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Transfusion history was obtained retrospectively from electronic records. Associations between blood transfusion, postoperative C-reactive protein (CRP), albumin, hemoglobin, complications, cancer-specific survival and overall survival (OS) were assessed using propensity score matching (<jats:italic>n\u2009<\/jats:italic>=116).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Of 544 patients, the majority were male (<jats:italic>n\u2009<\/jats:italic>=294, 54%), over 65\u00a0years of age (<jats:italic>n\u2009<\/jats:italic>=350, 64%), and with colonic (<jats:italic>n\u2009<\/jats:italic>=347, 64%) node-negative disease (<jats:italic>n\u2009<\/jats:italic>=353, 65%). Eighty-six patients (16%) required perioperative blood transfusion. In the unmatched cohort, blood transfusion was associated with higher median postoperative day (POD) 3 CRP {143 [interquartile range (IQR) 96\u2013221\u00a0mg\/L] vs. 120 (IQR 72\u2013188\u00a0mg\/L); <jats:italic>p<\/jats:italic>\u2009=\u20090.004}, lower median POD 3 albumin [24 (IQR 20\u201326\u00a0g\/L) vs. 27 (IQR 24\u201330\u00a0g\/L); <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001], more postoperative complications [odds ratio (OR) 3.28, 95% confidence interval (CI) 2.03\u20135.29] and poorer OS [hazard ratio (HR) 3.18, 95% CI 2.08\u20134.84]. In the propensity score matched cohort, blood transfusion was similarly associated with higher median POD 3 CRP [130 (IQR 93\u2013196\u00a0mg\/L) vs. 113 (IQR 66\u2013173\u00a0mg\/L); <jats:italic>p<\/jats:italic>\u2009=\u20090.046], lower median POD 3 albumin [24 (IQR 20\u201326\u00a0g\/L) vs. 26 (IQR 24\u201330\u00a0g\/L); <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001], more postoperative complications (OR 2.91, 95% CI 1.36\u20136.20) and poorer OS (HR 2.38, 95% CI 0.99\u20135.73).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Perioperative blood transfusion was associated with postoperative inflammation, complications, and poorer survival in patients undergoing colorectal cancer surgery, with and without propensity score techniques.<\/jats:p>\n<\/jats:sec>","DOI":"10.1245\/s10434-019-07984-7","type":"journal-article","created":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T20:27:04Z","timestamp":1572467224000},"page":"833-843","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Perioperative Blood Transfusion is Associated with Postoperative Systemic Inflammatory Response and Poorer Outcomes Following Surgery for Colorectal Cancer"],"prefix":"10.1245","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5459-8445","authenticated-orcid":false,"given":"Stephen T.","family":"McSorley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Tham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross D.","family":"Dolan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin W.","family":"Steele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Ramsingh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Campbell","family":"Roxburgh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul G.","family":"Horgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald C.","family":"McMillan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,10,29]]},"reference":[{"key":"7984_CR1","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1097\/SLA.0b013e31825b35d5","volume":"256","author":"AG Acheson","year":"2012","unstructured":"Acheson AG, Brookes MJ, Spahn DR. 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McSorley, Alexander Tham, Ross D. Dolan, Colin W. Steele, Jason Ramsingh, Campbell Roxburgh, Paul G. Horgan, and Donald C. McMillan have no conflicts of interest to declare.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure"}}]}}