{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:28:11Z","timestamp":1788517691116,"version":"build-2803163510"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:00:00Z","timestamp":1711324800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:00:00Z","timestamp":1711324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Johann Wolfgang Goethe-Universit\u00e4t, Frankfurt am Main"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Surg Oncol"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In-hospital mortality and complication rates after partial and radical nephrectomy in patients with history of heart-valve replacement are unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Relying on the National Inpatient Sample (2000\u20132019), kidney cancer patients undergoing partial or radical nephrectomy were stratified according to presence or absence of heart-valve replacement. Multivariable logistic and Poisson regression models addressed adverse hospital outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 39,673 patients underwent partial nephrectomy versus 94,890 radical nephrectomy. Of those, 248 (0.6%) and 676 (0.7%) had a history of heart-valve replacement. Heart-valve replacement patients were older (median partial nephrectomy 69 versus 60 years; radical nephrectomy 71 versus 63 years), and more frequently exhibited Charlson comorbidity index \u2265 3 (partial nephrectomy 22 versus 12%; radical nephrectomy 32 versus 23%). In partial nephrectomy patients, history of heart-valve replacement increased the risk of cardiac complications [odds ratio (OR) 4.33;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), blood transfusions (OR 2.00;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), intraoperative complications (OR 1.53;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.03), and longer hospital stay [rate ratio (RR) 1.25;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001], but not in-hospital mortality (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.5). In radical nephrectomy patients, history of heart-valve replacement increased risk of postoperative bleeding (OR 4.13;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), cardiac complications (OR 2.72;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), intraoperative complications (OR 1.53;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), blood transfusions (OR 1.27;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.02), and longer hospital stay (RR 1.12;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), but not in-hospital mortality (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.5).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>History of heart-valve replacement independently predicted four of twelve adverse outcomes in partial nephrectomy and five of twelve adverse outcomes in radical nephrectomy patients including intraoperative and cardiac complications, blood transfusions, and longer hospital stay. Conversely, no statistically significant differences were observed in in-hospital mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1245\/s10434-024-15228-6","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T09:02:21Z","timestamp":1711357341000},"page":"5449-5456","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Perioperative Complications and In-Hospital Mortality in Partial and Radical Nephrectomy Patients with Heart-Valve Replacement"],"prefix":"10.1245","volume":"31","author":[{"given":"Carolin","family":"Siech","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Baudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"de Angelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letizia Maria Ippolita","family":"Jannello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Di Bello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan A.","family":"Goyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Saad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahrokh F.","family":"Shariat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Longo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Carmignani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ottavio","family":"de Cobelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Briganti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Kosiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Mandel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A.","family":"Kluth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix K. H.","family":"Chun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre I.","family":"Karakiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,25]]},"reference":[{"key":"15228_CR1","doi-asserted-by":"publisher","first-page":"71","DOI":"10.6004\/jnccn.2022.0001","volume":"20","author":"RJ Motzer","year":"2022","unstructured":"Motzer RJ, Jonasch E, Agarwal N, Alva A, Baine M, Beckermann K, et al. Kidney cancer, version 3.2022, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2022;20:71\u201390. https:\/\/doi.org\/10.6004\/jnccn.2022.0001.","journal-title":"J Natl Compr Canc Netw."},{"key":"15228_CR2","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.eururo.2022.03.006","volume":"82","author":"B Ljungberg","year":"2022","unstructured":"Ljungberg B, Albiges L, Abu-Ghanem Y, Bedke J, Capitanio U, Dabestani S, et al. European association of urology guidelines on renal cell carcinoma: the 2022 update. Eur Urol. 2022;82:399\u2013410. https:\/\/doi.org\/10.1016\/j.eururo.2022.03.006.","journal-title":"Eur Urol."},{"key":"15228_CR3","unstructured":"Agency for Healthcare Research and Quality, Rockville, MD. HCUP Nationwide Inpatient Sample (NIS). Healthcare Cost and Utilization Project (HCUP). 2008-2019 n.d. www.hcup-us.ahrq.gov\/nisoverview.jsp (accessed September 2 2023)."},{"key":"15228_CR4","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1016\/j.juro.2007.01.037","volume":"177","author":"FN Joudi","year":"2007","unstructured":"Joudi FN, Veerasathpurush A, Kane CJ, Konety BR. Analysis of complications following partial and total nephrectomy for renal cancer in a population based sample. J Urol. 2007;177:1709\u201314. https:\/\/doi.org\/10.1016\/j.juro.2007.01.037.","journal-title":"J Urol."},{"key":"15228_CR5","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/j.jgo.2019.06.005","volume":"11","author":"C Palumbo","year":"2020","unstructured":"Palumbo C, Knipper S, Dzyuba-Negrean C, Pecoraro A, Rosiello G, Tian Z, et al. Complication rates, failure to rescue and in-hospital mortality after cytoreductive nephrectomy in the older patients. J Geriatr Oncol. 2020;11:718\u201323. https:\/\/doi.org\/10.1016\/j.jgo.2019.06.005.","journal-title":"J Geriatr Oncol."},{"key":"15228_CR6","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.1016\/j.ejso.2022.01.001","volume":"48","author":"G Rosiello","year":"2022","unstructured":"Rosiello G, Re C, Larcher A, Fallara G, Sorce G, Baiamonte G, et al. The effect of frailty on post-operative outcomes and health care expenditures in patients treated with partial nephrectomy. Eur J Surg Oncol. 2022;48:1840\u20137. https:\/\/doi.org\/10.1016\/j.ejso.2022.01.001.","journal-title":"Eur J Surg Oncol."},{"key":"15228_CR7","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.canep.2018.08.006","volume":"56","author":"E Mazzone","year":"2018","unstructured":"Mazzone E, Nazzani S, Preisser F, Tian Z, Marchioni M, Bandini M, et al. Partial nephrectomy seems to confer a survival benefit relative to radical nephrectomy in metastatic renal cell carcinoma. Cancer Epidemiol. 2018;56:118\u201325. https:\/\/doi.org\/10.1016\/j.canep.2018.08.006.","journal-title":"Cancer Epidemiol."},{"key":"15228_CR8","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1111\/echo.14473","volume":"36","author":"P Urja","year":"2019","unstructured":"Urja P, Walters RW, Vivekanandan R, Kumar M, Abdulghani S, Hari Belbase R, et al. Trends in the use of echocardiography in patients with Staphylococcus aureus bacteremia: an analysis using the Nationwide Inpatient Sample data. Echocardiography. 2019;36:1625\u201332. https:\/\/doi.org\/10.1111\/echo.14473.","journal-title":"Echocardiography."},{"key":"15228_CR9","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.6004\/jnccn.2018.7039","volume":"16","author":"KP Loh","year":"2018","unstructured":"Loh KP, Abdallah M, Shieh M-S, Stefan MS, Pekow PS, Lindenauer PK, et al. Use of inpatient palliative care services in patients with advanced cancer receiving critical care therapies. J Natl Compr Canc Netw. 2018;16:1055\u201364. https:\/\/doi.org\/10.6004\/jnccn.2018.7039.","journal-title":"J Natl Compr Canc Netw."},{"key":"15228_CR10","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.6004\/jnccn.2019.7319","volume":"17","author":"E Mazzone","year":"2019","unstructured":"Mazzone E, Knipper S, Mistretta FA, Palumbo C, Tian Z, Gallina A, et al. Trends and social barriers for inpatient palliative care in patients with metastatic bladder cancer receiving critical care therapies. J Natl Compr Canc Netw. 2019;17:1344\u201352. https:\/\/doi.org\/10.6004\/jnccn.2019.7319.","journal-title":"J Natl Compr Canc Netw."},{"key":"15228_CR11","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/s41391-019-0183-9","volume":"23","author":"E Mazzone","year":"2020","unstructured":"Mazzone E, Mistretta FA, Knipper S, Tian Z, Palumbo C, Gandaglia G, et al. Temporal trends and social barriers for inpatient palliative care delivery in metastatic prostate cancer patients receiving critical care therapies. Prostate Cancer Prostatic Dis. 2020;23:260\u20138. https:\/\/doi.org\/10.1038\/s41391-019-0183-9.","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"15228_CR12","unstructured":"United States Department of Labor, U.S. Bureau of labor statistics; consumer price index. n.d. https:\/\/www.bls.gov\/cpi, 2021 (accessed December 6, 2023)."},{"key":"15228_CR13","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/0895-4356(92)90133-8","volume":"45","author":"RA Deyo","year":"1992","unstructured":"Deyo RA, Cherkin DC, Ciol MA. Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol. 1992;45:613\u20139. https:\/\/doi.org\/10.1016\/0895-4356(92)90133-8.","journal-title":"J Clin Epidemiol."},{"key":"15228_CR14","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1097\/01.mlr.0000182534.19832.83","volume":"43","author":"H Quan","year":"2005","unstructured":"Quan H, Sundararajan V, Halfon P, Fong A, Burnand B, Luthi J-C, et al. Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data. Medical Care. 2005;43:1130\u20139.","journal-title":"Medical Care"},{"key":"15228_CR15","unstructured":"R Core Team. R: A Language and Environment for Statistical Computing. R: A Language and Environment for Statistical Computing 2022. https:\/\/www.R-project.org\/ (accessed August 27, 2023)."},{"key":"15228_CR16","doi-asserted-by":"publisher","first-page":"46.e1","DOI":"10.1016\/j.urolonc.2013.06.010","volume":"32","author":"M Bianchi","year":"2014","unstructured":"Bianchi M, Gandaglia G, Trinh Q-D, Hansen J, Becker A, Abdollah F, et al. A population-based competing-risks analysis of survival after nephrectomy for renal cell carcinoma. Urol Oncol. 2014;32:46.e1-46.e7. https:\/\/doi.org\/10.1016\/j.urolonc.2013.06.010.","journal-title":"Urol Oncol."},{"key":"15228_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2023.06.003","author":"C Cano Garcia","year":"2023","unstructured":"Cano Garcia C, Flammia RS, Piccinelli M, Panunzio A, Tappero S, Barletta F, et al. Differences in survival of clear cell metastatic renal cell carcinoma according to partial versus radical cytoreductive nephrectomy. Clin Genitourin Cancer. 2023. https:\/\/doi.org\/10.1016\/j.clgc.2023.06.003.","journal-title":"Clin Genitourin Cancer."},{"key":"15228_CR18","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.clgc.2023.10.011","volume":"22","author":"A Baudo","year":"2024","unstructured":"Baudo A, Incesu R-B, Morra S, Scheipner L, Jannello LMI, de Angelis M, et al. Other-cause mortality, according to partial versus radical nephrectomy: age and stage analyses. Clin Genitourin Cancer. 2024;22:181\u20138. https:\/\/doi.org\/10.1016\/j.clgc.2023.10.011.","journal-title":"Clin Genitourin Cancer."}],"container-title":["Annals of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-024-15228-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1245\/s10434-024-15228-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-024-15228-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T17:02:00Z","timestamp":1720630920000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1245\/s10434-024-15228-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,25]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["15228"],"URL":"https:\/\/doi.org\/10.1245\/s10434-024-15228-6","relation":{},"ISSN":["1068-9265","1534-4681"],"issn-type":[{"value":"1068-9265","type":"print"},{"value":"1534-4681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,25]]},"assertion":[{"value":"8 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflicts of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"DISCLOSURE"}}]}}