{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:32:13Z","timestamp":1792150333855,"version":"4.4.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T00:00:00Z","timestamp":1497916800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Surg Oncol"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1245\/s10434-017-5914-3","type":"journal-article","created":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T16:56:32Z","timestamp":1497977792000},"page":"2762-2769","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["CT Density in the Pancreas is a Promising Imaging Predictor for Pancreatic Ductal Adenocarcinoma"],"prefix":"10.1245","volume":"24","author":[{"given":"Yasunari","family":"Fukuda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisaku","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetoshi","family":"Eguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Hata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifumi","family":"Iwagami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiro","family":"Noda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadafumi","family":"Asaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Kawamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihito","family":"Gotoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Tanemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Doki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,6,20]]},"reference":[{"key":"5914_CR1","unstructured":"Cancer.net. Pancreatic cancer: Statistics. \n                        http:\/\/www.cancer.net\/cancer-types\/pancreatic-cancer\/statistics\n                        \n                    . Accessed 26 Feb 2017."},{"key":"5914_CR2","volume-title":"TNM classification of malignant tumors","author":"LH Sobin","year":"2009","unstructured":"Sobin LH, Gospodarowicz MK, Wittekind C. TNM classification of malignant tumors, 7th edn. Hoboken, NJ: John Wiley & Sons 2009.","edition":"7"},{"key":"5914_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2017.02.007","author":"SH Han","year":"2017","unstructured":"Han SH, Heo JS, Choi SH, et al. Actual long-term outcome of T1 and T2 pancreatic ductal adenocarcinoma after surgical resection. J Surg. 2017. DOI:\n                        10.1016\/j.ijsu.2017.02.007\n                        \n                    .","journal-title":"J Surg."},{"key":"5914_CR4","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1056\/NEJMoa1011923","volume":"364","author":"T Conroy","year":"2011","unstructured":"Conroy T, Desseigne F, Ychou M, et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med. 2011;364:1817\u201325.","journal-title":"N Engl J Med."},{"key":"5914_CR5","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1056\/NEJMoa1304369","volume":"369","author":"DD Hoff Von","year":"2013","unstructured":"Von Hoff DD, Ervin T, Arena FP, et al. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med. 2013;369:1691-703.","journal-title":"N Engl J Med."},{"key":"5914_CR6","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00595-015-1120-8","volume":"46","author":"T Mizuguchi","year":"2016","unstructured":"Mizuguchi T, Torigoe T, Satomi F, et al. Trials of vaccines for pancreatic ductal adenocarcinoma: Is there any hope of an improved prognosis? Surg Today. 2016;46:139-48.","journal-title":"Surg Today."},{"key":"5914_CR7","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1136\/gut.51.6.849","volume":"51","author":"D Malka","year":"2002","unstructured":"Malka D, Hammel P, Maire F, et al. Risk of pancreatic adenocarcinoma in chronic pancreatitis. Gut. 2002;51:849-52.","journal-title":"Gut."},{"key":"5914_CR8","unstructured":"Cancer.Net. Pancreatic cancer: risk factors. \n                        http:\/\/www.cancer.net\/cancer-types\/pancreatic-cancer\/risk-factors\n                        \n                    . Accessed 26 Feb 2017."},{"key":"5914_CR9","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/jjco\/hyf099","volume":"32","author":"H Furukawa","year":"2002","unstructured":"Furukawa H. Diagnostic clues for early pancreatic cancer. Jpn J Clin Oncol. 2002;32:391-2.","journal-title":"Jpn J Clin Oncol."},{"key":"5914_CR10","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1245\/s10434-014-3625-6","volume":"21","author":"P Batabyal","year":"2014","unstructured":"Batabyal P, Vander Hoorn S, Christophi C, Nikfarjam M. Association of diabetes mellitus and pancreatic adenocarcinoma: a meta-analysis of 88 studies. Ann Surg Oncol. 2014;21:2453-62.","journal-title":"Ann Surg Oncol."},{"key":"5914_CR11","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1038\/ctg.2014.5","volume":"5","author":"M Hori","year":"2014","unstructured":"Hori M, Takahashi M, Hiraoka N, et al. Association of pancreatic Fatty infiltration with pancreatic ductal adenocarcinoma. Clin Transl Gastroenterol. 2014;5:e53.","journal-title":"Clin Transl Gastroenterol."},{"key":"5914_CR12","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1097\/MPA.0000000000000159","volume":"43","author":"Y Tomita","year":"2014","unstructured":"Tomita Y, Azuma K, Nonaka Y, et al. Pancreatic fatty degeneration and fibrosis as predisposing factors for the development of pancreatic ductal adenocarcinoma. Pancreas. 2014;43:1032-41.","journal-title":"Pancreas."},{"key":"5914_CR13","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1158\/1078-0432.CCR-14-2385","volume":"21","author":"V Rebours","year":"2015","unstructured":"Rebours V, Gaujoux S, d\u2019Assignies G, et al. Obesity and fatty pancreatic infiltration are risk factors for pancreatic precancerous lesions (PanIN). Clin Cancer Res. 2015;21:3522-8.","journal-title":"Clin Cancer Res."},{"key":"5914_CR14","doi-asserted-by":"crossref","first-page":"87","DOI":"10.14740\/gr731w","volume":"9","author":"H Tariq","year":"2016","unstructured":"Tariq H, Nayudu S, Akella S, Glandt M, Chilimuri S. Non-alcoholic fatty pancreatic disease: a review of literature. Gastroenterology Res. 2016;9:87-91.","journal-title":"Gastroenterol Res."},{"key":"5914_CR15","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1158\/1078-0432.CCR-15-0718","volume":"21","author":"H Wang","year":"2015","unstructured":"Wang H, Maitra A, Wang H. Obesity, Intrapancreatic Fatty Infiltration, and Pancreatic Cancer. Clin Cancer Res. 2015;21:3369-71.","journal-title":"Clin Cancer Res."},{"key":"5914_CR16","doi-asserted-by":"crossref","first-page":"e000297","DOI":"10.1161\/JAHA.113.000297","volume":"3","author":"CY Wang","year":"2014","unstructured":"Wang CY, Ou HY, Chen MF, Chang TC, Chang CJ. Enigmatic ectopic fat: prevalence of nonalcoholic fatty pancreas disease and its associated factors in a Chinese population. Am J Heart Assoc. 2014;3:e000297.","journal-title":"Am J Heart Assoc."},{"key":"5914_CR17","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s12876-015-0404-1","volume":"15","author":"CR Lesmana","year":"2015","unstructured":"Lesmana CR, Pakasi LS, Inggriani S, Aidawati ML, Lesmana LA. Prevalence of Non-Alcoholic Fatty Pancreas Disease (NAFPD) and its risk factors among adult medical check-up patients in a private hospital: a large cross-sectional study. BMC Gastroenterol. 2015;15:174.","journal-title":"BMC Gastroenterol."},{"key":"5914_CR18","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/0002-9343(79)90740-X","volume":"67","author":"M Adler","year":"1979","unstructured":"Adler M, Schaffner F. Fatty liver hepatitis and cirrhosis in obese patients. Am J Med. 1979;67:811-6.","journal-title":"Am J Med."},{"key":"5914_CR19","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1111\/j.1572-0241.1999.01377.x","volume":"94","author":"EM Brunt","year":"1999","unstructured":"Brunt EM, Janney CG, Di Bisceglie AM, Neuschwander-Tetri BA, Bacon BR. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol. 1999;94:2467-74.","journal-title":"Am J Gastroenterol."},{"key":"5914_CR20","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S0168-8278(97)80288-7","volume":"27","author":"C Ricci","year":"1997","unstructured":"Ricci C, Longo R, Gioulis E, et al. Noninvasive in vivo quantitative assessment of fat content in human liver. J Hepatol. 1997;27:108-13.","journal-title":"J Hepatol."},{"key":"5914_CR21","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.2214\/AJR.06.0992","volume":"188","author":"Y Kodama","year":"2007","unstructured":"Kodama Y, Ng CS, Wu TT, et al. Comparison of CT methods for determining the fat content of the liver. Am J Roentgenol. 2007;188:1307-12.","journal-title":"Am J Roentgenol."},{"key":"5914_CR22","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1148\/radiol.13122883","volume":"271","author":"SY Kim","year":"2014","unstructured":"Kim SY, Kim H, Cho JY, et al. Quantitative assessment of pancreatic fat by using unenhanced CT: pathologic correlation and clinical implications. Radiology. 2014;271:104-12.","journal-title":"Radiology."},{"key":"5914_CR23","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1111\/j.1440-1746.2007.05001.x","volume":"22","author":"S Chitturi","year":"2007","unstructured":"Chitturi S, Farrell GC, Hashimoto E, Saibara T, Lau GK, Sollano JD. Non-alcoholic fatty liver disease in the Asia-Pacific region: definitions and overview of proposed guidelines. J Gastroenterol Hepatol. 2007;22:778-87.","journal-title":"J Gastroenterol Hepatol."},{"key":"5914_CR24","unstructured":"Japan Diabetes Society. 2015. Treatment guide for diabetes 2014\u20132015 (in Japanese): BUNKODO."},{"key":"5914_CR25","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-017-1495-9","author":"Y Fukuda","year":"2017","unstructured":"Fukuda Y, Yamada D, Eguchi H, et al. A novel preoperative predictor of pancreatic fistula using computed tomography after distal pancreatectomy with stapler closure. Surg Today. 2017 DOI:\n                        10.1007\/s00595-017-1495-9","journal-title":"Surg Today."},{"key":"5914_CR26","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/bjs.10063","volume":"103","author":"N Pecorelli","year":"2016","unstructured":"Pecorelli N, Carrara G, De Cobelli F, et al. Effect of sarcopenia and visceral obesity on mortality and pancreatic fistula following pancreatic cancer surgery. Br J Surg. 2016;103:434-42.","journal-title":"Br J Surg."},{"key":"5914_CR27","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1139\/H08-075","volume":"33","author":"M Mourtzakis","year":"2008","unstructured":"Mourtzakis M, Prado CM, Lieffers JR, Reiman T, McCargar LJ, Baracos VE. A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care. Appl Physiol Nutr Metab. 2008;33:997-1006.","journal-title":"Appl Physiol Nutr Metab."},{"key":"5914_CR28","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1093\/aje\/kwm361","volume":"167","author":"RZ Stolzenberg-Solomon","year":"2008","unstructured":"Stolzenberg-Solomon RZ, Adams K, Leitzmann M, et al. Adiposity, physical activity, and pancreatic cancer in the National Institutes of Health-AARP Diet and Health Cohort. Am J Epidemiol. 2008;167:586-97.","journal-title":"Am J Epidemiol."},{"key":"5914_CR29","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/path.1700370314","volume":"37","author":"RF Ogilvie","year":"1933","unstructured":"Ogilvie RF. The islands of Langerhans in 19 cases of obesity. J Pathol Bacterol. 1933;37:473-81.","journal-title":"J Pathol Bacterol."},{"key":"5914_CR30","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nrgastro.2011.4","volume":"8","author":"MM Smits","year":"2011","unstructured":"Smits MM, van Geenen EJ. The clinical significance of pancreatic steatosis. Nat Rev Gastroenterol Hepatol. 2011;8:169-77.","journal-title":"Nat Rev Gastroenterol Hepatol."},{"key":"5914_CR31","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1097\/SLA.0b013e31814a6906","volume":"246","author":"A Mathur","year":"2007","unstructured":"Mathur A, Pitt HA, Marine M, et al. Fatty pancreas: a factor in postoperative pancreatic fistula. Ann Surg. 2007;246:1058-64.","journal-title":"Ann Surg."},{"key":"5914_CR32","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1097\/MPA.0b013e318220e742","volume":"40","author":"M Hori","year":"2011","unstructured":"Hori M, Kitahashi T, Imai T, et al. Enhancement of carcinogenesis and fatty infiltration in the pancreas in N-nitrosobis(2-oxopropyl)amine-treated hamsters by high-fat diet. Pancreas. 2011;40:1234-40.","journal-title":"Pancreas."},{"key":"5914_CR33","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1053\/j.gastro.2013.08.018","volume":"145","author":"B Philip","year":"2013","unstructured":"Philip B, Roland CL, Daniluk J, et al. A high-fat diet activates oncogenic Kras and COX2 to induce development of pancreatic ductal adenocarcinoma in mice. Gastroenterology. 2013;145:1449\u201358.","journal-title":"Gastroenterology."},{"key":"5914_CR34","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1007\/s11605-015-2855-7","volume":"19","author":"S Yardimci","year":"2015","unstructured":"Yardimci S, Kara YB, Tuney D, Attaallah W, Ugurlu MU, Dulundu E, Yegen \u015eC. A simple method to evaluate whether pancreas texture can be used to predict pancreatic fistula risk after pancreatoduodenectomy. J Gastrointest Surg. 2015;19:1625-31.","journal-title":"J Gastrointest Surg."},{"key":"5914_CR35","doi-asserted-by":"crossref","first-page":"e1152","DOI":"10.1097\/MD.0000000000001152","volume":"94","author":"M Sandini","year":"2015","unstructured":"Sandini M, Bernasconi DP, Ippolito D, et al. Preoperative computed tomography to predict and stratify the risk of severe pancreatic fistula after pancreatoduodenectomy. Medicine (Baltimore). 2015;94:e1152.","journal-title":"Medicine."}],"container-title":["Annals of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1245\/s10434-017-5914-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-017-5914-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-017-5914-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T14:40:11Z","timestamp":1501598411000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1245\/s10434-017-5914-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,20]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["5914"],"URL":"https:\/\/doi.org\/10.1245\/s10434-017-5914-3","relation":{},"ISSN":["1068-9265","1534-4681"],"issn-type":[{"value":"1068-9265","type":"print"},{"value":"1534-4681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,20]]}}}