{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T10:25:58Z","timestamp":1771842358392,"version":"3.50.1"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"13","license":[{"start":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Clinical Research Project by Shanghai Shenkang Hospital Development Center","award":["SHDC12017X10"],"award-info":[{"award-number":["SHDC12017X10"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Surg Oncol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>To investigate the safety and efficacy of ureteroscopic cryoablation by a liquid-nitrogen system in a porcine model and for patients with upper tract urothelial carcinoma (UTUC) of a solitary kidney.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In the animal experiment, the right-sided ureter was frozen in nine pigs. Eight were randomly assigned to two different groups according to the freezing duration of 60 or 90 s. The other one was designed to receive a 10-min freeze. The treated ureters were harvested at 30 min, 2 days, 4 weeks, and 3 months after cryoablation for histological evaluation. After the animal study, we conducted a pilot clinical trial that enrolled six patients who were diagnosed with UTUC of a solitary kidney and received therapeutic management with ureteroscopic cryoablation at our center. Perioperative adverse events and oncological outcomes were evaluated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In the porcine model, the liquid-nitrogen system was capable of forming a therapeutic ice ball which infiltrated the full-thickness ureter and induced apoptosis and necrosis from mucosa to lamina muscularis through histological examination. In the clinical trial, cryoablation was successfully performed under ureteroscopy in all the\u00a0patients, without intraoperative ureteral perforation, avulsion, or active hemorrhage. No recurrence in situ was observed during a median follow-up period of 12.5 months. Hydronephrosis and ureteral stricture was observed in one patient and was managed with ureteroscopic balloon dilation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Ureteroscopic cryoablation induced by liquid nitrogen is a promising technique for conservative management of UTUC with benefits of improving local tumor control and preservation of a solitary kidney.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1245\/s10434-021-10233-5","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T14:03:08Z","timestamp":1623765788000},"page":"9201-9208","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Ureteroscopic Cryoablation for Patients with Upper Tract Urothelial Carcinoma of a\u00a0Solitary Kidney: A Porcine Model and Our Pilot Clinical Experience"],"prefix":"10.1245","volume":"28","author":[{"given":"Lujia","family":"Zou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongzong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenyang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimeng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haowen","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,6,15]]},"reference":[{"issue":"1","key":"10233_CR1","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.eururo.2020.05.042","volume":"79","author":"M Roupr\u00eat","year":"2021","unstructured":"Roupr\u00eat M, Babjuk M, Burger M, et al. European Association of Urology guidelines on upper urinary tract urothelial carcinoma: 2020 update. Eur Urol. 2021;79(1):62\u201379. https:\/\/doi.org\/10.1016\/j.eururo.2020.05.042.","journal-title":"Eur Urol."},{"issue":"6","key":"10233_CR2","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1016\/j.eururo.2016.07.014","volume":"70","author":"T Seisen","year":"2016","unstructured":"Seisen T, Peyronnet B, Dominguez-Escrig JL, et al. Oncologic outcomes of kidney-sparing surgery versus radical nephroureterectomy for upper tract urothelial carcinoma: a systematic review by the EAU Non-muscle Invasive Bladder Cancer Guidelines Panel. Eur Urol. 2016;70(6):1052\u201368. https:\/\/doi.org\/10.1016\/j.eururo.2016.07.014.","journal-title":"Eur Urol."},{"issue":"11","key":"10233_CR3","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1111\/j.1464-410X.2012.11066.x","volume":"110","author":"M Grasso","year":"2012","unstructured":"Grasso M, Fishman AI, Cohen J, Alexander B. Ureteroscopic and extirpative treatment of upper urinary tract urothelial carcinoma: a 15-year comprehensive review of 160 consecutive patients. BJU Int. 2012;110(11):1618\u201326. https:\/\/doi.org\/10.1111\/j.1464-410X.2012.11066.x.","journal-title":"BJU Int."},{"issue":"6","key":"10233_CR4","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.1016\/j.juro.2012.12.006","volume":"189","author":"ML Cutress","year":"2013","unstructured":"Cutress ML, Stewart GD, Tudor ECG, et al. Endoscopic versus laparoscopic management of noninvasive upper tract urothelial carcinoma: 20-year single center experience. J Urol. 2013;189(6):2054\u201360. https:\/\/doi.org\/10.1016\/j.juro.2012.12.006.","journal-title":"J Urol."},{"issue":"2","key":"10233_CR5","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.cryobiol.2016.02.007","volume":"72","author":"S Liu","year":"2016","unstructured":"Liu S, Zou L, Mao S, et al. The safety and efficacy of bladder cryoablation in a beagle model by using a novel balloon cryoprobe. Cryobiology. 2016;72(2):157\u201360. https:\/\/doi.org\/10.1016\/j.cryobiol.2016.02.007.","journal-title":"Cryobiology."},{"issue":"2","key":"10233_CR6","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.urology.2007.03.028","volume":"70","author":"GW Hruby","year":"2007","unstructured":"Hruby GW, Marruffo F, Ortiz J, et al. Transurethral bladder cryoablation in the porcine model. Urology. 2007;70(2):391\u20135. https:\/\/doi.org\/10.1016\/j.urology.2007.03.028.","journal-title":"Urology."},{"issue":"12","key":"10233_CR7","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1089\/end.2006.20.991","volume":"20","author":"S Permpongkosol","year":"2006","unstructured":"Permpongkosol S, Nicol TL, Kavoussi LR, Jarrett TW. Percutaneous bladder cryoablation in porcine model. J Endourol. 2006;20(12):991\u20135. https:\/\/doi.org\/10.1089\/end.2006.20.991.","journal-title":"J Endourol."},{"issue":"3","key":"10233_CR8","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1177\/1756287212465457","volume":"5","author":"NE Power","year":"2013","unstructured":"Power NE, Silberstein JL, Tarin T, et al. Endoscopic spray cryotherapy for genitourinary malignancies: safety and efficacy in a porcine model. Ther Adv Urol. 2013;5(3):135\u201341. https:\/\/doi.org\/10.1177\/1756287212465457.","journal-title":"Ther Adv Urol."},{"issue":"2","key":"10233_CR9","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.cryobiol.2016.07.001","volume":"73","author":"S Liu","year":"2016","unstructured":"Liu S, Zhang L, Zou L, Wen H, Ding Q, Jiang H. The feasibility and safety of cryoablation as an adjuvant therapy with transurethral resection of bladder tumor: A pilot study. Cryobiology. 2016;73(2):257\u201360. https:\/\/doi.org\/10.1016\/j.cryobiol.2016.07.001.","journal-title":"Cryobiology."},{"issue":"1","key":"10233_CR10","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1186\/s12894-020-00744-w","volume":"20","author":"F Dursun","year":"2020","unstructured":"Dursun F, Pan MM, Morgan M, Gonzalez RR, Satkunasivam R. 532 nm green-light laser vaporization of upper tract urothelial carcinoma. BMC Urol. 2020;20(1):172. https:\/\/doi.org\/10.1186\/s12894-020-00744-w.","journal-title":"BMC Urol."},{"issue":"4","key":"10233_CR11","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s11934-017-0675-x","volume":"18","author":"DP Verges","year":"2017","unstructured":"Verges DP, Lallas CD, Hubosky SG, Bagley DHJ. Endoscopic treatment of upper tract urothelial carcinoma. Curr Urol Rep. 2017;18(4):31. https:\/\/doi.org\/10.1007\/s11934-017-0675-x.","journal-title":"Curr Urol Rep."},{"key":"10233_CR12","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.cryobiol.2020.07.006","volume":"96","author":"C Wang","year":"2020","unstructured":"Wang C, Yang X, Fan Q, Yuan J, Li Y, Wang Y. Feasibility and safety of cryoablation on the porcine ureter using a new balloon cryoprobe. Cryobiology. 2020;96:130\u20136. https:\/\/doi.org\/10.1016\/j.cryobiol.2020.07.006.","journal-title":"Cryobiology."},{"issue":"1","key":"10233_CR13","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/S0008-6363(03)00336-5","volume":"59","author":"AN Cheema","year":"2003","unstructured":"Cheema AN, Nili N, Li CW, et al. Effects of intravascular cryotherapy on vessel wall repair in a balloon-injured rabbit iliac artery model. Cardiovasc Res. 2003;59(1):222\u201333.","journal-title":"Cardiovasc Res."},{"issue":"2 Pt 1","key":"10233_CR14","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1097\/01.ju.0000070437.14275.e0","volume":"170","author":"M-O Grimm","year":"2003","unstructured":"Grimm M-O, Steinhoff C, Simon X, Spiegelhalder P, Ackermann R, Vogeli TA. Effect of routine repeat transurethral resection for superficial bladder cancer: a long-term observational study. J Urol. 2003;170(2 Pt 1):433\u20137. https:\/\/doi.org\/10.1097\/01.ju.0000070437.14275.e0.","journal-title":"J Urol."}],"container-title":["Annals of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-021-10233-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1245\/s10434-021-10233-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-021-10233-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,14]],"date-time":"2021-11-14T15:06:47Z","timestamp":1636902407000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1245\/s10434-021-10233-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,15]]},"references-count":14,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10233"],"URL":"https:\/\/doi.org\/10.1245\/s10434-021-10233-5","relation":{},"ISSN":["1068-9265","1534-4681"],"issn-type":[{"value":"1068-9265","type":"print"},{"value":"1534-4681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,15]]},"assertion":[{"value":"16 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The  cryoablation probe is certified as a patent belonging to the corresponding author Prof. Haowen Jiang.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure"}}]}}