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This prospective study measured recovery and HRQL in the year after VATS for non-small cell lung cancer (NSCLC) and explored the feasibility of HRQL data collection in patients undergoing VATS or open lung resection.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Patients and Methods<\/jats:title>\n<jats:p>Consecutive patients referred for surgical assessment (VATS or open surgery) for proven\/suspected NSCLC completed HRQL and fatigue assessments before and 1, 3, 6 and 12\u00a0months post-surgery. Mean HRQL scores were calculated for patients who underwent VATS (segmental, wedge or lobectomy resection). Paired <jats:italic>t<\/jats:italic>-tests compared mean HRQL between baseline and expected worst (1\u00a0month), early (3\u00a0months) and longer-term (12\u00a0months) recovery time points.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 92 patients received VATS, and 18 open surgery. Questionnaire response rates were high (pre-surgery 96\u2013100%; follow-up 67\u201385%). Pre-surgery, VATS patients reported mostly high (good) functional health scores [(European Organisation for Research and Treatment of Cancer) EORTC function scores &gt;\u200980] and low (mild) symptom scores (EORTC symptom scores &lt;\u200920). One-month post-surgery, patients reported clinically and statistically significant deterioration in overall health and physical, role and social function (19\u201336 points), and increased fatigue, pain, dyspnoea, appetite loss and constipation [EORTC 12\u201326; multidimensional fatigue inventory (MFI-20) 3\u20135]. HRQL had not fully recovered 12\u00a0months post-surgery, with reduced physical, role and social function (10\u201314) and persistent fatigue and dyspnoea (EORTC 12\u201322; MFI-20 2.7\u20133.2).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Lung resection has a considerable detrimental impact on patients\u2019 HRQL that is not fully resolved 12\u00a0months post-surgery, despite a VATS approach.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Graphic Abstract<\/jats:title>\n\n<\/jats:sec>","DOI":"10.1245\/s10434-019-08090-4","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T16:18:54Z","timestamp":1575303534000},"page":"1259-1271","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Impact on Health-Related Quality of Life of Video-Assisted Thoracoscopic Surgery for Lung Cancer"],"prefix":"10.1245","volume":"27","author":[{"given":"Kerry N. 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DW is a member of the NHS England Clinical Expert Group on Lung Cancer (which develops commissioning guidance for lung cancer services within NHS England), Vice Chair for the Lung Cancer Guideline Update Committee 2018 (National Institute for Health and Care Excellence) and Audit Lead for Thoracic Surgery (Society for Cardiothoracic Surgery in Britain and Ireland). DW is a member of the Cardiothoracic Specialty Specific Group, Royal College of Surgeons of Edinburgh, advising the latter on issues related to cardiothoracic surgery. DW and TB declare personal fees from AstraZeneca, Johnson and Johnson, and Medtronic outside the submitted work. TB also declares personal fees from Medela. All other authors report no conflicts of interest, financial or otherwise, with respect to this work.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}