{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T04:17:06Z","timestamp":1769573826625,"version":"3.49.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Surg Oncol"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Many adrenal tumors are deemed radiologically indeterminate and surgically removed. Adrenal tissue, like parathyroid glands, exhibits near-infrared autofluorescence (NIRAF) properties. This study was designed to investigate the potential of NIRAF to differentiate benign versus malignant adrenal tumors.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Patients undergoing adrenalectomy between October 2021 and May 2023 were prospectively studied. Adrenalectomy specimens were inspected with NIRAF imaging. Specimen autofluorescence (AF) characteristics were recorded. Comparisons were made between different tumor types and a logistic regression model was constructed to differentiate benign versus malignant tumors. A receiver operating characteristic curve was used to identify an optimal AF threshold differentiating benign versus malignant tumors.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 108 adrenal specimens were examined: adrenocortical adenomas\/other benign lesions (<jats:italic>n<\/jats:italic> = 72), pheochromocytomas (<jats:italic>n<\/jats:italic> = 18), adrenocortical neoplasms of uncertain behavior (<jats:italic>n<\/jats:italic> = 4), and malignant tumors (<jats:italic>n<\/jats:italic> = 14). A significant difference in normalized AF intensity was identified when comparing adrenocortical adenomas (3.08 times background) with pheochromocytomas (1.95, <jats:italic>p<\/jats:italic> = 0.001) and malignant tumors (1.11, <jats:italic>p<\/jats:italic> &lt; 0.0001). The Area Under the Curve differentiating benign vs malignant tumors was 0.87, with an\u00a0optimal normalized AF threshold at 1.93.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Different adrenal pathologies exhibit diverse AF properties. These findings suggest a potential intraoperative utility of NIRAF in predicting benign versus malignant nature for radiologically indeterminate adrenal tumors.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1245\/s10434-024-15430-6","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T20:30:09Z","timestamp":1716841809000},"page":"5122-5127","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Comparison of Near-Infrared Autofluorescence Findings in Benign Versus Malignant Adrenal Tumors"],"prefix":"10.1245","volume":"31","author":[{"given":"Panagiotis","family":"Bletsis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ege","family":"Akgun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Romero-Velez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anibal","family":"La Riva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1964-9286","authenticated-orcid":false,"given":"Eren","family":"Berber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,5,27]]},"reference":[{"issue":"11","key":"15430_CR1","doi-asserted-by":"publisher","first-page":"3331","DOI":"10.1210\/clinem\/dgab512","volume":"106","author":"I Bancos","year":"2021","unstructured":"Bancos I, Prete A. Approach to the patient with adrenal incidentaloma. J Clin Endocrinol Metab. 2021;106(11):3331\u201353.","journal-title":"J Clin Endocrinol Metab."},{"issue":"10","key":"15430_CR2","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1001\/jamasurg.2022.3544","volume":"157","author":"L Yip","year":"2022","unstructured":"Yip L, Duh QY, Wachtel H, Jimenez C, et al. American Association of Endocrine Surgeons guidelines for adrenalectomy: executive summary. JAMA Surg. 2022;157(10):870\u20137.","journal-title":"JAMA Surg."},{"issue":"2","key":"15430_CR3","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s00423-011-0845-0","volume":"397","author":"B Harrison","year":"2012","unstructured":"Harrison B. The indeterminate adrenal mass. 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The authors are accountable for all aspects of the study and ensure accuracy and integrity of the data presented.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}