{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T03:53:59Z","timestamp":1768622039523,"version":"3.49.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,9,18]],"date-time":"2013-09-18T00:00:00Z","timestamp":1379462400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Surg Oncol"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1245\/s10434-013-3264-3","type":"journal-article","created":{"date-parts":[[2013,9,17]],"date-time":"2013-09-17T16:23:12Z","timestamp":1379434992000},"page":"205-212","source":"Crossref","is-referenced-by-count":71,"title":["Up-regulation of NEK2 by MicroRNA-128 Methylation is Associated with Poor Prognosis in Colorectal Cancer"],"prefix":"10.1245","volume":"21","author":[{"given":"Yusuke","family":"Takahashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Iwaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genta","family":"Sawada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junji","family":"Kurashige","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae","family":"Matsumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryutaro","family":"Uchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Ueo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Takano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetoshi","family":"Eguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoya","family":"Sudo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keishi","family":"Sugimachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichiro","family":"Doki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koshi","family":"Mimori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,9,18]]},"reference":[{"key":"3264_CR1","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1093\/emboj\/17.2.470","volume":"17","author":"AM Fry","year":"1998","unstructured":"Fry AM, Meraldi P, Nigg EA. A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators. EMBO J. 1998;17:470\u201381.","journal-title":"EMBO J."},{"key":"3264_CR2","doi-asserted-by":"crossref","first-page":"6184","DOI":"10.1038\/sj.onc.1205711","volume":"21","author":"AM Fry","year":"2002","unstructured":"Fry AM. The Nek2 protein kinase: a novel regulator of centrosome structure. Oncogene. 2002;21:6184\u201394.","journal-title":"Oncogene."},{"key":"3264_CR3","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1667\/RR3211","volume":"162","author":"L Fletcher","year":"2004","unstructured":"Fletcher L, Cerniglia GJ, Nigg EA, Yend TJ, Muschel RJ. Inhibition of centrosome separation after DNA damage: a role for Nek2. Radiat Res. 2004;162:128\u201335.","journal-title":"Radiat Res."},{"key":"3264_CR4","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/ncb2120","volume":"12","author":"BR Mardin","year":"2010","unstructured":"Mardin BR, Lange C, Baxter JE, et al. Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction. Nat Cell Biol. 2010;12:1166\u201376.","journal-title":"Nat Cell Biol."},{"key":"3264_CR5","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/01.LAB.0000053913.85892.E9","volume":"83","author":"S Vos de","year":"2003","unstructured":"de Vos S, Hofmann WK, Grogan TM, et al. Gene expression profile of serial samples of transformed B-cell lymphomas. Lab Investig. 2003;83:271\u201385.","journal-title":"Lab Investig."},{"key":"3264_CR6","doi-asserted-by":"crossref","first-page":"7370","DOI":"10.1158\/0008-5472.CAN-04-0960","volume":"64","author":"DG Hayward","year":"2004","unstructured":"Hayward DG, Clarke RB, Faragher AJ, Pillai MR, Hagan IM, Fry AM. The centrosomal kinase Nek2 displays elevated levels of protein expression in human breast cancer. Cancer Res. 2004;64:7370\u20136.","journal-title":"Cancer Res."},{"key":"3264_CR7","doi-asserted-by":"crossref","first-page":"8393","DOI":"10.1158\/0008-5472.CAN-08-1915","volume":"68","author":"G Wu","year":"2008","unstructured":"Wu G, Qiu XL, Zhou L, et al. Small molecule targeting the Hec1\/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal. Cancer Res. 2008;68:8393\u20139.","journal-title":"Cancer Res."},{"key":"3264_CR8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1349-7006.2008.01007.x","volume":"100","author":"N Tsunoda","year":"2009","unstructured":"Tsunoda N, Kokuryo T, Oda K, et al. Nek2 as a novel molecular target for the treatment of breast carcinoma. Cancer Sci. 2009;100:111\u20136.","journal-title":"Cancer Sci."},{"key":"3264_CR9","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/j.1365-2559.2011.03941.x","volume":"59","author":"S Wang","year":"2011","unstructured":"Wang S, Li W, Lv S, et al. Abnormal expression of Nek2 and beta-catenin in breast carcinoma: clinicopathological correlations. Histopathology. 2011;59:631\u201342.","journal-title":"Histopathology."},{"key":"3264_CR10","doi-asserted-by":"crossref","first-page":"9637","DOI":"10.1158\/0008-5472.CAN-07-1489","volume":"67","author":"T Kokuryo","year":"2007","unstructured":"Kokuryo T, Senga T, Yokoyama Y, Nagino M, Nimura Y, Hamaguchi M. Nek2 as an effective target for inhibition of tumorigenic growth and peritoneal dissemination of cholangiocarcinoma. Cancer Res. 2007;67:9637\u201342.","journal-title":"Cancer Res."},{"key":"3264_CR11","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1111\/j.1349-7006.2010.01504.x","volume":"101","author":"K Suzuki","year":"2010","unstructured":"Suzuki K, Kokuryo T, Senga T, Yokoyama Y, Nagino M, Hamaguchi M. Novel combination treatment for colorectal cancer using Nek2 siRNA and cisplatin. Cancer Sci. 2010;101:1163\u20139.","journal-title":"Cancer Sci."},{"key":"3264_CR12","doi-asserted-by":"crossref","first-page":"9125","DOI":"10.1158\/0008-5472.CAN-08-2629","volume":"68","author":"J Godlewski","year":"2008","unstructured":"Godlewski J, Nowicki MO, Bronisz A, et al. Targeting of the Bmi-1 oncogene\/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal. Cancer Res. 2008;68:9125\u201330.","journal-title":"Cancer Res."},{"key":"3264_CR13","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1038\/onc.2011.380","volume":"31","author":"T Papagiannakopoulos","year":"2012","unstructured":"Papagiannakopoulos T, Friedmann-Morvinski D, Neveu P, et al. Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases. Oncogene. 2012;31:1884\u201395.","journal-title":"Oncogene."},{"key":"3264_CR14","doi-asserted-by":"crossref","first-page":"e32709","DOI":"10.1371\/journal.pone.0032709","volume":"7","author":"ZM Shi","year":"2012","unstructured":"Shi ZM, Wang J, Yan Z, et al. MiR-128 inhibits tumor growth and angiogenesis by targeting p70S6K1. PLoS ONE. 2012;7:e32709.","journal-title":"PLoS One."},{"key":"3264_CR15","doi-asserted-by":"crossref","first-page":"4276","DOI":"10.1096\/fj.09-134965","volume":"23","author":"C Evangelisti","year":"2009","unstructured":"Evangelisti C, Florian MC, Massimi I, et al. MiR-128 up-regulation inhibits Reelin and DCX expression and reduces neuroblastoma cell motility and invasiveness. FASEB J. 2009;23:4276\u201387.","journal-title":"FASEB J."},{"key":"3264_CR16","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/ijc.22605","volume":"121","author":"K Ieta","year":"2007","unstructured":"Ieta K, Ojima E, Tanaka F, et al. Identification of overexpressed genes in hepatocellular carcinoma, with special reference to ubiquitin-conjugating enzyme E2C gene expression. J Int Cancer. 2007;121:33\u20138.","journal-title":"J Int Cancer."},{"key":"3264_CR17","doi-asserted-by":"crossref","first-page":"W170","DOI":"10.1093\/nar\/gkn294","volume":"36","author":"Y Kumaki","year":"2008","unstructured":"Kumaki Y, Oda M, Okano M. QUMA: quantification tool for methylation analysis. Nucleic Acids Res. 2008;36:W170\u20135.","journal-title":"Nucleic Acids Res."},{"key":"3264_CR18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","volume":"120","author":"BP Lewis","year":"2005","unstructured":"Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 2005;120:15\u201320.","journal-title":"Cell."},{"key":"3264_CR19","doi-asserted-by":"crossref","first-page":"6450","DOI":"10.1158\/0008-5472.CAN-11-0364","volume":"71","author":"T Tsuruta","year":"2011","unstructured":"Tsuruta T, Kozaki K, Uesugi A, et al. miR-152 is a tumor suppressor microRNA that is silenced by DNA hypermethylation in endometrial cancer. Cancer Res. 2011;71:6450\u201362.","journal-title":"Cancer Res."},{"issue":"5853","key":"3264_CR20","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1126\/science.1145720","volume":"318","author":"LD Wood","year":"2007","unstructured":"Wood LD, Parsons DW, Jones S, et al. The genomic landscapes of human breast and colorectal cancers. Science. 2007;318(5853):1108\u201313.","journal-title":"Science."},{"key":"3264_CR21","doi-asserted-by":"crossref","unstructured":"Cancer Genome Atlas N. Comprehensive molecular characterization of human colon and rectal cancer. Nature. 2012;487(7407):330\u20137.","DOI":"10.1038\/nature11252"},{"key":"3264_CR22","doi-asserted-by":"crossref","first-page":"7105","DOI":"10.1158\/1078-0432.CCR-11-0071","volume":"17","author":"Y Zhu","year":"2011","unstructured":"Zhu Y, Yu F, Jiao Y, et al. Reduced miR-128 in breast tumor-initiating cells induces chemotherapeutic resistance via Bmi-1 and ABCC5. Clin Cancer Res. 2011;17:7105\u201315.","journal-title":"Clin Cancer Res."}],"container-title":["Annals of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-013-3264-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1245\/s10434-013-3264-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-013-3264-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T11:23:07Z","timestamp":1559647387000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1245\/s10434-013-3264-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,18]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["3264"],"URL":"https:\/\/doi.org\/10.1245\/s10434-013-3264-3","relation":{},"ISSN":["1068-9265","1534-4681"],"issn-type":[{"value":"1068-9265","type":"print"},{"value":"1534-4681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,18]]}}}