekind CH. TMN classification of malignant tumours. 6th ed. New York: JWS; 2002.","edition":"6"},{"key":"568_CR26","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0928-4346(96)00325-8","volume":"6","author":"IchidaF TT","year":"1996","unstructured":"Ichida F TT, Omata M, et al. New Inuyama Classification; new criteria for histological assessment of chronic hepatitis. Int Hepatol Commun. 1996;6:112\u201319.","journal-title":"Int Hepatol Commun."},{"key":"568_CR27","first-page":"731","volume":"72","author":"K Murakami","year":"1995","unstructured":"Murakami K, Abe T, Miyazawa M, et al. Establishment of a new human cell line, LI90, exhibiting characteristics of hepatic Ito (fat-storing) cells. Lab Invest. 1995;72:731\u20139.","journal-title":"Lab Invest"},{"key":"568_CR28","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1136\/gut.2004.042127","volume":"54","author":"L Xu","year":"2005","unstructured":"Xu L, Hui AY, Albanis E, et al. Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis. Gut. 2005;54:142\u201351.","journal-title":"Gut."},{"key":"568_CR29","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nbt1396","volume":"26","author":"Y Sato","year":"2008","unstructured":"Sato Y, Murase K, Kato J, et al. Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone. Nat Biotechnol. 2008;26:431\u201342.","journal-title":"Nat Biotechnol"},{"issue":"7","key":"568_CR30","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1158\/1078-0432.CCR-06-2191","volume":"13","author":"T Tsujino","year":"2007","unstructured":"Tsujino T, Seshimo I, Yamamoto H, et al. Stromal myofibroblasts predict disease recurrence for colorectal cancer. Clin Cancer Res. 2007;13(7):2082\u201390.","journal-title":"Clin Cancer Res"},{"key":"568_CR31","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1073\/pnas.87.1.75","volume":"87","author":"JL Camps","year":"1990","unstructured":"Camps JL, Chang SM, Hsu TC, et al. Fibroblast-mediated acceleration of human epithelial tumor growth in vivo. Proc Natl Acad Sci USA. 1990;87:75\u20139.","journal-title":"Proc Natl Acad Sci USA."},{"key":"568_CR32","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nrc1477","volume":"4","author":"MM Mueller","year":"2004","unstructured":"Mueller MM, Fusenig NE. Friends or foes\u2014bipolar effects of the tumour stroma in cancer. Nat Rev Cancer. 2004;4:839\u201349.","journal-title":"Nat Rev Cancer"},{"key":"568_CR33","first-page":"5002","volume":"59","author":"AF Olumi","year":"1999","unstructured":"Olumi AF, Grossfeld GD, Hayward SW, et al. Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res. 1999;59:5002\u201311.","journal-title":"Cancer Res"},{"key":"568_CR34","first-page":"2917","volume":"27","author":"P Surowiak","year":"2007","unstructured":"Surowiak P, Murawa D, Materna V, et al. Occurrence of stromal myofibroblasts in the invasive ductal breast cancer tissue is an unfavourable prognostic factor. Anticancer Res. 2007;27:2917\u201324.","journal-title":"Anticancer Res"},{"key":"568_CR35","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1111\/j.1440-1746.2007.05040.x","volume":"23","author":"KY Paik","year":"2008","unstructured":"Paik KY, Jung JC, Heo JS, et al. What prognostic factors are important for resected intrahepatic cholangiocarcinoma? J Gastroenterol Hepatol. 2008;23:766\u201370.","journal-title":"J Gastroenterol Hepatol"},{"key":"568_CR36","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1002\/lt.21436","volume":"14","author":"S Carotti","year":"2008","unstructured":"Carotti S, Morini S, Corradini SG, et al. Glial fibrillary acidic protein as an early marker of hepatic stellate cell activation in chronic and posttransplant recurrent hepatitis C. Liver Transpl. 2008;14:806\u201314.","journal-title":"Liver Transpl."},{"key":"568_CR37","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF01324802","volume":"430","author":"ML Hautekeete","year":"1997","unstructured":"Hautekeete ML, Geerts A. The hepatic stellate (Ito) cell: its role in human liver disease. Virchows Arch. 1997;430:195\u2013207.","journal-title":"Virchows Arch"},{"key":"568_CR38","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/labinvest.3700537","volume":"87","author":"A Omenetti","year":"2007","unstructured":"Omenetti A, Yang L, Li YX, et al. Hedgehog-mediated mesenchymal-epithelial interactions modulate hepatic response to bile duct ligation. Lab Invest. 2007;87:499\u2013514.","journal-title":"Lab Invest"},{"key":"568_CR39","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1002\/ijc.23925","volume":"123","author":"O Wever De","year":"2008","unstructured":"De Wever O, Demetter P, Mareel M, Bracke M. Stromal myofibroblasts are drivers of invasive cancer growth. Int J Cancer. 2008;123:2229\u201338.","journal-title":"Int J Cancer"},{"key":"568_CR40","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/ijc.21808","volume":"119","author":"K Matsumoto","year":"2006","unstructured":"Matsumoto K, Nakamura T. Hepatocyte growth factor and the Met system as a mediator of tumor-stromal interactions. Int J Cancer. 2006;119:477\u201383.","journal-title":"Int J Cancer"},{"key":"568_CR41","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.ccr.2005.05.019","volume":"7","author":"LE Littlepage","year":"2005","unstructured":"Littlepage LE, Egeblad M, Werb Z. Coevolution of cancer and stromal cellular responses. Cancer Cell. 2005;7:499\u2013500.","journal-title":"Cancer Cell."},{"key":"568_CR42","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.cell.2005.02.034","volume":"121","author":"A Orimo","year":"2005","unstructured":"Orimo A, Gupta PB, Sgroi DC, et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1\/CXCL12 secretion. Cell. 2005;121:335\u201348.","journal-title":"Cell"}],"container-title":["Annals of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-009-0568-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1245\/s10434-009-0568-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-009-0568-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T16:33:59Z","timestamp":1572971639000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1245\/s10434-009-0568-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,23]]},"references-count":42,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["568"],"URL":"https:\/\/doi.org\/10.1245\/s10434-009-0568-4","relation":{},"ISSN":["1068-9265","1534-4681"],"issn-type":[{"value":"1068-9265","type":"print"},{"value":"1534-4681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6,23]]}}}