{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T01:10:25Z","timestamp":1775265025186,"version":"3.50.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T00:00:00Z","timestamp":1446508800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Istituto Toscano Tumori (ITT)","award":["Grant No. ITT-2007)"],"award-info":[{"award-number":["Grant No. ITT-2007)"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Surg Oncol"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1245\/s10434-015-4931-3","type":"journal-article","created":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T19:49:54Z","timestamp":1446580194000},"page":"943-950","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":113,"title":["Strong Prognostic Value of Microsatellite Instability in Intestinal Type Non-cardia Gastric Cancer"],"prefix":"10.1245","volume":"23","author":[{"given":"Daniele","family":"Marrelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karol","family":"Polom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Pascale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Vindigni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Piagnerelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"De Franco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Ferrara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giandomenico","family":"Roviello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Garosi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Petrioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Roviello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,11,3]]},"reference":[{"key":"4931_CR1","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","volume":"136","author":"J Ferlay","year":"2015","unstructured":"Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136:E359\u201386.","journal-title":"Int J Cancer"},{"key":"4931_CR2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/apm.1965.64.1.31","volume":"64","author":"P Lauren","year":"1965","unstructured":"Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand. 1965;64:31\u201349.","journal-title":"Acta Pathol Microbiol Scand"},{"key":"4931_CR3","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1007\/s00268-002-6344-2","volume":"26","author":"D Marrelli","year":"2002","unstructured":"Marrelli D, Roviello F, de Manzoni G, et al. Different patterns of recurrence in gastric cancer depending on Lauren\u2019s histological type: longitudinal study. World J Surg. 2002;26:1160\u20135.","journal-title":"World J Surg"},{"key":"4931_CR4","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/nature13480","volume":"513","author":"AJ Bass","year":"2014","unstructured":"Bass AJ, Thorsson V, Shmulevich I, et al. Comprehensive molecular characterization of gastric adenocarcinoma. Nature. 2014;513:202\u20139.","journal-title":"Nature"},{"key":"4931_CR5","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s11864-015-0331-y","volume":"16","author":"Y Sunakawa","year":"2015","unstructured":"Sunakawa Y, Lenz HJ. Molecular classification of gastric adenocarcinoma: translating new insights from the cancer genome atlas research network. Curr Treat Opt Oncol. 2015;16:331.","journal-title":"Curr Treat Options Oncol"},{"key":"4931_CR6","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.3748\/wjg.v18.i22.2745","volume":"18","author":"H Yamamoto","year":"2012","unstructured":"Yamamoto H, Adachi Y, Taniguchi H, Kunimoto H, Nosho K, Suzuki H, Shinomura Y. Interrelationship between microsatellite instability and microRNA in gastrointestinal cancer. World J Gastroenterol. 2012;18:2745\u201355.","journal-title":"World J Gastroenterol"},{"key":"4931_CR7","doi-asserted-by":"crossref","first-page":"272","DOI":"10.3389\/fonc.2013.00272","volume":"3","author":"K Heinimann","year":"2013","unstructured":"Heinimann K. Toward a molecular classification of colorectal cancer: the role of microsatellite instability status. Front Oncol. 2013;3:272.","journal-title":"Front Oncol"},{"key":"4931_CR8","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/modpathol.3880578","volume":"15","author":"HS Lee","year":"2002","unstructured":"Lee HS, Choi SI, Lee HK, Kim HS, Yang HK, Kang GH et al. Distinct clinical features and outcomes of gastric cancers with microsatellite instability. Mod Pathol. 2002;15:632\u201340.","journal-title":"Mod Pathol"},{"key":"4931_CR9","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.surg.2005.08.021","volume":"139","author":"S Beghelli","year":"2006","unstructured":"Beghelli S, de Manzoni G, Barbi S, et al. Microsatellite instability in gastric cancer is associated with better prognosis in only stage II cancers. Surgery. 2006;139:347\u201356.","journal-title":"Surgery"},{"key":"4931_CR10","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1001\/archsurg.2009.42","volume":"144","author":"G Corso","year":"2009","unstructured":"Corso G, Pedrazzani C, Marrelli D, Pascale V, Pinto E, Roviello F. Correlation of microsatellite instability at multiple loci with long\u2010term survival in advanced gastric carcinoma. Arch Surg. 2009;144:722\u20137.","journal-title":"Arch Surg"},{"key":"4931_CR11","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/jso.23618","volume":"110","author":"YY Choi","year":"2014","unstructured":"Choi YY, Bae JM, An JY, et al. Is microsatellite instability a prognostic marker in gastric cancer? A systematic review with meta-analysis. J Surg Oncol. 2014;110:129\u201335.","journal-title":"J Surg Oncol"},{"key":"4931_CR12","unstructured":"Edge SB, Byrd DR, Compton CC, eds. AJCC cancer staging manual, 7th edn. New York: Springer; 2010. p. 103\u201315."},{"key":"4931_CR13","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1097\/SLA.0b013e3182389b1a","volume":"255","author":"D Marrelli","year":"2012","unstructured":"Marrelli D, Morgagni P, de Manzoni G, et al. Prognostic value of the 7th AJCC\/UICC TNM classification of noncardia gastric cancer: analysis of a large series from specialized Western centers. Ann Surg. 2012;255:486\u201391.","journal-title":"Ann Surg"},{"key":"4931_CR14","unstructured":"Boland CR, Thibodeau SN, Hamilton SR, et al. A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res. 1998;58:5248\u201357."},{"key":"4931_CR15","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1053\/gast.1996.v110.pm8536886","volume":"110","author":"NR Santos dos","year":"1996","unstructured":"dos Santos NR, Seruca R, Constancia M, Seixas M, Sobrinho-Simoes M. Microsatellite instability at multiple loci in gastric carcinoma: clinicopathologic implications and prognosis. Gastroenterology. 1996;110:38\u201344.","journal-title":"Gastroenterology"},{"key":"4931_CR16","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jamcollsurg.2015.03.042","volume":"221","author":"D Marrelli","year":"2015","unstructured":"Marrelli D, Morgagni P, de Manzoni G, et al. Italian Research Group for Gastric Cancer. External validation of a score predictive of recurrence after radical surgery for non-cardia gastric cancer: results of a follow-up study. J Am Coll Surg. 2015;221:280\u201390.","journal-title":"J Am Coll Surg"},{"key":"4931_CR17","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1245\/s10434-009-0580-8","volume":"16","author":"E Oki","year":"2009","unstructured":"Oki E, Kakeji Y, Zhao Y, et al. Chemosensitivity and survival in gastric cancer patients with microsatellite instability. Ann Surg Oncol. 2009;16:2510\u201315.","journal-title":"Ann Surg Oncol"},{"key":"4931_CR18","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/jso.21220","volume":"99","author":"HM Seo","year":"2009","unstructured":"Seo HM, Chang YS, Joo SH, Kim YW, Park YK, Hong SW. Clinicopathologic characteristics and outcomes of gastric cancers with the MSI-H phenotype. J Surg Oncol. 2009;99:143\u20137.","journal-title":"J Surg Oncol"},{"key":"4931_CR19","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s10120-004-0300-9","volume":"7","author":"M Wu","year":"2004","unstructured":"Wu M, Semba S, Oue N, Ikehara N, Yasui W, Yokozaki H. BRAF\/K-ras mutation, microsatellite instability, and promoter hypermethylation of hMLH1\/MGMT in human gastric carcinomas. Gastric Cancer 2004;7:246\u201353.","journal-title":"Gastric Cancer"},{"key":"4931_CR20","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s10120-005-0346-3","volume":"8","author":"M Vauhkonen","year":"2005","unstructured":"Vauhkonen M, Vauhkonen H, Sajantila A, Sipponen P. Differences in genomic instability between intestinal- and diffuse-type gastric cancer. Gastric Cancer. 2005;8:238\u201344.","journal-title":"Gastric Cancer"},{"key":"4931_CR21","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.ejso.2010.03.008","volume":"36","author":"F Roviello","year":"2010","unstructured":"Roviello F, Pedrazzani C, Marrelli D, et al. Super-extended (D3) lymphadenectomy in advanced gastric cancer. Eur J Surg Oncol. 2010; 36:439-46.","journal-title":"Eur J Surg Oncol"},{"key":"4931_CR22","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s10120-012-0226-6","volume":"16","author":"T Arai","year":"2013","unstructured":"Arai T, Sakurai U, Sawabe M, et al. Frequent microsatellite instability in papillary and solid-type, poorly differentiated adenocarcinomas of the stomach. Gastric Cancer. 2013;16:505\u201312.","journal-title":"Gastric Cancer"},{"key":"4931_CR23","doi-asserted-by":"crossref","first-page":"7954","DOI":"10.3748\/wjg.v21.i26.7954","volume":"21","author":"D Marrelli","year":"2015","unstructured":"Marrelli D, Po\u0142om K, de Manzoni G, Morgagni P, Baiocchi GL, Roviello F. Multimodal treatment of non-cardia gastric cancer in West: where are we going? World J Gastroenterol. 2015;21:7954\u201369.","journal-title":"World J Gastroenterol"},{"key":"4931_CR24","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1002\/bjs.7528","volume":"98","author":"D Marrelli","year":"2011","unstructured":"Marrelli D, Pedrazzani C, Morgagni P, et al. Changing clinical and pathological features of gastric cancer over time. Br J Surg. 2011;98:1273\u201383.","journal-title":"Br J Surg"},{"key":"4931_CR25","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1158\/1055-9965.EPI-09-0250","volume":"18","author":"H Wu","year":"2009","unstructured":"Wu H, Rusiecki JA, Zhu K, Potter J, Devesa SS. Stomach carcinoma incidence patterns in the United States by histologic type and anatomic site. Cancer Epidemiol Biomarkers Prev. 2009;18:1945\u201352.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"4931_CR26","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s10434-999-0739-3","volume":"6","author":"F Roviello","year":"1999","unstructured":"Roviello F, Marrelli D, Vindigni C, De Stefano A, Spina D, Pinto E. P53 accumulation is a prognostic factor in intestinal-type gastric carcinoma but not in the diffuse type. Ann Surg Oncol. 1999;6:739\u201345.","journal-title":"Ann Surg Oncol"},{"key":"4931_CR27","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.clinre.2014.03.017","volume":"38","author":"M Yang","year":"2014","unstructured":"Yang M, Kim HS, Cho MY. Different methylation profiles between intestinal and diffuse sporadic gastric carcinogenesis. Clin Res Hepatol Gastroenterol 2014;38:613\u201320.","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"4931_CR28","doi-asserted-by":"crossref","first-page":"5029","DOI":"10.1007\/s13277-014-1664-z","volume":"35","author":"L Lou","year":"2014","unstructured":"Lou L, Wang Y, Cui J, Yan X, Xue L, Li Y. Differential expression of Pim-3, c-Myc, and p-p27 proteins in adenocarcinomas of the gastric cardia and distal stomach. Tumour Biol. 2014;35:5029\u201336.","journal-title":"Tumour Biol"},{"key":"4931_CR29","doi-asserted-by":"crossref","first-page":"765","DOI":"10.5858\/2004-128-765-DTITIA","volume":"128","author":"DE Henson","year":"2004","unstructured":"Henson DE, Dittus C, Younes M, Nguyen H, Albores-Saavedra J. Differential trends in the intestinal and diffuse types of gastric carcinoma in the United States, 1973\u20132000: increase in the signet ring cell type. Arch Pathol Lab Med. 2004;128:765\u201370.","journal-title":"Arch Pathol Lab Med"},{"key":"4931_CR30","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1053\/j.gastro.2011.04.042","volume":"141","author":"IB Tan","year":"2011","unstructured":"Tan IB, Ivanova T, Lim KH, et al. Intrinsic subtypes of gastric cancer, based on gene expression pattern, predict survival and respond differently to chemotherapy. Gastroenterology 2011;141:476\u201385.","journal-title":"Gastroenterology"},{"key":"4931_CR31","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.1200\/JCO.2012.42.6635","volume":"30","author":"S Taghavi","year":"2012","unstructured":"Taghavi S, Jayarajan SN, Davey A, Willis AI. Prognostic significance of signet ring gastric cancer. J Clin Oncol. 2012;30:3493\u20138.","journal-title":"J Clin Oncol"},{"key":"4931_CR32","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/ijc.26399","volume":"131","author":"JY An","year":"2012","unstructured":"An JY, Kim H, Cheong JH, Hyung WJ, Kim H, Noh SH. Microsatellite instability in sporadic gastric cancer: Its prognostic role and guidance for 5\u2010FU based chemotherapy after R0 resection. Int J Cancer. 2012;131:505\u201311.","journal-title":"Int J Cancer"}],"container-title":["Annals of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-015-4931-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1245\/s10434-015-4931-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-015-4931-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T03:07:57Z","timestamp":1653448077000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1245\/s10434-015-4931-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,3]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["4931"],"URL":"https:\/\/doi.org\/10.1245\/s10434-015-4931-3","relation":{},"ISSN":["1068-9265","1534-4681"],"issn-type":[{"value":"1068-9265","type":"print"},{"value":"1534-4681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,3]]}}}