{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T15:09:31Z","timestamp":1769008171169,"version":"3.49.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["5T32CA009599-33"],"award-info":[{"award-number":["5T32CA009599-33"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Surg Oncol"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1245\/s10434-024-16800-w","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T17:49:05Z","timestamp":1736444945000},"page":"2883-2890","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Surgical Margins and Oncologic Outcomes Following Wedge Resection of Pulmonary Metastases in Pediatric and Young Adult Patients with Sarcoma"],"prefix":"10.1245","volume":"32","author":[{"given":"Naveen","family":"Manisundaram","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mecklin V.","family":"Ragan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Mayon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ara","family":"Vaporciyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary T.","family":"Austin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,9]]},"reference":[{"key":"16800_CR1","unstructured":"SEER*Explorer: an interactive website for SEER cancer statistics [Internet]. Surveillance Research Program, National Cancer Institute; 2023 Apr 19. [Updated: 2023 Jun 8; cited 2023 Nov 3]. Available from: https:\/\/seer.cancer.gov\/statistics-network\/explorer\/. Data source(s): SEER Incidence Data, November 2022 Submission (1975-2020), SEER 22 registries."},{"issue":"2","key":"16800_CR2","doi-asserted-by":"publisher","first-page":"155","DOI":"10.6004\/jnccn.2017.0017","volume":"15","author":"JS Biermann","year":"2017","unstructured":"Biermann JS, Chow W, Reed DR, et al. NCCN guidelines insights: bone cancer, version 2.2017. J Natl Compr Cancer Netw. 2017;15(2):155\u201367.","journal-title":"J Natl Compr Cancer Netw."},{"issue":"1","key":"16800_CR3","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s40744-016-0050-2","volume":"4","author":"BA Lindsey","year":"2017","unstructured":"Lindsey BA, Markel JE, Kleinerman ES. Osteosarcoma overview. Rheumatol Ther. 2017;4(1):25\u201343. https:\/\/doi.org\/10.1007\/s40744-016-0050-2.","journal-title":"Rheumatol Ther."},{"issue":"4","key":"16800_CR4","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1097\/CCO.0b013e328303ba1d","volume":"20","author":"JA Ludwig","year":"2008","unstructured":"Ludwig JA. Ewing sarcoma: historical perspectives, current state-of-the-art, and opportunities for targeted therapy in the future. Curr Opin Oncol. 2008;20(4):412\u20138. https:\/\/doi.org\/10.1097\/CCO.0b013e328303ba1d.","journal-title":"Curr Opin Oncol."},{"key":"16800_CR5","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-1-4419-0284-9_1","volume":"152","author":"G Ottaviani","year":"2009","unstructured":"Ottaviani G, Jaffe N. The epidemiology of osteosarcoma. Cancer Treat Res. 2009;152:3\u201313. https:\/\/doi.org\/10.1007\/978-1-4419-0284-9_1.","journal-title":"Cancer Treat Res."},{"issue":"1","key":"16800_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.canlet.2006.12.009","volume":"254","author":"N Riggi","year":"2007","unstructured":"Riggi N, Stamenkovic I. The Biology of Ewing sarcoma. Cancer Lett. 2007;254(1):1\u201310. https:\/\/doi.org\/10.1016\/j.canlet.2006.12.009.","journal-title":"Cancer Lett."},{"key":"16800_CR7","doi-asserted-by":"publisher","first-page":"2279","DOI":"10.2147\/OTT.S170585","volume":"12","author":"D Van Mater","year":"2019","unstructured":"Van Mater D, Wagner L. Management of recurrent Ewing sarcoma: challenges and approaches. Onco Targets Ther. 2019;12:2279\u201388. https:\/\/doi.org\/10.2147\/OTT.S170585.","journal-title":"Onco Targets Ther."},{"issue":"5","key":"16800_CR8","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1634\/theoncologist.11-5-503","volume":"11","author":"M Bernstein","year":"2006","unstructured":"Bernstein M, Kovar H, Paulussen M, et al. Ewing\u2019s sarcoma family of tumors: current management. Oncologist. 2006;11(5):503\u201319. https:\/\/doi.org\/10.1634\/theoncologist.11-5-503.","journal-title":"Oncologist."},{"issue":"1\u20132","key":"16800_CR9","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1007\/s11864-009-0104-6","volume":"10","author":"V Subbiah","year":"2009","unstructured":"Subbiah V, Anderson P, Lazar AJ, Burdett E, Raymond K, Ludwig JA. Ewing\u2019s sarcoma: standard and experimental treatment options. Curr Treat Options Oncol. 2009;10(1\u20132):126\u201340. https:\/\/doi.org\/10.1007\/s11864-009-0104-6.","journal-title":"Curr Treat Options Oncol."},{"issue":"1\u20132","key":"16800_CR10","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1007\/s11864-009-0087-3","volume":"10","author":"N Federman","year":"2009","unstructured":"Federman N, Bernthal N, Eilber FC, Tap WD. The multidisciplinary management of osteosarcoma. Curr Treat Options Oncol. 2009;10(1\u20132):82\u201393. https:\/\/doi.org\/10.1007\/s11864-009-0087-3.","journal-title":"Curr Treat Options Oncol."},{"issue":"3","key":"16800_CR11","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1200\/JCO.2005.04.063","volume":"23","author":"B Kempf-Bielack","year":"2005","unstructured":"Kempf-Bielack B, Bielack SS, J\u00fcrgens H, et al. Osteosarcoma relapse after combined modality therapy: an analysis of unselected patients in the Cooperative Osteosarcoma study group (COSS). J Clin Oncol. 2005;23(3):559\u201368. https:\/\/doi.org\/10.1200\/JCO.2005.04.063.","journal-title":"J Clin Oncol."},{"issue":"6","key":"16800_CR12","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1016\/s0022-3468(81)80848-2","volume":"16","author":"MT Han","year":"1981","unstructured":"Han MT, Telander RL, Pairolero PC, et al. Aggressive thoracotomy for pulmonary metastatic osteogenic sarcoma in children and young adolescents. J Pediatr Surg. 1981;16(6):928\u201333. https:\/\/doi.org\/10.1016\/s0022-3468(81)80848-2.","journal-title":"J Pediatr Surg."},{"issue":"17","key":"16800_CR13","doi-asserted-by":"publisher","first-page":"3108","DOI":"10.1200\/JCO.2000.18.17.3108","volume":"18","author":"SJ Cotterill","year":"2000","unstructured":"Cotterill SJ, Ahrens S, Paulussen M, et al. Prognostic factors in Ewing\u2019s tumor of bone: analysis of 975 patients from the European intergroup cooperative Ewing\u2019s sarcoma study group. J Clin Oncol. 2000;18(17):3108\u201314. https:\/\/doi.org\/10.1200\/JCO.2000.18.17.3108.","journal-title":"J Clin Oncol."},{"issue":"1","key":"16800_CR14","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/s41572-022-00409-y","volume":"8","author":"HC Beird","year":"2022","unstructured":"Beird HC, Bielack SS, Flanagan AM, et al. Osteosarcoma. Nat Rev Dis Primers. 2022;8(1):77. https:\/\/doi.org\/10.1038\/s41572-022-00409-y.","journal-title":"Nat Rev Dis Primers."},{"issue":"4","key":"16800_CR15","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.soc.2016.05.005","volume":"25","author":"CS Digesu","year":"2016","unstructured":"Digesu CS, Wiesel O, Vaporciyan AA, Colson YL. Management of sarcoma metastases to the lung. Surg Oncol Clin N Am. 2016;25(4):721\u201333. https:\/\/doi.org\/10.1016\/j.soc.2016.05.005.","journal-title":"Surg Oncol Clin N Am."},{"issue":"1","key":"16800_CR16","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.jpedsurg.2005.10.089","volume":"41","author":"MT Harting","year":"2006","unstructured":"Harting MT, Blakely ML, Jaffe N, et al. Long-term survival after aggressive resection of pulmonary metastases among children and adolescents with osteosarcoma. J Pediatr Surg. 2006;41(1):194\u20139. https:\/\/doi.org\/10.1016\/j.jpedsurg.2005.10.089.","journal-title":"J Pediatr Surg."},{"issue":"2","key":"16800_CR17","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.jpedsurg.2010.11.013","volume":"46","author":"PA Letourneau","year":"2011","unstructured":"Letourneau PA, Shackett B, Xiao L, et al. Resection of pulmonary metastases in pediatric patients with Ewing sarcoma improves survival. J Pediatr Surg. 2011;46(2):332\u20135. https:\/\/doi.org\/10.1016\/j.jpedsurg.2010.11.013.","journal-title":"J Pediatr Surg."},{"key":"16800_CR18","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.12659\/MSM.913338","volume":"25","author":"Y Ren","year":"2019","unstructured":"Ren Y, Zhang Z, Shang L, You X. Surgical resection of primary Ewing\u2019s sarcoma of bone improves overall survival in patients presenting with metastasis. Med Sci Monit. 2019;25:1254\u201362. https:\/\/doi.org\/10.12659\/MSM.913338.","journal-title":"Med Sci Monit."},{"issue":"5","key":"16800_CR19","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.21037\/tcr-22-2459","volume":"12","author":"T Liu","year":"2023","unstructured":"Liu T, Lv X, Yang L, Yang Z, Jia C, Chen H. Surgical resection of primary tumors improves survival in patients with lung metastases: a population-based SEER analysis. Transl Cancer Res. 2023;12(5):1128\u201344. https:\/\/doi.org\/10.21037\/tcr-22-2459.","journal-title":"Transl Cancer Res."},{"issue":"4","key":"16800_CR20","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.1016\/j.jtcvs.2018.10.156","volume":"157","author":"DB Nelson","year":"2019","unstructured":"Nelson DB, Tayob N, Mitchell KG, et al. Surgical margins and risk of local recurrence after wedge resection of colorectal pulmonary metastases. J Thorac Cardiovasc Surg. 2019;157(4):1648\u201355. https:\/\/doi.org\/10.1016\/j.jtcvs.2018.10.156.","journal-title":"J Thorac Cardiovasc Surg."},{"issue":"9596","key":"16800_CR21","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","volume":"370","author":"E von Elm","year":"2007","unstructured":"von Elm E, Altman DG, Egger M, Pocock SJ, G\u00f8tzsche PC, Vandenbroucke JP. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet. 2007;370(9596):1453\u20137. https:\/\/doi.org\/10.1016\/S0140-6736(07)61602-X.","journal-title":"Lancet."},{"issue":"2","key":"16800_CR22","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","volume":"240","author":"D Dindo","year":"2004","unstructured":"Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240(2):205\u201313. https:\/\/doi.org\/10.1097\/01.sla.0000133083.54934.ae.","journal-title":"Ann Surg."},{"issue":"8","key":"16800_CR23","doi-asserted-by":"publisher","first-page":"3369","DOI":"10.21037\/jtd.2019.08.10","volume":"11","author":"W Dudek","year":"2019","unstructured":"Dudek W, Schreiner W, Mykoliuk I, Higaze M, Sirbu H. Pulmonary metastasectomy for sarcoma-survival and prognostic analysis. J Thorac Dis. 2019;11(8):3369\u201376. https:\/\/doi.org\/10.21037\/jtd.2019.08.10.","journal-title":"J Thorac Dis."},{"issue":"7","key":"16800_CR24","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1007\/s10147-019-01422-0","volume":"24","author":"Y Yamamoto","year":"2019","unstructured":"Yamamoto Y, Kanzaki R, Kanou T, et al. Long-term outcomes and prognostic factors of pulmonary metastasectomy for osteosarcoma and soft tissue sarcoma. Int J Clin Oncol. 2019;24(7):863\u201370. https:\/\/doi.org\/10.1007\/s10147-019-01422-0.","journal-title":"Int J Clin Oncol."},{"issue":"1","key":"16800_CR25","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1177\/03008916211053048","volume":"109","author":"U Pastorino","year":"2023","unstructured":"Pastorino U, Palmerini E, Porcu L, et al. Lung metastasectomy for osteosarcoma in children, adolescents, and young adults: proof of permanent cure. Tumori J. 2023;109(1):79\u201385. https:\/\/doi.org\/10.1177\/03008916211053048.","journal-title":"Tumori J."},{"issue":"9","key":"16800_CR26","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1200\/JCO.1994.12.9.1849","volume":"12","author":"WG Ward","year":"1994","unstructured":"Ward WG, Mikaelian K, Dorey F, et al. Pulmonary metastases of stage IIB extremity osteosarcoma and subsequent pulmonary metastases. J Clin Oncol. 1994;12(9):1849\u201358. https:\/\/doi.org\/10.1200\/JCO.1994.12.9.1849.","journal-title":"J Clin Oncol."},{"issue":"6","key":"16800_CR27","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.3390\/cancers15061733","volume":"15","author":"MA Smolle","year":"2023","unstructured":"Smolle MA, Kogler A, Andreou D, et al. Prognostic impact of pulmonary metastasectomy in bone sarcoma patients: a retrospective, single-centre study. Cancers (Basel). 2023;15(6):1733. https:\/\/doi.org\/10.3390\/cancers15061733.","journal-title":"Cancers (Basel)."},{"issue":"2","key":"16800_CR28","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1055\/s-0035-1546430","volume":"64","author":"L Okiror","year":"2016","unstructured":"Okiror L, Peleki A, Moffat D, et al. Survival following pulmonary metastasectomy for sarcoma. Thorac Cardiovasc Surg. 2016;64(2):146\u20139. https:\/\/doi.org\/10.1055\/s-0035-1546430.","journal-title":"Thorac Cardiovasc Surg."},{"issue":"8","key":"16800_CR29","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1055\/s-0038-1670688","volume":"67","author":"A \u00d6zdil","year":"2019","unstructured":"\u00d6zdil A, Tekneci AK, D\u00f6k\u00fcmc\u00fc Z, et al. Pulmonary metastasectomy of sarcoma: is the ratio of surgical margin to nodule size a prognostic factor? Thorac Cardiovasc Surg. 2019;67(8):675\u201382. https:\/\/doi.org\/10.1055\/s-0038-1670688.","journal-title":"Thorac Cardiovasc Surg."},{"issue":"6","key":"16800_CR30","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1007\/s11748-020-01560-7","volume":"69","author":"S Shiono","year":"2021","unstructured":"Shiono S, Matsutani N, Hashimoto H, et al. Prospective study of recurrence at the surgical margin after wedge resection of pulmonary metastases. Gen Thorac Cardiovasc Surg. 2021;69(6):950\u20139. https:\/\/doi.org\/10.1007\/s11748-020-01560-7.","journal-title":"Gen Thorac Cardiovasc Surg."},{"issue":"4","key":"16800_CR31","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1016\/j.jtcvs.2013.11.056","volume":"147","author":"K Mohiuddin","year":"2014","unstructured":"Mohiuddin K, Haneuse S, Sofer T, et al. Relationship between margin distance and local recurrence among patients undergoing wedge resection for small (\u2264 2 cm) non\u2013small cell lung cancer. J Thorac Cardiovasc Surg. 2014;147(4):1169\u201377. https:\/\/doi.org\/10.1016\/j.jtcvs.2013.11.056.","journal-title":"J Thorac Cardiovasc Surg."},{"issue":"4","key":"16800_CR32","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1016\/j.athoracsur.2017.04.024","volume":"104","author":"AS Wolf","year":"2017","unstructured":"Wolf AS, Swanson SJ, Yip R, et al. The impact of margins on outcomes after wedge resection for stage I non-small cell lung cancer. Ann Thorac Surg. 2017;104(4):1171\u20138. https:\/\/doi.org\/10.1016\/j.athoracsur.2017.04.024.","journal-title":"Ann Thorac Surg."},{"issue":"5","key":"16800_CR33","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1002\/ijc.33264","volume":"148","author":"TB Lautz","year":"2021","unstructured":"Lautz TB, Farooqui Z, Jenkins T, et al. Thoracoscopy versus thoracotomy for the management of metastatic osteosarcoma: a pediatric surgical oncology research collaborative study. Int J Cancer. 2021;148(5):1164\u201371. https:\/\/doi.org\/10.1002\/ijc.33264.","journal-title":"Int J Cancer."}],"container-title":["Annals of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-024-16800-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1245\/s10434-024-16800-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-024-16800-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T17:28:55Z","timestamp":1741195735000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1245\/s10434-024-16800-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,9]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["16800"],"URL":"https:\/\/doi.org\/10.1245\/s10434-024-16800-w","relation":{},"ISSN":["1068-9265","1534-4681"],"issn-type":[{"value":"1068-9265","type":"print"},{"value":"1534-4681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,9]]},"assertion":[{"value":"22 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors have no conflicts of interest to report. This study has not been previously presented or published.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}