{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:46:55Z","timestamp":1793724415626,"version":"4.6.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2021,2,7]],"date-time":"2021-02-07T00:00:00Z","timestamp":1612656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,7]],"date-time":"2021-02-07T00:00:00Z","timestamp":1612656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100012832","name":"Okinaka Memorial Institute for Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012832","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Surg Oncol"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1245\/s10434-021-09658-9","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T05:12:58Z","timestamp":1612847578000},"page":"6738-6746","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Adipose Tissue Distribution Predicts Prognosis of Cirrhotic Patients Undergoing Hepatectomy for Hepatocellular Carcinoma"],"prefix":"10.1245","volume":"28","author":[{"given":"Satoshi","family":"Okubo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Shindoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Umino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miho","family":"Akabane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutaka","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaji","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,7]]},"reference":[{"key":"9658_CR1","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1056\/NEJMoa021423","volume":"348","author":"EE Calle","year":"2003","unstructured":"Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of US adults. N Engl J Med. 2003;348:1625.","journal-title":"N Engl J Med"},{"key":"9658_CR2","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1007\/s00535-014-0973-8","volume":"50","author":"R Tateishi","year":"2015","unstructured":"Tateishi R, Okanoue T, Fujiwara N, Okita K, Kiyosawa K, Omata M, et al. Clinical characteristics, treatment, and prognosis of non-B, non-C hepatocellular carcinoma: a large retrospective multicenter cohort study. J Gastroenterol. 2015;50:350\u201360.","journal-title":"J Gastroenterol"},{"key":"9658_CR3","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1158\/1055-9965.EPI-16-0439","volume":"26","author":"S Strulov Shachar","year":"2017","unstructured":"Strulov Shachar S, Williams GR. The obesity paradox in cancer-moving beyond BMI. Cancer Epidemiol Biomarkers Prev. 2017;26:13\u20136.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"9658_CR4","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1111\/obr.12440","volume":"17","author":"AS Antonopoulos","year":"2016","unstructured":"Antonopoulos AS, Oikonomou EK, Antoniades C, Tousoulis D. From the BMI paradox to the obesity paradox: the obesity-mortality association in coronary heart disease. Obesity Rev. 2016;17:989\u20131000.","journal-title":"Obesity Rev"},{"key":"9658_CR5","doi-asserted-by":"crossref","unstructured":"Feng Z, Zhao H, Jiang Y, He Z, Sun X, Rong P, et al. Sarcopenia associates with increased risk of hepatocellular carcinoma among male patinets with cirrhosis. Clin Nutr. 2020;39:3132\u20139.","DOI":"10.1016\/j.clnu.2020.01.021"},{"key":"9658_CR6","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1002\/bjs.9258","volume":"100","author":"N Harimoto","year":"2013","unstructured":"Harimoto N, Shirabe K, Yamashita YI, Ikegami T, Yoshizumi T, Soejima Y, et al. Sarcopenia as a predictor of prognosis in patients following hepatectomy for hepatocellular carcinoma. Br J Surg. 2013;100:1523\u201330.","journal-title":"Br J Surg"},{"key":"9658_CR7","doi-asserted-by":"publisher","first-page":"527","DOI":"10.4251\/wjgo.v11.i7.527","volume":"11","author":"MY Chan","year":"2019","unstructured":"Chan MY, Chok KSH. Sarcopenia in pancreatic cancer: effects on surgical outcomes and chemotherapy. World J Gastrointest Oncol. 2019;11:527\u201337.","journal-title":"World J Gastrointest Oncol"},{"key":"9658_CR8","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1245\/s10434-018-6452-3","volume":"25","author":"T Kawamura","year":"2018","unstructured":"Kawamura T, Makuuchi R, Tokunaga M, Tanizawa Y, Bando E, Yasui H, et al. Long-term outcomes of gastric cancer patients with preoperative sarcopenia. Ann Surg Oncol. 2018;25:1625\u201332.","journal-title":"Ann Surg Oncol"},{"key":"9658_CR9","doi-asserted-by":"crossref","unstructured":"Deng HY, Zha P, Peng L, Hou L, Huang KL, Li XY. Preoperative sarcopenia is a predictor of poor prognosis of esophageal cancer after esophagectomy: a comprehensive systematic review and meta-analysis. Dis Esophagus. 2019;32:doy115.","DOI":"10.1093\/dote\/doy115"},{"key":"9658_CR10","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1097\/CCM.0000000000001870","volume":"44","author":"C Pisitsak","year":"2016","unstructured":"Pisitsak C, Lee JG, Boyd JH, Coxson HO, Russell JA, Walley KR. Increased ratio of visceral to subcutaneous adipose tissue in septic patients is associated with adverse outcome. Crit Care Med. 2016;44:1966\u201373.","journal-title":"Crit Care Med"},{"key":"9658_CR11","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1007\/s10620-017-4467-4","volume":"62","author":"EY Ze","year":"2017","unstructured":"Ze EY, Kim BJ, Kang H, Kim JG. Abdominal visceral to subcutaneous adipose tissue ratio is associated with increased risk of erosive esophagitis. Dig Dis Sci. 2017;62:1265\u201371.","journal-title":"Dig Dis Sci"},{"key":"9658_CR12","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1245\/s10434-008-9891-4","volume":"15","author":"HG Moon","year":"2008","unstructured":"Moon HG, Ju YT, Jeong CY, Jung EJ, Lee YJ, Hong SC, et al. Visceral obesity may affect oncologic outcome in patients with colorectal cancer. Ann Surg Oncol. 2008;15:1918\u201322.","journal-title":"Ann Surg Oncol"},{"key":"9658_CR13","doi-asserted-by":"publisher","first-page":"3732","DOI":"10.1245\/s10434-017-6077-y","volume":"24","author":"S Okumura","year":"2017","unstructured":"Okumura S, Kaido T, Hamaguchi Y, Kobayashi A, Shirai H, Yao S, et al. Visceral adiposity and sarcopenic visceral obesity are associated with poor prognosis after resection of pancreatic cancer. Ann Surg Oncol. 2017;24:3732\u201340.","journal-title":"Ann Surg Oncol"},{"key":"9658_CR14","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.suronc.2015.09.002","volume":"24","author":"VP Grignol","year":"2015","unstructured":"Grignol VP, Smith AD, Shlapak D, Zhang X, Del Campo SM, Carson WE. Increased visceral to subcutaneous fat ratio is associated with decreased overall survival in patients with metastatic melanoma receiving anti-angiogenic therapy. Surg Oncol. 2015;24:353\u20138.","journal-title":"Surg Oncol"},{"key":"9658_CR15","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1007\/s00384-006-0259-6","volume":"22","author":"DC McMillan","year":"2007","unstructured":"McMillan DC, Crozier JE, Canna K, Angerson WJ, McArdle CS. Evaluation of an inflammation-based prognostic score (GPS) in patients undergoing resection for colon and rectal cancer. Int J Colorectal Dis. 2007;22:881\u20136.","journal-title":"Int J Colorectal Dis"},{"key":"9658_CR16","first-page":"5","volume":"102","author":"R Zahorec","year":"2001","unstructured":"Zahorec R. Ratio of neutrophil-to-lymphocyte counts: rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy. 2001;102:5\u201314.","journal-title":"Bratisl Lek Listy"},{"key":"9658_CR17","first-page":"38","volume":"20","author":"J Ignacio de Ulibarri","year":"2005","unstructured":"Ignacio de Ulibarri J, Gonzalez-Madrono A, de Villar NG, Gonzalez P, Gonzalez B, Mancha A, et al. CONUT: a tool for controlling nutritional status: first validation in a hospital population. Nutr Hosp. 2005;20:38\u201345.","journal-title":"Nutr Hosp"},{"key":"9658_CR18","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1152\/jappl.1998.85.1.115","volume":"85","author":"N Mitsiopoulos","year":"1998","unstructured":"Mitsiopoulos N, Baumgartner RN, Heymsfield SB, Lyons W, Gallagher D, Ross R. Cadaver validation of skeletal muscle measurement by magnetic resonance imaging and computerized tomography. J Appl Physiol. 1998;85:115\u201322.","journal-title":"J Appl Physiol"},{"key":"9658_CR19","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1111\/hepr.12774","volume":"46","author":"H Nishikawa","year":"2016","unstructured":"Nishikawa H, Shiraki M, Hiramatsu A, Moriya K, Hino K, Nishiguchi S. Japan Society of Hepatology guidelines for sarcopenia in liver disease (1st ed): recommendation from the working group for creation of sarcopenia assessment criteria. Hepatol Res. 2016;46:951\u201363.","journal-title":"Hepatol Res"},{"key":"9658_CR20","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.jhep.2015.02.031","volume":"63","author":"N Fujiwara","year":"2015","unstructured":"Fujiwara N, Nakagawa H, Kudo Y, Tateishi R, Taguri M, Watadani T, et al. Sarcopenia, intramuscular fat deposition, and visceral adiposity independently predict the outcomes of hepatocellular carcinoma. J Hepatol. 2015;63:131\u201340.","journal-title":"J Hepatol"},{"key":"9658_CR21","doi-asserted-by":"crossref","unstructured":"Shindoh J, Kawamura Y, Kobayashi Y, Akuta N, Kobayashi M, Suzuki Y, et al. Time-to-interventional failure as a new surrogate measure for survival outcomes after resection of hepatocellular carcinoma. J Gastrointest Surg. 2020;24:50\u20137.","DOI":"10.1007\/s11605-019-04277-y"},{"key":"9658_CR22","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1177\/0272989X8300300403","volume":"3","author":"JR Beck","year":"1983","unstructured":"Beck JR, Pauker SG. The Markov process in medical prognosis. Med Decis Making. 1983;3:419\u201358.","journal-title":"Med Decis Making"},{"key":"9658_CR23","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1159\/000488779","volume":"8","author":"Y Hamaguchi","year":"2019","unstructured":"Hamaguchi Y, Kaido T, Okumura S, Kobayashi A, Shirai H, Yao S, et al. Preoperative visceral adiposity and muscularity predict poor outcomes after hepatectomy for hepatocellular carcinoma. Liver Cancer. 2019;8:92\u2013109.","journal-title":"Liver Cancer"},{"key":"9658_CR24","doi-asserted-by":"publisher","first-page":"699","DOI":"10.2337\/diabetes.47.5.699","volume":"47","author":"N Ruderman","year":"1998","unstructured":"Ruderman N, Chisholm D, Pi-Sunyer X, Schneider S. The metabolically obese, normal-weight individual revisited. Diabetes. 1998;47:699\u2013713.","journal-title":"Diabetes"},{"key":"9658_CR25","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1210\/jc.2004-0165","volume":"89","author":"AD Karelis","year":"2004","unstructured":"Karelis AD, St-Pierre DH, Conus F, Rabasa-Lhoret R, Poehlman ET. Metabolic and body composition factors in subgroups of obesity: what do we know? J Clin Endocrinol Metab. 2004;89:2569\u201375.","journal-title":"J Clin Endocrinol Metab"},{"key":"9658_CR26","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/j.1467-789X.2009.00623.x","volume":"11","author":"MM Ibrahim","year":"2010","unstructured":"Ibrahim MM. Subcutaneous and visceral adipose tissue: structural and functional differences. Obes Rev. 2010;11:11\u20138.","journal-title":"Obes Rev"},{"key":"9658_CR27","doi-asserted-by":"publisher","first-page":"2777","DOI":"10.1172\/JCI119824","volume":"100","author":"TG Kirchgessner","year":"1997","unstructured":"Kirchgessner TG, Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS. Tumor necrosis factor-alpha contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes. J Clin Invest. 1997;100:2777\u201382.","journal-title":"J Clin Invest"},{"key":"9658_CR28","doi-asserted-by":"publisher","first-page":"2476","DOI":"10.1073\/pnas.0308671100","volume":"101","author":"E Br\u00e5kenhielm","year":"2004","unstructured":"Br\u00e5kenhielm E, Veitonm\u00e4ki N, Cao R, Kihara S, Matsuzawa Y, Zhivotovsky B, et al. Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis. Proc Natl Acad Sci USA. 2004;101:2476\u201381.","journal-title":"Proc Natl Acad Sci USA"},{"key":"9658_CR29","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1038\/nri1937","volume":"6","author":"H Tilg","year":"2006","unstructured":"Tilg H, Moschen AR. Adipocytokines: mediators linking adipose tissue, inflammation, and immunity. Nat Rev Immunol. 2006;6:772\u201383.","journal-title":"Nat Rev Immunol"},{"key":"9658_CR30","doi-asserted-by":"publisher","first-page":"571","DOI":"10.4103\/ijmr.IJMR_1910_18","volume":"149","author":"B Mittal","year":"2019","unstructured":"Mittal B. Subcutaneous adipose tissue and visceral adipose tissue. Ind J Med Res. 2019;149:571\u20133.","journal-title":"Ind J Med Res"},{"key":"9658_CR31","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1038\/s41575-018-0069-7","volume":"15","author":"J O\u2019Sullivan","year":"2018","unstructured":"O\u2019Sullivan J, Lysaght J, Donohoe CL, Reynolds JV. Obesity and gastrointestinal cancer: the interrelationship of adipose and tumour microenvironments. Nat Rev Gastroenterol Hepatol. 2018;15:699\u2013714.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"9658_CR32","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1007\/s00125-003-1221-6","volume":"46","author":"S Miyazawa-Hoshimoto","year":"2003","unstructured":"Miyazawa-Hoshimoto S, Takahashi K, Bujo H, Hashimoto N, Saito Y. Elevated serum vascular endothelial growth factor is associated with visceral fat accumulation in human obese subjects. Diabetologia. 2003;46:1483\u20138.","journal-title":"Diabetologia"},{"key":"9658_CR33","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1002\/bjs.4594","volume":"91","author":"RT Poon","year":"2004","unstructured":"Poon RT, Ho JW, Tong CS, Lau C, Ng IO, Fan ST. Prognostic significance of serum vascular endothelial growth factor and endostatin in patients with hepatocellular carcinoma. Br J Surg. 2004;91:1354\u201360.","journal-title":"Br J Surg"},{"key":"9658_CR34","doi-asserted-by":"publisher","first-page":"3144","DOI":"10.12659\/MSM.894617","volume":"21","author":"G Cao","year":"2015","unstructured":"Cao G, Li X, Qin C, Li J. Prognostic value of VEGF in hepatocellular carcinoma patients treated with sorafenib: a meta-analysis. Med Sci Monitor. 2015;21:3144\u201351.","journal-title":"Med Sci Monitor"},{"key":"9658_CR35","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s12970-018-0236-9","volume":"15","author":"S Vargas","year":"2018","unstructured":"Vargas S, Romance R, Petro JL, Bonilla DA, Galancho I, Espinar S, et al. Efficacy of ketogenic diet on body composition during resistance training in trained men: a randomized controlled trial. J Int Soc Sports Nutr. 2018;15:31.","journal-title":"J Int Soc Sports Nutr"},{"key":"9658_CR36","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1007\/s12020-016-1050-2","volume":"54","author":"B Moreno","year":"2016","unstructured":"Moreno B, Crujeiras AB, Bellido D, Sajoux I, Casanueva FF. Obesity treatment by very low-calorie-ketogenic diet at two years: reduction in visceral fat and on the burden of disease. Endocrine. 2016;54:681\u201390.","journal-title":"Endocrine"},{"key":"9658_CR37","doi-asserted-by":"publisher","first-page":"2202","DOI":"10.1038\/oby.2012.70","volume":"20","author":"P Nordby","year":"2012","unstructured":"Nordby P, Auerbach PL, Rosenkilde M, Kristiansen L, Thomasen JR, Rygaard L, et al. Endurance training per se increases metabolic health in young, moderately overweight men. Obesity. 2012;20:2202\u201312.","journal-title":"Obesity"},{"key":"9658_CR38","doi-asserted-by":"publisher","first-page":"e56415","DOI":"10.1371\/journal.pone.0056415","volume":"8","author":"D Vissers","year":"2013","unstructured":"Vissers D, Hens W, Taeymans J, Baeyens JP, Poortmans J, Van Gaal L. The effect of exercise on visceral adipose tissue in overweight adults: a systematic review and meta-analysis. PLoS One. 2013;8:e56415.","journal-title":"PLoS One"}],"container-title":["Annals of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-021-09658-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1245\/s10434-021-09658-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-021-09658-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T00:50:22Z","timestamp":1632444622000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1245\/s10434-021-09658-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,7]]},"references-count":38,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["9658"],"URL":"https:\/\/doi.org\/10.1245\/s10434-021-09658-9","relation":{},"ISSN":["1068-9265","1534-4681"],"issn-type":[{"value":"1068-9265","type":"print"},{"value":"1534-4681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,7]]},"assertion":[{"value":"23 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"There are no conflicts of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}