{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:00:15Z","timestamp":1781712015868,"version":"3.54.5"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Medical Faculty at the University of T\u00fcbingen","award":["Project No. 338-0-0"],"award-info":[{"award-number":["Project No. 338-0-0"]}]},{"DOI":"10.13039\/100012940","name":"Universit\u00e4tsklinikum T\u00fcbingen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012940","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Surg Oncol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n              <jats:title>Background<\/jats:title>\n              <jats:p>Pancreatic ductal adenocarcinoma (PDAC) is a common fatal disease with unfavorable prognosis, even after oncological resection. To improve survival, adding hyperthermic intraperitoneal chemotherapy (HIPEC) has been suggested. Whether HIPEC entails disproportional short-term mortality is unknown and a prospectively determined adverse events profile is lacking. Since both pancreatic resection and HIPEC may relevantly influence morbidity and mortality, this uncontrolled single-arm, open-label, phase I\/II pilot trial was designed to assess the 30-day mortality rate, treatment feasibility, and adverse events connected with HIPEC after oncological pancreatic surgery.<\/jats:p>\n            <\/jats:sec><jats:sec>\n              <jats:title>Methods<\/jats:title>\n              <jats:p>This trial recruited patients scheduled for PDAC resection. A sample size of 16 patients receiving study interventions was estimated to establish a predefined margin of treatment-associated short-term mortality with a power of &gt;\u200980%. Patients achieving complete macroscopic resection received HIPEC with gemcitabine administered at 1000\u00a0mg\/m<jats:sup>2<\/jats:sup> body surface area heated to 42\u00a0\u00b0C for 1\u00a0hour.<\/jats:p>\n            <\/jats:sec><jats:sec>\n              <jats:title>Results<\/jats:title>\n              <jats:p>Within 30\u00a0days after intervention, no patient died or experienced any adverse events higher than grade 3 that were related to HIPEC. Furthermore, treatment-related adverse events were prospectively documented and categorized as expected or unexpected. This trial supports that the actual mortality rate after PDAC resection and HIPEC is below 10%. HIPEC treatment proved feasible in 89% of patients allocated to intervention. Pancreatic fistulas, as key complications after pancreas surgery, occurred in 3\/13 patients under risk.<\/jats:p>\n            <\/jats:sec><jats:sec>\n              <jats:title>Conclusion<\/jats:title>\n              <jats:p>Combined pancreas resection and gemcitabine HIPEC proved feasible and safe, with acceptable morbidity and mortality. Based on these results, further clinical evaluation can be justified.<\/jats:p>\n            <\/jats:sec><jats:sec>\n              <jats:title>Registration Number<\/jats:title>\n              <jats:p>NCT02863471 (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>).<\/jats:p>\n            <\/jats:sec>","DOI":"10.1245\/s10434-021-10187-8","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T18:03:16Z","timestamp":1623780196000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Prospective, Phase I\/II, Open-Label Pilot Trial to Assess the Safety of Hyperthermic Intraperitoneal Chemotherapy After Oncological Resection of Pancreatic Adenocarcinoma"],"prefix":"10.1245","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9720-8243","authenticated-orcid":false,"given":"Can","family":"Yurttas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Horvath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imma","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Meisner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio","family":"Nadalin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingmar","family":"K\u00f6nigsrainer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred","family":"K\u00f6nigsrainer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Beckert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2513-1317","authenticated-orcid":false,"given":"Markus W.","family":"L\u00f6ffler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,15]]},"reference":[{"issue":"4","key":"10187_CR1","doi-asserted-by":"publisher","first-page":"703","DOI":"10.21037\/jgo.2018.07.08","volume":"10","author":"I Azar","year":"2019","unstructured":"Azar I, Virk G, Esfandiarifard S, Wazir A, Mehdi S. Treatment and survival rates of stage IV pancreatic cancer at VA hospitals: a nation-wide study. J Gastrointest Oncol. 2019;10(4):703\u201311.","journal-title":"J Gastrointest Oncol."},{"issue":"11","key":"10187_CR2","doi-asserted-by":"publisher","first-page":"3157","DOI":"10.3748\/wjg.v21.i11.3157","volume":"21","author":"D Ansari","year":"2015","unstructured":"Ansari D, Gustafsson A, Andersson R. Update on the management of pancreatic cancer: surgery is not enough. World J Gastroenterol. 2015;21(11):3157\u201365.","journal-title":"World J Gastroenterol."},{"key":"10187_CR3","doi-asserted-by":"crossref","unstructured":"Geer RJ, Brennan MF. Prognostic indicators for survival after resection of pancreatic adenocarcinoma. Am J Surg. 1993;165(1):68\u201373.","DOI":"10.1016\/S0002-9610(05)80406-4"},{"issue":"14","key":"10187_CR4","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1001\/jama.2013.279201","volume":"310","author":"H Oettle","year":"2013","unstructured":"Oettle H, Neuhaus P, Hochhaus A, et al. Adjuvant chemotherapy with gemcitabine and long-term outcomes among patients with resected pancreatic cancer: the CONKO-001 randomized trial. JAMA. 2013;310(14):1473\u201381.","journal-title":"JAMA."},{"issue":"1","key":"10187_CR5","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1002\/1097-0142(19900701)66:1<56::AID-CNCR2820660112>3.0.CO;2-6","volume":"66","author":"JF Griffin","year":"1990","unstructured":"Griffin JF, Smalley SR, Jewell W, et al. Patterns of failure after curative resection of pancreatic carcinoma. Cancer. 1990;66(1):56\u201361.","journal-title":"Cancer."},{"issue":"2","key":"10187_CR6","doi-asserted-by":"publisher","first-page":"174","DOI":"10.2174\/157489209788452876","volume":"4","author":"A Kamath","year":"2009","unstructured":"Kamath A, Yoo D, Stuart OA, Bijelic L, Sugarbaker PH. Rationale for an intraperitoneal gemcitabine chemotherapy treatment for patients with resected pancreatic cancer. Recent Pat Anticancer Drug Discov. 2009;4(2):174\u20139.","journal-title":"Recent Pat Anticancer Drug Discov."},{"issue":"2","key":"10187_CR7","first-page":"161","volume":"1","author":"PH Sugarbaker","year":"2012","unstructured":"Sugarbaker PH, Stuart OA, Bijelic L. Intraperitoneal gemcitabine chemotherapy as an adjuvant treatment for patients with resected pancreatic cancer: phase II and pharmacologic studies. Transl Gastrointest Cancer. 2012;1(2):161\u20138.","journal-title":"Transl Gastrointest Cancer."},{"issue":"1","key":"10187_CR8","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1002\/jso.10000","volume":"79","author":"K Ridwelski","year":"2002","unstructured":"Ridwelski K, Meyer F, Hribaschek A, Kasper U, Lippert H. Intraoperative and early postoperative chemotherapy into the abdominal cavity using gemcitabine may prevent postoperative occurence of peritoneal carcinomatosis. J Surg Oncol. 2002;79(1):10\u20136.","journal-title":"J Surg Oncol."},{"issue":"4","key":"10187_CR9","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1007\/s00280-007-0647-9","volume":"62","author":"TC Gamblin","year":"2008","unstructured":"Gamblin TC, Egorin MJ, Zuhowski EG, et al. Intraperitoneal gemcitabine pharmacokinetics: a pilot and pharmacokinetic study in patients with advanced adenocarcinoma of the pancreas. Cancer Chemother Pharmacol. 2008;62(4):647\u201353.","journal-title":"Cancer Chemother Pharmacol."},{"key":"10187_CR10","first-page":"161862","volume":"2011","author":"PH Sugarbaker","year":"2011","unstructured":"Sugarbaker PH, Stuart OA, Bijelic L. Intraperitoneal gemcitabine chemotherapy treatment for patients with resected pancreatic cancer: rationale and report of early data. Int J Surg Oncol. 2011;2011:161862.","journal-title":"Int J Surg Oncol."},{"key":"10187_CR11","doi-asserted-by":"publisher","first-page":"506571","DOI":"10.1155\/2012\/506571","volume":"2012","author":"AA Tentes","year":"2012","unstructured":"Tentes AA, Kyziridis D, Kakolyris S, et al. Preliminary results of hyperthermic intraperitoneal intraoperative chemotherapy as an adjuvant in resectable pancreatic cancer. Gastroenterol Res Pract. 2012;2012:506571.","journal-title":"Gastroenterol Res Pract."},{"issue":"2","key":"10187_CR12","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1159\/000052029","volume":"19","author":"CM Halloran","year":"2002","unstructured":"Halloran CM, Ghaneh P, Bosonnet L, Hartley MN, Sutton R, Neoptolemos JP. Complications of pancreatic cancer resection. Dig Surg. 2002;19(2):138\u201346.","journal-title":"Dig Surg."},{"issue":"4","key":"10187_CR13","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1097\/00000658-199304000-00007","volume":"217","author":"KE Bakkevold","year":"1993","unstructured":"Bakkevold KE, Kambestad B. Morbidity and mortality after radical and palliative pancreatic cancer surgery. Risk factors influencing the short-term results. Ann Surg. 1993;217(4):356\u201368.","journal-title":"Ann Surg."},{"issue":"6","key":"10187_CR14","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1097\/00000658-200012000-00007","volume":"232","author":"DJ Gouma","year":"2000","unstructured":"Gouma DJ, van Geenen RC, van Gulik TM, et al. Rates of complications and death after pancreaticoduodenectomy: risk factors and the impact of hospital volume. Ann Surg. 2000;232(6):786\u201395.","journal-title":"Ann Surg."},{"issue":"4","key":"10187_CR15","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1002\/jso.21332","volume":"100","author":"G Glockzin","year":"2009","unstructured":"Glockzin G, Ghali N, Lang SA, Schlitt HJ, Piso P. Results of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis from colorectal cancer. J Surg Oncol. 2009;100(4):306\u201310.","journal-title":"J Surg Oncol."},{"issue":"8\u20139","key":"10187_CR16","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1016\/0959-8049(92)90510-9","volume":"28A","author":"E Verger","year":"1992","unstructured":"Verger E, Salamero M, Conill C. Can Karnofsky performance status be transformed to the eastern cooperative oncology group scoring scale and vice versa? Eur J Cancer. 1992;28A(8\u20139):1328\u201330.","journal-title":"Eur J Cancer."},{"issue":"4","key":"10187_CR17","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1002\/jso.21053","volume":"98","author":"J Esquivel","year":"2008","unstructured":"Esquivel J, Elias D, Baratti D, Kusamura S, Deraco M. Consensus statement on the loco regional treatment of colorectal cancer with peritoneal dissemination. J Surg Oncol. 2008;98(4):263\u20137.","journal-title":"J Surg Oncol."},{"key":"10187_CR18","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1001\/archinte.1916.00080130010002","volume":"17","author":"D Du Bois","year":"1916","unstructured":"Du Bois D, Du Bois EF. A formula to estimate the approximate surface area if height and weight be known. Arch Intern Med. 1916;17:863\u201371.","journal-title":"Arch Intern Med."},{"issue":"1","key":"10187_CR19","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1517\/14796694.1.1.7","volume":"1","author":"L Toschi","year":"2005","unstructured":"Toschi L, Finocchiaro G, Bartolini S, Gioia V, Cappuzzo F. Role of gemcitabine in cancer therapy. Future Oncol. 2005;1(1):7\u201317.","journal-title":"Future Oncol."},{"issue":"3","key":"10187_CR20","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.surg.2016.11.014","volume":"161","author":"C Bassi","year":"2017","unstructured":"Bassi C, Marchegiani G, Dervenis C, et al. The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 years after. Surgery. 2017;161(3):584\u201391.","journal-title":"Surgery."},{"key":"10187_CR21","doi-asserted-by":"crossref","unstructured":"Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240(2):205\u201313.","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"issue":"8","key":"10187_CR22","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1080\/02656736.2016.1227094","volume":"32","author":"AA Tentes","year":"2016","unstructured":"Tentes AA, Stamou K, Pallas N, Karamveri C, Kyziridis D, Hristakis C. The effect of hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) as an adjuvant in patients with resectable pancreatic cancer. Int J Hyperth. 2016;32(8):895\u20139.","journal-title":"Int J Hyperth."},{"issue":"2","key":"10187_CR23","first-page":"482","volume":"23","author":"AA Tentes","year":"2018","unstructured":"Tentes AA, Pallas N, Karamveri C, Kyziridis D, Hristakis C. Cytoreduction and HIPEC for peritoneal carcinomatosis of pancreatic cancer. J BUON. 2018;23(2):482\u20137.","journal-title":"J BUON."},{"issue":"1","key":"10187_CR24","doi-asserted-by":"publisher","first-page":"e186847","DOI":"10.1001\/jamanetworkopen.2018.6847","volume":"2","author":"JM Foster","year":"2019","unstructured":"Foster JM, Sleightholm R, Patel A, et al. Morbidity and chemotherapy compared with other high-risk surgical oncology procedures. JAMA Netw Open. 2019;2(1):e186847.","journal-title":"JAMA Netw Open."},{"issue":"6","key":"10187_CR25","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1002\/jso.22017","volume":"104","author":"RS Gill","year":"2011","unstructured":"Gill RS, Al-Adra DP, Nagendran J, et al. Treatment of gastric cancer with peritoneal carcinomatosis by cytoreductive surgery and HIPEC: a systematic review of survival, mortality, and morbidity. J Surg Oncol. 2011;104(6):692\u20138.","journal-title":"J Surg Oncol."},{"issue":"11","key":"10187_CR26","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1002\/bjs.11588","volume":"107","author":"RT van der Kaaij","year":"2020","unstructured":"van der Kaaij RT, Wassenaar ECE, Koemans WJ, et al. Treatment of peritoneal disease in stomach cancer with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: PERISCOPE I initial results. Br J Surg. 2020;107(11):1520\u20138.","journal-title":"Br J Surg."},{"issue":"2","key":"10187_CR27","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1097\/SLA.0000000000001225","volume":"263","author":"L Schwarz","year":"2016","unstructured":"Schwarz L, Votanopoulos K, Morris D, et al. Is the combination of distal pancreatectomy and cytoreductive surgery with HIPEC reasonable? Results of an international multicenter study. Ann Surg. 2016;263(2):369\u201375.","journal-title":"Ann Surg."},{"issue":"5","key":"10187_CR28","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1245\/s10434-014-4186-4","volume":"22","author":"S Downs-Canner","year":"2015","unstructured":"Downs-Canner S, Ding Y, Magge DR, et al. A comparative analysis of postoperative pancreatic fistulas after surgery with and without hyperthermic intraperitoneal chemoperfusion. Ann Surg Oncol. 2015;22(5):1651\u20137.","journal-title":"Ann Surg Oncol."},{"issue":"2","key":"10187_CR29","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1097\/SLA.0000000000001537","volume":"264","author":"MT McMillan","year":"2016","unstructured":"McMillan MT, Soi S, Asbun HJ, et al. Risk-adjusted outcomes of clinically relevant pancreatic fistula following pancreatoduodenectomy: a model for performance evaluation. Ann Surg. 2016;264(2):344\u201352.","journal-title":"Ann Surg."},{"issue":"2","key":"10187_CR30","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1159\/000456042","volume":"33","author":"C Krautz","year":"2017","unstructured":"Krautz C, Denz A, Weber GF, Grutzmann R. Influence of hospital volume effects and minimum caseload requirements on quality of care in pancreatic surgery in Germany. Visc Med. 2017;33(2):131\u20134.","journal-title":"Visc Med."},{"issue":"2","key":"10187_CR31","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/S1470-2045(20)30599-4","volume":"22","author":"F Quenet","year":"2021","unstructured":"Quenet F, Elias D, Roca L, et al. Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy versus cytoreductive surgery alone for colorectal peritoneal metastases (PRODIGE 7): a multicentre, randomised, open-label, phase 3 trial. Lancet Oncol. 2021;22(2):256\u201366.","journal-title":"Lancet Oncol."},{"issue":"10","key":"10187_CR32","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/S2468-1253(19)30239-0","volume":"4","author":"CEL Klaver","year":"2019","unstructured":"Klaver CEL, Wisselink DD, Punt CJA, et al. Adjuvant hyperthermic intraperitoneal chemotherapy in patients with locally advanced colon cancer (COLOPEC): a multicentre, open-label, randomised trial. Lancet Gastroenterol Hepatol. 2019;4(10):761\u201370.","journal-title":"Lancet Gastroenterol Hepatol."},{"issue":"5","key":"10187_CR33","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.jviscsurg.2019.08.002","volume":"156","author":"K Abboud","year":"2019","unstructured":"Abboud K, Andre T, Brunel M, et al. Management of colorectal peritoneal metastases: Expert opinion. J Visc Surg. 2019;156(5):377\u20139.","journal-title":"J Visc Surg."},{"issue":"3","key":"10187_CR34","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.ejso.2018.10.542","volume":"45","author":"W Ceelen","year":"2019","unstructured":"Ceelen W. HIPEC with oxaliplatin for colorectal peritoneal metastasis: the end of the road? Eur J Surg Oncol. 2019;45(3):400\u20132.","journal-title":"Eur J Surg Oncol."},{"issue":"4","key":"10187_CR35","doi-asserted-by":"publisher","first-page":"20180131","DOI":"10.1515\/pp-2018-0131","volume":"3","author":"A K\u00f6nigsrainer","year":"2018","unstructured":"K\u00f6nigsrainer A, Rau B. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC): don\u2019t throw the baby out with the bathwater. Pleura Peritoneum. 2018;3(4):20180131.","journal-title":"Pleura Peritoneum."},{"issue":"4","key":"10187_CR36","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1080\/00015458.2019.1610260","volume":"119","author":"G Liberale","year":"2019","unstructured":"Liberale G, Ameye L, Hendlisz A. PRODIGE 7 should be interpreted with caution. Acta Chir Belg. 2019;119(4):263\u20136.","journal-title":"Acta Chir Belg."},{"key":"10187_CR37","first-page":"434","volume":"13","author":"C Yurttas","year":"2020","unstructured":"Yurttas C, Fisher OM, Corts-Guiral D, et al. Cytoreductive surgery and HIPEC in colorectal cancer did we get hold of the wrong end of the stick. Memo Mag Eur Med Oncol. 2020;13:434\u20139.","journal-title":"Memo Mag Eur Med Oncol."},{"issue":"2","key":"10187_CR38","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/s10585-021-10074-2","volume":"38","author":"A Brind'Amour","year":"2021","unstructured":"Brind\u2019Amour A, Webb M, Parapini M, et al. The role of intraperitoneal chemotherapy in the surgical management of pancreatic ductal adenocarcinoma: a systematic review. Clin Exp Metastasis. 2021;38(2):187\u201396.","journal-title":"Clin Exp Metastasis."},{"issue":"1","key":"10187_CR39","doi-asserted-by":"publisher","first-page":"78","DOI":"10.3390\/cancers11010078","volume":"11","author":"RFCPA Helderman","year":"2019","unstructured":"Helderman RFCPA, Loke DR, Kok HP, et al. Variation in clinical application of hyperthermic intraperitoneal chemotherapy: a review. Cancers (Basel). 2019;11(1):78.","journal-title":"Cancers (Basel)"},{"issue":"12","key":"10187_CR40","doi-asserted-by":"publisher","first-page":"567","DOI":"10.3390\/jcm7120567","volume":"7","author":"C Yurttas","year":"2018","unstructured":"Yurttas C, Hoffmann G, Tolios A, et al. Systematic review of variations in hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal metastasis from colorectal cancer. J Clin Med. 2018;7(12):567.","journal-title":"J Clin Med."},{"issue":"6","key":"10187_CR41","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1245\/s10434-017-5790-x","volume":"24","author":"MW L\u00f6ffler","year":"2017","unstructured":"L\u00f6ffler MW, Schuster H, Zeck A, et al. Pharmacodynamics of oxaliplatin-derived platinum compounds during hyperthermic intraperitoneal chemotherapy (HIPEC): an emerging aspect supporting the rational design of treatment protocols. Ann Surg Oncol. 2017;24(6):1650\u20137.","journal-title":"Ann Surg Oncol."},{"issue":"10","key":"10187_CR42","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1002\/bjs.11206","volume":"106","author":"I Ubink","year":"2019","unstructured":"Ubink I, Bolhaqueiro ACF, Elias SG, et al. Organoids from colorectal peritoneal metastases as a platform for improving hyperthermic intraperitoneal chemotherapy. Br J Surg. 2019;106(10):1404\u201314.","journal-title":"Br J Surg."},{"issue":"2","key":"10187_CR43","doi-asserted-by":"publisher","first-page":"100","DOI":"10.4103\/0976-500X.72352","volume":"1","author":"KF Schulz","year":"2010","unstructured":"Schulz KF, Altman DG, Moher D. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. J Pharmacol Pharmacother. 2010;1(2):100\u20137.","journal-title":"J Pharmacol Pharmacother."}],"container-title":["Annals of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-021-10187-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1245\/s10434-021-10187-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-021-10187-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T18:03:29Z","timestamp":1623780209000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1245\/s10434-021-10187-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,15]]},"references-count":43,"alternative-id":["10187"],"URL":"https:\/\/doi.org\/10.1245\/s10434-021-10187-8","relation":{},"ISSN":["1068-9265","1534-4681"],"issn-type":[{"value":"1068-9265","type":"print"},{"value":"1534-4681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,15]]},"assertion":[{"value":"22 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Markus W. L\u00f6ffler and Alfred K\u00f6nigsrainer received a research grant from RanD S.r.l., the manufacturer of devices and consumables for HIPEC, unrelated to the present work. Can Yurttas, Philipp Horvath, Imma Fischer, Christoph Meisner, Silvio Nadalin, Ingmar K\u00f6nigsrainer, and Stefan Beckert declare no potential conflicts of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure"}}]}}