{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T22:14:31Z","timestamp":1774908871385,"version":"3.50.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100031022","name":"Center for Cancer Research","doi-asserted-by":"publisher","award":["P30CA016672"],"award-info":[{"award-number":["P30CA016672"]}],"id":[{"id":"10.13039\/100031022","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Surg Oncol"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1245\/s10434-024-16370-x","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T19:06:53Z","timestamp":1731092813000},"page":"1021-1032","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["CEA Rebound After Discontinuation of Pre-Hepatectomy Chemotherapy Predicts Worse Outcomes After Resection of Colorectal Cancer Liver Metastases"],"prefix":"10.1245","volume":"32","author":[{"given":"Antony","family":"Haddad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mateo","family":"Lendoire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhineet","family":"Uppal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harufumi","family":"Maki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Folkert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reed I.","family":"Ayabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy E.","family":"Newhook","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun Shin","family":"Chun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Wei D.","family":"Tzeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Nicolas","family":"Vauthey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8612-8272","authenticated-orcid":false,"given":"Hop S.","family":"Tran Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"issue":"3","key":"16370_CR1","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s11605-021-05110-1","volume":"26","author":"Y Kawaguchi","year":"2022","unstructured":"Kawaguchi Y, Kopetz S, Panettieri E, et al. Improved survival over time after resection of colorectal liver metastases and clinical impact of multigene alteration testing in patients with metastatic colorectal cancer. J Gastrointest Surg. 2022;26(3):583\u201393.","journal-title":"J Gastrointest Surg."},{"issue":"1","key":"16370_CR2","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/s41698-023-00353-4","volume":"7","author":"FA Zeineddine","year":"2023","unstructured":"Zeineddine FA, Zeineddine MA, Yousef A, et al. Survival improvement for patients with metastatic colorectal cancer over twenty\u00a0year. NPJ Precis Oncol. 2023;7(1):16\u20138.","journal-title":"NPJ Precis Oncol."},{"issue":"8","key":"16370_CR3","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1200\/JCO.2010.32.6132","volume":"29","author":"A Brouquet","year":"2011","unstructured":"Brouquet A, Abdalla EK, Kopetz S, et al. High survival rate after two-stage resection of advanced colorectal liver metastases: response-based selection and complete resection define outcome. J Clin Oncol. 2011;29(8):1083\u201390.","journal-title":"J Clin Oncol."},{"issue":"1","key":"16370_CR4","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1097\/SLA.0000000000001194","volume":"263","author":"Y Mise","year":"2016","unstructured":"Mise Y, Aloia TA, Brudvik KW, Schwarz L, Vauthey JN, Conrad C. Parenchymal-sparing hepatectomy in colorectal liver metastasis improves salvageability and survival. Ann Surg. 2016;263(1):146\u201352.","journal-title":"Ann Surg."},{"key":"16370_CR5","doi-asserted-by":"crossref","unstructured":"Chun YS, Vauthey JN. Local therapy for colorectal liver metastases: establishing today\u2019s level of evidence and defining tomorrow\u2019s roadmap. J Natl Cancer Inst. 2017;109(9).","DOI":"10.1093\/jnci\/djx018"},{"issue":"6","key":"16370_CR6","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1245\/s10434-018-6439-0","volume":"25","author":"E Simoneau","year":"2018","unstructured":"Simoneau E, Vauthey JN. Progression of colorectal cancer liver metastasis after chemotherapy: a new test of time? Ann Surg Oncol. 2018;25(6):1469\u201370.","journal-title":"Ann Surg Oncol."},{"key":"16370_CR7","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1016\/j.gassur.2024.05.002","volume":"28","author":"M Lendoire","year":"2024","unstructured":"Lendoire M, Maki H, Haddad A, et al. Exceptional pathologic response to preoperative therapy in the context of mutational profiling for colorectal liver metastases. J Gastrointest Surg. 2024;28:1181\u20134.","journal-title":"J Gastrointest Surg."},{"issue":"1","key":"16370_CR8","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1097\/SLA.0000000000002319","volume":"269","author":"KW Brudvik","year":"2019","unstructured":"Brudvik KW, Jones RP, Giuliante F, et al. RAS mutation clinical risk score to predict survival after resection of colorectal liver metastases. Ann Surg. 2019;269(1):120\u20136.","journal-title":"Ann Surg."},{"issue":"2","key":"16370_CR9","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.jamcollsurg.2021.05.027","volume":"233","author":"Y Kawaguchi","year":"2021","unstructured":"Kawaguchi Y, Kopetz S, Kwong L, et al. Genomic sequencing and insight into clinical heterogeneity and prognostic pathway genes in patients with metastatic colorectal cancer. J Am Coll Surg. 2021;233(2):272-284e213.","journal-title":"J Am Coll Surg."},{"issue":"19","key":"16370_CR10","doi-asserted-by":"publisher","first-page":"5843","DOI":"10.1158\/1078-0432.CCR-19-0863","volume":"25","author":"Y Kawaguchi","year":"2019","unstructured":"Kawaguchi Y, Kopetz S, Newhook TE, et al. Mutation status of RAS, TP53, and SMAD4 is superior to mutation status of RAS alone for predicting prognosis after resection of colorectal liver metastases. Clin Cancer Res. 2019;25(19):5843\u201351.","journal-title":"Clin Cancer Res."},{"issue":"3","key":"16370_CR11","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1084\/jem.122.3.467","volume":"122","author":"P Gold","year":"1965","unstructured":"Gold P, Freedman SO. Specific carcinoembryonic antigens of the human digestive system. J Exp Med. 1965;122(3):467\u201381.","journal-title":"J Exp Med."},{"issue":"3","key":"16370_CR12","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1084\/jem.121.3.439","volume":"121","author":"P Gold","year":"1965","unstructured":"Gold P, Freedman SO. Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. J Exp Med. 1965;121(3):439\u201362.","journal-title":"J Exp Med."},{"issue":"8","key":"16370_CR13","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1001\/jama.1993.03510080047030","volume":"270","author":"CG Moertel","year":"1993","unstructured":"Moertel CG, Fleming TR, Macdonald JS, Haller DG, Laurie JA, Tangen C. An evaluation of the carcinoembryonic antigen (CEA) test for monitoring patients with resected colon cancer. JAMA. 1993;270(8):943\u20137.","journal-title":"JAMA."},{"issue":"3","key":"16370_CR14","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1002\/1097-0142(19860801)58:3<603::AID-CNCR2820580302>3.0.CO;2-K","volume":"58","author":"CG Moertel","year":"1986","unstructured":"Moertel CG, O\u2019Fallon JR, Go VL, O\u2019Connell MJ, Thynne GS. The preoperative carcinoembryonic antigen test in the diagnosis, staging, and prognosis of colorectal cancer. Cancer. 1986;58(3):603\u201310.","journal-title":"Cancer."},{"issue":"12","key":"16370_CR15","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1016\/j.hpb.2016.09.004","volume":"18","author":"K Sasaki","year":"2016","unstructured":"Sasaki K, Margonis GA, Andreatos N, et al. Pre-hepatectomy carcinoembryonic antigen (CEA) levels among patients undergoing resection of colorectal liver metastases: do CEA levels still have prognostic implications? HPB (Oxford). 2016;18(12):1000\u20139.","journal-title":"HPB (Oxford)."},{"issue":"13","key":"16370_CR16","doi-asserted-by":"publisher","first-page":"8385","DOI":"10.1245\/s10434-022-12301-w","volume":"29","author":"K Yoshino","year":"2022","unstructured":"Yoshino K, Osumi H, Ito H, et al. Clinical usefulness of postoperative serum carcinoembryonic antigen in patients with colorectal cancer with liver metastases. Ann Surg Oncol. 2022;29(13):8385\u201393.","journal-title":"Ann Surg Oncol."},{"issue":"12","key":"16370_CR17","doi-asserted-by":"publisher","first-page":"2890","DOI":"10.4240\/wjgs.v15.i12.2890","volume":"15","author":"F Tang","year":"2023","unstructured":"Tang F, Huang CW, Tang ZH, et al. Prognostic role of serum carcinoembryonic antigen in patients receiving liver resection for colorectal cancer liver metastasis: A meta-analysis. World J Gastrointest Surg. 2023;15(12):2890\u2013906.","journal-title":"World J Gastrointest Surg."},{"issue":"9","key":"16370_CR18","doi-asserted-by":"publisher","first-page":"3087","DOI":"10.1245\/s10434-014-4358-2","volume":"22","author":"RL Araujo","year":"2015","unstructured":"Araujo RL, Gonen M, Allen P, et al. Positive postoperative CEA is a strong predictor of recurrence for patients after resection for colorectal liver metastases. Ann Surg Oncol. 2015;22(9):3087\u201393.","journal-title":"Ann Surg Oncol."},{"issue":"4","key":"16370_CR19","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1002\/jso.24152","volume":"113","author":"T Takamoto","year":"2016","unstructured":"Takamoto T, Sugawara Y, Hashimoto T, et al. Dynamic assessment of carcinoembryonic antigen in the first\u00a0month after liver resection for colorectal liver metastases as a rapid-recurrence predictor. J Surg Oncol. 2016;113(4):463\u20138.","journal-title":"J Surg Oncol."},{"issue":"3","key":"16370_CR20","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1001\/jama.2013.285718","volume":"311","author":"JN Primrose","year":"2014","unstructured":"Primrose JN, Perera R, Gray A, et al. Effect of 3 to 5\u00a0years of scheduled CEA and CT follow-up to detect recurrence of colorectal cancer: the FACS randomized clinical trial. JAMA. 2014;311(3):263\u201370.","journal-title":"JAMA."},{"issue":"35","key":"16370_CR21","doi-asserted-by":"publisher","first-page":"4465","DOI":"10.1200\/JCO.2013.50.7442","volume":"31","author":"JA Meyerhardt","year":"2013","unstructured":"Meyerhardt JA, Mangu PB, Flynn PJ, et al. Follow-up care, surveillance protocol, and secondary prevention measures for survivors of colorectal cancer: American Society of Clinical Oncology clinical practice guideline endorsement. J Clin Oncol. 2013;31(35):4465\u201370.","journal-title":"J Clin Oncol."},{"issue":"3","key":"16370_CR22","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.jamcollsurg.2019.04.027","volume":"229","author":"Y Kawaguchi","year":"2019","unstructured":"Kawaguchi Y, Lillemoe HA, Panettieri E, et al. Conditional recurrence-free survival after resection of colorectal liver metastases: persistent deleterious association with RAS and TP53 co-mutation. J Am Coll Surg. 2019;229(3):286-294e281.","journal-title":"J Am Coll Surg."},{"issue":"3","key":"16370_CR23","doi-asserted-by":"publisher","first-page":"e99","DOI":"10.1016\/S1470-2045(24)00039-1","volume":"25","author":"A Haddad","year":"2024","unstructured":"Haddad A, Lendoire M, Paolucci I, Kang HC, Vauthey JN. Optimal imaging before local therapy of colorectal liver metastases. Lancet Oncol. 2024;25(3):e99.","journal-title":"Lancet Oncol."},{"issue":"17","key":"16370_CR24","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1056\/NEJMoa0804385","volume":"359","author":"CS Karapetis","year":"2008","unstructured":"Karapetis CS, Khambata-Ford S, Jonker DJ, et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med. 2008;359(17):1757\u201365.","journal-title":"N Engl J Med."},{"issue":"4","key":"16370_CR25","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1097\/SLA.0b013e3181b674df","volume":"250","author":"Y Kishi","year":"2009","unstructured":"Kishi Y, Abdalla EK, Chun YS, et al. Three hundred and one consecutive extended right hepatectomies: evaluation of outcome based on systematic liver volumetry. Ann Surg. 2009;250(4):540\u20138.","journal-title":"Ann Surg."},{"key":"16370_CR26","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/j.gassur.2024.02.020","volume":"28","author":"A Haddad","year":"2024","unstructured":"Haddad A, Lendoire M, Maki H, et al. Liver volumetry and liver-regenerative interventions: history, rationale, and emerging tools. J Gastrointest Surg. 2024;28:766\u201375.","journal-title":"J Gastrointest Surg."},{"issue":"4","key":"16370_CR27","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1002\/ags3.12689","volume":"7","author":"H Maki","year":"2023","unstructured":"Maki H, Jain AJ, Haddad A, Lendoire M, Chun YS, Vauthey JN. Locoregional treatment for colorectal liver metastases aiming for precision medicine. Ann Gastroenterol Surg. 2023;7(4):543\u201352.","journal-title":"Ann Gastroenterol Surg."},{"key":"16370_CR28","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1097\/XCS.0000000000001108","volume":"239","author":"A Haddad","year":"2024","unstructured":"Haddad A, Odisio BC, Vauthey JN. Should patients with colorectal liver metastases undergo ablation? J Am Coll Surg. 2024;239:285\u20137.","journal-title":"J Am Coll Surg."},{"issue":"9","key":"16370_CR29","doi-asserted-by":"publisher","first-page":"5390","DOI":"10.1245\/s10434-023-13656-4","volume":"30","author":"H Maki","year":"2023","unstructured":"Maki H, Ayabe RI, Nishioka Y, et al. Hepatectomy before primary tumor resection as preferred approach for synchronous liver metastases from rectal cancer. Ann Surg Oncol. 2023;30(9):5390\u2013400.","journal-title":"Ann Surg Oncol."},{"issue":"11","key":"16370_CR30","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.6004\/jnccn.2020.7596","volume":"18","author":"Y Kawaguchi","year":"2020","unstructured":"Kawaguchi Y, Kopetz S, Lillemoe HA, et al. A new surveillance algorithm after resection of colorectal liver metastases based on changes in recurrence risk and RAS mutation status. J Natl Compr Canc Netw. 2020;18(11):1500\u20138.","journal-title":"J Natl Compr Canc Netw."},{"issue":"4","key":"16370_CR31","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1007\/s11605-021-05173-0","volume":"26","author":"Y Nishioka","year":"2022","unstructured":"Nishioka Y, Paez-Arango N, Boettcher FO, et al. Neither surgical margin status nor somatic mutation predicts local recurrence after R0-intent resection for colorectal liver metastases. J Gastrointest Surg. 2022;26(4):791\u2013801.","journal-title":"J Gastrointest Surg."},{"key":"16370_CR32","doi-asserted-by":"crossref","unstructured":"Amin MB, Greene FL, Edge SB, et al. The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population-based to a more \u201cpersonalized\u201d approach to cancer staging. CA Cancer J Clin. Mar 2017;67(2):93-99.","DOI":"10.3322\/caac.21388"},{"issue":"33","key":"16370_CR33","doi-asserted-by":"publisher","first-page":"5344","DOI":"10.1200\/JCO.2008.17.5299","volume":"26","author":"DG Blazer 3rd","year":"2008","unstructured":"Blazer DG 3rd, Kishi Y, Maru DM, et al. Pathologic response to preoperative chemotherapy: a new outcome end point after resection of hepatic colorectal metastases. J Clin Oncol. 2008;26(33):5344\u201351.","journal-title":"J Clin Oncol."},{"issue":"11","key":"16370_CR34","doi-asserted-by":"publisher","first-page":"2597","DOI":"10.1007\/s11605-023-05759-w","volume":"27","author":"H Maki","year":"2023","unstructured":"Maki H, Haddad A, Ayabe RI, et al. TP53 alteration and its effect on pathologic response are associated with survival after resection of colorectal liver metastases. J Gastrointest Surg. 2023;27(11):2597\u2013600.","journal-title":"J Gastrointest Surg."},{"issue":"3","key":"16370_CR35","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1001\/jamaoncol.2017.4420","volume":"4","author":"T Konishi","year":"2018","unstructured":"Konishi T, Shimada Y, Hsu M, et al. Association of preoperative and postoperative serum carcinoembryonic antigen and colon cancer outcome. JAMA Oncol. 2018;4(3):309\u201315.","journal-title":"JAMA Oncol."},{"issue":"8","key":"16370_CR36","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1001\/jamasurg.2015.0871","volume":"150","author":"P Thirunavukarasu","year":"2015","unstructured":"Thirunavukarasu P, Talati C, Munjal S, Attwood K, Edge SB, Francescutti V. Effect of incorporation of pretreatment serum carcinoembryonic antigen levels into AJCc staging for colon cancer on 5-year survival. JAMA Surg. 2015;150(8):747\u201355.","journal-title":"JAMA Surg."},{"issue":"3","key":"16370_CR37","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/S1470-2045(19)30798-3","volume":"21","author":"JA Bridgewater","year":"2020","unstructured":"Bridgewater JA, Pugh SA, Maishman T, et al. Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis (New EPOC): long-term results of a multicentre, randomised, controlled, phase 3 trial. Lancet Oncol. 2020;21(3):398\u2013411.","journal-title":"Lancet Oncol."},{"issue":"6","key":"16370_CR38","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1245\/s10434-018-6387-8","volume":"25","author":"L Vigano","year":"2018","unstructured":"Vigano L, Darwish SS, Rimassa L, et al. Progression of colorectal liver metastases from the end of chemotherapy to resection: a new contraindication to surgery? Ann Surg Oncol. 2018;25(6):1676\u201385.","journal-title":"Ann Surg Oncol."},{"key":"16370_CR39","doi-asserted-by":"crossref","unstructured":"Boyev A, Tzeng CD, Maki H, et al. Local therapy improves survival for early recurrence after resection of colorectal liver metastases. Ann Surg Oncol. Dec 27 2023.","DOI":"10.1016\/j.hpb.2023.05.039"},{"issue":"12","key":"16370_CR40","doi-asserted-by":"publisher","first-page":"2503","DOI":"10.1007\/s11605-022-05456-0","volume":"26","author":"E Panettieri","year":"2022","unstructured":"Panettieri E, Kim BJ, Kawaguchi Y, et al. Survival by number and sites of resections of recurrence after first curative resection of colorectal liver metastases. J Gastrointest Surg. 2022;26(12):2503\u201311.","journal-title":"J Gastrointest Surg."}],"container-title":["Annals of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-024-16370-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1245\/s10434-024-16370-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-024-16370-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T17:04:42Z","timestamp":1735923882000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1245\/s10434-024-16370-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,8]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["16370"],"URL":"https:\/\/doi.org\/10.1245\/s10434-024-16370-x","relation":{},"ISSN":["1068-9265","1534-4681"],"issn-type":[{"value":"1068-9265","type":"print"},{"value":"1534-4681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,8]]},"assertion":[{"value":"23 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors have no conflict of interest to disclose. The authors are willing to make their data, analytical methods, and study materials available to other researchers upon reasonable request, including relevant ethical and legal statements, to the corresponding author.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Discolsure"}}]}}