{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T21:54:11Z","timestamp":1761429251144},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T00:00:00Z","timestamp":1526342400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Surg Oncol"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1245\/s10434-018-6459-9","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T16:46:12Z","timestamp":1526402772000},"page":"1836-1842","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Effect of Temperature and Perfusion Time on Response, Toxicity, and Survival in Patients with In-transit Melanoma Metastases Treated with Isolated Limb Perfusion"],"prefix":"10.1245","volume":"25","author":[{"given":"Dimitrios","family":"Katsarelias","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"R\u00e5dbo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilan","family":"Ben-Shabat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Mattsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Olofsson Bagge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,5,15]]},"reference":[{"issue":"8","key":"6459_CR1","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1245\/ASO.2005.05.025","volume":"12","author":"TM Pawlik","year":"2005","unstructured":"Pawlik TM, et al Predictors and natural history of in-transit melanoma after sentinel lymphadenectomy. Ann Surg Oncol. 2005;12(8):587\u201396.","journal-title":"Ann Surg Oncol."},{"issue":"4","key":"6459_CR2","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1097\/00000658-195810000-00009","volume":"148","author":"O Creech Jr","year":"1958","unstructured":"Creech O Jr, et al. Chemotherapy of cancer: regional perfusion utilizing an extracorporeal circuit. Ann Surg. 1958;148(4):616\u201332.","journal-title":"Ann Surg."},{"issue":"11","key":"6459_CR3","doi-asserted-by":"publisher","first-page":"2638","DOI":"10.1002\/1097-0142(19850601)55:11<2638::AID-CNCR2820551118>3.0.CO;2-E","volume":"55","author":"DR Minor","year":"1985","unstructured":"Minor DR, et al. A clinical and pharmacokinetic study of isolated limb perfusion with heat and melphalan for melanoma. Cancer, 1985. 55(11):2638\u201344.","journal-title":"Cancer"},{"issue":"9","key":"6459_CR4","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1002\/1097-0142(196709)20:9<1351::AID-CNCR2820200902>3.0.CO;2-#","volume":"20","author":"R Cavaliere","year":"1967","unstructured":"Cavaliere R, et al. Selective heat sensitivity of cancer cells. Biochemical and clinical studies. Cancer. 1967;20(9):1351\u201381.","journal-title":"Cancer."},{"issue":"2","key":"6459_CR5","first-page":"305","volume":"129","author":"JS Stehlin Jr","year":"1969","unstructured":"Stehlin JS Jr. Hyperthermic perfusion with chemotherapy for cancers of the extremities. Surg Gynecol Obstet. 1969;129(2):305\u20138.","journal-title":"Surg Gynecol Obstet."},{"issue":"2","key":"6459_CR6","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1097\/CCO.0b013e3283424dbc","volume":"23","author":"JP Deroose","year":"2011","unstructured":"Deroose JP, et al. Isolated limb perfusion for melanoma in-transit metastases: developments in recent years and the role of tumor necrosis factor alpha. Curr Opin Oncol. 2011;23(2):183\u20138.","journal-title":"Curr Opin Oncol."},{"key":"6459_CR7","unstructured":"World Health Organization, WHO handbook for reporting results of cancer treatment. WHO offset publication No 48. 1979, Geneva: World Health Organization. P. 45."},{"issue":"10","key":"6459_CR8","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/0277-5379(82)90235-8","volume":"18","author":"J Wieberdink","year":"1982","unstructured":"Wieberdink J, et al. Dosimetry in isolation perfusion of the limbs by assessment of perfused tissue volume and grading of toxic tissue reactions. Eur J Cancer Clin Oncol. 1982;18(10):905\u201310.","journal-title":"Eur J Cancer Clin Oncol."},{"issue":"3","key":"6459_CR9","doi-asserted-by":"publisher","first-page":"234","DOI":"10.3109\/02656736.2013.782428","volume":"29","author":"R Olofsson","year":"2013","unstructured":"Olofsson R, et al. Melan-A specific CD8+ T lymphocytes after hyperthermic isolated limb perfusion: a pilot study in patients with in-transit metastases of malignant melanoma. Int J Hyperthermia. 2013;29(3):234\u20138.","journal-title":"Int J Hyperthermia."},{"issue":"8","key":"6459_CR10","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1158\/0008-5472.CAN-14-2089","volume":"75","author":"AM Dudek-Peric","year":"2015","unstructured":"Dudek-Peric, A.M., et al. Antitumor immunity triggered by melphalan is potentiated by melanoma cell surface-associated calreticulin. Cancer Res. 2015; 75(8):1603\u20131614.","journal-title":"Cancer Res."},{"issue":"24","key":"6459_CR11","doi-asserted-by":"publisher","first-page":"5398","DOI":"10.1158\/0008-5472.CAN-15-1184","volume":"75","author":"A Martner","year":"2015","unstructured":"Martner, A., et al. Melphalan, antimelanoma immunity, and inflammation [letter]. Cancer Res. 2015;75(24):5398\u20139.","journal-title":"Cancer Res."},{"issue":"10","key":"6459_CR12","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/0277-5379(82)90235-8","volume":"18","author":"J Wieberdink","year":"1982","unstructured":"Wieberdink J, et al. Dosimetry in isolation perfusion of the limbs by assessment of perfused tissue volume and grading of toxic tissue reactions. Eur Jf Cancer Clin Oncol. 1982;18(10):905\u201310.","journal-title":"Eur Jf Cancer Clin Oncol."},{"issue":"9","key":"6459_CR13","doi-asserted-by":"publisher","first-page":"2570","DOI":"10.1245\/s10434-009-0563-9","volume":"16","author":"AA Santillan","year":"2009","unstructured":"Santillan AA, et al. Predictive factors of regional toxicity and serum creatine phosphokinase levels after isolated limb infusion for melanoma: a multi-institutional analysis. Ann Surg Oncol. 2009;16(9):2570\u20138.","journal-title":"Ann Surg Oncol."},{"issue":"3","key":"6459_CR14","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1097\/00008390-199606000-00010","volume":"6","author":"JF Thompson","year":"1996","unstructured":"Thompson JF, et al. Determinants of acute regional toxicity following isolated limb perfusion for melanoma. Melanoma Res. 1996;6(3):267\u201371.","journal-title":"Melanoma Res."},{"issue":"6","key":"6459_CR15","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/0002-9610(94)90111-2","volume":"167","author":"JM Klaase","year":"1994","unstructured":"Klaase JM, et al. Patient- and treatment-related factors associated with acute regional toxicity after isolated perfusion for melanoma of the extremities. Am J Surg. 1994;167(6):618\u201320.","journal-title":"Am J Surg."},{"issue":"6","key":"6459_CR16","doi-asserted-by":"publisher","first-page":"551","DOI":"10.3109\/02656736.2013.802374","volume":"29","author":"R Olofsson","year":"2013","unstructured":"Olofsson R, Mattsson J, Lindner P. Long-term follow-up of 163 consecutive patients treated with isolated limb perfusion for in-transit metastases of malignant melanoma. Int J Hyperthermia. 2013;29(6):551\u20137.","journal-title":"Int J Hyperthermia."},{"key":"6459_CR17","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/978-3-642-83260-4_23","volume":"107","author":"O Dahl","year":"1988","unstructured":"Dahl O. Interaction of hyperthermia and chemotherapy. Recent Results Cancer Res. 1988;107:157\u201369.","journal-title":"Recent Results Cancer Res."},{"issue":"6","key":"6459_CR18","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1007\/BF02067073","volume":"16","author":"G Omlor","year":"1992","unstructured":"Omlor G, et al. Optimization of isolated hyperthermic limb perfusion. World J Surg. 1992;16(6):1117\u20139.","journal-title":"World J Surg."},{"issue":"6","key":"6459_CR19","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1097\/00008390-199412000-00004","volume":"4","author":"J Clark","year":"1994","unstructured":"Clark J, et al. Melphalan uptake, hyperthermic synergism and drug resistance in a human cell culture model for the isolated limb perfusion of melanoma. Melanoma Res. 1994;4(6):365\u201370.","journal-title":"Melanoma Res."},{"issue":"3","key":"6459_CR20","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1002\/(SICI)1098-2388(199804\/05)14:3<215::AID-SSU5>3.0.CO;2-B","volume":"14","author":"F Filippo Di","year":"1998","unstructured":"Di Filippo F, et al. The application of hyperthermia in regional chemotherapy. Semin Surg Oncol. 1998;14(3):215\u201323.","journal-title":"Semin Surg Oncol."},{"issue":"2","key":"6459_CR21","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1158\/2326-6066.CIR-17-0356","volume":"6","author":"CE Ariyan","year":"2018","unstructured":"Ariyan CE, et al. Robust antitumor responses result from local chemotherapy and CTLA-4 blockade. Cancer Immunol Res. 2018;6(2):189\u2013200.","journal-title":"Cancer Immunol Res."}],"container-title":["Annals of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1245\/s10434-018-6459-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-018-6459-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-018-6459-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T20:22:26Z","timestamp":1557865346000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1245\/s10434-018-6459-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,15]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["6459"],"URL":"https:\/\/doi.org\/10.1245\/s10434-018-6459-9","relation":{},"ISSN":["1068-9265","1534-4681"],"issn-type":[{"value":"1068-9265","type":"print"},{"value":"1534-4681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,15]]},"assertion":[{"value":"19 February 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2018","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}