{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:27:57Z","timestamp":1791192477972,"version":"4.1.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"S5","license":[{"start":{"date-parts":[[2016,9,6]],"date-time":"2016-09-06T00:00:00Z","timestamp":1473120000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Grant-in-Aid from the Japan Society for the Promotion of Science","award":["#15K10263"],"award-info":[{"award-number":["#15K10263"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Surg Oncol"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1245\/s10434-016-5530-7","type":"journal-article","created":{"date-parts":[[2016,9,6]],"date-time":"2016-09-06T14:05:38Z","timestamp":1473170738000},"page":"1012-1020","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prognostic Significance of Expression of the Epithelial-Mesenchymal Transition-Related Factor Brachyury in Intrathoracic Lymphatic Spread of Non-Small Cell Lung Cancer"],"prefix":"10.1245","volume":"23","author":[{"given":"Shinichiro","family":"Shimamatsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuro","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Haro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Kitahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikihiro","family":"Kohno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Morodomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuzo","family":"Tagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Okano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinao","family":"Oda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Maehara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,9,6]]},"reference":[{"key":"5530_CR1","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/ncb3015","volume":"16","author":"SS McAllister","year":"2014","unstructured":"McAllister SS, Weinberg RA. The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis. Nat Cell Biol. 2014;16:717\u2013727.","journal-title":"Nat Cell Biol."},{"key":"5530_CR2","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.ceb.2005.08.001","volume":"17","author":"MA Huber","year":"2005","unstructured":"Huber MA, Kraut N, Beug H. Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr Opin Cell Biol. 2005;17:548\u2013558.","journal-title":"Curr Opin Cell Biol."},{"key":"5530_CR3","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10555-008-9179-y","volume":"28","author":"O Schmalhofer","year":"2009","unstructured":"Schmalhofer O, Brabletz S, Brabletz T. E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer. Cancer Metastasis Rev. 2009;28:151\u2013166.","journal-title":"Cancer Metastasis Rev."},{"key":"5530_CR4","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrc2131","volume":"7","author":"H Peinado","year":"2007","unstructured":"Peinado H, Olmeda D, Cano A. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer. 2007;7:415\u2013428.","journal-title":"Nat Rev Cancer."},{"key":"5530_CR5","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/dvdy.10480","volume":"229","author":"C Showell","year":"2004","unstructured":"Showell C, Binder O, Conlon FL. T-box genes in early embryogenesis. Dev Dyn. 2004;229:201\u2013218.","journal-title":"Dev Dyn."},{"key":"5530_CR6","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/dbio.1994.1019","volume":"161","author":"A Kispert","year":"1994","unstructured":"Kispert A, Herrmann BG. Immunohistochemical analysis of the Brachyury protein in wild-type and mutant mouse embryos. Dev Biol. 1994;161:179\u2013193.","journal-title":"Dev Biol."},{"key":"5530_CR7","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1172\/JCI38379","volume":"120","author":"RI Fernando","year":"2010","unstructured":"Fernando RI, Litzinger M, Trono P, Hamilton DH, Schlom J, Palena C. The T-box transcription factor Brachyury promotes epithelial-mesenchymal transition in human tumor cells. J Clin Invest. 2010;120:533\u2013544.","journal-title":"J Clin Invest."},{"key":"5530_CR8","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1158\/1535-7163.MCT-12-1007","volume":"12","author":"C Larocca","year":"2013","unstructured":"Larocca C, Cohen JR, Fernando RI, Huang B, Hamilton DH, Palena C. An autocrine loop between TGF-beta1 and the transcription factor brachyury controls the transition of human carcinoma cells into a mesenchymal phenotype. Mol Cancer Ther. 2013;12:1805\u20131815.","journal-title":"Mol Cancer Ther."},{"key":"5530_CR9","doi-asserted-by":"crossref","first-page":"3868","DOI":"10.1158\/1078-0432.CCR-11-3211","volume":"18","author":"M Roselli","year":"2012","unstructured":"Roselli M, Fernando RI, Guadagni F, Spila A, Alessandroni J, Palmirotta R, et al. Brachyury, a driver of the epithelial-mesenchymal transition, is overexpressed in human lung tumors: an opportunity for novel interventions against lung cancer. Clin Cancer Res. 2012;18:3868\u20133879.","journal-title":"Clin Cancer Res."},{"key":"5530_CR10","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.ejca.2010.11.015","volume":"47","author":"N Kilic","year":"2011","unstructured":"Kilic N, Feldhaus S, Kilic E, Tennstedt P, Wicklein D, Wasielewski R, et al. Brachyury expression predicts poor prognosis at early stages of colorectal cancer. Eur J Cancer. 2011;47:1080\u20131085.","journal-title":"Eur J Cancer."},{"key":"5530_CR11","doi-asserted-by":"crossref","unstructured":"Palena C, Roselli M, Litzinger MT, Ferroni P, Costarelli L, Spila A, et al. Overexpression of the EMT driver brachyury in breast carcinomas: association with poor prognosis. J Natl Cancer Inst. 2014;106: pii: dju054","DOI":"10.1093\/jnci\/dju054"},{"key":"5530_CR12","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.3892\/ijo.2012.1673","volume":"41","author":"I Imajyo","year":"2012","unstructured":"Imajyo I, Sugiura T, Kobayashi Y, Shimoda M, Ishii K, Akimoto N, et al. T-box transcription factor Brachyury expression is correlated with epithelial-mesenchymal transition and lymph node metastasis in oral squamous cell carcinoma. Int J Oncol. 2012;41:1985\u20131995.","journal-title":"Int J Oncol."},{"key":"5530_CR13","doi-asserted-by":"crossref","first-page":"4949","DOI":"10.1158\/1078-0432.CCR-14-0421","volume":"20","author":"F Pinto","year":"2014","unstructured":"Pinto F, Pertega-Gomes N, Pereira MS, Vizcaino JR, Monteiro P, Henrique RM, et al. T-box transcription factor brachyury is associated with prostate cancer progression and aggressiveness. Clin Cancer Res. 2014;20:4949\u20134961.","journal-title":"Clin Cancer Res."},{"issue":"Suppl 3","key":"5530_CR14","doi-asserted-by":"crossref","first-page":"S509","DOI":"10.1245\/s10434-013-2914-9","volume":"20","author":"A Haro","year":"2013","unstructured":"Haro A, Yano T, Kohno M, Yoshida T, Koga T, Okamoto T, et al. Expression of Brachyury gene is a significant prognostic factor for primary lung carcinoma. Ann Surg Oncol. 2013;20 Suppl 3:S509\u2013516.","journal-title":"Ann Surg Oncol."},{"key":"5530_CR15","doi-asserted-by":"crossref","first-page":"995","DOI":"10.3892\/mmr.2015.3348","volume":"12","author":"K Xu","year":"2015","unstructured":"Xu K, Liu B, Liu Y. Impact of Brachyury on epithelial-mesenchymal transitions and chemosensitivity in non-small cell lung cancer. Mol Med Rep. 2015;12:995\u20131001.","journal-title":"Mol Med Rep."},{"key":"5530_CR16","doi-asserted-by":"crossref","first-page":"4499","DOI":"10.1038\/onc.2011.602","volume":"31","author":"A Alitalo","year":"2012","unstructured":"Alitalo A, Detmar M. Interaction of tumor cells and lymphatic vessels in cancer progression. Oncogene. 2012;31:4499\u20134508.","journal-title":"Oncogene."},{"key":"5530_CR17","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1007\/s00109-015-1351-6","volume":"93","author":"JP Sleeman","year":"2015","unstructured":"Sleeman JP. The lymph node pre-metastatic niche. J Mol Med (Berl). 2015;93:1173\u201384.","journal-title":"J Mol Med (Berl)."},{"key":"5530_CR18","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1245\/s10434-014-3567-z","volume":"21","author":"WY Lee","year":"2014","unstructured":"Lee WY, Shin DY, Kim HJ, Ko YH, Kim S, Jeong HS. Prognostic significance of epithelial-mesenchymal transition of extracapsular spread tumors in lymph node metastases of head and neck cancer. Ann Surg Oncol. 2014;21:1904\u20131911.","journal-title":"Ann Surg Oncol."},{"key":"5530_CR19","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/1479-5876-10-226","volume":"10","author":"A Markiewicz","year":"2012","unstructured":"Markiewicz A, Ahrends T, Welnicka-Jaskiewicz M, Seroczynska B, Skokowski J, Jaskiewicz J, et al. Expression of epithelial to mesenchymal transition-related markers in lymph node metastases as a surrogate for primary tumor metastatic potential in breast cancer. J Transl Med. 2012;10:226.","journal-title":"J Transl Med."},{"key":"5530_CR20","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1111\/cas.12434","volume":"105","author":"R Matsuwaki","year":"2014","unstructured":"Matsuwaki R, Ishii G, Zenke Y, Neri S, Aokage K, Hishida T, et al. Immunophenotypic features of metastatic lymph node tumors to predict recurrence in N2 lung squamous cell carcinoma. Cancer Sci. 2014;105:905\u2013911.","journal-title":"Cancer Sci."},{"key":"5530_CR21","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.cell.2008.03.027","volume":"133","author":"SA Mani","year":"2008","unstructured":"Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell. 2008;133:704\u2013715.","journal-title":"Cell."},{"key":"5530_CR22","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/ijc.26029","volume":"130","author":"D Sarkar","year":"2012","unstructured":"Sarkar D, Shields B, Davies ML, Muller J, Wakeman JA. BRACHYURY confers cancer stem cell characteristics on colorectal cancer cells. Int J Cancer. 2012;130:328\u2013337.","journal-title":"Int J Cancer."},{"key":"5530_CR23","doi-asserted-by":"crossref","first-page":"268","DOI":"10.2174\/156800910791190175","volume":"10","author":"N Ahmed","year":"2010","unstructured":"Ahmed N, Abubaker K, Findlay J, Quinn M. Epithelial mesenchymal transition and cancer stem cell-like phenotypes facilitate chemoresistance in recurrent ovarian cancer. Curr Cancer Drug Targets. 2010;10:268\u2013278.","journal-title":"Curr Cancer Drug Targets."},{"key":"5530_CR24","doi-asserted-by":"crossref","first-page":"e682","DOI":"10.1038\/cddis.2013.208","volume":"4","author":"B Huang","year":"2013","unstructured":"Huang B, Cohen JR, Fernando RI, Hamilton DH, Litzinger MT, Hodge JW, et al. The embryonic transcription factor Brachyury blocks cell cycle progression and mediates tumor resistance to conventional antitumor therapies. Cell Death Dis. 2013;4:e682.","journal-title":"Cell Death Dis."}],"container-title":["Annals of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-016-5530-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1245\/s10434-016-5530-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-016-5530-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T06:51:17Z","timestamp":1568357477000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1245\/s10434-016-5530-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,6]]},"references-count":24,"journal-issue":{"issue":"S5","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["5530"],"URL":"https:\/\/doi.org\/10.1245\/s10434-016-5530-7","relation":{},"ISSN":["1068-9265","1534-4681"],"issn-type":[{"value":"1068-9265","type":"print"},{"value":"1534-4681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,6]]}}}