{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:31:10Z","timestamp":1791873070952,"version":"4.3.4"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003790","name":"Hiroshima University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003790","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Surg Oncol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Although segmentectomy is less invasive than lobectomy, little is known about the effect of these procedures on postoperative outcomes of patients with low muscle mass. This study examined the postoperative prognosis of patients with non-small cell lung cancer according to the surgical procedure type and preoperative muscle mass.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>This study retrospectively reviewed data of patients who underwent lobectomy or segmentectomy for early-stage non-small cell lung cancer with ground glass opacity-dominant tumor up to 3\u00a0cm in size or solid-dominant tumor up to 2\u00a0cm in size between 2010 and 2020. The preoperative muscle mass was evaluated based on the height-adjusted erector spinae muscle mass on preoperative chest computed tomography images. The overall survival was compared between patients with low and high muscle mass in the lobectomy and segmentectomy groups. Multivariable analyses were performed to identify prognostic factors for overall survival.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The study enrolled 371 patients: 162 in the lobectomy group and 209 in the segmentectomy group. The 5-year overall survival was significantly poorer for the patients with low muscle mass than for those with high muscle mass in the lobectomy group (83.9 % vs. 91.9 %; <jats:italic>p<\/jats:italic> = 0.018), whereas no significant difference was observed in the segmentectomy group (93.5 % vs. 94.9 %; <jats:italic>p =<\/jats:italic> 0.54). In the several multivariable models, low muscle mass was an independent prognostic factor in the lobectomy group (hazard ratio [HR], range, 2.3\u22122.4; <jats:italic>p<\/jats:italic> value range, 0.027\u22120.042) but not in the segmentectomy group (HR range, 1.6\u22122.0; <jats:italic>p<\/jats:italic> value range, 0.19\u22120.36).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Segmentectomy should be actively considered for patients with low muscle mass because of its lower invasiveness.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1245\/s10434-024-16384-5","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T17:14:16Z","timestamp":1745514856000},"page":"4660-4669","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prognostic Benefit of Segmentectomy for Patients with Low Muscle Mass in Early-Stage Lung Cancer"],"prefix":"10.1245","volume":"32","author":[{"given":"Daisuke","family":"Ueda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Mimae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Kamigaichi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norifumi","family":"Tsubokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Miyata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morihito","family":"Okada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,24]]},"reference":[{"key":"16384_CR1","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1056\/NEJMoa2212083","volume":"388","author":"N Altorki","year":"2023","unstructured":"Altorki N, Wang X, Kozono D, et al. Lobar or sublobar resection for peripheral stage IA non-small-cell lung cancer. N Engl J Med. 2023;388:489\u201398.","journal-title":"N Engl J Med."},{"key":"16384_CR2","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/S2213-2600(23)00041-3","volume":"11","author":"K Aokage","year":"2023","unstructured":"Aokage K, Suzuki K, Saji H, et al. Segmentectomy for ground-glass-dominant lung cancer with a tumour diameter of 3 cm or less including ground-glass opacity (JCOG1211): a multicentre, single-arm, confirmatory, phase 3 trial. Lancet Respir Med. 2023;11:540\u20139.","journal-title":"Lancet Respir Med."},{"key":"16384_CR3","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1093\/icvts\/ivac028","volume":"34","author":"A Kagimoto","year":"2022","unstructured":"Kagimoto A, Tsutani Y, Mimae T, Miyata Y, Okada M. Segmentectomy versus wedge resection for radiological solid predominant and low metabolic non-small cell lung cancer. Interact Cardiovasc Thorac Surg. 2022;34:814\u201321.","journal-title":"Interact Cardiovasc Thorac Surg."},{"key":"16384_CR4","doi-asserted-by":"publisher","first-page":"e224","DOI":"10.1016\/j.cllc.2020.10.021","volume":"22","author":"Y Handa","year":"2021","unstructured":"Handa Y, Tsutani Y, Mimae T, Miyata Y, Okada M. Surgical procedure selection for stage I lung cancer: complex segmentectomy versus wedge resection. Clin Lung Cancer. 2021;22:e224\u201333.","journal-title":"Clin Lung Cancer."},{"key":"16384_CR5","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1016\/S0140-6736(21)02333-3","volume":"399","author":"H Saji","year":"2022","unstructured":"Saji H, Okada M, Tsuboi M, et al. Segmentectomy versus lobectomy in small-sized peripheral non-small-cell lung cancer (JCOG0802\/WJOG4607L): a multicentre, open-label, phase 3, randomised, controlled, non-inferiority trial. Lancet. 2022;399:1607\u201317.","journal-title":"Lancet."},{"key":"16384_CR6","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1093\/ageing\/afy169","volume":"48","author":"AJ Cruz-Jentoft","year":"2019","unstructured":"Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48:16\u201331.","journal-title":"Age Ageing."},{"key":"16384_CR7","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.jtcvs.2020.10.133","volume":"163","author":"C Sun","year":"2022","unstructured":"Sun C, Anraku M, Kawahara T, et al. Respiratory strength and pectoralis muscle mass as measures of sarcopenia: relation to outcomes in resected non-small cell lung cancer. J Thorac Cardiovasc Surg. 2022;163:779-787.e2.","journal-title":"J Thorac Cardiovasc Surg."},{"key":"16384_CR8","doi-asserted-by":"publisher","first-page":"ezac510","DOI":"10.1093\/ejcts\/ezac510","volume":"63","author":"D Ueda","year":"2022","unstructured":"Ueda D, Tsutani Y, Kamigaichi A, et al. Impact of the amount of preoperative erector spinae muscle in stage I non-small-cell lung cancer. Eur J Cardiothorac Surg. 2022;63:ezac510.","journal-title":"Eur J Cardiothorac Surg."},{"key":"16384_CR9","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s00421-011-1952-x","volume":"112","author":"T Ikezoe","year":"2012","unstructured":"Ikezoe T, Mori N, Nakamura M, Ichihashi N. Effects of age and inactivity due to prolonged bed rest on atrophy of trunk muscles. Eur J Appl Physiol. 2012;112:43\u20138.","journal-title":"Eur J Appl Physiol."},{"key":"16384_CR10","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.cllc.2019.06.004","volume":"20","author":"A Kamigaichi","year":"2019","unstructured":"Kamigaichi A, Tsutani Y, Fujiwara M, Mimae T, Miyata Y, Okada M. Postoperative recurrence and survival after segmentectomy for clinical stage 0 or IA lung cancer. Clin Lung Cancer. 2019;20:397-403.e1.","journal-title":"Clin Lung Cancer."},{"key":"16384_CR11","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.1200\/JCO.2013.53.4115","volume":"32","author":"HC Fernando","year":"2014","unstructured":"Fernando HC, Landreneau RJ, Mandrekar SJ, et al. Impact of brachytherapy on local recurrence rates after sublobar resection: results from ACOSOG Z4032 (Alliance), a phase III randomized trial for high-risk operable non-small-cell lung cancer. J Clin Oncol. 2014;32:2456\u201362.","journal-title":"J Clin Oncol."},{"key":"16384_CR12","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1097\/JTO.0000000000000630","volume":"10","author":"WD Travis","year":"2015","unstructured":"Travis WD, Brambilla E, Nicholson AG, et al. The 2015 World Health Organization classification of lung tumors: impact of genetic, clinical and radiologic advances since the 2004 classification. J Thorac Oncol. 2015;10:1243\u201360.","journal-title":"J Thorac Oncol."},{"key":"16384_CR13","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.jtho.2015.09.009","volume":"11","author":"P Goldstraw","year":"2016","unstructured":"Goldstraw P, Chansky K, Crowley J, et al. The IASLC lung cancer staging project: proposals for revision of the TNM stage groupings in the forthcoming (eighth) edition of the TNM classification for lung cancer. J Thorac Oncol. 2016;11:39\u201351.","journal-title":"J Thorac Oncol."},{"key":"16384_CR14","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.1007\/s00259-010-1490-5","volume":"37","author":"SF Barrington","year":"2010","unstructured":"Barrington SF, Qian W, Somer EJ, et al. Concordance between four European centres of PET reporting criteria designed for use in multicentre trials in Hodgkin lymphoma. Eur J Nucl Med Mol Imaging. 2010;37:1824\u201333.","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"16384_CR15","doi-asserted-by":"publisher","first-page":"2068","DOI":"10.1245\/s10434-020-09150-w","volume":"28","author":"A Kagimoto","year":"2021","unstructured":"Kagimoto A, Tsutani Y, Handa Y, Mimae T, Miyata Y, Okada M. Patient selection of sublobar resection using visual evaluation of positron-emission tomography (PET) for early-stage lung adenocarcinoma. Ann Surg Oncol. 2021;28:2068\u201375.","journal-title":"Ann Surg Oncol."},{"key":"16384_CR16","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1513\/AnnalsATS.201507-446OC","volume":"13","author":"K Tanimura","year":"2016","unstructured":"Tanimura K, Sato S, Fuseya Y, et al. Quantitative assessment of erector spinae muscles in patients with chronic obstructive pulmonary disease: novel chest computed tomography-derived index for prognosis. Ann Am Thorac Soc. 2016;13:334\u201341.","journal-title":"Ann Am Thorac Soc."},{"key":"16384_CR17","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/bmt.2012.244","volume":"48","author":"Y Kanda","year":"2013","unstructured":"Kanda Y. Investigation of the freely available easy-to-use software \u201cEZR\u201d for medical statistics. Bone Marrow Transplant. 2013;48:452\u20138.","journal-title":"Bone Marrow Transplant."},{"key":"16384_CR18","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1093\/jjco\/hyab122","volume":"51","author":"T Mimae","year":"2021","unstructured":"Mimae T, Miyata Y, Yoshimura K, et al. Risk of death due to other causes is lower among octogenarians with non-small cell lung cancer after wedge resection than lobectomy\/segmentectomy. Jpn J Clin Oncol. 2021;51:1561\u20139.","journal-title":"Jpn J Clin Oncol."},{"key":"16384_CR19","doi-asserted-by":"publisher","first-page":"ezac458","DOI":"10.1093\/ejcts\/ezac458","volume":"63","author":"T Isaka","year":"2022","unstructured":"Isaka T, Ito H, Yokose T, et al. Impact of segmentectomy and lobectomy on non-lung cancer death in early-stage lung cancer patients. Eur J Cardiothorac Surg. 2022;63:ezac458.","journal-title":"Eur J Cardiothorac Surg."},{"key":"16384_CR20","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.1245\/s10434-020-08224-z","volume":"27","author":"S Shinohara","year":"2020","unstructured":"Shinohara S, Otsuki R, Kobayashi K, Sugaya M, Matsuo M, Nakagawa M. Impact of sarcopenia on surgical outcomes in non-small cell lung cancer. Ann Surg Oncol. 2020;27:2427\u201335.","journal-title":"Ann Surg Oncol."},{"key":"16384_CR21","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1016\/j.athoracsur.2019.05.052","volume":"108","author":"S Tane","year":"2019","unstructured":"Tane S, Nishio W, Nishioka Y, et al. Evaluation of the residual lung function after thoracoscopic segmentectomy compared with lobectomy. Ann Thorac Surg. 2019;108:1543\u201350.","journal-title":"Ann Thorac Surg."},{"key":"16384_CR22","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/j.ejcts.2007.07.033","volume":"32","author":"F Venuta","year":"2007","unstructured":"Venuta F, Sciomer S, Andreetti C, et al. Long-term Doppler echocardiographic evaluation of the right heart after major lung resections. Eur J Cardiothorac Surg. 2007;32:787\u201390.","journal-title":"Eur J Cardiothorac Surg."},{"key":"16384_CR23","doi-asserted-by":"publisher","first-page":"afac003","DOI":"10.1093\/ageing\/afac003","volume":"51","author":"C Hurst","year":"2022","unstructured":"Hurst C, Robinson SM, Witham MD, et al. Resistance exercise as a treatment for sarcopenia: prescription and delivery. Age Ageing. 2022;51:afac003.","journal-title":"Age Ageing."}],"container-title":["Annals of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-024-16384-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1245\/s10434-024-16384-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-024-16384-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T12:58:13Z","timestamp":1748869093000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1245\/s10434-024-16384-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,24]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["16384"],"URL":"https:\/\/doi.org\/10.1245\/s10434-024-16384-5","relation":{},"ISSN":["1068-9265","1534-4681"],"issn-type":[{"value":"1068-9265","type":"print"},{"value":"1534-4681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,24]]},"assertion":[{"value":"28 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"There are no conflicts of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure"}}]}}